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Updates on eosinophilic disorders.
Tzankov A, Reichard KK, Hasserjian RP, Arber DA, Orazi A, Wang SA. Tzankov A, et al. Virchows Arch. 2023 Jan;482(1):85-97. doi: 10.1007/s00428-022-03402-8. Epub 2022 Sep 7. Virchows Arch. 2023. PMID: 36068374 Review.
This review addresses changes and updates in eosinophilic disorders under the International Consensus Classification (ICC). The previous category of myeloid/lymphoid neoplasm with eosinophilia (M/LN-eo) and a specific gene rearrangement is changed to M/LN-eo with tyrosine …
This review addresses changes and updates in eosinophilic disorders under the International Consensus Classification (ICC). The previ …
The international consensus classification of eosinophilic disorders and systemic mastocytosis.
Wang SA, Orazi A, Gotlib J, Reiter A, Tzankov A, Hasserjian RP, Arber DA, Tefferi A. Wang SA, et al. Am J Hematol. 2023 Aug;98(8):1286-1306. doi: 10.1002/ajh.26966. Epub 2023 Jun 7. Am J Hematol. 2023. PMID: 37283522 Review.
Myeloid/lymphoid neoplasms with eosinophilia (M/LN-eo) and gene rearrangements have been renamed as M/LN-eo with tyrosine kinase gene fusions (M/LN-eo-TK). The category has been expanded to include ETV6::ABL1 and FLT3 fusions, and to accept PCM1::JAK2 and its geneti …
Myeloid/lymphoid neoplasms with eosinophilia (M/LN-eo) and gene rearrangements have been renamed as M/LN-eo with tyrosine kinase gene fusion …
Characteristics and literature review of ETV6::ABL1 fusion gene-positive acute myeloid leukemia.
Xue S, Sun HP, Huang XB, Chen X, Wang T, Ma W, Tian Y, Pan ZL, Li LH, Zhang L, Liu HX, Cao XY. Xue S, et al. Int J Hematol. 2024 May;119(5):564-572. doi: 10.1007/s12185-024-03729-9. Epub 2024 Mar 5. Int J Hematol. 2024. PMID: 38441775 Review.
OBJECTIVE: To describe the features of ETV6::ABL1 AML as well as the clinical treatment and outcomes. METHODS: Clinical data were collected from three patients diagnosed with ETV6::ABL1 AML at Hebei Yanda Lu Daopei Hospital and Beijing Lu Daopei Hospit …
OBJECTIVE: To describe the features of ETV6::ABL1 AML as well as the clinical treatment and outcomes. METHODS: Clinical data w …
Available and emerging therapies for bona fide advanced systemic mastocytosis and primary eosinophilic neoplasms.
Gotlib J. Gotlib J. Hematology Am Soc Hematol Educ Program. 2022 Dec 9;2022(1):34-46. doi: 10.1182/hematology.2022000368. Hematology Am Soc Hematol Educ Program. 2022. PMID: 36485158 Free PMC article. Review.
In the new World Health Organization and International Consensus Classifications, the category of "myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase (TK) gene fusions" is inclusive of rearrangements involving PDGFRA, PDGFRB, FGFR1, JAK2, FLT3, and ETV6::A
In the new World Health Organization and International Consensus Classifications, the category of "myeloid/lymphoid neoplasms with eosinophi …
Myeloproliferative neoplasm with ETV6-ABL1 fusion: a case report and literature review.
Gancheva K, Virchis A, Howard-Reeves J, Cross NC, Brazma D, Grace C, Kotzampaltiris P, Partheniou F, Nacheva E. Gancheva K, et al. Mol Cytogenet. 2013 Sep 20;6(1):39. doi: 10.1186/1755-8166-6-39. Mol Cytogenet. 2013. PMID: 24053143 Free PMC article.
In addition, we confirm the association of the ETV6-ABL1 fusion with imatinib resistance reported so far in three other patients, while recording excellent response to the 2nd generation tyrosine kinase inhibitor (TKI) nilotinib. In summary, we highlight the value o …
In addition, we confirm the association of the ETV6-ABL1 fusion with imatinib resistance reported so far in three other patien …
Eosinophilia in acute myeloid leukemia: Overlooked and underexamined.
