Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2015 2
2016 4
2017 2
2018 2
2019 2
2020 4
2021 3
2022 3
2023 2
2024 1

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

24 results

Results by year

Filters applied: . Clear all
Page 1
p53 directly regulates the glycosidase FUCA1 to promote chemotherapy-induced cell death.
Baudot AD, Crighton D, O'Prey J, Somers J, Sierra Gonzalez P, Ryan KM. Baudot AD, et al. Cell Cycle. 2016 Sep;15(17):2299-308. doi: 10.1080/15384101.2016.1191714. Epub 2016 Jun 17. Cell Cycle. 2016. PMID: 27315169 Free PMC article.
We present here another level of control in p53-mediated tumor suppression by showing that p53 activates the glycosidase, FUCA1, a modulator of N-linked glycosylation. We show that p53 transcriptionally activates FUCA1 and that p53 modulates fucosidase activity via …
We present here another level of control in p53-mediated tumor suppression by showing that p53 activates the glycosidase, FUCA1, a mo …
Potential predictive value of immune-related genes FUCA1 and NCKAP1L for osteosarcoma metastasis.
Wang X, Dou J, Liu M, Zhang Y, Li Y, Tong Z. Wang X, et al. Gene. 2024 Nov 15;927:148645. doi: 10.1016/j.gene.2024.148645. Epub 2024 Jun 5. Gene. 2024. PMID: 38844271 Free article.
Validation of gene expression patterns was performed using polymerase chain reaction, western blot, and immunohistochemistry. RESULTS: The study identified FUCA1 and NCKAP1L as significantly enriched in non-metastatic osteosarcoma, with higher expression associated with be …
Validation of gene expression patterns was performed using polymerase chain reaction, western blot, and immunohistochemistry. RESULTS: The s …
FUCA1 is induced by wild-type p53 and expressed at different levels in thyroid cancers depending on p53 status.
Tsuchida N, Ikeda MA, Ιshino Υ, Grieco M, Vecchio G. Tsuchida N, et al. Int J Oncol. 2017 Jun;50(6):2043-2048. doi: 10.3892/ijo.2017.3968. Epub 2017 Apr 20. Int J Oncol. 2017. PMID: 28440416
By the differential display method, we isolated a 3' non-coding region of alpha-L-fucosidase-1 (FUCA1) (a gene coding for the lysosomal fucosidase-1 enzyme) as a wild-type p53-inducible gene: 18S and 20S FUCA1 mRNA species were induced in Saos-2 cells transfected wi …
By the differential display method, we isolated a 3' non-coding region of alpha-L-fucosidase-1 (FUCA1) (a gene coding for the lysosom …
Novel p53 target gene FUCA1 encodes a fucosidase and regulates growth and survival of cancer cells.
Ezawa I, Sawai Y, Kawase T, Okabe A, Tsutsumi S, Ichikawa H, Kobayashi Y, Tashiro F, Namiki H, Kondo T, Semba K, Aburatani H, Taya Y, Nakagama H, Ohki R. Ezawa I, et al. Cancer Sci. 2016 Jun;107(6):734-45. doi: 10.1111/cas.12933. Epub 2016 May 16. Cancer Sci. 2016. PMID: 26998741 Free PMC article.
FUCA1 loss-of-function mutations are found in several cancers, its expression is reduced in cancers of the large intestine, and low FUCA1 expression is associated with poorer prognosis in several cancers. These results show that protein defucosylation mediated by …
FUCA1 loss-of-function mutations are found in several cancers, its expression is reduced in cancers of the large intestine, and low …
A Novel Homozygous Mutation in the FUCA1 Gene Highlighting Fucosidosis as a Cause of Dystonia: Case Report and Literature Review.
Wali G, Wali GM, Sue CM, Kumar KR. Wali G, et al. Neuropediatrics. 2019 Aug;50(4):248-252. doi: 10.1055/s-0039-1684052. Epub 2019 May 7. Neuropediatrics. 2019. PMID: 31064022 Review.
