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2020 3
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2023 17
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Neutrophil extracellular traps in systemic autoimmune and autoinflammatory diseases.
Wigerblad G, Kaplan MJ. Wigerblad G, et al. Nat Rev Immunol. 2023 May;23(5):274-288. doi: 10.1038/s41577-022-00787-0. Epub 2022 Oct 18. Nat Rev Immunol. 2023. PMID: 36257987 Free PMC article. Review.
Recent discoveries have highlighted that neutrophils, and in particular the neutrophil extracellular traps that they can release upon activation, can have central roles in the initiation and perpetuation of systemic autoimmune disorders and orchestrate complex inflammatory …
Recent discoveries have highlighted that neutrophils, and in particular the neutrophil extracellular traps that they can release upon …
Autoinflammatory Diseases/Periodic Fevers.
Schutt C, Siegel DM. Schutt C, et al. Pediatr Rev. 2023 Sep 1;44(9):481-490. doi: 10.1542/pir.2022-005635. Pediatr Rev. 2023. PMID: 37653132 Review.
This review discusses the current conceptualization of autoinflammatory diseases with specific focus and detail on familial Mediterranean fever; tumor necrosis factor receptor-associated periodic syndrome; mevalonate kinase deficie …
This review discusses the current conceptualization of autoinflammatory diseases with specific focus and detail on familial Mediterranean fe …
The 2021 EULAR/American College of Rheumatology points to consider for diagnosis, management and monitoring of the interleukin-1 mediated autoinflammatory diseases: cryopyrin-associated periodic syndromes, tumour necrosis factor receptor-associated periodic syndrome, mevalonate kinase deficiency, and deficiency of the interleukin-1 receptor antagonist.
Romano M, Arici ZS, Piskin D, Alehashemi S, Aletaha D, Barron KS, Benseler S, Berard R, Broderick L, Dedeoglu F, Diebold M, Durrant KL, Ferguson P, Foell D, Hausmann J, Jones OY, Kastner DL, Lachmann HJ, Laxer RM, Rivera D, Ruperto N, Simon A, Twilt M, Frenkel J, Hoffman H, de Jesus AA, Kuemmerle-Deschner JB, Ozen S, Gattorno M, Goldbach-Mansky R, Demirkaya E. Romano M, et al. Ann Rheum Dis. 2022 Jul;81(7):907-921. doi: 10.1136/annrheumdis-2021-221801. Epub 2022 May 27. Ann Rheum Dis. 2022. PMID: 35623638
BACKGROUND: The interleukin-1 (IL-1) mediated systemic autoinflammatory diseases, including the cryopyrin-associated periodic syndromes (CAPS), tumour necrosis factor receptor-associated periodic syndrome (TRAPS), mevalonate kinase deficiency (MKD) and deficiency of the IL …
BACKGROUND: The interleukin-1 (IL-1) mediated systemic autoinflammatory diseases, including the cryopyrin-associated periodic syndromes (CAP …
Neutrophil, NETs and Behçet's disease: A review.
Le Joncour A, Cacoub P, Boulaftali Y, Saadoun D. Le Joncour A, et al. Clin Immunol. 2023 May;250:109318. doi: 10.1016/j.clim.2023.109318. Epub 2023 Apr 3. Clin Immunol. 2023. PMID: 37019424 Review.
Neutrophils seem to play an instrumental role in BD and recent works regarding the role of neutrophils extracellular traps (NETs) provides new insight in the pathophysiology of BD and the mechanisms involved in immune thrombosis. ...
Neutrophils seem to play an instrumental role in BD and recent works regarding the role of neutrophils extracellular traps (NETs) pro …
Reduction of Neutrophil Activation by Phosphodiesterase 4 Blockade in Behçet's Disease.
Le Joncour A, Régnier P, Maciejewski-Duval A, Charles E, Barete S, Fouret P, Rosenzwajg M, Klatzmann D, Cacoub P, Saadoun D. Le Joncour A, et al. Arthritis Rheumatol. 2023 Sep;75(9):1628-1637. doi: 10.1002/art.42486. Epub 2023 Jul 4. Arthritis Rheumatol. 2023. PMID: 36862398
METHODS: We studied surface markers and reactive oxygen species (ROS) production by flow cytometry, and neutrophil extracellular traps (NETs) production and molecular signature of neutrophils by transcriptome analysis before and after PDE4 inhibition. ...
METHODS: We studied surface markers and reactive oxygen species (ROS) production by flow cytometry, and neutrophil extracellular traps …
The Clinical Chameleon of Autoinflammatory Diseases in Children.
Sangiorgi E, Rigante D. Sangiorgi E, et al. Cells. 2022 Jul 18;11(14):2231. doi: 10.3390/cells11142231. Cells. 2022. PMID: 35883675 Free PMC article. Review.
