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51 results

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Page 1
PRMT1 driven PTX3 regulates ferritinophagy in glioma.
Lathoria K, Gowda P, Umdor SB, Patrick S, Suri V, Sen E. Lathoria K, et al. Autophagy. 2023 Jul;19(7):1997-2014. doi: 10.1080/15548627.2023.2165757. Epub 2023 Jan 16. Autophagy. 2023. PMID: 36647288 Free PMC article.
Of clinical importance, our study suggests that the PRMT1-PTX3 ferritinophagy regulatory circuit could be exploited for therapeutic gains.Abbreviations: 2-HG: D-2-hydroxyglutarate; BafA(1): bafilomycin A(1); ChIP: chromatin immunoprecipitation; FTH1: ferritin heavy chain 1; FT …
Of clinical importance, our study suggests that the PRMT1-PTX3 ferritinophagy regulatory circuit could be exploited for therapeutic gains.Ab …
Transcriptome Landscape of Cancer-Associated Fibroblasts in Human PDAC.
Tao M, Liu W, Chen J, Liu R, Zou J, Yu B, Wang C, Huang M, Chen Q, Zhang Z, Chen Z, Sun H, Zhou C, Tan S, Zheng Y, Wang H. Tao M, et al. Adv Sci (Weinh). 2025 May;12(20):e2415196. doi: 10.1002/advs.202415196. Epub 2025 Feb 28. Adv Sci (Weinh). 2025. PMID: 40019403 Free PMC article.
CDCP1(+)FTL(+) CAFs, pCAFs, and ISG(+) myCAFs are associated with unfavorable clinical outcomes. CDCP1(+)FTL(+) CAFs exhibit enhanced glycolysis and iron metabolism, resisting ferroptosis. The antigen-presenting CAFs (apCAFs) show high heterogeneity, consisting of m …
CDCP1(+)FTL(+) CAFs, pCAFs, and ISG(+) myCAFs are associated with unfavorable clinical outcomes. CDCP1(+)FTL(+) CAFs exhibit e …
Iron promotes ovarian cancer malignancy and advances platinum resistance by enhancing DNA repair via FTH1/FTL/POLQ/RAD51 axis.
Zhang Q, Chen C, Zou X, Wu W, Di Y, Li N, Fu A. Zhang Q, et al. Cell Death Dis. 2024 May 13;15(5):329. doi: 10.1038/s41419-024-06688-5. Cell Death Dis. 2024. PMID: 38740757 Free PMC article.
Additionally, iron tightly regulated by ferritin (FTH1/FTL) which is indispensable for iron-triggered DNA repair. Finally, we discovered that iron chelators combined with platinum exhibit a synergistic inhibitory effect on ovarian cancer in vitro and in vivo. Our findings …
Additionally, iron tightly regulated by ferritin (FTH1/FTL) which is indispensable for iron-triggered DNA repair. Finally, we discove …
Activation of ferritin light chain (FTL) by transcription factor salmonella pathogenicity island 1 modulates glycolysis to drive metastasis of ovarian cancer cells.
Li C, Yang Y, Lin Y, Lian Y, Pan D, Lin L, Li L. Li C, et al. Expert Rev Anticancer Ther. 2024 Dec;24(12):1271-1282. doi: 10.1080/14737140.2024.2439558. Epub 2024 Dec 16. Expert Rev Anticancer Ther. 2024. PMID: 39675923
Xenografted tumor models in nude mice verified the role of FTL in vivo. RESULTS: Cell function experiments revealed that FTL facilitated proliferation, migration, and invasion of OC cells. Rescue experiments unveiled that 2-Deoxy-D-glucose attenuated stimulation on …
Xenografted tumor models in nude mice verified the role of FTL in vivo. RESULTS: Cell function experiments revealed that FTL f …
Regulated cell death joins in atherosclerotic plaque silent progression.
Uyy E, Suica VI, Boteanu RM, Cerveanu-Hogas A, Ivan L, Hansen R, Antohe F. Uyy E, et al. Sci Rep. 2022 Feb 18;12(1):2814. doi: 10.1038/s41598-022-06762-y. Sci Rep. 2022. PMID: 35181730 Free PMC article.
Dysregulation of five proteins involved in non-apoptotic regulated cell death proteins (VDAC1, VDAC3, FTL, TF and PCBP1) and nine associated DAMPs (HSP90AA1, HSP90AB1, ANXA1, LGALS3, HSP90B1, S100A11, FN, CALR, H3-3A) was not corrected by the treatment. ...
Dysregulation of five proteins involved in non-apoptotic regulated cell death proteins (VDAC1, VDAC3, FTL, TF and PCBP1) and nine ass …
Targeting FTL regulates ferroptosis and remodels lymph node metastasis microenvironment in esophageal squamous cell carcinoma.