Naymagon L, Marcellino B, Mascarenhas J. Naymagon L, et al. Blood Rev. 2019 Jul;36:23-31. doi: 10.1016/j.blre.2019.03.007. Epub 2019 Mar 30. Blood Rev. 2019. PMID: 30948162 Review.
The presence of eosinophilia in acute myeloid leukemia (AML) suggests an underlying core binding factor (CBF) lesion, a platelet derived growth factor (PDGFR) translocation, or another rare translocation (such as ETV6-ABL1). Each of these cytogenetic entities carrie …
The presence of eosinophilia in acute myeloid leukemia (AML) suggests an underlying core binding factor (CBF) lesion, a platelet derived gro …
ABL1 fusion genes in hematological malignancies: a review.
De Braekeleer E, Douet-Guilbert N, Rowe D, Bown N, Morel F, Berthou C, Férec C, De Braekeleer M. De Braekeleer E, et al. Eur J Haematol. 2011 May;86(5):361-71. doi: 10.1111/j.1600-0609.2011.01586.x. Epub 2011 Mar 23. Eur J Haematol. 2011. PMID: 21435002 Review.
These latter domains allow oligomerization of the protein that is required for tyrosine kinase activation, cytoskeletal localization, and neoplastic transformation. Fusion genes that have a break in intron 1 or 2 (BCR-ABL1, ETV6-ABL1, ZMIZ1-ABL1, EML1-ABL1, and NUP2 …
These latter domains allow oligomerization of the protein that is required for tyrosine kinase activation, cytoskeletal localization, and ne …
Mixed-phenotype (B-lymphocytic/myeloid) acute leukemia with ETV6-ABL1 expression.
Wang L, He D, Lu L, Wang H, Wang S. Wang L, et al. Pak J Med Sci. 2024 Jul;40(6):1294-1299. doi: 10.12669/pjms.40.6.8497. Pak J Med Sci. 2024. PMID: 38952502 Free PMC article. Review.
Positivity of both MPAL and ETV6-ABL1 suggest a poor prognosis. This is the first report of B lymphocytic/myeloid mixed-phenotype acute leukemia with ETV6-ABL1 fusion gene positivity. ...There are 126 cases of ETV6-ABL1 fusion gene transc …
Positivity of both MPAL and ETV6-ABL1 suggest a poor prognosis. This is the first report of B lymphocytic/myeloid mixed-phenot …
A novel three-way rearrangement involving ETV6 (12p13) and ABL1 (9q34) with an unknown partner on 3p25 resulting in a possible ETV6-ABL1 fusion in a patient with acute myeloid leukemia: a case report and a review of the literature.
Tirado CA, Siangchin K, Shabsovich DS, Sharifian M, Schiller G. Tirado CA, et al. Biomark Res. 2016 Aug 25;4(1):16. doi: 10.1186/s40364-016-0070-7. eCollection 2016. Biomark Res. 2016. PMID: 27570624 Free PMC article.
BACKGROUND: Acute myeloid leukemia (AML) is commonly characterized by several chromosomal abnormalities resulting in the formation of chimeric genes that play various roles in leukemogenesis. Translocations resulting in the ETV6-ABL1 fusion gene are rare in AML and …
BACKGROUND: Acute myeloid leukemia (AML) is commonly characterized by several chromosomal abnormalities resulting in the formation of chimer …
Myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase fusion genes: A workshop report with focus on novel entities and a literature review including paediatric cases.
Saft L, Kvasnicka HM, Boudova L, Gianelli U, Lazzi S, Rozman M. Saft L, et al. Histopathology. 2023 Dec;83(6):829-849. doi: 10.1111/his.15021. Epub 2023 Aug 8. Histopathology. 2023. PMID: 37551450 Free article. Review.
Therefore, additional evaluation with fluorescence in-situ hybridisation and other molecular genetic techniques (array-based comparative genomic hybridisation, RNA sequencing) are recommended for the identification of specific TK gene fusions. M/LN-eo with JAK2 and FLT3-rearrange …
Therefore, additional evaluation with fluorescence in-situ hybridisation and other molecular genetic techniques (array-based comparative gen …
17 results