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Page 1
Inhibition of DYRK1B BY C81 impedes inflammatory processes in leukocytes by reducing STAT3 activity.
Ciurus S, Elewa MAF, Palmer MA, Wolf A, Hector M, Fuhrmann DC, Thomas D, Gurke R, Schwalm MP, Berger L, Zech TJ, Burgers LD, Marschalek R, Geisslinger G, Knapp S, Langmann T, Bracher F, Weigert A, Fürst R. Ciurus S, et al. Among authors: fuhrmann dc. Cell Mol Life Sci. 2025 Feb 22;82(1):85. doi: 10.1007/s00018-025-05579-y. Cell Mol Life Sci. 2025. PMID: 39985685 Free PMC article.
Inflammation in a ferroptotic environment.
Wickert A, Schwantes A, Fuhrmann DC, Brüne B. Wickert A, et al. Among authors: fuhrmann dc. Front Pharmacol. 2024 Sep 20;15:1474285. doi: 10.3389/fphar.2024.1474285. eCollection 2024. Front Pharmacol. 2024. PMID: 39372215 Free PMC article. Review.
Ferroptosis in health and disease.
Berndt C, Alborzinia H, Amen VS, Ayton S, Barayeu U, Bartelt A, Bayir H, Bebber CM, Birsoy K, Böttcher JP, Brabletz S, Brabletz T, Brown AR, Brüne B, Bulli G, Bruneau A, Chen Q, DeNicola GM, Dick TP, Distéfano A, Dixon SJ, Engler JB, Esser-von Bieren J, Fedorova M, Friedmann Angeli JP, Friese MA, Fuhrmann DC, García-Sáez AJ, Garbowicz K, Götz M, Gu W, Hammerich L, Hassannia B, Jiang X, Jeridi A, Kang YP, Kagan VE, Konrad DB, Kotschi S, Lei P, Le Tertre M, Lev S, Liang D, Linkermann A, Lohr C, Lorenz S, Luedde T, Methner A, Michalke B, Milton AV, Min J, Mishima E, Müller S, Motohashi H, Muckenthaler MU, Murakami S, Olzmann JA, Pagnussat G, Pan Z, Papagiannakopoulos T, Pedrera Puentes L, Pratt DA, Proneth B, Ramsauer L, Rodriguez R, Saito Y, Schmidt F, Schmitt C, Schulze A, Schwab A, Schwantes A, Soula M, Spitzlberger B, Stockwell BR, Thewes L, Thorn-Seshold O, Toyokuni S, Tonnus W, Trumpp A, Vandenabeele P, Vanden Berghe T, Venkataramani V, Vogel FCE, von Karstedt S, Wang F, Westermann F, Wientjens C, Wilhelm C, Wölk M, Wu K, Yang X, Yu F, Zou Y, Conrad M. Berndt C, et al. Among authors: fuhrmann dc. Redox Biol. 2024 Sep;75:103211. doi: 10.1016/j.redox.2024.103211. Epub 2024 May 30. Redox Biol. 2024. PMID: 38908072 Free PMC article. Review.
BI-3231, an enzymatic inhibitor of HSD17B13, reduces lipotoxic effects induced by palmitic acid in murine and human hepatocytes.
Alcober-Boquet L, Kraus N, Huber LS, Vutukuri R, Fuhrmann DC, Stross C, Schaefer L, Scholich K, Zeuzem S, Piiper A, Schulz MH, Trebicka J, Welsch C, Ortiz C. Alcober-Boquet L, et al. Among authors: fuhrmann dc. Am J Physiol Cell Physiol. 2024 Mar 1;326(3):C880-C892. doi: 10.1152/ajpcell.00413.2023. Epub 2024 Jan 15. Am J Physiol Cell Physiol. 2024. PMID: 38223924 Free article.
PDP1 is a key metabolic gatekeeper and modulator of drug resistance in FLT3-ITD-positive acute myeloid leukemia.
