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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 1
1974 2
1975 6
1976 2
1977 1
1978 3
1979 4
1980 6
1981 3
1982 5
1983 2
1984 4
1985 6
1986 5
1987 7
1988 7
1989 7
1990 8
1991 19
1992 14
1993 16
1994 20
1995 18
1996 20
1997 21
1998 24
1999 35
2000 33
2001 31
2002 38
2003 28
2004 39
2005 48
2006 51
2007 36
2008 50
2009 54
2010 48
2011 57
2012 50
2013 49
2014 70
2015 72
2016 74
2017 66
2018 83
2019 71
2020 76
2021 35
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1,348 results
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Page 1
Charge Regulation during Amyloid Formation of α-Synuclein.
Pálmadóttir T, Malmendal A, Leiding T, Lund M, Linse S. Pálmadóttir T, et al. Among authors: linse s. J Am Chem Soc. 2021 May 17. doi: 10.1021/jacs.1c01925. Online ahead of print. J Am Chem Soc. 2021. PMID: 33998793
Antibody Affinity Governs the Inhibition of SARS-CoV-2 Spike/ACE2 Binding in Patient Serum.
Fiedler S, Piziorska MA, Denninger V, Morgunov AS, Ilsley A, Malik AY, Schneider MM, Devenish SRA, Meisl G, Kosmoliaptsis V, Aguzzi A, Fiegler H, Knowles TPJ. Fiedler S, et al. Among authors: knowles tpj. ACS Infect Dis. 2021 Apr 20:acsinfecdis.1c00047. doi: 10.1021/acsinfecdis.1c00047. Online ahead of print. ACS Infect Dis. 2021. PMID: 33876632 Free PMC article.
Comparative Studies in the A30P and A53T α-Synuclein C. elegans Strains to Investigate the Molecular Origins of Parkinson's Disease.
Perni M, van der Goot A, Limbocker R, van Ham TJ, Aprile FA, Xu CK, Flagmeier P, Thijssen K, Sormanni P, Fusco G, Chen SW, Challa PK, Kirkegaard JB, Laine RF, Ma KY, Müller MBD, Sinnige T, Kumita JR, Cohen SIA, Seinstra R, Kaminski Schierle GS, Kaminski CF, Barbut D, De Simone A, Knowles TPJ, Zasloff M, Nollen EAA, Vendruscolo M, Dobson CM. Perni M, et al. Among authors: knowles tpj, dobson cm, vendruscolo m. Front Cell Dev Biol. 2021 Mar 22;9:552549. doi: 10.3389/fcell.2021.552549. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 33829010 Free PMC article.
Guest-protein incorporation into solvent channels of a protein host crystal (hostal).
Sprenger J, Carey J, Schulz A, Drouard F, Lawson CL, von Wachenfeldt C, Linse S, Lo Leggio L. Sprenger J, et al. Among authors: linse s. Acta Crystallogr D Struct Biol. 2021 Apr 1;77(Pt 4):471-485. doi: 10.1107/S2059798321001078. Epub 2021 Mar 30. Acta Crystallogr D Struct Biol. 2021. PMID: 33825708 Free PMC article.
Scaling analysis reveals the mechanism and rates of prion replication in vivo.
Meisl G, Kurt T, Condado-Morales I, Bett C, Sorce S, Nuvolone M, Michaels TCT, Heinzer D, Avar M, Cohen SIA, Hornemann S, Aguzzi A, Dobson CM, Sigurdson CJ, Knowles TPJ. Meisl G, et al. Among authors: knowles tpj, dobson cm. Nat Struct Mol Biol. 2021 Apr;28(4):365-372. doi: 10.1038/s41594-021-00565-x. Epub 2021 Mar 25. Nat Struct Mol Biol. 2021. PMID: 33767451
From Protein Building Blocks to Functional Materials.
Shen Y, Levin A, Kamada A, Toprakcioglu Z, Rodriguez-Garcia M, Xu Y, Knowles TPJ. Shen Y, et al. Among authors: knowles tpj. ACS Nano. 2021 Apr 27;15(4):5819-5837. doi: 10.1021/acsnano.0c08510. Epub 2021 Mar 24. ACS Nano. 2021. PMID: 33760579 Review.
Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions.
Krainer G, Welsh TJ, Joseph JA, Espinosa JR, Wittmann S, de Csilléry E, Sridhar A, Toprakcioglu Z, Gudiškytė G, Czekalska MA, Arter WE, Guillén-Boixet J, Franzmann TM, Qamar S, George-Hyslop PS, Hyman AA, Collepardo-Guevara R, Alberti S, Knowles TPJ. Krainer G, et al. Among authors: knowles tpj. Nat Commun. 2021 Feb 17;12(1):1085. doi: 10.1038/s41467-021-21181-9. Nat Commun. 2021. PMID: 33597515 Free PMC article.
One-Step Generation of Multisomes from Lipid-Stabilized Double Emulsions.
Czekalska MA, Jacobs AMJ, Toprakcioglu Z, Kong L, Baumann KN, Gang H, Zubaite G, Ye R, Mu B, Levin A, Huck WTS, Knowles TPJ. Czekalska MA, et al. Among authors: knowles tpj. ACS Appl Mater Interfaces. 2021 Feb 10;13(5):6739-6747. doi: 10.1021/acsami.0c16019. Epub 2021 Feb 1. ACS Appl Mater Interfaces. 2021. PMID: 33522221
The extent of protein hydration dictates the preference for heterogeneous or homogeneous nucleation generating either parallel or antiparallel β-sheet α-synuclein aggregates.
