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2005 1
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2010 6
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2016 10
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2018 8
2019 14
2020 11
2021 7
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116 results
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Page 1
Malaria Vaccines: Recent Advances and New Horizons.
Draper SJ, Sack BK, King CR, Nielsen CM, Rayner JC, Higgins MK, Long CA, Seder RA. Draper SJ, et al. Cell Host Microbe. 2018 Jul 11;24(1):43-56. doi: 10.1016/j.chom.2018.06.008. Cell Host Microbe. 2018. PMID: 30001524 Free PMC article. Review.
The development of highly effective and durable vaccines against the human malaria parasites Plasmodium falciparum and P. vivax remains a key priority. Decades of endeavor have taught that achieving this goal will be challenging; however, recent innovation in malaria va
The development of highly effective and durable vaccines against the human malaria parasites Plasmodium falciparum and P. vivax remai …
The RH5-CyRPA-Ripr Complex as a Malaria Vaccine Target.
Ragotte RJ, Higgins MK, Draper SJ. Ragotte RJ, et al. Among authors: draper sj. Trends Parasitol. 2020 Jun;36(6):545-559. doi: 10.1016/j.pt.2020.04.003. Epub 2020 Apr 28. Trends Parasitol. 2020. PMID: 32359873 Free PMC article. Review.
Despite ongoing efforts, a highly effective vaccine against Plasmodium falciparum remains elusive. Vaccines targeting the pre-erythrocytic stages of the P. falciparum life cycle are the most advanced to date, affording moderate levels of efficacy in field trials. .. …
Despite ongoing efforts, a highly effective vaccine against Plasmodium falciparum remains elusive. Vaccines targeting the pre- …
Erythroferrone inhibits the induction of hepcidin by BMP6.
Arezes J, Foy N, McHugh K, Sawant A, Quinkert D, Terraube V, Brinth A, Tam M, LaVallie ER, Taylor S, Armitage AE, Pasricha SR, Cunningham O, Lambert M, Draper SJ, Jasuja R, Drakesmith H. Arezes J, et al. Among authors: draper sj. Blood. 2018 Oct 4;132(14):1473-1477. doi: 10.1182/blood-2018-06-857995. Epub 2018 Aug 10. Blood. 2018. PMID: 30097509 Free PMC article.
Better Epitope Discovery, Precision Immune Engineering, and Accelerated Vaccine Design Using Immunoinformatics Tools.
De Groot AS, Moise L, Terry F, Gutierrez AH, Hindocha P, Richard G, Hoft DF, Ross TM, Noe AR, Takahashi Y, Kotraiah V, Silk SE, Nielsen CM, Minassian AM, Ashfield R, Ardito M, Draper SJ, Martin WD. De Groot AS, et al. Among authors: draper sj. Front Immunol. 2020 Apr 7;11:442. doi: 10.3389/fimmu.2020.00442. eCollection 2020. Front Immunol. 2020. PMID: 32318055 Free PMC article. Review.
Commercial and academic applications of iVAX have included identifying immunogenic T cell epitopes in the development of a T-cell based human multi-epitope Q fever vaccine, designing novel influenza vaccines, identifying cross-conserved T cell epitopes for a malaria …
Commercial and academic applications of iVAX have included identifying immunogenic T cell epitopes in the development of a T-cell based huma …
A Monovalent Chimpanzee Adenovirus Ebola Vaccine Boosted with MVA.
Ewer K, Rampling T, Venkatraman N, Bowyer G, Wright D, Lambe T, Imoukhuede EB, Payne R, Fehling SK, Strecker T, Biedenkopf N, Krähling V, Tully CM, Edwards NJ, Bentley EM, Samuel D, Labbé G, Jin J, Gibani M, Minhinnick A, Wilkie M, Poulton I, Lella N, Roberts R, Hartnell F, Bliss C, Sierra-Davidson K, Powlson J, Berrie E, Tedder R, Roman F, De Ryck I, Nicosia A, Sullivan NJ, Stanley DA, Mbaya OT, Ledgerwood JE, Schwartz RM, Siani L, Colloca S, Folgori A, Di Marco S, Cortese R, Wright E, Becker S, Graham BS, Koup RA, Levine MM, Volkmann A, Chaplin P, Pollard AJ, Draper SJ, Ballou WR, Lawrie A, Gilbert SC, Hill AV. Ewer K, et al. Among authors: draper sj. N Engl J Med. 2016 Apr 28;374(17):1635-46. doi: 10.1056/NEJMoa1411627. Epub 2015 Jan 28. N Engl J Med. 2016. PMID: 25629663 Free PMC article. Clinical Trial.
