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2015 3
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87 results

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Page 1
Single-cell dissection reveals immunosuppressive F13A1+ macrophage as a hallmark for multiple primary lung cancers.
Yang C, Qu J, Wu J, Cai S, Liu W, Deng Y, Meng Y, Zheng L, Zhang L, Wang L, Guo X. Yang C, et al. Clin Transl Med. 2024 Dec;14(12):e70091. doi: 10.1002/ctm2.70091. Clin Transl Med. 2024. PMID: 39601163 Free PMC article.
CONCLUSIONS: This study unveils shared molecular mechanismsbetween MPLCs and SPLCs, while identifying MPLC-specific cellular and molecularfeatures, such as the role of F13A1+ macrophages. The findings provide novelinsights into MPLC pathogenesis, supporting the development …
CONCLUSIONS: This study unveils shared molecular mechanismsbetween MPLCs and SPLCs, while identifying MPLC-specific cellular and molecularfe …
F13A1 transglutaminase expression in human adipose tissue increases in acquired excess weight and associates with inflammatory status of adipocytes.
Kaartinen MT, Arora M, Heinonen S, Hang A, Barry A, Lundbom J, Hakkarainen A, Lundholm N, Rissanen A, Kaprio J, Pietiläinen KH. Kaartinen MT, et al. Int J Obes (Lond). 2021 Mar;45(3):577-587. doi: 10.1038/s41366-020-00722-0. Epub 2020 Nov 21. Int J Obes (Lond). 2021. PMID: 33221826

RESULTS: F13A1 mRNA showed significant increase in adipose tissue (p < 0.0001) and an adipocyte-enriched fraction (p = 0.0012) of the heavier co-twin. ...F13A1 did not associate with liver fat accumulation. CONCLUSIONS: F13A1 levels in adipose tissue incre

…

RESULTS: F13A1 mRNA showed significant increase in adipose tissue (p < 0.0001) and an adipocyte-enriched fraction (p = 0.0012) of