Camino JD, Gracia P, Chen SW, Sot J, de la Arada I, Sebastián V, Arrondo JLR, Goñi FM, Dobson CM, Cremades N. Camino JD, et al. Among authors: dobson cm. Chem Sci. 2020 Oct 15;11(43):11902-11914. doi: 10.1039/d0sc05297c. eCollection 2020 Nov 21. Chem Sci. 2020. PMID: 33520152 Free PMC article.
Publisher Correction: A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers.
Cataldi R, Chia S, Pisani K, Ruggeri FS, Xu CK, Šneideris T, Perni M, Sarwat S, Joshi P, Kumita JR, Linse S, Habchi J, Knowles TPJ, Mannini B, Dobson CM, Vendruscolo M. Cataldi R, et al. Among authors: knowles tpj, dobson cm, linse s, vendruscolo m. Commun Biol. 2021 Jan 26;4(1):154. doi: 10.1038/s42003-021-01680-7. Commun Biol. 2021. PMID: 33500508 Free PMC article. No abstract available.
A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers.
Cataldi R, Chia S, Pisani K, Ruggeri FS, Xu CK, Šneideris T, Perni M, Sarwat S, Joshi P, Kumita JR, Linse S, Habchi J, Knowles TPJ, Mannini B, Dobson CM, Vendruscolo M. Cataldi R, et al. Among authors: knowles tpj, dobson cm, linse s, vendruscolo m. Commun Biol. 2021 Jan 4;4(1):19. doi: 10.1038/s42003-020-01490-3. Commun Biol. 2021. PMID: 33398040 Free PMC article.
Interactions of α-synuclein oligomers with lipid membranes.
Musteikytė G, Jayaram AK, Xu CK, Vendruscolo M, Krainer G, Knowles TPJ. Musteikytė G, et al. Among authors: knowles tpj, vendruscolo m. Biochim Biophys Acta Biomembr. 2021 Apr 1;1863(4):183536. doi: 10.1016/j.bbamem.2020.183536. Epub 2020 Dec 26. Biochim Biophys Acta Biomembr. 2021. PMID: 33373595 Review.
Physical mechanisms of amyloid nucleation on fluid membranes.
Krausser J, Knowles TPJ, Šarić A. Krausser J, et al. Among authors: knowles tpj. Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):33090-33098. doi: 10.1073/pnas.2007694117. Epub 2020 Dec 16. Proc Natl Acad Sci U S A. 2020. PMID: 33328273
Widespread occurrence of the droplet state of proteins in the human proteome.
Hardenberg M, Horvath A, Ambrus V, Fuxreiter M, Vendruscolo M. Hardenberg M, et al. Among authors: vendruscolo m. Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):33254-33262. doi: 10.1073/pnas.2007670117. Epub 2020 Dec 14. Proc Natl Acad Sci U S A. 2020. PMID: 33318217 Free PMC article.
Therapeutic Strategies to Reduce the Toxicity of Misfolded Protein Oligomers.
Kreiser RP, Wright AK, Block NR, Hollows JE, Nguyen LT, LeForte K, Mannini B, Vendruscolo M, Limbocker R. Kreiser RP, et al. Among authors: vendruscolo m. Int J Mol Sci. 2020 Nov 17;21(22):8651. doi: 10.3390/ijms21228651. Int J Mol Sci. 2020. PMID: 33212787 Free PMC article. Review.
On the Mechanism of Self-Assembly by a Hydrogel-Forming Peptide.
Braun GA, Ary BE, Dear AJ, Rohn MCH, Payson AM, Lee DSM, Parry RC, Friedman C, Knowles TPJ, Linse S, Åkerfeldt KS. Braun GA, et al. Among authors: knowles tpj, linse s. Biomacromolecules. 2020 Dec 14;21(12):4781-4794. doi: 10.1021/acs.biomac.0c00989. Epub 2020 Nov 10. Biomacromolecules. 2020. PMID: 33170649
Making biological membrane resistant to the toxicity of misfolded protein oligomers: a lesson from trodusquemine.
Errico S , Lucchesi G , Odino D , Muscat S , Capitini C , Bugelli C , Canale C , Ferrando R , Grasso G , Barbut D , Calamai M , Danani A , Zasloff M , Relini A , Caminati G , Vendruscolo M , Chiti F . Errico S , et al. Among authors: vendruscolo m. Nanoscale. 2020 Nov 19;12(44):22596-22614. doi: 10.1039/d0nr05285j. Nanoscale. 2020. PMID: 33150350
Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer's disease.
Heller GT, Aprile FA, Michaels TCT, Limbocker R, Perni M, Ruggeri FS, Mannini B, Löhr T, Bonomi M, Camilloni C, De Simone A, Felli IC, Pierattelli R, Knowles TPJ, Dobson CM, Vendruscolo M. Heller GT, et al. Among authors: knowles tpj, dobson cm, vendruscolo m. Sci Adv. 2020 Nov 4;6(45):eabb5924. doi: 10.1126/sciadv.abb5924. Print 2020 Nov. Sci Adv. 2020. PMID: 33148639 Free PMC article.
Cholesterol-rich naked mole-rat brain lipid membranes are susceptible to amyloid beta-induced damage in vitro.
Frankel D, Davies M, Bhushan B, Kulaberoglu Y, Urriola-Munoz P, Bertrand-Michel J, Pergande MR, Smith AA, Preet S, Park TJ, Vendruscolo M, Rankin KS, Cologna SM, Kumita JR, Cenac N, St John Smith E. Frankel D, et al. Among authors: vendruscolo m. Aging (Albany NY). 2020 Nov 4;12(21):22266-22290. doi: 10.18632/aging.202138. Epub 2020 Nov 4. Aging (Albany NY). 2020. PMID: 33147569 Free PMC article.
Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies.
