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Year Number of Results
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108 results

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Page 1
Mammalian TMC1 or 2 are necessary for scramblase activity in auditory hair cells.
Peineau T, Marcovich I, Rodriguez CVM, O'Malley S, Cui R, Ballesteros A, Holt JR. Peineau T, et al. Among authors: holt jr. Hear Res. 2025 May;460:109229. doi: 10.1016/j.heares.2025.109229. Epub 2025 Mar 6. Hear Res. 2025. PMID: 40073458
Sensory transduction in auditory hair cells gates mechanosensitive ion channels, converting sound information into electrical signals (Zheng and Holt, 2021). ...Here, we investigated lipid scramblase activity in live auditory hair cells w …
Sensory transduction in auditory hair cells gates mechanosensitive ion channels, converting sound information into elec …
Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels.
Giese APJ, Weng WH, Kindt KS, Chang HHV, Montgomery JS, Ratzan EM, Beirl AJ, Aponte Rivera R, Lotthammer JM, Walujkar S, Foster MP, Zobeiri OA, Holt JR, Riazuddin S, Cullen KE, Sotomayor M, Ahmed ZM. Giese APJ, et al. Among authors: holt jr. Elife. 2025 Jan 8;12:RP89719. doi: 10.7554/eLife.89719. Elife. 2025. PMID: 39773557 Free PMC article.
Overall, our work demonstrates that intact CIB2/3 and TMC1/2 complexes are integral to hair-cell MET function in vertebrate mechanosensory epithelia....
Overall, our work demonstrates that intact CIB2/3 and TMC1/2 complexes are integral to hair-cell MET function in vertebrate me …
Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels.
Giese APJ, Weng WH, Kindt KS, Chang HHV, Montgomery JS, Ratzan EM, Beirl AJ, Rivera RA, Lotthammer JM, Walujkar S, Foster MP, Zobeiri OA, Holt JR, Riazuddin S, Cullen KE, Sotomayor M, Ahmed ZM. Giese APJ, et al. Among authors: holt jr. bioRxiv [Preprint]. 2024 Jul 5:2023.05.26.542533. doi: 10.1101/2023.05.26.542533. bioRxiv. 2024. Update in: Elife. 2025 Jan 08;12:RP89719. doi: 10.7554/eLife.89719. PMID: 37398045 Free PMC article. Updated. Preprint.
Overall, our work demonstrates that intact CIB2/3 and TMC1/2 complexes are integral to hair-cell MET function in vertebrate mechanosensory epithelia....
Overall, our work demonstrates that intact CIB2/3 and TMC1/2 complexes are integral to hair-cell MET function in vertebrate me …
Sensory transduction in auditory hair cells-PIEZOs can't touch this.
Holt JR, Fettiplace R, Müller U. Holt JR, et al. J Gen Physiol. 2024 Jun 3;156(6):e202413585. doi: 10.1085/jgp.202413585. Epub 2024 May 10. J Gen Physiol. 2024. PMID: 38727631 Free PMC article.
In this Viewpoint, Holt, Fettiplace, and Muller weigh the evidence supporting a role for PIEZO and TMC channels in mechanosensory transduction in inner ear hair cells....
In this Viewpoint, Holt, Fettiplace, and Muller weigh the evidence supporting a role for PIEZO and TMC channels in mechanosensory transducti …
TMC function, dysfunction, and restoration in mouse vestibular organs.
Ratzan EM, Lee J, Madison MA, Zhu H, Zhou W, Géléoc GSG, Holt JR. Ratzan EM, et al. Among authors: holt jr, geleoc gsg. Front Neurol. 2024 Apr 4;15:1356614. doi: 10.3389/fneur.2024.1356614. eCollection 2024. Front Neurol. 2024. PMID: 38638308 Free PMC article.
Tmc1 and Tmc2 are essential pore-forming subunits of mechanosensory transduction channels localized to the tips of stereovilli in auditory and vestibular hair cells of the inner ear. To investigate expression and function of Tmc1 and Tmc2 in vestibular organs …
Tmc1 and Tmc2 are essential pore-forming subunits of mechanosensory transduction channels localized to the tips of stereovilli in auditor …
TMEM63 proteins function as monomeric high-threshold mechanosensitive ion channels.
Zheng W, Rawson S, Shen Z, Tamilselvan E, Smith HE, Halford J, Shen C, Murthy SE, Ulbrich MH, Sotomayor M, Fu TM, Holt JR. Zheng W, et al. Among authors: holt jr. Neuron. 2023 Oct 18;111(20):3195-3210.e7. doi: 10.1016/j.neuron.2023.07.006. Epub 2023 Aug 4. Neuron. 2023. PMID: 37543036 Free PMC article.
Delivery of gene therapy through a cerebrospinal fluid conduit to rescue hearing in adult mice.
Mathiesen BK, Miyakoshi LM, Cederroth CR, Tserga E, Versteegh C, Bork PAR, Hauglund NL, Gomolka RS, Mori Y, Edvall NK, Rouse S, Møllgård K, Holt JR, Nedergaard M, Canlon B. Mathiesen BK, et al. Among authors: holt jr. Sci Transl Med. 2023 Jun 28;15(702):eabq3916. doi: 10.1126/scitranslmed.abq3916. Epub 2023 Jun 28. Sci Transl Med. 2023. PMID: 37379370
Alternative delivery routes may advance auditory research and also prove useful when translated to humans with progressive genetic-mediated hearing loss. ...A single intracisternal injection of adeno-associated virus carrying solute carrier family 17, member 8 (Slc17A8), w …
Alternative delivery routes may advance auditory research and also prove useful when translated to humans with progressive genetic-me …
Light at the end of the tunnel of Corti.
Hanlon K, Büning H, Géléoc GSG. Hanlon K, et al. Among authors: geleoc gsg. Mol Ther Methods Clin Dev. 2023 May 23;29:437-438. doi: 10.1016/j.omtm.2023.05.006. eCollection 2023 Jun 8. Mol Ther Methods Clin Dev. 2023. PMID: 37273898 Free PMC article. No abstract available.
Molecular earplugs to protect the inner ear.
Chaves MG, Holt JR. Chaves MG, et al. Among authors: holt jr. Mol Ther Methods Clin Dev. 2023 Apr 26;29:284-285. doi: 10.1016/j.omtm.2023.04.001. eCollection 2023 Jun 8. Mol Ther Methods Clin Dev. 2023. PMID: 37168274 Free PMC article. No abstract available.
108 results