Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2019 5
2020 9
2021 8
2022 4
2023 2
2024 7
2025 1

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

31 results

Results by year

Filters applied: . Clear all
Page 1
MiR-612 regulates invadopodia of hepatocellular carcinoma by HADHA-mediated lipid reprogramming.
Liu Y, Lu LL, Wen D, Liu DL, Dong LL, Gao DM, Bian XY, Zhou J, Fan J, Wu WZ. Liu Y, et al. J Hematol Oncol. 2020 Feb 7;13(1):12. doi: 10.1186/s13045-019-0841-3. J Hematol Oncol. 2020. PMID: 32033570 Free PMC article.

The levels of acetyl CoA were significantly decreased, about 1/3 (p > 0.05) or 1/2 (p < 0.05) of their controls, in exogenous miR-612 or hadha-shRNA transfected HCCLM3 cell lines. Besides, overexpression of hadha cell lines had a high expression level of total

…

The levels of acetyl CoA were significantly decreased, about 1/3 (p > 0.05) or 1/2 (p < 0.05) of their controls, in exogenous miR-612

…
TFP/LCHAD Deficiency Due to HADHA Gene Mutation.
Chen QL, Zhang CM. Chen QL, et al. Clin Pediatr (Phila). 2024 Nov;63(11):1604-1607. doi: 10.1177/00099228241233099. Epub 2024 Feb 20. Clin Pediatr (Phila). 2024. PMID: 38379183 No abstract available.
HADHA promotes glioma progression by accelerating MDM2-mediated p53 ubiquitination.
Chen R, Chen H, Hu C. Chen R, et al. Cancer Gene Ther. 2024 Sep;31(9):1380-1389. doi: 10.1038/s41417-024-00801-8. Epub 2024 Jul 22. Cancer Gene Ther. 2024. PMID: 39039194
In this study, we used immunohistochemistry staining to assess the expression level of HADHA in glioma tissues. We also evaluated the correlation between HADHA expression and patient survival using the Kaplan-Meier method. ...Our research findings indicate that glio …
In this study, we used immunohistochemistry staining to assess the expression level of HADHA in glioma tissues. We also evaluated the …
Mitochondrial bioenergetics and cardiolipin remodeling abnormalities in mitochondrial trifunctional protein deficiency.
Vieira Neto E, Wang M, Szuminsky AJ, Ferraro L, Koppes E, Wang Y, Van't Land C, Mohsen AW, Zanatta G, El-Gharbawy AH, Anthonymuthu TS, Tyurina YY, Tyurin VA, Kagan V, Bayır H, Vockley J. Vieira Neto E, et al. JCI Insight. 2024 Sep 10;9(17):e176887. doi: 10.1172/jci.insight.176887. JCI Insight. 2024. PMID: 39088276 Free PMC article.
Mitochondrial trifunctional protein (TFP) deficiency is an inherited metabolic disorder leading to a block in long-chain fatty acid beta-oxidation. Mutations in HADHA and HADHB, which encode the TFP alpha and beta subunits, respectively, usually result in combined TFP defi …
Mitochondrial trifunctional protein (TFP) deficiency is an inherited metabolic disorder leading to a block in long-chain fatty acid beta-oxi …
Genetic diversity in Kashubs: the regional increase in the frequency of several disease-causing variants.
Jankowski M, Daca-Roszak P, Obracht-Prondzyński C, Płoski R, Lipska-Ziętkiewicz BS, Ziętkiewicz E. Jankowski M, et al. J Appl Genet. 2022 Dec;63(4):691-701. doi: 10.1007/s13353-022-00713-z. Epub 2022 Aug 15. J Appl Genet. 2022. PMID: 35971028 Free PMC article. Review.
These include the following: (1) c.662A > G (p.Asp221Gly) in LDLR, causing heterozygous familial hypercholesterolemia; (2) c.3700_3704del in BRCA1, associated with hereditary breast and ovarian cancer syndrome; (3) c.1528G > C (p.Glu510Gln) in HADHA, seen in long-cha …