Linse S, Scheidt T, Bernfur K, Vendruscolo M, Dobson CM, Cohen SIA, Sileikis E, Lundqvist M, Qian F, O'Malley T, Bussiere T, Weinreb PH, Xu CK, Meisl G, Devenish SRA, Knowles TPJ, Hansson O. Linse S, et al. Among authors: knowles tpj, dobson cm, vendruscolo m. Nat Struct Mol Biol. 2020 Dec;27(12):1125-1133. doi: 10.1038/s41594-020-0505-6. Epub 2020 Sep 28. Nat Struct Mol Biol. 2020. PMID: 32989305
Identification of on- and off-pathway oligomers in amyloid fibril formation.
Dear AJ, Meisl G, Šarić A, Michaels TCT, Kjaergaard M, Linse S, Knowles TPJ. Dear AJ, et al. Among authors: knowles tpj, linse s. Chem Sci. 2020 Jun 8;11(24):6236-6247. doi: 10.1039/c9sc06501f. eCollection 2020 Jun 28. Chem Sci. 2020. PMID: 32953019 Free PMC article.
A rationally designed bicyclic peptide remodels Aβ42 aggregation in vitro and reduces its toxicity in a worm model of Alzheimer's disease.
Ikenoue T, Aprile FA, Sormanni P, Ruggeri FS, Perni M, Heller GT, Haas CP, Middel C, Limbocker R, Mannini B, Michaels TCT, Knowles TPJ, Dobson CM, Vendruscolo M. Ikenoue T, et al. Among authors: knowles tpj, dobson cm, vendruscolo m. Sci Rep. 2020 Sep 17;10(1):15280. doi: 10.1038/s41598-020-69626-3. Sci Rep. 2020. PMID: 32943652 Free PMC article.
Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors.
Michaels TCT, Šarić A, Meisl G, Heller GT, Curk S, Arosio P, Linse S, Dobson CM, Vendruscolo M, Knowles TPJ. Michaels TCT, et al. Among authors: knowles tpj, dobson cm, linse s, vendruscolo m. Proc Natl Acad Sci U S A. 2020 Sep 29;117(39):24251-24257. doi: 10.1073/pnas.2006684117. Epub 2020 Sep 14. Proc Natl Acad Sci U S A. 2020. PMID: 32929030 Free PMC article.
Probing the unfolded protein response in long-lived naked mole-rats.
Du Z, Chakrabarti S, Kulaberoglu Y, Smith ESJ, Dobson CM, Itzhaki LS, Kumita JR. Du Z, et al. Among authors: dobson cm. Biochem Biophys Res Commun. 2020 Sep 3;529(4):1151-1157. doi: 10.1016/j.bbrc.2020.06.118. Epub 2020 Aug 3. Biochem Biophys Res Commun. 2020. PMID: 32819579 Free PMC article.
Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism.
Limbocker R, Mannini B, Ruggeri FS, Cascella R, Xu CK, Perni M, Chia S, Chen SW, Habchi J, Bigi A, Kreiser RP, Wright AK, Albright JA, Kartanas T, Kumita JR, Cremades N, Zasloff M, Cecchi C, Knowles TPJ, Chiti F, Vendruscolo M, Dobson CM. Limbocker R, et al. Among authors: knowles tpj, dobson cm, vendruscolo m. Commun Biol. 2020 Aug 13;3(1):435. doi: 10.1038/s42003-020-01140-8. Commun Biol. 2020. PMID: 32792544 Free PMC article.
Half a century of amyloids: past, present and future.
Ke PC , Zhou R , Serpell LC , Riek R , Knowles TPJ , Lashuel HA , Gazit E , Hamley IW , Davis TP , Fändrich M , Otzen DE , Chapman MR , Dobson CM , Eisenberg DS , Mezzenga R . Ke PC , et al. Among authors: knowles tpj, dobson cm. Chem Soc Rev. 2020 Aug 7;49(15):5473-5509. doi: 10.1039/c9cs00199a. Epub 2020 Jul 7. Chem Soc Rev. 2020. PMID: 32632432 Review.
Rationally Designed Antibodies as Research Tools to Study the Structure-Toxicity Relationship of Amyloid-β Oligomers.
Limbocker R, Mannini B, Cataldi R, Chhangur S, Wright AK, Kreiser RP, Albright JA, Chia S, Habchi J, Sormanni P, Kumita JR, Ruggeri FS, Dobson CM, Chiti F, Aprile FA, Vendruscolo M. Limbocker R, et al. Among authors: dobson cm, vendruscolo m. Int J Mol Sci. 2020 Jun 25;21(12):4542. doi: 10.3390/ijms21124542. Int J Mol Sci. 2020. PMID: 32630615 Free PMC article.
Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation.
Kelmer Sacramento E, Kirkpatrick JM, Mazzetto M, Baumgart M, Bartolome A, Di Sanzo S, Caterino C, Sanguanini M, Papaevgeniou N, Lefaki M, Childs D, Bagnoli S, Terzibasi Tozzini E, Di Fraia D, Romanov N, Sudmant PH, Huber W, Chondrogianni N, Vendruscolo M, Cellerino A, Ori A. Kelmer Sacramento E, et al. Among authors: vendruscolo m. Mol Syst Biol. 2020 Jun;16(6):e9596. doi: 10.15252/msb.20209596. Mol Syst Biol. 2020. PMID: 32558274 Free PMC article.
Rational design of a conformation-specific antibody for the quantification of Aβ oligomers.
Aprile FA, Sormanni P, Podpolny M, Chhangur S, Needham LM, Ruggeri FS, Perni M, Limbocker R, Heller GT, Sneideris T, Scheidt T, Mannini B, Habchi J, Lee SF, Salinas PC, Knowles TPJ, Dobson CM, Vendruscolo M. Aprile FA, et al. Among authors: knowles tpj, dobson cm, vendruscolo m. Proc Natl Acad Sci U S A. 2020 Jun 16;117(24):13509-13518. doi: 10.1073/pnas.1919464117. Epub 2020 Jun 3. Proc Natl Acad Sci U S A. 2020. PMID: 32493749 Free PMC article.