Alshamleh I, Kurrle N, Makowka P, Bhayadia R, Kumar R, Süsser S, Seibert M, Ludig D, Wolf S, Koschade SE, Stoschek K, Kreitz J, Fuhrmann DC, Toenges R, Notaro M, Comoglio F, Schuringa JJ, Berg T, Brüne B, Krause DS, Klusmann JH, Oellerich T, Schnütgen F, Schwalbe H, Serve H. Alshamleh I, et al. Among authors: fuhrmann dc. Leukemia. 2023 Dec;37(12):2367-2382. doi: 10.1038/s41375-023-02041-5. Epub 2023 Nov 7. Leukemia. 2023. PMID: 37935978 Free PMC article.
Adaptive responses of neuronal cells to chronic endoplasmic reticulum (ER) stress.
Pham TNM, Perumal N, Manicam C, Basoglu M, Eimer S, Fuhrmann DC, Pietrzik CU, Clement AM, Körschgen H, Schepers J, Behl C. Pham TNM, et al. Among authors: fuhrmann dc. Redox Biol. 2023 Nov;67:102943. doi: 10.1016/j.redox.2023.102943. Epub 2023 Oct 20. Redox Biol. 2023. PMID: 37883843 Free PMC article.
Hypoxia induced deregulation of sphingolipids in colon cancer is a prognostic marker for patient outcome.
El Hindi K, Brachtendorf S, Hartel JC, Renné C, Birod K, Schilling K, Labocha S, Thomas D, Ferreirós N, Hahnefeld L, Dorochow E, Del Turco D, Deller T, Scholich K, Fuhrmann DC, Weigert A, Brüne B, Geisslinger G, Wittig I, Link KH, Grösch S. El Hindi K, et al. Among authors: fuhrmann dc. Biochim Biophys Acta Mol Basis Dis. 2024 Jan;1870(1):166906. doi: 10.1016/j.bbadis.2023.166906. Epub 2023 Oct 4. Biochim Biophys Acta Mol Basis Dis. 2024. PMID: 37802156 Free article.
Hypoxia-altered cholesterol homeostasis enhances the expression of interferon-stimulated genes upon SARS-CoV-2 infections in monocytes.
Bauer R, Meyer SP, Raue R, Palmer MA, Guerrero Ruiz VM, Cardamone G, Rösser S, Heffels M, Roesmann F, Wilhelm A, Lütjohann D, Zarnack K, Fuhrmann DC, Widera M, Schmid T, Brüne B. Bauer R, et al. Among authors: fuhrmann dc. Front Immunol. 2023 Jun 12;14:1121864. doi: 10.3389/fimmu.2023.1121864. eCollection 2023. Front Immunol. 2023. PMID: 37377965 Free PMC article.
HIF1α-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex.
Leisegang MS, Bains JK, Seredinski S, Oo JA, Krause NM, Kuo CC, Günther S, Sentürk Cetin N, Warwick T, Cao C, Boos F, Izquierdo Ponce J, Haydar S, Bednarz R, Valasarajan C, Fuhrmann DC, Preussner J, Looso M, Pullamsetti SS, Schulz MH, Jonker HRA, Richter C, Rezende F, Gilsbach R, Pflüger-Müller B, Wittig I, Grummt I, Ribarska T, Costa IG, Schwalbe H, Brandes RP. Leisegang MS, et al. Among authors: fuhrmann dc. Nat Commun. 2022 Nov 2;13(1):6563. doi: 10.1038/s41467-022-34252-2. Nat Commun. 2022. PMID: 36323673 Free PMC article.
SAFit2 reduces neuroinflammation and ameliorates nerve injury-induced neuropathic pain.
Wedel S, Mathoor P, Rauh O, Heymann T, Ciotu CI, Fuhrmann DC, Fischer MJM, Weigert A, de Bruin N, Hausch F, Geisslinger G, Sisignano M. Wedel S, et al. Among authors: fuhrmann dc. J Neuroinflammation. 2022 Oct 10;19(1):254. doi: 10.1186/s12974-022-02615-7. J Neuroinflammation. 2022. PMID: 36217203 Free PMC article.
MicroRNA-200c Attenuates the Tumor-Infiltrating Capacity of Macrophages.