BACKGROUND: The West African outbreak of Ebola virus disease that peaked in 2014 has caused more than 11,000 deaths. The development of an effective Ebola vaccine is a priority for control of a future outbreak. METHODS: In this phase 1 study, we administered a single dose …
BACKGROUND: The West African outbreak of Ebola virus disease that peaked in 2014 has caused more than 11,000 deaths. The development of an e …
Engineering a Rugged Nanoscaffold To Enhance Plug-and-Display Vaccination.
Bruun TUJ, Andersson AC, Draper SJ, Howarth M. Bruun TUJ, et al. Among authors: draper sj. ACS Nano. 2018 Sep 25;12(9):8855-8866. doi: 10.1021/acsnano.8b02805. Epub 2018 Jul 26. ACS Nano. 2018. PMID: 30028591 Free PMC article.
Such multimerization platforms are generally based on icosahedral viruses and have led to vaccines given to millions of people. It is unclear whether synthetic protein nanoassemblies would show similar potency. ...The simple production, precise derivatization, and exceptio …
Such multimerization platforms are generally based on icosahedral viruses and have led to vaccines given to millions of people. It is …
Overcoming Symmetry Mismatch in Vaccine Nanoassembly through Spontaneous Amidation.
Rahikainen R, Rijal P, Tan TK, Wu HJ, Andersson AC, Barrett JR, Bowden TA, Draper SJ, Townsend AR, Howarth M. Rahikainen R, et al. Among authors: draper sj. Angew Chem Int Ed Engl. 2021 Jan 4;60(1):321-330. doi: 10.1002/anie.202009663. Epub 2020 Oct 27. Angew Chem Int Ed Engl. 2021. PMID: 32886840 Free PMC article.
However, symmetry mismatch can prohibit vaccine nanoassembly. We established an approach for coupling VLPs to diverse antigen symmetries. ...SpyCatcher003 conjugation enables nanodisplay of diverse symmetries towards generation of potent vaccines....
However, symmetry mismatch can prohibit vaccine nanoassembly. We established an approach for coupling VLPs to diverse antigen symmetr …
Plug-and-Display: decoration of Virus-Like Particles via isopeptide bonds for modular immunization.
Brune KD, Leneghan DB, Brian IJ, Ishizuka AS, Bachmann MF, Draper SJ, Biswas S, Howarth M. Brune KD, et al. Among authors: draper sj. Sci Rep. 2016 Jan 19;6:19234. doi: 10.1038/srep19234. Sci Rep. 2016. PMID: 26781591 Free PMC article.
This simple, efficient and modular decoration of nanoparticles should accelerate vaccine development, as well as other applications of nanoparticle devices....
This simple, efficient and modular decoration of nanoparticles should accelerate vaccine development, as well as other applications o …
Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies.
Alanine DGW, Quinkert D, Kumarasingha R, Mehmood S, Donnellan FR, Minkah NK, Dadonaite B, Diouf A, Galaway F, Silk SE, Jamwal A, Marshall JM, Miura K, Foquet L, Elias SC, Labbé GM, Douglas AD, Jin J, Payne RO, Illingworth JJ, Pattinson DJ, Pulido D, Williams BG, de Jongh WA, Wright GJ, Kappe SHI, Robinson CV, Long CA, Crabb BS, Gilson PR, Higgins MK, Draper SJ. Alanine DGW, et al. Among authors: draper sj. Cell. 2019 Jun 27;178(1):216-228.e21. doi: 10.1016/j.cell.2019.05.025. Epub 2019 Jun 13. Cell. 2019. PMID: 31204103 Free PMC article.
The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) is the leading target for next-generation vaccines against the disease-causing blood-stage of malaria. However, little is known about how human antibodies confer functional immunity against this antig …
The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) is the leading target for next-generation vaccines against t …
Viruses as vaccine vectors for infectious diseases and cancer.
Draper SJ, Heeney JL. Draper SJ, et al. Nat Rev Microbiol. 2010 Jan;8(1):62-73. doi: 10.1038/nrmicro2240. Nat Rev Microbiol. 2010. PMID: 19966816 Review.
Recent developments in the use of viruses as vaccine vectors have been facilitated by a better understanding of viral biology. Advances occur as we gain greater insight into the interrelationship of viruses and the immune system. Viral-vector vaccines remain the bes …
Recent developments in the use of viruses as vaccine vectors have been facilitated by a better understanding of viral biology. Advanc …
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