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Spatial multiomics atlas reveals smooth muscle phenotypic transformation and metabolic reprogramming in diabetic macroangiopathy.
Qian Y, Xiong S, Li L, Sun Z, Zhang L, Yuan W, Cai H, Feng G, Wang X, Yao H, Gao Y, Guo L, Wang Z. Qian Y, et al. Cardiovasc Diabetol. 2024 Oct 12;23(1):358. doi: 10.1186/s12933-024-02458-x. Cardiovasc Diabetol. 2024. PMID: 39395983 Free PMC article.
In addition, in order to focus on metabolic reprogramming apart from abnormal glucose and lipid metabolism, we constructed a metabolic network of diabetic vascular activation, and found that HNMT and CYP27A1 participate in diabetic vascular metabolic reprogramming by combi …
In addition, in order to focus on metabolic reprogramming apart from abnormal glucose and lipid metabolism, we constructed a metabolic netwo …
TUBB2B facilitates progression of hepatocellular carcinoma by regulating cholesterol metabolism through targeting HNF4A/CYP27A1.
Wang X, Shi J, Huang M, Chen J, Dan J, Tang Y, Guo Z, He X, Zhao Q. Wang X, et al. Cell Death Dis. 2023 Mar 6;14(3):179. doi: 10.1038/s41419-023-05687-2. Cell Death Dis. 2023. PMID: 36872411 Free PMC article.
Mechanistically, TUBB2B induces the expression of CYP27A1, an enzyme responsible for the conversion of cholesterol to 27-hydroxycholesterol, which leads to the up-regulation of cholesterol and the progression of HCC. In addition, TUBB2B regulates CYP27A1 via human h …
Mechanistically, TUBB2B induces the expression of CYP27A1, an enzyme responsible for the conversion of cholesterol to 27-hydroxychole …
Optimization of CYP27A1 recombinant protein expression.
Papa JE, Vaughn LR, Bartholomew-Schoch JL, Stone EK, Culpepper MA, Reddish MJ. Papa JE, et al. Protein Expr Purif. 2025 Sep;233:106748. doi: 10.1016/j.pep.2025.106748. Epub 2025 May 26. Protein Expr Purif. 2025. PMID: 40436227 Free PMC article.
Vitamin D deficiency and genetic polymorphisms of vitamin D-associated genes in Parkinson's disease.
Pal R, Choudhury S, Kumar H, Dey S, Das N, Basu BR. Pal R, et al. Eur J Neurosci. 2023 Sep;58(5):3362-3377. doi: 10.1111/ejn.16098. Epub 2023 Jul 24. Eur J Neurosci. 2023. PMID: 37485791 Review.
Specifically, explicating the effect of VDD and genetic polymorphisms of vitamin D-associated genes in PD, like VDR (vitamin D receptor) or GC (vitamin D binding protein) may aid the process along with polymorphisms of vitamin D metabolising genes (e.g., CYP2R1 and CYP27A1 …
Specifically, explicating the effect of VDD and genetic polymorphisms of vitamin D-associated genes in PD, like VDR (vitamin D receptor) or …
Genetic Heterogeneity of Familial Hypercholesterolemia: Repercussions for Molecular Diagnosis.
Di Taranto MD, Fortunato G. Di Taranto MD, et al. Int J Mol Sci. 2023 Feb 6;24(4):3224. doi: 10.3390/ijms24043224. Int J Mol Sci. 2023. PMID: 36834635 Free PMC article. Review.
In addition, variants in genes causing other dyslipidemias showing phenotypes overlapping with FH may mimic FH in patients without causative variants (FH-phenocopies; ABCG5, ABCG8, CYP27A1 and LIPA genes) or act as phenotype modifiers in patients with a pathogenic variant …
In addition, variants in genes causing other dyslipidemias showing phenotypes overlapping with FH may mimic FH in patients without causative …
Genetic Polymorphism of CYP2R1, CYP27A1, CYP27B1, and Vitamin D Metabolites Plasma Levels in Patients with Cardiovascular Disease: A Pilot Study.
Abouzid M, Kruszyna Ł, Kaczmarek D, Kagan L, Mikulska-Sauermann AA, Filipowicz D, Resztak M, Główka FK, Karaźniewicz-Łada M. Abouzid M, et al. Biomolecules. 2025 May 11;15(5):699. doi: 10.3390/biom15050699. Biomolecules. 2025. PMID: 40427592 Free PMC article.