Zheng S, Liu Y, Zhang B, Huang J, Fang X, Huang C, Gong L, Luo J, Yang Y, Liu S, Wong CN, Huang J, Li S, Tan Y, Chen Q, Qin Y, Guan XY. Zheng S, et al. Int J Biol Sci. 2025 Oct 16;21(15):6616-6632. doi: 10.7150/ijbs.112017. eCollection 2025. Int J Biol Sci. 2025. PMID: 41281761 Free PMC article.
Mechanism studies have shown that FTL promotes ESCC development and metastasis via NRF2 pathway and inhibits ferroptosis via NCOA4 protein. In vivo treatment, Brusatol, was found to inhibit FTL expression and have a significant inhibitory effect on ESCC growth and m …
Mechanism studies have shown that FTL promotes ESCC development and metastasis via NRF2 pathway and inhibits ferroptosis via NCOA4 pr …
Multi-omics Analysis Reveals the Propagation Mechanism of Ferroptosis in Acute Kidney Injury.
Hong Y, An Q, Wang Z, Hu B, Yang Y, Zeng R, Yao Y. Hong Y, et al. Inflammation. 2025 Dec;48(6):4062-4079. doi: 10.1007/s10753-025-02311-7. Epub 2025 May 13. Inflammation. 2025. PMID: 40358793 Free PMC article.
The analysis revealed notable differences in ferroptosis activity within proximal tubule (PT) cells of AKI patients, specifically highlighting a strong correlation between ferroptosis and the expression of genes GPX4, FTH1, and FTL. Spatial transcriptomics confirmed that t …
The analysis revealed notable differences in ferroptosis activity within proximal tubule (PT) cells of AKI patients, specifically highlighti …
Downregulation of ALDH5A1 suppresses cisplatin resistance in esophageal squamous cell carcinoma by regulating ferroptosis signaling pathways.
Song K, Ma C, Maswikiti EP, Gu B, Wang B, Wang N, Jiang P, Chen H. Song K, et al. Mol Carcinog. 2024 Oct;63(10):1892-1906. doi: 10.1002/mc.23778. Epub 2024 Jun 24. Mol Carcinog. 2024. PMID: 38923019
Our in vitro and in vivo experiments demonstrate that DDP treatment promotes the accumulation of ROS, lipid ROS, MDA, LPO, and intracellular Fe(2+) content, increases the levels of proteins that promote ferroptosis (ACSL4 and FTH1), and decreases the expression of anti-ferroptosi …
Our in vitro and in vivo experiments demonstrate that DDP treatment promotes the accumulation of ROS, lipid ROS, MDA, LPO, and intracellular …
Crosstalk between FTH1 and PYCR1 dysregulates proline metabolism and mediates cell growth in KRAS-mutant pancreatic cancer cells.
Park JM, Su YH, Fan CS, Chen HH, Qiu YK, Chen LL, Chen HA, Ramasamy TS, Chang JS, Huang SY, Chang WW, Lee AY, Huang TS, Kuo CC, Chiu CF. Park JM, et al. Exp Mol Med. 2024 Sep;56(9):2065-2081. doi: 10.1038/s12276-024-01300-4. Epub 2024 Sep 18. Exp Mol Med. 2024. PMID: 39294443 Free PMC article.
Ferritin, comprising heavy (FTH1) and light (FTL) chains, is the main iron storage protein, and pancreatic cancer patients exhibit elevated serum ferritin levels. ...
Ferritin, comprising heavy (FTH1) and light (FTL) chains, is the main iron storage protein, and pancreatic cancer patients exhibit el …
1,4-Naphthoquinone-coated black carbon nanoparticles up-regulation POR/FTL/IL-33 axis in THP1 cells.
Cui Y, Li Z, Xiao Q, Ge J, Jiang W, Wang X, Wang Z, Yuan Y, Zhuang Y, Hao W, Jiang J, Meng Q, Wei X. Cui Y, et al. Ecotoxicol Environ Saf. 2023 Jan 1;249:114381. doi: 10.1016/j.ecoenv.2022.114381. Epub 2022 Dec 9. Ecotoxicol Environ Saf. 2023. PMID: 36508801 Free article.
It is worth noting that 1,4 NQ-BC prevented the removal of FTL by inhibiting autophagy, and increased IL-33 level by POR/FTL/IL-33 axis. We first applied proteomics to study the damage mechanism of 1,4 NQ-BC on THP1 cells. ...
It is worth noting that 1,4 NQ-BC prevented the removal of FTL by inhibiting autophagy, and increased IL-33 level by POR/FTL/I …
51 results