Outcome and toxicities associated to chemotherapy in children with acute lymphoblastic leukemia and Gilbert syndrome. Usefulness of UGT1A1 mutational screening.
Berrueco R, Alonso-Saladrigues A, Martorell-Sampol L, Català-Temprano A, Ruiz-Llobet A, Toll T, Torrebadell M, Naudó M, Camós M, Rives S.
Berrueco R, et al.
Pediatr Blood Cancer. 2015 Jul;62(7):1195-201. doi: 10.1002/pbc.25457. Epub 2015 Apr 8.
Pediatr Blood Cancer. 2015.
PMID: 25855413
Although intensive chemotherapy has improved survival in those patients, important side effects, including hyperbilirubinemia, are frequent. Gilbert syndrome (GS) is a frequent condition that causes a reduction in glucuronidation and intermittent hyperbilirubinemia …
Although intensive chemotherapy has improved survival in those patients, important side effects, including hyperbilirubinemia, are frequent. …