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Effects of the Bowen-Conradi syndrome mutation in EMG1 on its nuclear import, stability and nucleolar recruitment.
Warda AS, Freytag B, Haag S, Sloan KE, Görlich D, Bohnsack MT. Warda AS, et al. Hum Mol Genet. 2016 Dec 15;25(24):5353-5364. doi: 10.1093/hmg/ddw351. Hum Mol Genet. 2016. PMID: 27798105 Free PMC article.
This disease is caused by a single mutation leading to the aspartate 86 to glycine (D86G) exchange in the essential nucleolar RNA methyltransferase EMG1. EMG1 is required for the synthesis of the small ribosomal subunit and is involved in modification of the 18S rib …
This disease is caused by a single mutation leading to the aspartate 86 to glycine (D86G) exchange in the essential nucleolar RNA methyltran …
The role of EMG1 in lung adenocarcinoma progression: Implications for prognosis and immune cell infiltration.
Wu X, Wu Z, Xie Z, Huang H, Wang Y, Lv K, Yang H, Liu X. Wu X, et al. Int Immunopharmacol. 2024 Sep 10;138:112553. doi: 10.1016/j.intimp.2024.112553. Epub 2024 Jun 28. Int Immunopharmacol. 2024. PMID: 38943975 Free article.
RESULTS: EMG1 expression was elevated in LUAD patients compared to normal tissues, and EMG1 expression was strongly correlated with prognosis in LUAD patients. ...EMG1 expression level was significantly increased in LUAD cell lines and tissues. Knockdown of …
RESULTS: EMG1 expression was elevated in LUAD patients compared to normal tissues, and EMG1 expression was strongly correlated …
EMG1 cooperates with GRHL3 in beta-catenin-mediated surface ectoderm differentiation to regulate neural tube closure.
Kimura-Yoshida C, Mochida K, Matsuno C, Kano K, Mishiro-Sato E, Matsuo I. Kimura-Yoshida C, et al. Development. 2025 Aug 1;152(15):dev204700. doi: 10.1242/dev.204700. Epub 2025 Aug 5. Development. 2025. PMID: 40761126
Here, we show that the essential for mitotic growth 1 (EMG1) protein constitutes a protein complex with GRHL3, and that EMG1 is required for correct nuclear localization of GRHL3, and for activation of the canonical Wnt signaling pathway. ...These lines of evidence …
Here, we show that the essential for mitotic growth 1 (EMG1) protein constitutes a protein complex with GRHL3, and that EMG1 i …
Panax notoginseng saponins provide neuroprotection by regulating NgR1/RhoA/ROCK2 pathway expression, in vitro and in vivo.
Shi X, Yu W, Yang T, Liu W, Zhao Y, Sun Y, Chai L, Gao Y, Dong B, Zhu L. Shi X, et al. J Ethnopharmacol. 2016 Aug 22;190:301-12. doi: 10.1016/j.jep.2016.06.017. Epub 2016 Jun 8. J Ethnopharmacol. 2016. PMID: 27288754
The rats were randomly separated into sham, model, NEP1-40, PNS, and NEP1-40 plus PNS (N+P) groups. After 7 days of treatment, body mass and neurological deficit scores were analyzed. ...Following optimal administration of PNS (160mug/ml) and NEP1-40 (10ng/ml …
The rats were randomly separated into sham, model, NEP1-40, PNS, and NEP1-40 plus PNS (N+P) groups. After 7 days of treatment, …
EMG1 methyltransferase activity affects ribosome occupancy at KSHV uORFs.
Harrington EM, Murphy JC, Harper KL, Hayward C, Mottram TJ, Aspden JL, Whitehouse A. Harrington EM, et al. Cell Rep. 2025 Apr 22;44(4):115516. doi: 10.1016/j.celrep.2025.115516. Epub 2025 Apr 10. Cell Rep. 2025. PMID: 40215162 Free article.
Here, we highlight the enhanced association of the ribosomal biogenesis factor EMG1 with precursor-40S ribosome complexes during KSHV lytic replication. Depletion of EMG1 results in significantly reduced expression of viral proteins and progression through the lytic …
Here, we highlight the enhanced association of the ribosomal biogenesis factor EMG1 with precursor-40S ribosome complexes during KSHV …
A UTP3-dependent nucleolar translocation pathway facilitates pre-rRNA 5'ETS processing.
