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2021 13
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2024 3

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Primary Aldosteronism: Spatial Multiomics Mapping of Genotype-Dependent Heterogeneity and Tumor Expansion of Aldosterone-Producing Adenomas.
Gong S, Sun N, Meyer LS, Tetti M, Koupourtidou C, Krebs S, Masserdotti G, Blum H, Rainey WE, Reincke M, Walch A, Williams TA. Gong S, et al. Hypertension. 2023 Jul;80(7):1555-1567. doi: 10.1161/HYPERTENSIONAHA.123.20921. Epub 2023 May 1. Hypertension. 2023. PMID: 37125608
Common transcriptomic signatures were established across all APA specimens which encompassed 2 distinct transcriptional profiles in CYP11B2-immunopositive regions (CYP11B2-type 1 or 2). The CYP11B2-type 1 signature was characterized by zona glomerulosa gene m …
Common transcriptomic signatures were established across all APA specimens which encompassed 2 distinct transcriptional profiles in CYP11
Update on the Genetics of Primary Aldosteronism and Aldosterone-Producing Adenomas.
Pitsava G, Faucz FR, Stratakis CA, Hannah-Shmouni F. Pitsava G, et al. Curr Cardiol Rep. 2022 Sep;24(9):1189-1195. doi: 10.1007/s11886-022-01735-z. Epub 2022 Jul 16. Curr Cardiol Rep. 2022. PMID: 35841527 Free PMC article. Review.
Some of these genes are found mutated in the germline state (CYP11B2, CLCN2, KCNJ5, CACNA1H, and CACNA1D), leading then to familial hyperaldosteronism, and often BAH rather than single APAs. ...
Some of these genes are found mutated in the germline state (CYP11B2, CLCN2, KCNJ5, CACNA1H, and CACNA1D), leading then to familial h …
Pathology and gene mutations of aldosterone-producing lesions.
Nishimoto K, Ogishima T, Sugiura Y, Suematsu M, Mukai K. Nishimoto K, et al. Endocr J. 2023 Dec 28;70(12):1113-1122. doi: 10.1507/endocrj.EJ22-0492. Epub 2023 Sep 26. Endocr J. 2023. PMID: 37766569 Free article. Review.
The human adrenal cortex secretes aldosterone and cortisol as major corticosteroids. For their production, CYP11B2 and CYP11B1 catalyze the last steps in the syntheses of aldosterone and cortisol, respectively. In our previous study, CYP11B2 was the first successful …
The human adrenal cortex secretes aldosterone and cortisol as major corticosteroids. For their production, CYP11B2 and CYP11B1 cataly …
Histopathology and Genetic Causes of Primary Aldosteronism in Young Adults.
Nanba K, Baker JE, Blinder AR, Bick NR, Liu CJ, Lim JS, Wachtel H, Cohen DL, Williams TA, Reincke M, Lyden ML, Bancos I, Young WF, Else T, Giordano TJ, Udager AM, Rainey WE. Nanba K, et al. J Clin Endocrinol Metab. 2022 Aug 18;107(9):2473-2482. doi: 10.1210/clinem/dgac408. J Clin Endocrinol Metab. 2022. PMID: 35779252 Free PMC article.
METHODS: Formalin-fixed, paraffin-embedded adrenal tissue sections from 74 young patients with lateralized PA (<35 years old) were used for this study. Immunohistochemistry (IHC) for aldosterone synthase (CYP11B2) was performed to define the histopathologic diagnosis. S …
METHODS: Formalin-fixed, paraffin-embedded adrenal tissue sections from 74 young patients with lateralized PA (<35 years old) were used f …
Molecular and Epigenetic Control of Aldosterone Synthase, CYP11B2 and 11-Hydroxylase, CYP11B1.
Takeda Y, Demura M, Kometani M, Karashima S, Yoneda T, Takeda Y. Takeda Y, et al. Int J Mol Sci. 2023 Mar 17;24(6):5782. doi: 10.3390/ijms24065782. Int J Mol Sci. 2023. PMID: 36982850 Free PMC article. Review.
Hypomethylation status of the CYP11B2 promoter region is seen in aldosterone-producing adenomas. ...A methyl-CpG-binding protein 2 cooperates directly with the methylated CpG dinucleotides of CYP11B2. A low-salt diet, treatment with angiotensin II, and potassium inc …
Hypomethylation status of the CYP11B2 promoter region is seen in aldosterone-producing adenomas. ...A methyl-CpG-binding protein 2 co …
Approaches to Gene Mutation Analysis Using Formalin-Fixed Paraffin-Embedded Adrenal Tumor Tissue From Patients With Primary Aldosteronism.