These include the following: (1) c.662A > G (p.Asp221Gly) in LDLR, causing heterozygous familial hypercholesterolemia; (2) c.3700_3704del …
Defects in long-chain 3-hydroxy acyl-CoA dehydrogenase lead to hepatocellular carcinoma: A novel etiology of hepatocellular carcinoma.
Khare T, Khare S, Angdisen JJ, Zhang Q, Stuckel A, Mooney BP, Ridenhour SE, Gitan RS, Hammoud GM, Ibdah JA. Khare T, et al. Int J Cancer. 2020 Sep 1;147(5):1461-1473. doi: 10.1002/ijc.32943. Epub 2020 Mar 16. Int J Cancer. 2020. PMID: 32115688
Here we report, for the first time, generation of a mouse model with a defect in long-chain 3-hydoxy acyl-CoA dehydrogenase (LCHAD). The LCHAD exon 15 deletion was embryonic lethal to the homozygous mice whereas heterozygous mice (HT) develop significant hepatic ste …
Here we report, for the first time, generation of a mouse model with a defect in long-chain 3-hydoxy acyl-CoA dehydrogenase (LCHAD). …
Generation of an induced pluripotent stem cell line, ICGi028-A, by reprogramming peripheral blood mononuclear cells of a patient suffering from hypertrophic cardiomyopathy and carrying a heterozygous p.E510Q mutation in HADHA.
Dementyeva EV, Vyatkin YV, Chernyavsky AM, Zakian SM. Dementyeva EV, et al. Stem Cell Res. 2021 May;53:102348. doi: 10.1016/j.scr.2021.102348. Epub 2021 Apr 19. Stem Cell Res. 2021. PMID: 33887580 Free article.
We generated an iPSC line from peripheral blood mononuclear cells of an HCM patient with a heterozygous p.E510Q mutation in HADHA using non-integrating episomal vectors. The iPSC line showed typical morphology, expression of pluripotency markers, capacity to be differentia …
We generated an iPSC line from peripheral blood mononuclear cells of an HCM patient with a heterozygous p.E510Q mutation in HADHA usi …
An Autopsy Analysis of a Patient With Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency Caused by Compound Heterozygous HADHA Gene Mutations.
Zhang Q, Yao N, Liu Z, Xu C, Ding Z. Zhang Q, et al. Am J Forensic Med Pathol. 2023 Dec 1;44(4):336-339. doi: 10.1097/PAF.0000000000000872. Epub 2023 Aug 5. Am J Forensic Med Pathol. 2023. PMID: 37549033
It is an autosomal recessive disease induced by a mutation in the HADHA gene, which encodes the LCHAD deficiency. The clinical manifestations of this disease are diverse, primarily affecting the heart, liver, and skeletal muscles. ...Collectively, our study may cont …
It is an autosomal recessive disease induced by a mutation in the HADHA gene, which encodes the LCHAD deficiency. The clinical …
Fatty acid beta oxidation enzyme HADHA is a novel potential therapeutic target in malignant lymphoma.
Yamamoto K, Abe S, Honda A, Hashimoto J, Aizawa Y, Ishibashi S, Takemura T, Hanagata N, Yamamoto M, Miura O, Kurata M, Kitagawa M. Yamamoto K, et al. Lab Invest. 2020 Mar;100(3):353-362. doi: 10.1038/s41374-019-0318-6. Epub 2019 Sep 16. Lab Invest. 2020. PMID: 31527828 Free article.
Moreover, downregulation of HADHA increased the susceptibility to doxorubicin (P = 0.002) and etoposide (P = 0.004). Moreover, these phenotypes were confirmed in an HADHA knockout system. Thus, we provide a basis for a novel therapeutic strategy through the regulati …
Moreover, downregulation of HADHA increased the susceptibility to doxorubicin (P = 0.002) and etoposide (P = 0.004). Moreover, these …
31 results