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B-Cell Precursor-Acute Lymphoblastic Leukemia With EBF1-PDGFRB Fusion Treated With Hematopoietic Stem Cell Transplantation and Imatinib: A Case Report and Literature Review.
Sakurai Y, Sarashina T, Toriumi N, Hatakeyama N, Kanayama T, Imamura T, Osumi T, Ohki K, Kiyokawa N, Azuma H. Sakurai Y, et al. J Pediatr Hematol Oncol. 2021 Jan;43(1):e105-e108. doi: 10.1097/MPH.0000000000001743. J Pediatr Hematol Oncol. 2021. PMID: 32068648 Review.
Although she entered remission after induction therapy, she relapsed 15 months after maintenance therapy cessation. Since further investigation revealed EBF1-PDGFRB fusion, her condition was treated as BCR-ABL1-like acute lymphoblastic leukemia. ...
Although she entered remission after induction therapy, she relapsed 15 months after maintenance therapy cessation. Since further investigat …
Platelet-derived growth factor receptors (PDGFRs) fusion genes involvement in hematological malignancies.
Appiah-Kubi K, Lan T, Wang Y, Qian H, Wu M, Yao X, Wu Y, Chen Y. Appiah-Kubi K, et al. Crit Rev Oncol Hematol. 2017 Jan;109:20-34. doi: 10.1016/j.critrevonc.2016.11.008. Epub 2016 Nov 21. Crit Rev Oncol Hematol. 2017. PMID: 28010895 Review.
RESULTS: Out of the 36 fusions detected, ETV6(TEL)-PDGFRB and FIP1L1-PDGFRA fusions were frequently detected, 33 are as a result of chromosomal translocation, FIP1L1-PDGFRA and EBF1-PDGFRB are the result of chromosomal deletion and CDK5RAP2- PDGFRalpha is the result …
RESULTS: Out of the 36 fusions detected, ETV6(TEL)-PDGFRB and FIP1L1-PDGFRA fusions were frequently detected, 33 are as a result of chromoso …