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14 results

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Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction.
Condon KJ, Orozco JM, Adelmann CH, Spinelli JB, van der Helm PW, Roberts JM, Kunchok T, Sabatini DM. Condon KJ, et al. Proc Natl Acad Sci U S A. 2021 Jan 26;118(4):e2022120118. doi: 10.1073/pnas.2022120118. Proc Natl Acad Sci U S A. 2021. PMID: 33483422 Free PMC article.
Along with almost all known positive components of the mTORC1 pathway, we identified many genes that impact mTORC1 activity, including DCAF7, CSNK2B, SRSF2, IRS4, CCDC43, and HSD17B10 Using the genome-wide screening data, we generated a focused sublibrary containing single …
Along with almost all known positive components of the mTORC1 pathway, we identified many genes that impact mTORC1 activity, including DCAF7 …
Infantile Neurodegeneration Results from Mutants of 17β-Hydroxysteroid Dehydrogenase Type 10 Rather Than Aβ-Binding Alcohol Dehydrogenase.
He XY, Dobkin C, Brown WT, Yang SY. He XY, et al. Int J Mol Sci. 2023 May 9;24(10):8487. doi: 10.3390/ijms24108487. Int J Mol Sci. 2023. PMID: 37239833 Free PMC article. Review.
Furthermore, the rediscovery of ABAD/ERAB's mitochondrial localization did not cite any published research on 17beta-HSD10. Clarification of the purported ABAD/ERAB function derived from these reports on ABAD/ERAB may invigorate this rese …
Furthermore, the rediscovery of ABAD/ERAB's mitochondrial localization did not cite any published research on 17beta-HSD10. Cl …
Astragaloside IV protects renal tubular epithelial cells against oxidative stress-induced injury by upregulating CPT1A-mediated HSD17B10 lysine succinylation in diabetic kidney disease.
Wang M, Li Q, Wang S, Zuo L, Hai Y, Yuan S, Li X, Huang X, Yang C, Yao L, Cao W, Zuo G, Wang J. Wang M, et al. Phytother Res. 2024 Sep;38(9):4519-4540. doi: 10.1002/ptr.8298. Epub 2024 Jul 22. Phytother Res. 2024. PMID: 39038923
Molecular dynamics simulations demonstrated K99 succinylation of HSD17B10 maintained mitochondrial RNA ribonuclease P (RNase P) stability. The K99R mutation of HSD17B10 induced oxidative stress and disrupted its binding to CPT1A or mitochondrial ribonuclease P prote …
Molecular dynamics simulations demonstrated K99 succinylation of HSD17B10 maintained mitochondrial RNA ribonuclease P (RNase P) stabi …
Deacetylation of HSD17B10 by SIRT3 regulates cell growth and cell resistance under oxidative and starvation stresses.
Liu L, Chen S, Yu M, Ge C, Ren M, Liu B, Yang X, Christian TW Jr, Hou YM, Zou J, Zhu WG, Luo J. Liu L, et al. Cell Death Dis. 2020 Jul 23;11(7):563. doi: 10.1038/s41419-020-02763-9. Cell Death Dis. 2020. PMID: 32703935 Free PMC article.
HSD17B10 missense mutations cause HSD10 mitochondrial disease (HSD10MD). HSD17B10 with mutations identified from cases of HSD10MD show loss of function in dehydrogenase activity and mitochondrial tRNA maturation, resulting in mitochondrial dysfunction. ...HSD17B1 …
HSD17B10 missense mutations cause HSD10 mitochondrial disease (HSD10MD). HSD17B10 with mutations identified from cases of HSD1 …
Identification of Multidimensional Phenotypes Using Cluster Analysis in Sarcoid Uveitis Patients.
Fermon C, El-Jammal T, Kodjikian L, Burillon C, Hot A, Pérard L, Mathis T, Jamilloux Y, Sève P. Fermon C, et al. Am J Ophthalmol. 2022 Oct;242:107-115. doi: 10.1016/j.ajo.2022.06.001. Epub 2022 Jun 23. Am J Ophthalmol. 2022. PMID: 35752321
Systemic sarcoidosis was diagnosed according to the Abad's modified criteria and uveitis was classified according to the Standardization of Uveitis Nomenclature. ...
Systemic sarcoidosis was diagnosed according to the Abad's modified criteria and uveitis was classified according to the Standardizat …
Estrogen-related genes for thyroid cancer prognosis, immune infiltration, staging, and drug sensitivity.
Zhang L, Zhou M, Gao X, Xie Y, Xiao J, Liu T, Zeng X. Zhang L, et al. BMC Cancer. 2023 Oct 31;23(1):1048. doi: 10.1186/s12885-023-11556-0. BMC Cancer. 2023. PMID: 37907864 Free PMC article.

RESULTS: The expression of 120 ERDEGs differed significantly between the two groups (P < 0.05). Five (CD24, CAV1, TACC1, TIPARP, and HSD17B10) of the eight ERDEGs identified using univariate Cox and LASSO regression were validated via RT-qPCR and immunohistochemistry an

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RESULTS: The expression of 120 ERDEGs differed significantly between the two groups (P < 0.05). Five (CD24, CAV1, TACC1, TIPARP, and H

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Abnormal DNA methylation within genes of the steroidogenesis pathway two years after paediatric critical illness and association with stunted growth in height further in time.
Vanhorebeek I, Coppens G, Güiza F, Derese I, Wouters PJ, Joosten KF, Verbruggen SC, Van den Berghe G. Vanhorebeek I, et al. Clin Epigenetics. 2023 Jul 19;15(1):116. doi: 10.1186/s13148-023-01530-9. Clin Epigenetics. 2023. PMID: 37468957 Free PMC article.

Adjusting for technical variation and baseline risk factors and corrected for multiple testing (false discovery rate < 0.05), former PICU patients showed abnormal DNA methylation of 23 CpG sites (within CYP11A1, POR, CYB5A, HSD17B1, HSD17B2, HSD17B3, HSD17B6, HSD17B10,

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Adjusting for technical variation and baseline risk factors and corrected for multiple testing (false discovery rate < 0.05), former PICU

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14 results