The active form of vitamin D, calcitriol (1,25(OH)(2)D(3)), is produced from 25(OH)D(3) via enzymes encoded by CYP2R1, CYP27A1, and CYP27B1. Polymorphisms in these genes may alter vitamin D metabolism and increase cardiovascular disease risk. ...Furthermore, the TT genotyp …
The active form of vitamin D, calcitriol (1,25(OH)(2)D(3)), is produced from 25(OH)D(3) via enzymes encoded by CYP2R1, CYP27A1, and C …
A Clinical and Integrated Genetic Study of Isolated and Combined Dystonia in Taiwan.
Wu MC, Chang YY, Lan MY, Chen YF, Tai CH, Lin YF, Tsai SF, Chen PL, Lin CH. Wu MC, et al. J Mol Diagn. 2022 Mar;24(3):262-273. doi: 10.1016/j.jmoldx.2021.12.003. Epub 2022 Jan 15. J Mol Diagn. 2022. PMID: 35041927 Free article.
Genetic causes were identified from single cases in TOR1A, TUBB4A, THAP1, ATP1A3, ANO3, GNAL, KMT2B, SLC6A3, ADCY5, CYP27A1, PANK2, C19orf12, and SPG11. The whole-genome sequencing analysis identified a novel intragenic deletion in OPHN1 in a multiplex family with X-linked …
Genetic causes were identified from single cases in TOR1A, TUBB4A, THAP1, ATP1A3, ANO3, GNAL, KMT2B, SLC6A3, ADCY5, CYP27A1, PANK2, C …
Machine learning developed a macrophage signature for predicting prognosis, immune infiltration and immunotherapy features in head and neck squamous cell carcinoma.
Wang Y, Mou YK, Liu WC, Wang HR, Song XY, Yang T, Ren C, Song XC. Wang Y, et al. Sci Rep. 2024 Aug 22;14(1):19538. doi: 10.1038/s41598-024-70430-6. Sci Rep. 2024. PMID: 39174693 Free PMC article.
A macrophage-related risk signature (MRS) model, comprising nine genes: IGF2BP2, PPP1R14C, SLC7A5, KRT9, RAC2, NTN4, CTLA4, APOC1, and CYP27A1, was formulated by integrating 101 machine learning algorithm combinations. We observed lower overall survival (OS) in the high-ri …
A macrophage-related risk signature (MRS) model, comprising nine genes: IGF2BP2, PPP1R14C, SLC7A5, KRT9, RAC2, NTN4, CTLA4, APOC1, and CY …
Exploring of bladder cancer immune-related genes and potential therapeutic targets based on transcriptomic data and Mendelian randomization analysis.
Xu Z, Yang J, Ma Y, Tao B, He Y, Wu J, Zhao Y, Niu Y, Wang L. Xu Z, et al. Front Immunol. 2025 Jul 18;16:1607098. doi: 10.3389/fimmu.2025.1607098. eCollection 2025. Front Immunol. 2025. PMID: 40755754 Free PMC article.
Eight significantly downregulated genes were identified: LIMS2, TP53INP2, IRAK3, STX2, CYP27A1, IL11RA, KCNMB1, and PDLM7. These genes were significantly associated with immune cell infiltration and exhibited good diagnostic efficacy, as demonstrated by ROC curve analysis …
Eight significantly downregulated genes were identified: LIMS2, TP53INP2, IRAK3, STX2, CYP27A1, IL11RA, KCNMB1, and PDLM7. These gene …
Vitamin D endocrine system in breast cancer.
Linowiecka K, Wolnicka-Głubisz A, Brożyna AA. Linowiecka K, et al. Acta Biochim Pol. 2021 Nov 15;68(4):489-497. doi: 10.18388/abp.2020_5961. Acta Biochim Pol. 2021. PMID: 34851599 Free article. Review.
In order to exert its functions, vitamin D has to be hydroxylated (via CYP27A1 and CYP27B1 hydroxylases), which is followed by its interaction with the vitamin D receptor (VDR) or retinoic acid-related orphan receptors alpha or gamma (RORalpha and RORgamma). ...
In order to exert its functions, vitamin D has to be hydroxylated (via CYP27A1 and CYP27B1 hydroxylases), which is followed by its in …
61 results