The recent progress of cellular biology has clarified many molecular mechanisms behind monogenic ADs, such as familial Mediterranean fever, tumor necrosis factor receptor-associated periodic syndrome (or 'autosomal dominant familia …
The recent progress of cellular biology has clarified many molecular mechanisms behind monogenic ADs, such as familial Mediterranean fever, …
Ocular involvement in adult and paediatric patients with monogenic autoinflammatory diseases: a Spanish multicentre retrospective study.
Fonollosa A, Pelegrín L, García-Morillo S, Buján-Rivas S, Distefano L, Robles-Maruenda A, Fernández-Martín J, González-García A, Garcia-Aparicio Á, Ortego-Centeno N, Llorenç V, Sainz de la Maza M, Pinedo C, Sopeña B, Cocho L, Carreño E, Blanco R, Antón J, Pérez-Quintana M, Marques-Soares JR, Artaraz J, Ruiz-Arruza I, Soto-Peleteiro A, Gómez-Caverzaschi V, Araújo O, Espinosa G, Adan A, Fabiani C, Cantarini L, Hernández-Rodríguez J; Spanish Society of Ocular Inflammation (SEIOC) and the AutoInflammatory Diseases Alliance (AIDA) Network. Fonollosa A, et al. Clin Exp Rheumatol. 2023 Oct;41(10):2105-2114. doi: 10.55563/clinexprheumatol/ukegcc. Epub 2023 Sep 28. Clin Exp Rheumatol. 2023. PMID: 37812477 Free article.
Twelve (26.1%) patients developed structural complications, being cataracts (n=11/24%) and posterior synechiae (n=10/22%) the most frequent. Conjunctivitis predominated in TRAPS, FMF, MWS and HIDS (mainly in adults), and uveitis, in Blau syndrome. ...CONCLUSIONS: Conjuncti …
Twelve (26.1%) patients developed structural complications, being cataracts (n=11/24%) and posterior synechiae (n=10/22%) the most frequent. …
Interleukin-6 inhibition in the treatment of autoinflammatory diseases.
Koga T, Kawakami A. Koga T, et al. Front Immunol. 2022 Jul 26;13:956795. doi: 10.3389/fimmu.2022.956795. eCollection 2022. Front Immunol. 2022. PMID: 35958618 Free PMC article. Review.
Studies of autoinflammatory diseases, such as familial Mediterranean fever, cryopyrin-associated periodic syndrome, and tumor necrosis factor receptor-associated periodic syndrome, have shown IL-6 to be a promising therapeutic targ …
Studies of autoinflammatory diseases, such as familial Mediterranean fever, cryopyrin-associated periodic syndrome, and tumor necr …
Ocular involvement in monogenic autoinflammatory disease.
Maccora I, Marrani E, Mastrolia MV, Abu-Rumeileh S, Maniscalco V, Fusco E, Barbati F, Pagnini I, Simonini G. Maccora I, et al. Autoimmun Rev. 2021 Nov;20(11):102944. doi: 10.1016/j.autrev.2021.102944. Epub 2021 Sep 9. Autoimmun Rev. 2021. PMID: 34509650 Review.
Data about 1353 patients with a diagnosis of autoinflammatory disease and ocular involvement were collected (680 CAPS, 211 FMF, 138 TRAPS, 238 Blau, 32 MKD, 21 SIFD, 7 Aicardi Goutieres, 3 CANDLE, 8 DADA2, 9 HA20, 6 APLAID). Conjunctivitis was significantly more frequent i …
Data about 1353 patients with a diagnosis of autoinflammatory disease and ocular involvement were collected (680 CAPS, 211 FMF, 138 TRAPS …
Efficacy and safety of thalidomide in children with monogenic autoinflammatory diseases: a single-center, real-world-evidence study.
Zhang C, Yu Z, Gao S, Ma M, Gou L, Wang C, Wang L, Li J, Zhong L, Zhou Y, Wang W, Song H. Zhang C, et al. Pediatr Rheumatol Online J. 2023 Oct 17;21(1):124. doi: 10.1186/s12969-023-00881-0. Pediatr Rheumatol Online J. 2023. PMID: 37848905 Free PMC article.
RESULTS: A total of 16 patients entered this study, including 3 with Aicardi-Goutieres syndrome (AGS), 4 Blau syndrome, 2 chronic infantile neurologic cutaneous articular syndrome (CINCA), 2 A20 haploinsufficiency (HA20), 1 adenosine deaminase 2 deficiency(DADA2), 1 familial Medi …
RESULTS: A total of 16 patients entered this study, including 3 with Aicardi-Goutieres syndrome (AGS), 4 Blau syndrome, 2 chronic infantile …
45 results