BACKGROUND: Fucosidosis is a rare lysosomal disorder caused by mutations in the FUCA1 gene. We describe here a novel homozygous mutation in FUCA1 in an Indian fucosidosis case. ...Whole exome sequencing analysis detected a homozygous canonical splice variant in the …
BACKGROUND: Fucosidosis is a rare lysosomal disorder caused by mutations in the FUCA1 gene. We describe here a novel homozygous mutat …
Novel mutations in the FUCA1 gene that cause fucosidosis.
Panmontha W, Amarinthnukrowh P, Damrongphol P, Desudchit T, Suphapeetiporn K, Shotelersuk V. Panmontha W, et al. Genet Mol Res. 2016 Sep 16;15(3). doi: 10.4238/gmr.15038733. Genet Mol Res. 2016. PMID: 27706744 Free article.
The disease is caused by mutations in the FUCA1 gene that lead to deficiency of a-L-fucosidase. Here, we describe the clinical and molecular features of a Thai boy with fucosidosis. ...Neither mutation has been reported before so the FUCA1 mutational spectrum is her …
The disease is caused by mutations in the FUCA1 gene that lead to deficiency of a-L-fucosidase. Here, we describe the clinical and mo …
Fucosidosis with Pathogenic Variant in FUCA1 Gene.
Gowda VK, Srinivasan VM, Vegda H, Bhat M. Gowda VK, et al. Indian J Pediatr. 2020 Oct;87(10):867-868. doi: 10.1007/s12098-020-03246-7. Epub 2020 Mar 3. Indian J Pediatr. 2020. PMID: 32125660 No abstract available.
Fucosidosis in Tunisian patients: mutational analysis and homology-based modeling of FUCA1 enzyme.
Chkioua L, Amri Y, Chaima S, Fenni F, Boudabous H, Ben Turkia H, Messaoud T, Tebib N, Laradi S. Chkioua L, et al. BMC Med Genomics. 2021 Aug 23;14(1):208. doi: 10.1186/s12920-021-01061-3. BMC Med Genomics. 2021. PMID: 34425818 Free PMC article.
METHODS: All exons and flanking intron regions of FUCA1 were screened by direct sequencing to identify mutations and polymorphisms in three unrelated families with fucosidosis. ...We verified that this sequence variation did not correspond to a polymorphism by testing 50 u …
METHODS: All exons and flanking intron regions of FUCA1 were screened by direct sequencing to identify mutations and polymorphisms in …
Gene expression analysis for evaluation of potential biomarkers in hepatocellular carcinoma.
Hass HG, Jobst J, Scheurlen M, Vogel U, Nehls O. Hass HG, et al. Anticancer Res. 2015 Apr;35(4):2021-8. Anticancer Res. 2015. PMID: 25862856
RESULTS: Four candidate genes (FUCA1, HGF, IGF1, CgA) showed low median fold changes (fc) of expression compared to corresponding non-malignant liver tissues (fc range=0.2-0.8; maximum 15% of samples). ...CONCLUSION: Unlike previous studies, our results did not confirm …
RESULTS: Four candidate genes (FUCA1, HGF, IGF1, CgA) showed low median fold changes (fc) of expression compared to corresponding non …
Transcriptomic analysis of FUCA1 knock-down in keratinocytes reveals new insights into the pathogenesis of fucosidosis skin lesions.
Valero-Rubio D, Jiménez KM, Fonseca DJ, Payán-Gómez C, Laissue P. Valero-Rubio D, et al. Exp Dermatol. 2018 Jun;27(6):663-667. doi: 10.1111/exd.13532. Exp Dermatol. 2018. PMID: 29518279
The effect of FUCA1 dysfunction on gene expression is unknown. The aim of this study was to analyse, in keratinocytes, the transcriptomic effect of FUCA1 knock-down for a better understanding of skin lesions' pathogenesis affecting fucosidosis patients. FUCA1 …
The effect of FUCA1 dysfunction on gene expression is unknown. The aim of this study was to analyse, in keratinocytes, the transcript …
24 results