Sequence-based prediction of protein binding mode landscapes.
Horvath A, Miskei M, Ambrus V, Vendruscolo M, Fuxreiter M. Horvath A, et al. Among authors: vendruscolo m. PLoS Comput Biol. 2020 May 26;16(5):e1007864. doi: 10.1371/journal.pcbi.1007864. eCollection 2020 May. PLoS Comput Biol. 2020. PMID: 32453748 Free PMC article.
Kinetic diversity of amyloid oligomers.
Dear AJ, Michaels TCT, Meisl G, Klenerman D, Wu S, Perrett S, Linse S, Dobson CM, Knowles TPJ. Dear AJ, et al. Among authors: knowles tpj, dobson cm, linse s. Proc Natl Acad Sci U S A. 2020 Jun 2;117(22):12087-12094. doi: 10.1073/pnas.1922267117. Epub 2020 May 15. Proc Natl Acad Sci U S A. 2020. PMID: 32414930 Free PMC article.
Sequence-Based Prediction of Fuzzy Protein Interactions.
Miskei M, Horvath A, Vendruscolo M, Fuxreiter M. Miskei M, et al. Among authors: vendruscolo m. J Mol Biol. 2020 Mar 27;432(7):2289-2303. doi: 10.1016/j.jmb.2020.02.017. Epub 2020 Feb 27. J Mol Biol. 2020. PMID: 32112804 Free article.
Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid-β Peptide Aggregation and Reduces the Toxicity of Its Oligomers.
Ghadami SA, Chia S, Ruggeri FS, Meisl G, Bemporad F, Habchi J, Cascella R, Dobson CM, Vendruscolo M, Knowles TPJ, Chiti F. Ghadami SA, et al. Among authors: knowles tpj, dobson cm, vendruscolo m. Biomacromolecules. 2020 Mar 9;21(3):1112-1125. doi: 10.1021/acs.biomac.9b01475. Epub 2020 Feb 17. Biomacromolecules. 2020. PMID: 32011129 Free PMC article.
The catalytic nature of protein aggregation.
Dear AJ, Meisl G, Michaels TCT, Zimmermann MR, Linse S, Knowles TPJ. Dear AJ, et al. Among authors: knowles tpj, linse s. J Chem Phys. 2020 Jan 31;152(4):045101. doi: 10.1063/1.5133635. J Chem Phys. 2020. PMID: 32007046 Free PMC article.
Coating and Stabilization of Liposomes by Clathrin-Inspired DNA Self-Assembly.
Baumann KN, Piantanida L, García-Nafría J, Sobota D, Voïtchovsky K, Knowles TPJ, Hernández-Ainsa S. Baumann KN, et al. Among authors: knowles tpj. ACS Nano. 2020 Feb 25;14(2):2316-2323. doi: 10.1021/acsnano.9b09453. Epub 2020 Feb 5. ACS Nano. 2020. PMID: 31976654 Free PMC article.
Chris Dobson (1949-2019).
Knowles TPJ, Vendruscolo M. Knowles TPJ, et al. Among authors: vendruscolo m. Nat Chem Biol. 2020 Feb;16(2):105. doi: 10.1038/s41589-019-0456-6. Nat Chem Biol. 2020. PMID: 31974526 No abstract available.
Homage to Chris Dobson.
Baum J, Chiti F, De Simone A, Knowles TPJ, Kumita JR, Radford SE, Robinson CV, Salvatella X, Valelli K, Vendruscolo M, Pastore A, Tartaglia GG. Baum J, et al. Among authors: knowles tpj, vendruscolo m. Front Mol Biosci. 2019 Dec 12;6:137. doi: 10.3389/fmolb.2019.00137. eCollection 2019. Front Mol Biosci. 2019. PMID: 31921887 Free PMC article. No abstract available.
Proteome-wide observation of the phenomenon of life on the edge of solubility.
Vecchi G, Sormanni P, Mannini B, Vandelli A, Tartaglia GG, Dobson CM, Hartl FU, Vendruscolo M. Vecchi G, et al. Among authors: dobson cm, vendruscolo m. Proc Natl Acad Sci U S A. 2020 Jan 14;117(2):1015-1020. doi: 10.1073/pnas.1910444117. Epub 2019 Dec 31. Proc Natl Acad Sci U S A. 2020. PMID: 31892536 Free PMC article.
Inherent Biophysical Properties Modulate the Toxicity of Soluble Amyloidogenic Light Chains.
Maritan M, Romeo M, Oberti L, Sormanni P, Tasaki M, Russo R, Ambrosetti A, Motta P, Rognoni P, Mazzini G, Barbiroli A, Palladini G, Vendruscolo M, Diomede L, Bolognesi M, Merlini G, Lavatelli F, Ricagno S. Maritan M, et al. Among authors: vendruscolo m. J Mol Biol. 2020 Feb 14;432(4):845-860. doi: 10.1016/j.jmb.2019.12.015. Epub 2019 Dec 24. J Mol Biol. 2020. PMID: 31874151
A metastable subproteome underlies inclusion formation in muscle proteinopathies.
Ciryam P, Antalek M, Cid F, Tartaglia GG, Dobson CM, Guettsches AK, Eggers B, Vorgerd M, Marcus K, Kley RA, Morimoto RI, Vendruscolo M, Weihl CC. Ciryam P, et al. Among authors: dobson cm, vendruscolo m. Acta Neuropathol Commun. 2019 Dec 3;7(1):197. doi: 10.1186/s40478-019-0853-9. Acta Neuropathol Commun. 2019. PMID: 31796104 Free PMC article.
