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Page 1
Updates on eosinophilic disorders.
Tzankov A, Reichard KK, Hasserjian RP, Arber DA, Orazi A, Wang SA. Tzankov A, et al. Virchows Arch. 2023 Jan;482(1):85-97. doi: 10.1007/s00428-022-03402-8. Epub 2022 Sep 7. Virchows Arch. 2023. PMID: 36068374 Review.
This review addresses changes and updates in eosinophilic disorders under the International Consensus Classification (ICC). ...Two new members, M/LN-eo with ETV6::ABL1 fusion and M/LN-eo with various FLT3 fusions, have been added to the category; and M/LN-eo with PCM1::JAK …
This review addresses changes and updates in eosinophilic disorders under the International Consensus Classification (ICC). ...Two ne …
Optical Genome Mapping Helps to Identify BCR::JAK2 Rearrangement Arising from Cryptic Complex Chromosomal Aberrations: A Case Report and Literature Review.
Vanjari N, Tang G, Toruner GA, Wang W, Thakral B, Zhao M, Dave BJ, Khoury JD, Medeiros LJ, Tang Z. Vanjari N, et al. Genes (Basel). 2023 Dec 8;14(12):2188. doi: 10.3390/genes14122188. Genes (Basel). 2023. PMID: 38137010 Free PMC article. Review.
Optical genome mapping (OGM) analysis confirmed BCR::JAK2 derived through an inv(9)(p24p13) after a t(9;22)(p13;q11.2) in this case. ...We also reviewed all cases with BCR::JAK2 rearrangement reported in the literature. In conclusion, a suspected t(9;2 …
Optical genome mapping (OGM) analysis confirmed BCR::JAK2 derived through an inv(9)(p24p13) after a t(9;22)(p13;q11.2) in this …
Should myeloid and lymphoid neoplasms with PCM1-JAK2 and other rearrangements of JAK2 be recognized as specific entities?
Bain BJ, Ahmad S. Bain BJ, et al. Br J Haematol. 2014 Sep;166(6):809-17. doi: 10.1111/bjh.12963. Epub 2014 Jun 10. Br J Haematol. 2014. PMID: 24913195 Free article. Review.
Furthermore, lymphoid and myeloid neoplasms associated respectively with t(9;12)(p24;p13); ETV6-JAK2 and with t(9;22)(p24;q11.2); BCR-JAK2 should be documented carefully in order to define their features more clearly and assess whether they can be recognized as enti …
Furthermore, lymphoid and myeloid neoplasms associated respectively with t(9;12)(p24;p13); ETV6-JAK2 and with t(9;22)(p24;q11.2); BCR …
Myelodysplastic syndrome with t(9;22)(p24;q11.2), a BCR-JAK2 fusion: case report and review of the literature.
Kantarcioglu B, Kaygusuz-Atagunduz I, Uzay A, Toptas T, Tuglular TF, Bayik M. Kantarcioglu B, et al. Int J Hematol. 2015 Sep;102(3):383-7. doi: 10.1007/s12185-015-1792-2. Epub 2015 Apr 2. Int J Hematol. 2015. PMID: 25833723 Review.
Here we report a t(9;22)(p24;q11.2) translocation, in a MDS patient and review results associated with BCR-JAK2 fusion reported in the literature....
Here we report a t(9;22)(p24;q11.2) translocation, in a MDS patient and review results associated with BCR-JAK2 fusion …
JAK and MPL mutations in myeloid malignancies.
Tefferi A. Tefferi A. Leuk Lymphoma. 2008 Mar;49(3):388-97. doi: 10.1080/10428190801895360. Leuk Lymphoma. 2008. PMID: 18297515 Review.
JAK3A572V, JAK3V722I, JAK3P132T) and fusion JAK2 (e.g. ETV6-JAK2, PCM1-JAK2, BCR-JAK2) mutations have respectively been described in acute megakaryocytic leukemia and acute leukemia/chronic myeloid malignancies. ...
JAK3A572V, JAK3V722I, JAK3P132T) and fusion JAK2 (e.g. ETV6-JAK2, PCM1-JAK2, BCR-JAK2) mutations have respectively been descri …
JAK/STAT signal transduction: regulators and implication in hematological malignancies.
Valentino L, Pierre J. Valentino L, et al. Biochem Pharmacol. 2006 Mar 14;71(6):713-21. doi: 10.1016/j.bcp.2005.12.017. Epub 2006 Jan 19. Biochem Pharmacol. 2006. PMID: 16426581 Review.
Fusion proteins implicating the JH1 domain of JAK2 (TEL-JAK2, BCR-JAK2), leading to deregulated activity of JAK2, have been described as the result of translocation. ...
Fusion proteins implicating the JH1 domain of JAK2 (TEL-JAK2, BCR-JAK2), leading to deregulated activity of JAK2, have been de …
BCR-JAK2 fusion in a myeloproliferative neoplasm with associated eosinophilia.
He R, Greipp PT, Rangan A, Mai M, Chen D, Reichard KK, Nelsen LL, Pardanani A, Hanson CA, Viswanatha DS. He R, et al. Cancer Genet. 2016 May;209(5):223-8. doi: 10.1016/j.cancergen.2016.03.002. Epub 2016 Apr 6. Cancer Genet. 2016. PMID: 27134074
Our results, together with literature review, reveal BCR-JAK2 fusions as oncogenic genetic alterations that are associated with myeloid or lymphoid neoplasms and are frequently characterized by eosinophilia. Further, patients with BCR-JAK2 are c …
Our results, together with literature review, reveal BCR-JAK2 fusions as oncogenic genetic alterations that are associa …
A BCR-JAK2 fusion gene as the result of a t(9;22)(p24;q11.2) translocation in a patient with a clinically typical chronic myeloid leukemia.
Griesinger F, Hennig H, Hillmer F, Podleschny M, Steffens R, Pies A, Wörmann B, Haase D, Bohlander SK. Griesinger F, et al. Genes Chromosomes Cancer. 2005 Nov;44(3):329-33. doi: 10.1002/gcc.20235. Genes Chromosomes Cancer. 2005. PMID: 16001431 Review.
By means of a candidate gene approach, the JAK2 gene, at 9p24, was identified as the fusion partner of BCR in this case. The BCR-JAK2 fusion protein contains the coiled-coil dimerization domain of BCR and the protein tyrosine kinase domain (JH1) of JAK2. The patient …
By means of a candidate gene approach, the JAK2 gene, at 9p24, was identified as the fusion partner of BCR in this case. The BCR-J …
Chronic Myeloid Leukemia as Secondary Malignancy Following the Treatment of Hodgkin Lymphoma: A Case Series.
Millett R, Aggarwal A, Tabbara I, Nassereddine S. Millett R, et al. Anticancer Res. 2019 Aug;39(8):4333-4335. doi: 10.21873/anticanres.13600. Anticancer Res. 2019. PMID: 31366526
More rarely, chronic myeloid leukemias (CML) may arise subsequent to treatment of a primary malignancy. Literature review on such developments following treatment of Hodgkin's Lymphoma (HL) is scant. Herein, the authors present three cases of CML diagnosed within five year …
More rarely, chronic myeloid leukemias (CML) may arise subsequent to treatment of a primary malignancy. Literature review on such dev …