Raue R, Frank AC, Fuhrmann DC, de la Cruz-Ojeda P, Rösser S, Bauer R, Cardamone G, Weigert A, Syed SN, Schmid T, Brüne B. Raue R, et al. Among authors: fuhrmann dc. Biology (Basel). 2022 Feb 22;11(3):349. doi: 10.3390/biology11030349. Biology (Basel). 2022. PMID: 35336722 Free PMC article.
The proteogenomic subtypes of acute myeloid leukemia.
Jayavelu AK, Wolf S, Buettner F, Alexe G, Häupl B, Comoglio F, Schneider C, Doebele C, Fuhrmann DC, Wagner S, Donato E, Andresen C, Wilke AC, Zindel A, Jahn D, Splettstoesser B, Plessmann U, Münch S, Abou-El-Ardat K, Makowka P, Acker F, Enssle JC, Cremer A, Schnütgen F, Kurrle N, Chapuy B, Löber J, Hartmann S, Wild PJ, Wittig I, Hübschmann D, Kaderali L, Cox J, Brüne B, Röllig C, Thiede C, Steffen B, Bornhäuser M, Trumpp A, Urlaub H, Stegmaier K, Serve H, Mann M, Oellerich T. Jayavelu AK, et al. Among authors: fuhrmann dc. Cancer Cell. 2022 Mar 14;40(3):301-317.e12. doi: 10.1016/j.ccell.2022.02.006. Epub 2022 Mar 3. Cancer Cell. 2022. PMID: 35245447 Free article.
Reduced exploratory behavior in neuronal nucleoredoxin knockout mice.
Tran BN, Valek L, Wilken-Schmitz A, Fuhrmann DC, Namgaladze D, Wittig I, Tegeder I. Tran BN, et al. Among authors: fuhrmann dc. Redox Biol. 2021 Sep;45:102054. doi: 10.1016/j.redox.2021.102054. Epub 2021 Jun 23. Redox Biol. 2021. PMID: 34198070 Free PMC article.
Sphingosine kinase 2 is a negative regulator of inflammatory macrophage activation.
Weigert A, von Knethen A, Thomas D, Faria I, Namgaladze D, Zezina E, Fuhrmann D, Petcherski A, Heringdorf DMZ, Radeke HH, Brüne B. Weigert A, et al. Among authors: fuhrmann d. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Sep;1864(9):1235-1246. doi: 10.1016/j.bbalip.2019.05.008. Epub 2019 May 23. Biochim Biophys Acta Mol Cell Biol Lipids. 2019. PMID: 31128248 Free article.
GPER1 influences cellular homeostasis and cytostatic drug resistance via influencing long chain ceramide synthesis in breast cancer cells.
Wegner MS, Gruber L, Schömel N, Trautmann S, Brachtendorf S, Fuhrmann D, Schreiber Y, Olesch C, Brüne B, Geisslinger G, Grösch S. Wegner MS, et al. Among authors: fuhrmann d. Int J Biochem Cell Biol. 2019 Jul;112:95-106. doi: 10.1016/j.biocel.2019.05.002. Epub 2019 May 11. Int J Biochem Cell Biol. 2019. PMID: 31082617
Chemosensitivity of human colon cancer cells is influenced by a p53-dependent enhancement of ceramide synthase 5 and induction of autophagy.
Brachtendorf S, Wanger RA, Birod K, Thomas D, Trautmann S, Wegner MS, Fuhrmann DC, Brüne B, Geisslinger G, Grösch S. Brachtendorf S, et al. Among authors: fuhrmann dc. Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Oct;1863(10):1214-1227. doi: 10.1016/j.bbalip.2018.07.011. Epub 2018 Jul 27. Biochim Biophys Acta Mol Cell Biol Lipids. 2018. PMID: 30059758
Redox-signals and macrophage biology.
Weigert A, von Knethen A, Fuhrmann D, Dehne N, Brüne B. Weigert A, et al. Among authors: fuhrmann d. Mol Aspects Med. 2018 Oct;63:70-87. doi: 10.1016/j.mam.2018.01.003. Epub 2018 Jan 12. Mol Aspects Med. 2018. PMID: 29329794 Review.