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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
1994 1
1996 3
1997 1
1998 1
1999 2
2000 2
2001 6
2002 6
2003 1
2004 5
2005 8
2006 6
2007 11
2008 14
2009 12
2010 15
2011 18
2012 14
2013 15
2014 8
2015 11
2016 12
2017 8
2018 9
2019 10
2020 16
2021 11
2022 16
2023 11
2024 8
2025 3
2026 8

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251 results

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Page 1
Novel drug targets in 2025.
Avram S, Halip L, Curpan R, Aliper A, Ren F, Zhavoronkov A, Oprea TI. Avram S, et al. Among authors: oprea ti. Nat Rev Drug Discov. 2026 Jul;25(7):503. doi: 10.1038/d41573-026-00102-9. Nat Rev Drug Discov. 2026. PMID: 42286267 No abstract available.
Target identification and assessment in the era of AI.
Pun FW, Podolskiy D, Izumchenko E, Mortlock A, Oprea TI, Scheibye-Knudsen M, Fortney K, Morgen E, Ren F, Zhavoronkov A. Pun FW, et al. Among authors: oprea ti. Nat Rev Drug Discov. 2026 Jul;25(7):534-552. doi: 10.1038/s41573-026-01412-8. Epub 2026 Apr 20. Nat Rev Drug Discov. 2026. PMID: 42009769 Review.
How many protein pairs can we chemically target?
Falaguera MJ, Oprea TI, Mestres J. Falaguera MJ, et al. Among authors: oprea ti. Drug Discov Today. 2026 Jun 18;31(4):104718. doi: 10.1016/j.drudis.2026.104718. Online ahead of print. Drug Discov Today. 2026. PMID: 42314832 Free article. Review.
The Common Fund Data Ecosystem (CFDE).
Jurgens JA, Bueckle A, Vora J, Maurya MR, Ahooyi TM, Zheng E, Stear B, Wang D, Ree C, Ramachandran S, Nekrutenko A, Brandes M, Thaker S, Katz DH, Munoz-Torres MC, Diamant I, Chun HE, Simmons JA, Tasian SK, Jenkins SL, Evangelista JE, Dodia H, Saha S, Lindquist MA, Gajjala V, Nemarich C, Zhen J, Ross KE, Byrd AI, Shilin A, Metzger VT, Bologa CG, Srinivasan S, Jang D, Kumar P, Taub LD, Levanto MP, Petrosyan V, Anandakrishnan M, Kim M, Clarke DJB, Ivich A, Crichton DJ, Smallen S, Bordelon D, Chen C, Schroeder AJ, Mahabal A, Cao-Berg I, Kim S, Masood D, Yu K, Gaulton KJ, Jimenez-Morales D, Rincon JM, Honick BJ, Wang W, Wu CH, Milosavljevic A, Blood PD, Boline J, Oprea TI, Lambert CG, de Bono B, Park PJ, Silverstein JC, Flannick J, Yang JJ, Grethe JS, Subramaniam S, Tiemeyer M, Clark T, Wheeler MT, Kahn A, Burnette J, Ranzinger R, Schatz MC, Gibson L, Burtt NP, Carson JP, Chen JY, Ping P, Davis S, Taylor DM, Börner K, Dillman A, Bursey K, Ma'ayan A; CFDE Consortium; Mazumder R, Roth ME, Greene CS. Jurgens JA, et al. Among authors: oprea ti. bioRxiv [Preprint]. 2026 Apr 16:2026.04.10.717672. doi: 10.64898/2026.04.10.717672. bioRxiv. 2026. PMID: 41993383 Free PMC article. Preprint.
Mondo: integrating disease terminology across communities.