Lipid Dynamics and Phase Transition within α-Synuclein Amyloid Fibrils.
Galvagnion C, Topgaard D, Makasewicz K, Buell AK, Linse S, Sparr E, Dobson CM. Galvagnion C, et al. Among authors: dobson cm, linse s. J Phys Chem Lett. 2019 Dec 19;10(24):7872-7877. doi: 10.1021/acs.jpclett.9b03005. Epub 2019 Dec 6. J Phys Chem Lett. 2019. PMID: 31790267 Free PMC article.
Label-Free Analysis of Protein Aggregation and Phase Behavior.
Toprakcioglu Z, Challa P, Xu C, Knowles TPJ. Toprakcioglu Z, et al. Among authors: knowles tpj. ACS Nano. 2019 Dec 24;13(12):13940-13948. doi: 10.1021/acsnano.9b05552. Epub 2019 Nov 26. ACS Nano. 2019. PMID: 31738513
Protein Microgels from Amyloid Fibril Networks.
Roode LWY, Shimanovich U, Wu S, Perrett S, Knowles TPJ. Roode LWY, et al. Among authors: knowles tpj. Adv Exp Med Biol. 2019;1174:223-263. doi: 10.1007/978-981-13-9791-2_7. Adv Exp Med Biol. 2019. PMID: 31713201 Review.
Dynamics and Control of Peptide Self-Assembly and Aggregation.
Meisl G, Michaels TCT, Arosio P, Vendruscolo M, Dobson CM, Knowles TPJ. Meisl G, et al. Among authors: knowles tpj, dobson cm, vendruscolo m. Adv Exp Med Biol. 2019;1174:1-33. doi: 10.1007/978-981-13-9791-2_1. Adv Exp Med Biol. 2019. PMID: 31713195 Review.
Bacterial production and direct functional screening of expanded molecular libraries for discovering inhibitors of protein aggregation.
Delivoria DC, Chia S, Habchi J, Perni M, Matis I, Papaevgeniou N, Reczko M, Chondrogianni N, Dobson CM, Vendruscolo M, Skretas G. Delivoria DC, et al. Among authors: dobson cm, vendruscolo m. Sci Adv. 2019 Oct 16;5(10):eaax5108. doi: 10.1126/sciadv.aax5108. eCollection 2019 Oct. Sci Adv. 2019. PMID: 31663025 Free PMC article.
Million-fold sensitivity enhancement in proteopathic seed amplification assays for biospecimens by Hofmeister ion comparisons.
Metrick MA 2nd, do Carmo Ferreira N, Saijo E, Hughson AG, Kraus A, Orrú C, Miller MW, Zanusso G, Ghetti B, Vendruscolo M, Caughey B. Metrick MA 2nd, et al. Among authors: vendruscolo m. Proc Natl Acad Sci U S A. 2019 Nov 12;116(46):23029-23039. doi: 10.1073/pnas.1909322116. Epub 2019 Oct 22. Proc Natl Acad Sci U S A. 2019. PMID: 31641070 Free PMC article.
Rapid two-dimensional characterisation of proteins in solution.
Saar KL, Peter Q, Müller T, Challa PK, Herling TW, Knowles TPJ. Saar KL, et al. Among authors: knowles tpj. Microsyst Nanoeng. 2019 Jul 1;5:33. doi: 10.1038/s41378-019-0072-3. eCollection 2019. Microsyst Nanoeng. 2019. PMID: 31636924 Free PMC article.
RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether.
Liao YC, Fernandopulle MS, Wang G, Choi H, Hao L, Drerup CM, Patel R, Qamar S, Nixon-Abell J, Shen Y, Meadows W, Vendruscolo M, Knowles TPJ, Nelson M, Czekalska MA, Musteikyte G, Gachechiladze MA, Stephens CA, Pasolli HA, Forrest LR, St George-Hyslop P, Lippincott-Schwartz J, Ward ME. Liao YC, et al. Among authors: knowles tpj, vendruscolo m. Cell. 2019 Sep 19;179(1):147-164.e20. doi: 10.1016/j.cell.2019.08.050. Cell. 2019. PMID: 31539493 Free PMC article.
Probing the dynamic stalk region of the ribosome using solution NMR.
Wang X, Kirkpatrick JP, Launay HMM, de Simone A, Häussinger D, Dobson CM, Vendruscolo M, Cabrita LD, Waudby CA, Christodoulou J. Wang X, et al. Among authors: dobson cm, vendruscolo m. Sci Rep. 2019 Sep 19;9(1):13528. doi: 10.1038/s41598-019-49190-1. Sci Rep. 2019. PMID: 31537834 Free PMC article.
Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification.
Lindstedt PR, Aprile FA, Matos MJ, Perni M, Bertoldo JB, Bernardim B, Peter Q, Jiménez-Osés G, Knowles TPJ, Dobson CM, Corzana F, Vendruscolo M, Bernardes GJL. Lindstedt PR, et al. Among authors: knowles tpj, dobson cm, vendruscolo m. ACS Cent Sci. 2019 Aug 28;5(8):1417-1424. doi: 10.1021/acscentsci.9b00467. Epub 2019 Jul 19. ACS Cent Sci. 2019. PMID: 31482124 Free PMC article.
Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression.
De S, Whiten DR, Ruggeri FS, Hughes C, Rodrigues M, Sideris DI, Taylor CG, Aprile FA, Muyldermans S, Knowles TPJ, Vendruscolo M, Bryant C, Blennow K, Skoog I, Kern S, Zetterberg H, Klenerman D. De S, et al. Among authors: knowles tpj, vendruscolo m. Acta Neuropathol Commun. 2019 Jul 26;7(1):120. doi: 10.1186/s40478-019-0777-4. Acta Neuropathol Commun. 2019. PMID: 31349874 Free PMC article.
