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GNAI3 inhibits tumor cell migration and invasion and is post-transcriptionally regulated by miR-222 in hepatocellular carcinoma.
Zhang Y, Yao J, Huan L, Lian J, Bao C, Li Y, Ge C, Li J, Yao M, Liang L, He X. Zhang Y, et al. Cancer Lett. 2015 Jan 28;356(2 Pt B):978-84. doi: 10.1016/j.canlet.2014.11.013. Epub 2014 Nov 13. Cancer Lett. 2015. PMID: 25444921
Guanine nucleotide binding protein, alpha inhibiting activity polypeptide 3 (GNAI3) is involved in many biological processes. ...Using software predictions and experimental screening, we found that miR-222 could directly bind to GNAI3 mRN …
Guanine nucleotide binding protein, alpha inhibiting activity polypeptide 3 (GNAI3) is involved in many b …
A human homeotic transformation resulting from mutations in PLCB4 and GNAI3 causes auriculocondylar syndrome.
Rieder MJ, Green GE, Park SS, Stamper BD, Gordon CT, Johnson JM, Cunniff CM, Smith JD, Emery SB, Lyonnet S, Amiel J, Holder M, Heggie AA, Bamshad MJ, Nickerson DA, Cox TC, Hing AV, Horst JA, Cunningham ML. Rieder MJ, et al. Am J Hum Genet. 2012 May 4;90(5):907-14. doi: 10.1016/j.ajhg.2012.04.002. Am J Hum Genet. 2012. PMID: 22560091 Free PMC article.
We used exome sequencing of five probands and identified two novel (exclusive to the patient and/or family studied) missense mutations in PLCB4 and a shared mutation in GNAI3 in two unrelated probands. In confirmatory studies, three additional novel PLCB4 mutations were fo …
We used exome sequencing of five probands and identified two novel (exclusive to the patient and/or family studied) missense mutations in PL …
Role of GATA binding protein 4 (GATA4) in the regulation of tooth development via GNAI3.
Guo S, Zhang Y, Zhou T, Wang D, Weng Y, Wang L, Ma J. Guo S, et al. Sci Rep. 2017 May 8;7(1):1534. doi: 10.1038/s41598-017-01689-1. Sci Rep. 2017. PMID: 28484278 Free PMC article.
In this study, both GATA4 deletion in the mouse root and knock-down in human SCAPs decreased the expression of GNAI3. Dual-luciferase and ChIP assay confirmed the direct binding of GATA4 to the GNAI3 promoter, both in vitro and in vivo. GNAI3 knock-down signi …
In this study, both GATA4 deletion in the mouse root and knock-down in human SCAPs decreased the expression of GNAI3. Dual-luciferase …
Auriculocondylar syndrome: Pathogenesis, clinical manifestations and surgical therapies.
Li Q, Jiang Z, Zhang L, Cai S, Cai Z. Li Q, et al. J Formos Med Assoc. 2023 Sep;122(9):822-842. doi: 10.1016/j.jfma.2023.04.024. Epub 2023 May 17. J Formos Med Assoc. 2023. PMID: 37208246 Free article. Review.
Auriculocondylar syndrome (ARCND) is a genetic and rare craniofacial condition caused by abnormal development of the first and second pharyngeal arches during the embryonic stage and is characterized by peculiar auricular malformations (question mark ears), mandibular condyle hyp …
Auriculocondylar syndrome (ARCND) is a genetic and rare craniofacial condition caused by abnormal development of the first and second pharyn …
Novel variants in GNAI3 associated with auriculocondylar syndrome strengthen a common dominant negative effect.
Romanelli Tavares VL, Gordon CT, Zechi-Ceide RM, Kokitsu-Nakata NM, Voisin N, Tan TY, Heggie AA, Vendramini-Pittoli S, Propst EJ, Papsin BC, Torres TT, Buermans H, Capelo LP, den Dunnen JT, Guion-Almeida ML, Lyonnet S, Amiel J, Passos-Bueno MR. Romanelli Tavares VL, et al. Eur J Hum Genet. 2015 Apr;23(4):481-5. doi: 10.1038/ejhg.2014.132. Epub 2014 Jul 16. Eur J Hum Genet. 2015. PMID: 25026904 Free PMC article.
