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Updates on eosinophilic disorders.
Tzankov A, Reichard KK, Hasserjian RP, Arber DA, Orazi A, Wang SA. Tzankov A, et al. Virchows Arch. 2023 Jan;482(1):85-97. doi: 10.1007/s00428-022-03402-8. Epub 2022 Sep 7. Virchows Arch. 2023. PMID: 36068374 Review.
This review addresses changes and updates in eosinophilic disorders under the International Consensus Classification (ICC). ...Two new members, M/LN-eo with ETV6::ABL1 fusion and M/LN-eo with various FLT3 fusions, have been added to the category; and M/LN-eo with PCM1::JAK …
This review addresses changes and updates in eosinophilic disorders under the International Consensus Classification (ICC). ...Two ne …
Should myeloid and lymphoid neoplasms with PCM1-JAK2 and other rearrangements of JAK2 be recognized as specific entities?
Bain BJ, Ahmad S. Bain BJ, et al. Br J Haematol. 2014 Sep;166(6):809-17. doi: 10.1111/bjh.12963. Epub 2014 Jun 10. Br J Haematol. 2014. PMID: 24913195 Free article. Review.
Furthermore, lymphoid and myeloid neoplasms associated respectively with t(9;12)(p24;p13); ETV6-JAK2 and with t(9;22)(p24;q11.2); BCR-JAK2 should be documented carefully in order to define their features more clearly and assess whether they can be recognized as enti …
Furthermore, lymphoid and myeloid neoplasms associated respectively with t(9;12)(p24;p13); ETV6-JAK2 and with t(9;22)(p24;q11. …
JAK and MPL mutations in myeloid malignancies.
Tefferi A. Tefferi A. Leuk Lymphoma. 2008 Mar;49(3):388-97. doi: 10.1080/10428190801895360. Leuk Lymphoma. 2008. PMID: 18297515 Review.
JAK3A572V, JAK3V722I, JAK3P132T) and fusion JAK2 (e.g. ETV6-JAK2, PCM1-JAK2, BCR-JAK2) mutations have respectively been described in acute megakaryocytic leukemia and acute leukemia/chronic myeloid malignancies. ...
JAK3A572V, JAK3V722I, JAK3P132T) and fusion JAK2 (e.g. ETV6-JAK2, PCM1-JAK2, BCR-JAK2) mutations have respectively been descri …
Fusion genes in leukemia: an emerging network.
Bohlander SK. Bohlander SK. Cytogenet Cell Genet. 2000;91(1-4):52-6. doi: 10.1159/000056818. Cytogenet Cell Genet. 2000. PMID: 11173830 Review.
Not only does one find star-shaped topologies, with one gene forming fusions with several others (e.g. ETV6/PDGFRB, ETV6/JAK2, ETV6/ABL etc.), but also networks connecting several genes with more than one fusion partner (e.g. ...
Not only does one find star-shaped topologies, with one gene forming fusions with several others (e.g. ETV6/PDGFRB, ETV6/JAK2, …