Universality of filamentous aggregation phenomena.
Michaels TCT, Dear AJ, Knowles TPJ. Michaels TCT, et al. Among authors: knowles tpj. Phys Rev E. 2019 Jun;99(6-1):062415. doi: 10.1103/PhysRevE.99.062415. Phys Rev E. 2019. PMID: 31330719
Nature and Regulation of Protein Folding on the Ribosome.
Waudby CA, Dobson CM, Christodoulou J. Waudby CA, et al. Among authors: dobson cm. Trends Biochem Sci. 2019 Nov;44(11):914-926. doi: 10.1016/j.tibs.2019.06.008. Epub 2019 Jul 10. Trends Biochem Sci. 2019. PMID: 31301980 Free PMC article. Review.
Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of α-Synuclein and Polyglutamine in Aging Caenorhabditis elegans.
Laine RF, Sinnige T, Ma KY, Haack AJ, Poudel C, Gaida P, Curry N, Perni M, Nollen EAA, Dobson CM, Vendruscolo M, Kaminski Schierle GS, Kaminski CF. Laine RF, et al. Among authors: dobson cm, vendruscolo m. ACS Chem Biol. 2019 Jul 19;14(7):1628-1636. doi: 10.1021/acschembio.9b00354. Epub 2019 Jun 27. ACS Chem Biol. 2019. PMID: 31246415
Defining α-synuclein species responsible for Parkinson's disease phenotypes in mice.
Froula JM, Castellana-Cruz M, Anabtawi NM, Camino JD, Chen SW, Thrasher DR, Freire J, Yazdi AA, Fleming S, Dobson CM, Kumita JR, Cremades N, Volpicelli-Daley LA. Froula JM, et al. Among authors: dobson cm. J Biol Chem. 2019 Jul 5;294(27):10392-10406. doi: 10.1074/jbc.RA119.007743. Epub 2019 May 29. J Biol Chem. 2019. PMID: 31142553 Free PMC article.
Common Regulatory Pathways Mediate Activity of MicroRNAs Inducing Cardiomyocyte Proliferation.
Torrini C, Cubero RJ, Dirkx E, Braga L, Ali H, Prosdocimo G, Gutierrez MI, Collesi C, Licastro D, Zentilin L, Mano M, Zacchigna S, Vendruscolo M, Marsili M, Samal A, Giacca M. Torrini C, et al. Among authors: vendruscolo m. Cell Rep. 2019 May 28;27(9):2759-2771.e5. doi: 10.1016/j.celrep.2019.05.005. Cell Rep. 2019. PMID: 31141697 Free PMC article.
Effects of α-tubulin acetylation on microtubule structure and stability.
Eshun-Wilson L, Zhang R, Portran D, Nachury MV, Toso DB, Löhr T, Vendruscolo M, Bonomi M, Fraser JS, Nogales E. Eshun-Wilson L, et al. Among authors: vendruscolo m. Proc Natl Acad Sci U S A. 2019 May 21;116(21):10366-10371. doi: 10.1073/pnas.1900441116. Epub 2019 May 9. Proc Natl Acad Sci U S A. 2019. PMID: 31072936 Free PMC article.
Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging in Caenorhabditis elegans.
Huang C, Wagner-Valladolid S, Stephens AD, Jung R, Poudel C, Sinnige T, Lechler MC, Schlörit N, Lu M, Laine RF, Michel CH, Vendruscolo M, Kaminski CF, Kaminski Schierle GS, David DC. Huang C, et al. Among authors: vendruscolo m. Elife. 2019 May 3;8:e43059. doi: 10.7554/eLife.43059. Elife. 2019. PMID: 31050339 Free PMC article.
Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease.
Boza-Serrano A, Ruiz R, Sanchez-Varo R, García-Revilla J, Yang Y, Jimenez-Ferrer I, Paulus A, Wennström M, Vilalta A, Allendorf D, Davila JC, Stegmayr J, Jiménez S, Roca-Ceballos MA, Navarro-Garrido V, Swanberg M, Hsieh CL, Real LM, Englund E, Linse S, Leffler H, Nilsson UJ, Brown GC, Gutierrez A, Vitorica J, Venero JL, Deierborg T. Boza-Serrano A, et al. Among authors: linse s. Acta Neuropathol. 2019 Aug;138(2):251-273. doi: 10.1007/s00401-019-02013-z. Epub 2019 Apr 20. Acta Neuropathol. 2019. PMID: 31006066 Free PMC article.
Secondary nucleation and elongation occur at different sites on Alzheimer's amyloid-β aggregates.
Scheidt T, Łapińska U, Kumita JR, Whiten DR, Klenerman D, Wilson MR, Cohen SIA, Linse S, Vendruscolo M, Dobson CM, Knowles TPJ, Arosio P. Scheidt T, et al. Among authors: knowles tpj, dobson cm, linse s, vendruscolo m. Sci Adv. 2019 Apr 17;5(4):eaau3112. doi: 10.1126/sciadv.aau3112. eCollection 2019 Apr. Sci Adv. 2019. PMID: 31001578 Free PMC article.
Biophysical Techniques in Structural Biology.
Dobson CM. Dobson CM. Annu Rev Biochem. 2019 Jun 20;88:25-33. doi: 10.1146/annurev-biochem-013118-111947. Epub 2019 Apr 15. Annu Rev Biochem. 2019. PMID: 30986087 Review.
Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms.
De S, Wirthensohn DC, Flagmeier P, Hughes C, Aprile FA, Ruggeri FS, Whiten DR, Emin D, Xia Z, Varela JA, Sormanni P, Kundel F, Knowles TPJ, Dobson CM, Bryant C, Vendruscolo M, Klenerman D. De S, et al. Among authors: knowles tpj, dobson cm, vendruscolo m. Nat Commun. 2019 Apr 4;10(1):1541. doi: 10.1038/s41467-019-09477-3. Nat Commun. 2019. PMID: 30948723 Free PMC article.
