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Year Number of Results
2016 1
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23 results

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Page 1
Bola3 Regulates Beige Adipocyte Thermogenesis via Maintaining Mitochondrial Homeostasis and Lipolysis.
Bai N, Ma J, Alimujiang M, Xu J, Hu F, Xu Y, Leng Q, Chen S, Li X, Han J, Jia W, Bao Y, Yang Y. Bai N, et al. Front Endocrinol (Lausanne). 2021 Jan 11;11:592154. doi: 10.3389/fendo.2020.592154. eCollection 2020. Front Endocrinol (Lausanne). 2021. PMID: 33505355 Free PMC article.
Here, we identified BolA family member 3 (Bola3), as one of 17 mitochondrial Fe-S cluster assembly genes, was the most significant induced gene in the browning program of white adipose tissue. Using lentiviral-delivered shRNA in vitro, we determined that Bola3 defic …
Here, we identified BolA family member 3 (Bola3), as one of 17 mitochondrial Fe-S cluster assembly genes, was the most significant in …
Engineered bacterial lipoate protein ligase A (lplA) restores lipoylation in cell models of lipoylation deficiency.
Bick NR, Dreishpoon MB, Perry A, Rogachevskaya A, Bottomley SS, Fleming MD, Ducamp S, Tsvetkov P. Bick NR, et al. J Biol Chem. 2024 Dec;300(12):107995. doi: 10.1016/j.jbc.2024.107995. Epub 2024 Nov 14. J Biol Chem. 2024. PMID: 39547509 Free PMC article.
Engineered lplA restored lipoylation in all tested lipoylation null cell models, mimicking defects in mitochondrial fatty acid synthesis (MECR KO), Fe-S cluster biosynthesis (BOLA3 KO), and specific lipoylation-regulating enzymes (FDX1 [ferredoxin 1], LIAS [lipoyl synthase …
Engineered lplA restored lipoylation in all tested lipoylation null cell models, mimicking defects in mitochondrial fatty acid synthesis (ME …
Dysregulated inclusion of BOLA3 exon 3 promoted by HNRNPC accelerates the progression of esophageal squamous cell carcinoma.
Tian B, Bian Y, Pang Y, Gao Y, Yu C, Zhang X, Zhou S, Li Z, Xin L, Lin H, Wang L. Tian B, et al. Front Med. 2024 Dec;18(6):1035-1053. doi: 10.1007/s11684-024-1068-4. Epub 2024 Oct 26. Front Med. 2024. PMID: 39455467
Here, we unveiled a novel alternative splicing axis of BOLA3 transcripts and its regulator HNRNPC in ESCC. The long-form BOLA3 (BOLA3-L) containing exon 3 exhibited high expression levels in ESCC and was associated with poor prognosis. Functional assays demon …
Here, we unveiled a novel alternative splicing axis of BOLA3 transcripts and its regulator HNRNPC in ESCC. The long-form BOLA3 …
Biochemical impact of a disease-causing Ile67Asn substitution on BOLA3 protein.
Sen S, Thompson Z, Wachnowsky C, Cleary S, Harvey SR, Cowan JA. Sen S, et al. Metallomics. 2021 Apr 14;13(4):mfab010. doi: 10.1093/mtomcs/mfab010. Metallomics. 2021. PMID: 33693876 Free PMC article.
Herein, we investigate the effect of Ile67Asn substitution in the BOLA3 protein that results in the MMDS2 phenotype. Although the exact functional role of BOLA3 in Fe-S cluster biosynthesis is not known, the [2Fe-2S]-bridged complex of BOLA3 with GLRX5, anoth …
Herein, we investigate the effect of Ile67Asn substitution in the BOLA3 protein that results in the MMDS2 phenotype. Although the exa …
BOLA (BolA Family Member 3) Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension.
Yu Q, Tai YY, Tang Y, Zhao J, Negi V, Culley MK, Pilli J, Sun W, Brugger K, Mayr J, Saggar R, Saggar R, Wallace WD, Ross DJ, Waxman AB, Wendell SG, Mullett SJ, Sembrat J, Rojas M, Khan OF, Dahlman JE, Sugahara M, Kagiyama N, Satoh T, Zhang M, Feng N, Gorcsan J 3rd, Vargas SO, Haley KJ, Kumar R, Graham BB, Langer R, Anderson DG, Wang B, Shiva S, Bertero T, Chan SY. Yu Q, et al. Circulation. 2019 May 7;139(19):2238-2255. doi: 10.1161/CIRCULATIONAHA.118.035889. Circulation. 2019. PMID: 30759996 Free PMC article.