Vasilevsky NA, Toro S, Matentzoglu N, Flack JE, Mullen KR, Hegde H, Gehrke S, Whetzel PL, Shwetar Y, Harris NL, Ngu MS, Alyea GL, Kane MS, Roncaglia P, Sid E, Thaxton CL, Wood V, Abraham RS, Achatz MI, Ajuyah P, Amberger JS, Babb L, Baker J, Balhoff JP, Berg JS, Bhalla A, Bofill-De Ros X, Braun IR, Broeren EC, Byer BK, Byrne AB, Callahan TJ, Carmody LC, Chan LE, Clause AR, Cohen JS, DeLuca M, Deuitch NT, Flowers M, Fraser J, Fujiwara T, Gitau V, Goldstein JL, Gration D, Groza T, Gyori BM, Hankey W, Hilton JA, Himmelstein DS, Hong SS, Hoyt CT, Huether R, Hurwitz E, Jacobsen JOB, Kikuchi A, Köhler S, Korn DR, Lagorce D, Laraway BJ, Li JY, Malheiro AJ, McLaughlin J, Meldal BHM, Mohan S, Moxon SAT, Munoz-Torres MC, Nelson TH, Nicholas FW, Ochoa D, Olson D, Oprea TI, Oskotsky TT, Osumi-Sutherland D, Paris K, Parkinson HE, Pendlington ZM, Peng XP, Pizzino A, Plon SE, Powell BC, Ratliff JC, Rehm HL, Remennik L, Riggs ER, Roberts S, Robinson PN, Ross JE, Schaper K, Schilder BM, Schmidt JL, Sharp EW, Similuk MN, Smedley D, Sneddon TP, Sparks R, Stefancsik R, Stupp GS, Sundar S, Takatsuki T, Tammen I, Tshering KC, Unni DR, Valasek E, Vanderver A, Wagner AH, Webb RF, Welter D, Yaya-St… See abstract for full author list ➔ Vasilevsky NA, et al. Among authors: oprea ti. Genetics. 2026 Apr 4;232(4):iyaf215. doi: 10.1093/genetics/iyaf215. Genetics. 2026. PMID: 41052288 Free PMC article.
CACHE Challenge #3: Targeting the Nsp3 Macrodomain of SARS-CoV-2.
Herasymenko O, Silva M, Correy GJ, Abu-Saleh AAA, Ackloo S, Arrowsmith C, Ashworth A, Ban F, Beck H, Bishop KP, Bohórquez HJ, Bolotokova A, Breznik M, Chau I, Chen Y, Cherkasov A, Dehaen W, Della Corte D, Denzinger K, Doering NP, Edfeldt K, Edwards A, Fayne D, Gentile F, Gibson E, Gokdemir O, Gunnarsson A, Günther J, Irwin JJ, Jensen JH, Harding RJ, Hillisch A, Hoffer L, Hogner A, Hutchinson A, Kandwal S, Karlova A, Koirala K, Kotelnikov S, Kozakov D, Lee J, Lee S, Lessel U, Liu S, Liu X, Loppnau P, Meiler J, Moretti R, Moroz YS, Muvva C, Oprea TI, Paige B, Pandit A, Park K, Poda G, Protopopov MV, Pütter V, Ravichandran R, Rognan D, Rosta E, Sabnis Y, Scott T, Seitova A, Sharma P, Sindt F, Song M, Steinmann C, Stevens R, Talagayev V, Tararina VV, Tarkhanova O, Tingey D, Trant JF, Treleaven D, Tropsha A, Walters P, Wells J, Westermaier Y, Wolber G, Wortmann L, Zheng S, Fraser JS, Schapira M. Herasymenko O, et al. Among authors: oprea ti. J Chem Inf Model. 2026 Feb 9;66(3):1566-1581. doi: 10.1021/acs.jcim.5c02441. Epub 2026 Jan 21. J Chem Inf Model. 2026. PMID: 41565251 Free PMC article.
Fat Mass Is Associated with Aging Rather than Menopausal Transition.
Barbu CG, Nistor IM, Albu A, Martin SC, Oprea TE, Sirbu AE, Vlad A, Fica S. Barbu CG, et al. Among authors: oprea te. Healthcare (Basel). 2026 Jan 28;14(3):333. doi: 10.3390/healthcare14030333. Healthcare (Basel). 2026. PMID: 41682183 Free PMC article.
Medicines, Diseases, Indications, and Contraindications (MeDIC): a foundational resource to support drug repurposing.
DeLuca M, Matentzoglu N, Sharp E, Li J, Hempstead C, Lim M, Kaniewski P, Carter EK, Koirala K, Ding E, Vijnck L, Brokmeier P, Toro S, Schaper K, Vergine J, Li O, Oprea TI, Fajgenbaum DC, Bizon C, Haendel M, Tropsha A. DeLuca M, et al. Among authors: oprea ti. Nucleic Acids Res. 2026 Jan 6;54(D1):D1477-D1487. doi: 10.1093/nar/gkaf1312. Nucleic Acids Res. 2026. PMID: 41385096 Free PMC article.
Novel drug targets in 2024.
Avram S, Halip L, Curpan R, Oprea TI. Avram S, et al. Among authors: oprea ti. Nat Rev Drug Discov. 2025 May;24(5):323. doi: 10.1038/d41573-025-00069-z. Nat Rev Drug Discov. 2025. PMID: 40186036 No abstract available.
251 results