Lipid-protein interactions in amyloid formation.
Sparr E, Linse S. Sparr E, et al. Among authors: linse s. Biochim Biophys Acta Proteins Proteom. 2019 May;1867(5):455-457. doi: 10.1016/j.bbapap.2019.03.006. Biochim Biophys Acta Proteins Proteom. 2019. PMID: 30948160 No abstract available.
The Amyloid Phenomenon and Its Significance in Biology and Medicine.
Dobson CM, Knowles TPJ, Vendruscolo M. Dobson CM, et al. Among authors: knowles tpj, vendruscolo m. Cold Spring Harb Perspect Biol. 2020 Feb 3;12(2):a033878. doi: 10.1101/cshperspect.a033878. Cold Spring Harb Perspect Biol. 2020. PMID: 30936117 Review.
Charting a course for chemistry.
Aspuru-Guzik A, Baik MH, Balasubramanian S, Banerjee R, Bart S, Borduas-Dedekind N, Chang S, Chen P, Corminboeuf C, Coudert FX, Cronin L, Crudden C, Cuk T, Doyle AG, Fan C, Feng X, Freedman D, Furukawa S, Ghosh S, Glorius F, Jeffries-El M, Katsonis N, Li A, Linse SS, Marchesan S, Maulide N, Milo A, Narayan ARH, Naumov P, Nevado C, Nyokong T, Palacin R, Reid M, Robinson C, Robinson G, Sarpong R, Schindler C, Schlau-Cohen GS, Schmidt TW, Sessoli R, Shao-Horn Y, Sleiman H, Sutherland J, Taylor A, Tezcan A, Tortosa M, Walsh A, Watson AJB, Weckhuysen BM, Weiss E, Wilson D, Yam VW, Yang X, Ying JY, Yoon T, You SL, Zarbin AJG, Zhang H. Aspuru-Guzik A, et al. Among authors: linse ss. Nat Chem. 2019 Apr;11(4):286-294. doi: 10.1038/s41557-019-0236-7. Nat Chem. 2019. PMID: 30903035 No abstract available.
Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine-Selective Protein Modification and Charge Modulation.
Matos MJ, Navo CD, Hakala T, Ferhati X, Guerreiro A, Hartmann D, Bernardim B, Saar KL, Compañón I, Corzana F, Knowles TPJ, Jiménez-Osés G, Bernardes GJL. Matos MJ, et al. Among authors: knowles tpj. Angew Chem Int Ed Engl. 2019 May 13;58(20):6640-6644. doi: 10.1002/anie.201901405. Epub 2019 Apr 9. Angew Chem Int Ed Engl. 2019. PMID: 30897271 Free PMC article.
Reprint of "Ganglioside lipids accelerate α-synuclein amyloid formation".
Gaspar R, Pallbo J, Weininger U, Linse S, Sparr E. Gaspar R, et al. Among authors: linse s. Biochim Biophys Acta Proteins Proteom. 2019 May;1867(5):508-518. doi: 10.1016/j.bbapap.2019.02.003. Epub 2019 Mar 13. Biochim Biophys Acta Proteins Proteom. 2019. PMID: 30878495 Free article.
Human pregnancy zone protein stabilizes misfolded proteins including preeclampsia- and Alzheimer's-associated amyloid beta peptide.
Cater JH, Kumita JR, Zeineddine Abdallah R, Zhao G, Bernardo-Gancedo A, Henry A, Winata W, Chi M, Grenyer BSF, Townsend ML, Ranson M, Buhimschi CS, Charnock-Jones DS, Dobson CM, Wilson MR, Buhimschi IA, Wyatt AR. Cater JH, et al. Among authors: dobson cm. Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6101-6110. doi: 10.1073/pnas.1817298116. Epub 2019 Mar 8. Proc Natl Acad Sci U S A. 2019. PMID: 30850528 Free PMC article.
Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated Aβ42 Species Aβ5-42.
Weiffert T, Meisl G, Flagmeier P, De S, Dunning CJR, Frohm B, Zetterberg H, Blennow K, Portelius E, Klenerman D, Dobson CM, Knowles TPJ, Linse S. Weiffert T, et al. Among authors: knowles tpj, dobson cm, linse s. ACS Chem Neurosci. 2019 May 15;10(5):2374-2384. doi: 10.1021/acschemneuro.8b00676. Epub 2019 Mar 8. ACS Chem Neurosci. 2019. PMID: 30793584
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes.
Limbocker R, Chia S, Ruggeri FS, Perni M, Cascella R, Heller GT, Meisl G, Mannini B, Habchi J, Michaels TCT, Challa PK, Ahn M, Casford ST, Fernando N, Xu CK, Kloss ND, Cohen SIA, Kumita JR, Cecchi C, Zasloff M, Linse S, Knowles TPJ, Chiti F, Vendruscolo M, Dobson CM. Limbocker R, et al. Among authors: knowles tpj, dobson cm, linse s, vendruscolo m. Nat Commun. 2019 Jan 15;10(1):225. doi: 10.1038/s41467-018-07699-5. Nat Commun. 2019. PMID: 30644384 Free PMC article.
Physical Determinants of Amyloid Assembly in Biofilm Formation.
Andreasen M, Meisl G, Taylor JD, Michaels TCT, Levin A, Otzen DE, Chapman MR, Dobson CM, Matthews SJ, Knowles TPJ. Andreasen M, et al. Among authors: knowles tpj, dobson cm. mBio. 2019 Jan 8;10(1):e02279-18. doi: 10.1128/mBio.02279-18. mBio. 2019. PMID: 30622185 Free PMC article.