Nanba K, Rainey WE, Udager AM. Nanba K, et al. Front Endocrinol (Lausanne). 2021 Jun 29;12:683588. doi: 10.3389/fendo.2021.683588. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34267727 Free PMC article. Review.
The adrenal's capacity to produce aldosterone relies heavily on the expression of a single enzyme, aldosterone synthase (CYP11B2). This enzyme carries out the final reactions in the synthesis of aldosterone and is expressed almost solely in the adrenal zona glomerulosa. .. …
The adrenal's capacity to produce aldosterone relies heavily on the expression of a single enzyme, aldosterone synthase (CYP11B2). Th …
Clinical Translationality of KCNJ5 Mutation in Aldosterone Producing Adenoma.
Kitamoto T, Nishikawa T. Kitamoto T, et al. Int J Mol Sci. 2022 Aug 12;23(16):9042. doi: 10.3390/ijms23169042. Int J Mol Sci. 2022. PMID: 36012306 Free PMC article. Review.
The discovery of the KCNJ5 somatic mutation in aldosteroene producing adenoma (APA) in 2011 and the development of specific CYP11B2 antibodies in 2012 have greatly advanced our understanding of the pathophysiology of primary aldosteronism. In particular, the presence of …
The discovery of the KCNJ5 somatic mutation in aldosteroene producing adenoma (APA) in 2011 and the development of specific CYP11B2 a …
Effect of ACE, ACE2 and CYP11B2 gene polymorphisms and noise on essential hypertension among steelworkers in China: a case-control study.
Zhang X, Wang Y, Zheng Y, Yuan J, Tong J, Xu J, Li Q, Li P, Jiang S, Wang Z, Chai F, Li X. Zhang X, et al. BMC Med Genomics. 2022 Feb 8;15(1):22. doi: 10.1186/s12920-022-01177-0. BMC Med Genomics. 2022. PMID: 35130889 Free PMC article.
There was a negative additive interaction between ACE2 G8790A and CYP11B2-344T/C on EH (U3 = - 2.221, P = 0.026, and S = 0.128) and a positive multiplicative interaction between ACE I/D and CYP11B2-344T/C on essential hypertension (P = 0.041). ...Simultaneously carr …
There was a negative additive interaction between ACE2 G8790A and CYP11B2-344T/C on EH (U3 = - 2.221, P = 0.026, and S = 0.128) and a …
Genetic determinants of intracranial large artery stenosis in the northern Manhattan study.
Liu M, Sariya S, Khasiyev F, Tosto G, Dueker ND, Cheung YK, Wright CB, Sacco RL, Rundek T, Elkind MSV, Gutierrez J. Liu M, et al. J Neurol Sci. 2022 May 15;436:120218. doi: 10.1016/j.jns.2022.120218. Epub 2022 Mar 3. J Neurol Sci. 2022. PMID: 35259553 Free PMC article.
When participants were further stratified by race/ethnicity, the estimates were consistent for CYP11B2 rs1799998 across race/ethnic groups but not for LPL rs320. CONCLUSION: The CYP11B2 rs1799998 variant may be a protective genetic factor for ILAS across race/ethnic …
When participants were further stratified by race/ethnicity, the estimates were consistent for CYP11B2 rs1799998 across race/ethnic g …
Genetic Risk of Primary Aldosteronism and Its Contribution to Hypertension: A Cross-Ancestry Meta-Analysis of Genome-Wide Association Studies.
Naito T, Inoue K, Sonehara K, Baba R, Kodama T, Otagaki Y, Okada A, Itcho K, Kobuke K, Kishimoto S, Yamamoto K; BioBank Japan; Morisaki T, Higashi Y, Hinata N, Arihiro K, Hattori N, Okada Y, Oki K. Naito T, et al. Circulation. 2023 Apr 4;147(14):1097-1109. doi: 10.1161/CIRCULATIONAHA.122.062349. Epub 2023 Feb 21. Circulation. 2023. PMID: 36802911 Free PMC article.
We further identified 1 nearly genome-wide significant locus (8q24, CYP11B2), which presented a significant association in the gene-based test (P=7.210(-7)). ...
We further identified 1 nearly genome-wide significant locus (8q24, CYP11B2), which presented a significant association in the gene-b …
42 results