…
Factor XIII-A in Diseases: Role Beyond Blood Coagulation.
Dull K, Fazekas F, Törőcsik D. Dull K, et al. Int J Mol Sci. 2021 Feb 1;22(3):1459. doi: 10.3390/ijms22031459. Int J Mol Sci. 2021. PMID: 33535700 Free PMC article. Review.
Here, we aim to summarize data from studies involving patients with mutations in the F13A1 gene, performed in FXIII-A knock-out mice models, clinical and histological studies assessing correlations between diseases severity and FXIII-A levels, as well as from in vitro expe …
Here, we aim to summarize data from studies involving patients with mutations in the F13A1 gene, performed in FXIII-A knock-out mice …
RUNX1 isoforms regulate RUNX1 and target genes differentially in platelets-megakaryocytes: association with clinical cardiovascular events.
Guan L, Voora D, Myers R, Del Carpio-Cano F, Rao AK. Guan L, et al. J Thromb Haemost. 2024 Dec;22(12):3581-3598. doi: 10.1016/j.jtha.2024.07.032. Epub 2024 Aug 23. J Thromb Haemost. 2024. PMID: 39181539
RUNX1B and RUNX1C regulated target genes (MYL9, F13A1, PCTP, PDE5A, and others) differentially in HEL cells. In platelets, RUNX1B transcripts (by RNA sequencing) correlated negatively with RUNX1C and RUNX1A; RUNX1C correlated positively with RUNX1A. RUNX1B correlated posit …
RUNX1B and RUNX1C regulated target genes (MYL9, F13A1, PCTP, PDE5A, and others) differentially in HEL cells. In platelets, RUNX1B tra …
Genetic polymorphisms associated with upper gastrointestinal bleeding: a systematic review.
Forgerini M, Lucchetta RC, Urbano G, de Nadai TR, de Carvalho Mastroianni P. Forgerini M, et al. Pharmacogenomics J. 2021 Feb;21(1):20-36. doi: 10.1038/s41397-020-00185-6. Epub 2020 Sep 18. Pharmacogenomics J. 2021. PMID: 32948830
Genetic polymorphisms involved in platelet activation and aggregation, angiogenesis, inflammatory process, and drug metabolism were associated with risk of non-variceal UGIB (NOS3, COX-1; COX-2; PLA2G7; GP1BA; GRS; IL1RN; F13A1; CDKN2B-AS1; DPP6; TBXA2R; TNF-alpha; VKORC1; …
Genetic polymorphisms involved in platelet activation and aggregation, angiogenesis, inflammatory process, and drug metabolism were associat …
Diagnostic biomarker for type 2 diabetic peripheral neuropathy via comprehensive bioinformatics analysis.
Chen X, Liu Q, Chen N, Ma J, Wu X, Zhang H, Yu L, Huang H. Chen X, et al. J Diabetes. 2024 Mar;16(3):e13506. doi: 10.1111/1753-0407.13506. Epub 2023 Nov 29. J Diabetes. 2024. PMID: 38018513 Free PMC article.
By protein-protein interaction (PPI) network analysis, FCER1G, SYK, ITGA4, F13A1, MS4A2, and PTK2B were screened as hub genes with higher expression in DPN patients, among which half were immune genes (FCER1G, PTK2B, and SYK). ...
By protein-protein interaction (PPI) network analysis, FCER1G, SYK, ITGA4, F13A1, MS4A2, and PTK2B were screened as hub genes with hi …
Comprehensive analyses for the coagulation and macrophage-related genes to reveal their joint roles in the prognosis and immunotherapy of lung adenocarcinoma patients.
Li Z, Yin Z, Luan Z, Zhang C, Wang Y, Zhang K, Chen F, Yang Z, Tian Y. Li Z, et al. Front Immunol. 2023 Oct 31;14:1273422. doi: 10.3389/fimmu.2023.1273422. eCollection 2023. Front Immunol. 2023. PMID: 38022584 Free PMC article.
Finally, 10 survival-associated genes (APOE, ARRB2, C1QB, F13A1, FCGR2A, FYN, ITGB2, MMP9, OLR1, and VSIG4) were involved in the COMAR risk score model. ...
Finally, 10 survival-associated genes (APOE, ARRB2, C1QB, F13A1, FCGR2A, FYN, ITGB2, MMP9, OLR1, and VSIG4) were involved in the COMA …
Cryo-EM structure of the human native plasma coagulation factor XIII complex.
Singh S, Hagelueken G, Ugurlar D, Ramaraje Urs SU, Sharma A, Mahapatra M, Drepper F, Imhof D, Huesgen PF, Oldenburg J, Geyer M, Biswas A. Singh S, et al. Blood. 2025 Jan 23;145(4):438-449. doi: 10.1182/blood.2024025369. Blood. 2025. PMID: 39447073
We also report 4 novel mutations in the F13A1 gene encoding the FXIII-A subunit from a cohort of patients with severe FXIII deficiency. ...
We also report 4 novel mutations in the F13A1 gene encoding the FXIII-A subunit from a cohort of patients with severe FXIII deficienc …
Transglutaminases and Obesity in Humans: Association of F13A1 to Adipocyte Hypertrophy and Adipose Tissue Immune Response.
Kaartinen MT, Arora M, Heinonen S, Rissanen A, Kaprio J, Pietiläinen KH. Kaartinen MT, et al. Int J Mol Sci. 2020 Nov 5;21(21):8289. doi: 10.3390/ijms21218289. Int J Mol Sci. 2020. PMID: 33167412 Free PMC article.
Our previous work linked adipocyte F13A1 to increased weight, body fat mass, adipocyte size, and pro-inflammatory pathways. ...Our work brings further support to the role of F13A1 in the human adipose tissue pathology, suggesting a role in the cascade that links hyp …
Our previous work linked adipocyte F13A1 to increased weight, body fat mass, adipocyte size, and pro-inflammatory pathways. ...Our wo …
87 results