The mechanistic role of BOLA3 in PH remains undefined. METHODS: In vitro assessment of BOLA3 regulation and gain- and loss-of-function assays were performed in human pulmonary artery endothelial cells using siRNA and lentiviral vectors expressing the mitochondrial i …
The mechanistic role of BOLA3 in PH remains undefined. METHODS: In vitro assessment of BOLA3 regulation and gain- and loss-of- …
Hinokitiol preferentially suppresses metastatic lung adenocarcinoma via TMDD1-mediated ferroptosis induction and iron-sulfur cluster inhibition.
Kuang Y, Yang S, Tian X, Cheng H, Liu B, Zhang C, Han B, Zhang W, Zhang X, Lou Y. Kuang Y, et al. Cancer Lett. 2025 Dec 1;634:218046. doi: 10.1016/j.canlet.2025.218046. Epub 2025 Sep 18. Cancer Lett. 2025. PMID: 40975161
Here, we demonstrate that ISC biogenesis is significantly upregulated in LUAD, driven by transcription factors KLF15 and ZNF384, which activate GLRX5, LYRM4, NFS1 and BOLA3 promoters. IL-1beta promotes PCAF mitochondrial translocation, releasing EP300 to amplify KLF15/ZNF3 …
Here, we demonstrate that ISC biogenesis is significantly upregulated in LUAD, driven by transcription factors KLF15 and ZNF384, which activ …
BOLA family genes are the drivers and potential biomarkers of survival in kidney renal clear cell carcinoma patients.
Alissa M, Alghamdi A, Alghamdi SA, Alshehri MA, Alsuwat MA, Allahyani M, Alkhathami AG. Alissa M, et al. Saudi Med J. 2024 Nov;45(11):1207-1218. doi: 10.15537/smj.2024.45.11.20240604. Saudi Med J. 2024. PMID: 39510574 Free PMC article.
Kaplan-Meier plotter data revealed that high BOLA1, BOLA2, and BOLA3 expression correlated with shorter overall survival and relapse-free survival in KIRC. Tumor-immune system interactions database analysis linked BOLA1 expression to immune and molecular subtypes. Gene sil …
Kaplan-Meier plotter data revealed that high BOLA1, BOLA2, and BOLA3 expression correlated with shorter overall survival and relapse- …
Molecular Basis of Multiple Mitochondrial Dysfunctions Syndrome 2 Caused by CYS59TYR BOLA3 Mutation.
Saudino G, Suraci D, Nasta V, Ciofi-Baffoni S, Banci L. Saudino G, et al. Int J Mol Sci. 2021 May 3;22(9):4848. doi: 10.3390/ijms22094848. Int J Mol Sci. 2021. PMID: 34063696 Free PMC article.
To do so, we first investigated the structural impact of the Cys59Tyr mutation on BOLA3 by NMR, and then we analyzed how the mutation affects both the formation of a hetero-complex between BOLA3 and its protein partner GLRX5 and the iron-sulfur cluster-binding prope …
To do so, we first investigated the structural impact of the Cys59Tyr mutation on BOLA3 by NMR, and then we analyzed how the mutation …
Understanding the Molecular Basis of the Multiple Mitochondrial Dysfunctions Syndrome 2: The Disease-Causing His96Arg Mutation of BOLA3.
Bargagna B, Banci L, Camponeschi F. Bargagna B, et al. Int J Mol Sci. 2023 Jul 21;24(14):11734. doi: 10.3390/ijms241411734. Int J Mol Sci. 2023. PMID: 37511493 Free PMC article.
To better understand the role of BOLA3 in MMDS2, we have investigated the impact of the p.His96Arg (c.287A > G) point mutation, which involves a highly conserved residue, previously identified as a [2Fe-2S] cluster ligand in the BOLA3-[2Fe-2S]-GLRX5 heterocomplex …
To better understand the role of BOLA3 in MMDS2, we have investigated the impact of the p.His96Arg (c.287A > G) point mutation, wh …
Novel IBA57 mutations in two chinese patients and literature review of multiple mitochondrial dysfunction syndrome.
Zhan F, Liu X, Ni R, Liu T, Cao Y, Wu J, Tian W, Luan X, Cao L. Zhan F, et al. Metab Brain Dis. 2022 Feb;37(2):311-317. doi: 10.1007/s11011-021-00856-8. Epub 2021 Oct 28. Metab Brain Dis. 2022. PMID: 34709542 Review.
So far, six types of MMDS have been identified based on different genotypes, which are caused by mutations in NFU1, BOLA3, IBA57, ISCA2, ISCA1 and PMPCB, respectively. IBA57 encodes a protein involved in the mitochondrial Fe/S cluster assembly process, which plays a vital …
So far, six types of MMDS have been identified based on different genotypes, which are caused by mutations in NFU1, BOLA3, IBA57, ISC …
23 results