Bao J, Su B, Chen Z, Sun Z, Peng J, Zhao S. Bao J, et al. Nucleic Acids Res. 2024 Sep 9;52(16):9671-9694. doi: 10.1093/nar/gkae631. Nucleic Acids Res. 2024. PMID: 39036955 Free PMC article.
For the remaining 25 proteins we found that UTP3/SAS10 assists the nucleolar localization of five proteins (MPP10, UTP25, EMG1 and the two UTP-B components UTP12 and UTP13), likely through its interaction with nuclear importin alpha. ...
For the remaining 25 proteins we found that UTP3/SAS10 assists the nucleolar localization of five proteins (MPP10, UTP25, EMG1 and th …
Transcriptomic analysis of ribosome biogenesis and pre-rRNA processing during growth stress in Entamoeba histolytica.
Naiyer S, Singh SS, Kaur D, Mukherjee A, Singh YP, Bhattacharya A, Bhattacharya S. Naiyer S, et al. Exp Parasitol. 2022 Aug;239:108308. doi: 10.1016/j.exppara.2022.108308. Epub 2022 Jun 17. Exp Parasitol. 2022. PMID: 35718007
Transcriptomic studies revealed the differential regulation of ribosomal factors both in serum starved and RRP6 down-regulation conditions. These included the NEP1 and TSR3 proteins that chemically modify 18S-rRNA. Pre-rRNA precursors accumulate upon downregulation of the …
Transcriptomic studies revealed the differential regulation of ribosomal factors both in serum starved and RRP6 down-regulation conditions. …
Lithocholic bile acid induces apoptosis in human nephroblastoma cells: a non-selective treatment option.
Trah J, Arand J, Oh J, Pagerols-Raluy L, Trochimiuk M, Appl B, Heidelbach H, Vincent D, Saleem MA, Reinshagen K, Mühlig AK, Boettcher M. Trah J, et al. Sci Rep. 2020 Nov 23;10(1):20349. doi: 10.1038/s41598-020-77436-w. Sci Rep. 2020. PMID: 33230229 Free PMC article.
To test the effects of LCA, nephroblastoma cell line WT CLS1 was used. SK NEP1 was tested as well. It was originally classified as a nephroblastoma cell line but was meanwhile reclassified as an ewing sarcoma cell line. ...
To test the effects of LCA, nephroblastoma cell line WT CLS1 was used. SK NEP1 was tested as well. It was originally classified as a …
Ribosomal modifications are associated with mesenchymal fate selection in the neural crest lineage.
Poverennaya I, Murtazina A, Li L, Maili L, Sourada L, Montano-Gutierrez LF, Galimullina R, Steinschaden T, Kaiser M, Zikmund T, Goralija A, Gao T, Attina A, Clara O, Bartenhagen C, Erickson A, Gershtein Y, Chen S, Polaskova K, Sterba J, Semasch B, Anderson ER, Prakash V, Vincent T, Arceo M, Kogner P, Schlisio S, Kharchenko PV, David A, Kaiser J, Fischer M, Skoda J, Trainor PA, Chagin AS, Adameyko I. Poverennaya I, et al. Nat Commun. 2026 Mar 9;17(1):2326. doi: 10.1038/s41467-026-70375-6. Nat Commun. 2026. PMID: 41803115 Free PMC article.
Using Smart-seq2 single-cell transcriptomics, we show that mesenchymal fate commitment correlates specifically with the expression of rRNA-modifying and ribosome assembly factors, rather than structural ribosomal proteins. Notably, EMG1 and NHP2 introduce key post-transcri …
Using Smart-seq2 single-cell transcriptomics, we show that mesenchymal fate commitment correlates specifically with the expression of rRNA-m …
Targeting NgR1/NogoA Signalling Enhances Natural Killer Cell Cytotoxicity and Alters Immune and Oncogenic Pathways in TNBC Cells.
Korak T, Albayrak MGB, Kasap M, Yanar S, Akpinar G. Korak T, et al. Scand J Immunol. 2026 Feb;103(2):e70085. doi: 10.1111/sji.70085. Scand J Immunol. 2026. PMID: 41681012
NK-92 and MDA-MB-231 cells were co-cultured at optimised effector-to-target ratios, followed by treatment with the NgR1 antagonist NEP1-40. Cell viability was assessed by WST-1 assay, apoptosis was evaluated using AO/DAPI staining, gene expression was analysed by RT-PCR, a …
NK-92 and MDA-MB-231 cells were co-cultured at optimised effector-to-target ratios, followed by treatment with the NgR1 antagonist NEP1 …
11 results