To date, two GNAI3 variants in three families have been reported. Here we report three novel GNAI3 variants, one segregating with affected members in a family previously linked to 1p21.1-q23.3 and two de novo variants in simplex cases. ...Structural modeling shows t …
To date, two GNAI3 variants in three families have been reported. Here we report three novel GNAI3 variants, one segregating w …
GNAI3: Another Candidate Gene to Screen in Persons with Ocular Albinism.
Young A, Dandekar U, Pan C, Sader A, Zheng JJ, Lewis RA, Farber DB. Young A, et al. PLoS One. 2016 Sep 8;11(9):e0162273. doi: 10.1371/journal.pone.0162273. eCollection 2016. PLoS One. 2016. PMID: 27607449 Free PMC article.
Using computational methods, we modeled the GNAI3 protein and its non-synonymous exonic mutations and determined that several of these may be the cause of disease in the patients studied. Thus, we have identified GNAI3 as a second gene possibly responsible for X-lin …
Using computational methods, we modeled the GNAI3 protein and its non-synonymous exonic mutations and determined that several of thes …
Pan-Cancer Analysis of G Protein-Coupled Receptors as Cancer Driver Genes and Drug Repurposing Targets.
Hou Y, Liu Y, Pang C, Shi N, Huang X, Cao C, Shu C. Hou Y, et al. J Chem Inf Model. 2025 Jul 14;65(13):7209-7224. doi: 10.1021/acs.jcim.5c00689. Epub 2025 Jul 3. J Chem Inf Model. 2025. PMID: 40607519
Notably, most cancer prognosis-related GPCRs are coupled with Gi (GNAI1, GNAI2, and GNAI3) and Gq/11 signaling pathways. Moreover, G4s, SEs, and mRNA structure could be utilized to explain some of the abnormal expression for cancer prognosis-related GPCRs. ...
Notably, most cancer prognosis-related GPCRs are coupled with Gi (GNAI1, GNAI2, and GNAI3) and Gq/11 signaling pathways. Moreover, G4 …
Pilocytic astrocytoma harboring a novel GNAI3-BRAF fusion.
Lin R, Kenyon A, Wang ZX, Cai J, Iacovitti L, Kenyon LC. Lin R, et al. Neuropathology. 2023 Oct;43(5):391-395. doi: 10.1111/neup.12896. Epub 2023 Feb 14. Neuropathology. 2023. PMID: 36786200
Here, we report a case of a young adult patient with a large, right-sided posterior fossa cerebellar and cerebellopontine angle region mass consistent with a PA. Of note, NGS detected a novel GNAI3-BRAF fusion, which results in an in-frame fusion protein containing the kin …
Here, we report a case of a young adult patient with a large, right-sided posterior fossa cerebellar and cerebellopontine angle region mass …
Novel CpG-SNPs in the gastric acid secretion pathway GNAI3 and susceptibility to gastric cancer.
Liu M, Li S, Du M, Chu H, Wang M, Zhang Z. Liu M, et al. Gene. 2020 Apr 30;736:144447. doi: 10.1016/j.gene.2020.144447. Epub 2020 Feb 4. Gene. 2020. PMID: 32032744
RESULTS: We identified that the CpG-SNP rs11810577 in GNAI3 was significantly increased gastric cancer risk (OR = 1.19, 95% CI = 1.07-1.32, P = 1.12 10(-3)). ...Moreover, we found AMIGO1 had a lower expression levels in gastric cancer tissues than normal tissues (P = 0.0 …
RESULTS: We identified that the CpG-SNP rs11810577 in GNAI3 was significantly increased gastric cancer risk (OR = 1.19, 95% CI = 1.07 …
A Four Autophagy-Related Gene-Based Prognostic Signature for Pancreatic Cancer.
Zhou Q, Chen X, Chen Q, Liu H, Hao L. Zhou Q, et al. Crit Rev Eukaryot Gene Expr. 2021;31(4):89-100. doi: 10.1615/CritRevEukaryotGeneExpr.2021038733. Crit Rev Eukaryot Gene Expr. 2021. PMID: 34587439
Multivariate Cox regression analysis found that ATG16L2, GNAI3, APOL1, and PTK6 genes may be the key ARGs affecting the prognosis of pancreatic cancer patients. ...Pearson's correlation coefficient showed that the four key ARGs may affect the development of pancreatic canc …
Multivariate Cox regression analysis found that ATG16L2, GNAI3, APOL1, and PTK6 genes may be the key ARGs affecting the prognosis of …
37 results