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Year Number of Results
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Page 1
International Consensus Classification of acute lymphoblastic leukemia/lymphoma.
Duffield AS, Mullighan CG, Borowitz MJ. Duffield AS, et al. Virchows Arch. 2023 Jan;482(1):11-26. doi: 10.1007/s00428-022-03448-8. Epub 2022 Nov 24. Virchows Arch. 2023. PMID: 36422706 Free PMC article. Review.
Four provisional entities are also included in the updated B-ALL classification, although definitive identification of these subtypes requires GEX studies. T-ALL classification is also updated to incorporate BCL11B-activating rearrangements into early T-precursor (ETP) ALL …
Four provisional entities are also included in the updated B-ALL classification, although definitive identification of these subtypes requir …
T-Cell Acute Lymphoblastic Leukemia: Biomarkers and Their Clinical Usefulness.
Bardelli V, Arniani S, Pierini V, Di Giacomo D, Pierini T, Gorello P, Mecucci C, La Starza R. Bardelli V, et al. Genes (Basel). 2021 Jul 23;12(8):1118. doi: 10.3390/genes12081118. Genes (Basel). 2021. PMID: 34440292 Free PMC article. Review.
Hence, TAL and/or LMO deregulation is typical of T-ALL with a mature phenotype (sCD3 positive) that of TLX1, NKX2-1, or TLX3, of cortical T-ALL (CD1a positive); HOXA and MEF2C are instead over-expressed in subsets of Early T-cell Precursor (ETP; immature phenotype) and early T-AL …
Hence, TAL and/or LMO deregulation is typical of T-ALL with a mature phenotype (sCD3 positive) that of TLX1, NKX2-1, or TLX3, of cortical T- …
Emerging molecular subtypes and therapies in acute lymphoblastic leukemia.
Davis K, Sheikh T, Aggarwal N. Davis K, et al. Semin Diagn Pathol. 2023 May;40(3):202-215. doi: 10.1053/j.semdp.2023.04.003. Epub 2023 Apr 9. Semin Diagn Pathol. 2023. PMID: 37120350 Review.
This increased diagnostic and therapeutic complexity can be overwhelming, and this review compares nomenclature differences between the ICC and WHO 5th edition publications, compiles key features of each entity, and provides a diagnostic algorithmic approach. ...It was cla …
This increased diagnostic and therapeutic complexity can be overwhelming, and this review compares nomenclature differences between t …
The role of transcription factors in shaping regulatory T cell identity.
Trujillo-Ochoa JL, Kazemian M, Afzali B. Trujillo-Ochoa JL, et al. Nat Rev Immunol. 2023 Dec;23(12):842-856. doi: 10.1038/s41577-023-00893-7. Epub 2023 Jun 19. Nat Rev Immunol. 2023. PMID: 37336954 Review.
Indeed, the heterogeneity of T(reg) cells can be at least partially attributed to differential expression of transcription factors that fine-tune their trafficking, survival and functional properties, some of which are niche-specific. In this Review, we discuss the emergin …
Indeed, the heterogeneity of T(reg) cells can be at least partially attributed to differential expression of transcription factors that fine …
Transcriptional control of ILC identity.
Korchagina AA, Shein SA, Koroleva E, Tumanov AV. Korchagina AA, et al. Front Immunol. 2023 Mar 9;14:1146077. doi: 10.3389/fimmu.2023.1146077. eCollection 2023. Front Immunol. 2023. PMID: 36969171 Free PMC article. Review.
Accumulating evidence suggests that the plasticity and the maintenance of ILC identity is controlled by a balance between these and additional transcription factors such as STATs, Batf, Ikaros, Runx3, c-Maf, Bcl11b, and Zbtb46, activated in response to lineage-guiding cyto …
Accumulating evidence suggests that the plasticity and the maintenance of ILC identity is controlled by a balance between these and addition …
Interventions for Neurocognitive Dysfunction.
Ellero J, Lubomski M, Brew B. Ellero J, et al. Curr HIV/AIDS Rep. 2017 Feb;14(1):8-16. doi: 10.1007/s11904-017-0346-z. Curr HIV/AIDS Rep. 2017. PMID: 28110422 Review.
PURPOSE OF REVIEW: This study aimed to evaluate current barriers to HIV cure strategies and interventions for neurocognitive dysfunction with a particular focus on recent advancements over the last 3 years. RECENT FINDINGS: Optimal anti-retroviral therapy (ART) poses chall …
PURPOSE OF REVIEW: This study aimed to evaluate current barriers to HIV cure strategies and interventions for neurocognitive dysfunct …
Bcl11b/Ctip2 in Skin, Tooth, and Craniofacial System.
Daher MT, Bausero P, Agbulut O, Li Z, Parlakian A. Daher MT, et al. Front Cell Dev Biol. 2020 Dec 10;8:581674. doi: 10.3389/fcell.2020.581674. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 33363142 Free PMC article. Review.
Ctip2/Bcl11b is a zinc finger transcription factor with dual action (repression/activation) that couples epigenetic regulation to gene transcription during the development of various tissues. ...The impact of mutations in the coding sequences of Bcl11b on the develo …
Ctip2/Bcl11b is a zinc finger transcription factor with dual action (repression/activation) that couples epigenetic regulation to gen …
Role of the transcription factor Bcl11b in development and lymphomagenesis.
Kominami R. Kominami R. Proc Jpn Acad Ser B Phys Biol Sci. 2012;88(3):72-87. doi: 10.2183/pjab.88.72. Proc Jpn Acad Ser B Phys Biol Sci. 2012. PMID: 22450536 Free PMC article. Review.
On the other hand, Bcl11b is a haploinsufficient tumor suppressor and loss of a Bcl11b allele provides susceptibility to mouse thymic lymphoma and human T-cell acute lymphoblastic leukemia. Although there are many transcription factors affecting both cell differenti …
On the other hand, Bcl11b is a haploinsufficient tumor suppressor and loss of a Bcl11b allele provides susceptibility to mouse …
Biologic and Therapeutic Implications of Genomic Alterations in Acute Lymphoblastic Leukemia.
Iacobucci I, Kimura S, Mullighan CG. Iacobucci I, et al. J Clin Med. 2021 Aug 25;10(17):3792. doi: 10.3390/jcm10173792. J Clin Med. 2021. PMID: 34501239 Free PMC article. Review.
., those with rearrangements of MEF2D, DUX4, NUTM1, ZNF384 and BCL11B; the PAX5 P80R and IKZF1 N159Y mutations; and genomic phenocopies such as Ph-like ALL) and the genomic basis of disease evolution. These advances have been complemented by the development of novel therap …
., those with rearrangements of MEF2D, DUX4, NUTM1, ZNF384 and BCL11B; the PAX5 P80R and IKZF1 N159Y mutations; and genomic phenocopi …
Bcl11b-A Critical Neurodevelopmental Transcription Factor-Roles in Health and Disease.
Lennon MJ, Jones SP, Lovelace MD, Guillemin GJ, Brew BJ. Lennon MJ, et al. Front Cell Neurosci. 2017 Mar 29;11:89. doi: 10.3389/fncel.2017.00089. eCollection 2017. Front Cell Neurosci. 2017. PMID: 28424591 Free PMC article. Review.
B cell leukemia 11b (Bcl11b) is a zinc finger protein transcription factor with a multiplicity of functions. ...This review summarizes the current literature on Bcl11b and its functions in development, health, and disease as well as future directions for rese …
B cell leukemia 11b (Bcl11b) is a zinc finger protein transcription factor with a multiplicity of functions. ...This review su …
49 results