A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology.
Fu H, Possenti A, Freer R, Nakano Y, Hernandez Villegas NC, Tang M, Cauhy PVM, Lassus BA, Chen S, Fowler SL, Figueroa HY, Huey ED, Johnson GVW, Vendruscolo M, Duff KE. Fu H, et al. Among authors: vendruscolo m. Nat Neurosci. 2019 Jan;22(1):47-56. doi: 10.1038/s41593-018-0298-7. Epub 2018 Dec 17. Nat Neurosci. 2019. PMID: 30559469 Free PMC article.
Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale.
Lee JE, Sang JC, Rodrigues M, Carr AR, Horrocks MH, De S, Bongiovanni MN, Flagmeier P, Dobson CM, Wales DJ, Lee SF, Klenerman D. Lee JE, et al. Among authors: dobson cm. Nano Lett. 2018 Dec 12;18(12):7494-7501. doi: 10.1021/acs.nanolett.8b02916. Epub 2018 Nov 7. Nano Lett. 2018. PMID: 30380895 Free PMC article.
Quantifying Co-Oligomer Formation by α-Synuclein.
Iljina M, Dear AJ, Garcia GA, De S, Tosatto L, Flagmeier P, Whiten DR, Michaels TCT, Frenkel D, Dobson CM, Knowles TPJ, Klenerman D. Iljina M, et al. Among authors: knowles tpj, dobson cm. ACS Nano. 2018 Nov 27;12(11):10855-10866. doi: 10.1021/acsnano.8b03575. Epub 2018 Oct 29. ACS Nano. 2018. PMID: 30371053 Free PMC article.
Direct Observation of Murine Prion Protein Replication in Vitro.
Sang JC, Meisl G, Thackray AM, Hong L, Ponjavic A, Knowles TPJ, Bujdoso R, Klenerman D. Sang JC, et al. Among authors: knowles tpj. J Am Chem Soc. 2018 Nov 7;140(44):14789-14798. doi: 10.1021/jacs.8b08311. Epub 2018 Oct 23. J Am Chem Soc. 2018. PMID: 30351023 Free PMC article.
SAR by kinetics for drug discovery in protein misfolding diseases.
Chia S, Habchi J, Michaels TCT, Cohen SIA, Linse S, Dobson CM, Knowles TPJ, Vendruscolo M. Chia S, et al. Among authors: knowles tpj, dobson cm, linse s, vendruscolo m. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10245-10250. doi: 10.1073/pnas.1807884115. Epub 2018 Sep 26. Proc Natl Acad Sci U S A. 2018. PMID: 30257937 Free PMC article.
Systematic mapping of free energy landscapes of a growing filamin domain during biosynthesis.
Waudby CA, Wlodarski T, Karyadi ME, Cassaignau AME, Chan SHS, Wentink AS, Schmidt-Engler JM, Camilloni C, Vendruscolo M, Cabrita LD, Christodoulou J. Waudby CA, et al. Among authors: vendruscolo m. Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):9744-9749. doi: 10.1073/pnas.1716252115. Epub 2018 Sep 10. Proc Natl Acad Sci U S A. 2018. PMID: 30201720 Free PMC article.
DNA-Coated Functional Oil Droplets.
Caciagli A, Zupkauskas M, Levin A, Knowles TPJ, Mugemana C, Bruns N, O'Neill T, Frith WJ, Eiser E. Caciagli A, et al. Among authors: knowles tpj. Langmuir. 2018 Aug 28;34(34):10073-10080. doi: 10.1021/acs.langmuir.8b01828. Epub 2018 Aug 17. Langmuir. 2018. PMID: 30086643
Origin of metastable oligomers and their effects on amyloid fibril self-assembly.
Hasecke F, Miti T, Perez C, Barton J, Schölzel D, Gremer L, Grüning CSR, Matthews G, Meisl G, Knowles TPJ, Willbold D, Neudecker P, Heise H, Ullah G, Hoyer W, Muschol M. Hasecke F, et al. Among authors: knowles tpj. Chem Sci. 2018 Jun 13;9(27):5937-5948. doi: 10.1039/c8sc01479e. eCollection 2018 Jul 21. Chem Sci. 2018. PMID: 30079208 Free PMC article.
Ganglioside lipids accelerate α-synuclein amyloid formation.
Gaspar R, Pallbo J, Weininger U, Linse S, Sparr E. Gaspar R, et al. Among authors: linse s. Biochim Biophys Acta Proteins Proteom. 2018 Aug 2;1866(10):1062-72. doi: 10.1016/j.bbapap.2018.07.004. Online ahead of print. Biochim Biophys Acta Proteins Proteom. 2018. PMID: 30077783 Free PMC article.
Disaggregation of gold nanoparticles by Daphnia magna.
Mattsson K, Aguilar R, Torstensson O, Perry D, Bernfur K, Linse S, Hansson LA, Åkerfeldt KS, Cedervall T. Mattsson K, et al. Among authors: linse s. Nanotoxicology. 2018 Oct;12(8):885-900. doi: 10.1080/17435390.2018.1485982. Epub 2018 Jul 27. Nanotoxicology. 2018. PMID: 30053796
Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells.
Whiten DR, Zuo Y, Calo L, Choi ML, De S, Flagmeier P, Wirthensohn DC, Kundel F, Ranasinghe RT, Sanchez SE, Athauda D, Lee SF, Dobson CM, Gandhi S, Spillantini MG, Klenerman D, Horrocks MH. Whiten DR, et al. Among authors: dobson cm. Chembiochem. 2018 Oct 4;19(19):2033-2038. doi: 10.1002/cbic.201800209. Epub 2018 Sep 11. Chembiochem. 2018. PMID: 30051958 Free PMC article.
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