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2017 1
2018 33
2019 67
2020 12
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Page 1
Human cellular models of medium spiny neuron development and Huntington disease.
Golas MM. Golas MM. Life Sci. 2018 Sep 15;209:179-196. doi: 10.1016/j.lfs.2018.07.030. Epub 2018 Jul 18. Life Sci. 2018. PMID: 30031060 Review.
The loss of gamma-aminobutyric acid (GABA)-ergic medium spiny neurons (MSNs) in the striatum is the hallmark of Huntington disease (HD), an incurable neurodegenerative disorder characterized by progressive motor, psychiatric, and cognitive symptoms. ...
The loss of gamma-aminobutyric acid (GABA)-ergic medium spiny neurons (MSNs) in the striatum is the hallmark of Huntington disease
Alterations in synaptic function and plasticity in Huntington disease.
Smith-Dijak AI, Sepers MD, Raymond LA. Smith-Dijak AI, et al. J Neurochem. 2019 Aug;150(4):346-365. doi: 10.1111/jnc.14723. Epub 2019 Jun 6. J Neurochem. 2019. PMID: 31095731 Review.
Huntington disease (HD) is an inherited neurodegenerative disorder caused by an expansion of the CAG repeat region in the first exon of the huntingtin gene. ...
Huntington disease (HD) is an inherited neurodegenerative disorder caused by an expansion of the CAG repeat region in the firs
Therapeutic approaches to Huntington disease: from the bench to the clinic.
Caron NS, Dorsey ER, Hayden MR. Caron NS, et al. Nat Rev Drug Discov. 2018 Oct;17(10):729-750. doi: 10.1038/nrd.2018.133. Epub 2018 Sep 21. Nat Rev Drug Discov. 2018. PMID: 30237454 Review.
The 25 years since the identification of the gene responsible for Huntington disease (HD) have stood witness to profound discoveries about the nature of the disease and its pathogenesis. Despite this progress, however, the development of disease-modify …
The 25 years since the identification of the gene responsible for Huntington disease (HD) have stood witness to profound disco …
The psychopharmacology of Huntington disease.
Petersén Å, Weydt P. Petersén Å, et al. Handb Clin Neurol. 2019;165:179-189. doi: 10.1016/B978-0-444-64012-3.00010-1. Handb Clin Neurol. 2019. PMID: 31727211 Review.
Huntington disease (HD) is a hereditary neurodegenerative disorder caused by an expanded cytosine-adenine-guanine triplet repeat in the huntingtin gene. ...The motor onset of the disease is usually between 30 and 50 years of age, and the disease then p
Huntington disease (HD) is a hereditary neurodegenerative disorder caused by an expanded cytosine-adenine-guanine triplet repe
Huntington disease: A quarter century of progress since the gene discovery.
Testa CM, Jankovic J. Testa CM, et al. J Neurol Sci. 2019 Jan 15;396:52-68. doi: 10.1016/j.jns.2018.09.022. Epub 2018 Sep 27. J Neurol Sci. 2019. PMID: 30419368 Review.
Huntington disease (HD) is an autosomal dominant neurodegenerative disorder characterized by motor, behavioral, and cognitive manifestations. ...Although disease onset is currently clinically defined by motor signs, the presence of non-motor symptoms prior to
Huntington disease (HD) is an autosomal dominant neurodegenerative disorder characterized by motor, behavioral, and cognitive
Huntington's Disease Clinical Trials Corner: January 2019.
Rodrigues FB, Quinn L, Wild EJ. Rodrigues FB, et al. J Huntingtons Dis. 2019;8(1):115-125. doi: 10.3233/JHD-190001. J Huntingtons Dis. 2019. PMID: 30776019 Review.
In this edition of the Huntington's Disease Clinical Trials Corner we expand on the GENERATION-HD1 and PACE-HD trials, and we list all currently registered and ongoing clinical trials in Huntington's disease....
In this edition of the Huntington's Disease Clinical Trials Corner we expand on the GENERATION-HD1 and PACE-HD trials, and we …
Myelin Breakdown in Human Huntington's Disease: Multi-Modal Evidence from Diffusion MRI and Quantitative Magnetization Transfer.
Bourbon-Teles J, Bells S, Jones DK, Coulthard E, Rosser A, Metzler-Baddeley C. Bourbon-Teles J, et al. Neuroscience. 2019 Apr 1;403:79-92. doi: 10.1016/j.neuroscience.2017.05.042. Epub 2017 Jun 1. Neuroscience. 2019. PMID: 28579146 Free PMC article.
Huntington's disease (HD) leads to white matter (WM) degeneration that may be due to an early breakdown in axon myelination but in vivo imaging correlates of demyelination remain relatively unexplored in HD compared to other neurodegenerative diseases. ...Inter-indi
Huntington's disease (HD) leads to white matter (WM) degeneration that may be due to an early breakdown in axon myelination bu
AAV5-miHTT Gene Therapy Demonstrates Broad Distribution and Strong Human Mutant Huntingtin Lowering in a Huntington's Disease Minipig Model.
Evers MM, Miniarikova J, Juhas S, Vallès A, Bohuslavova B, Juhasova J, Skalnikova HK, Vodicka P, Valekova I, Brouwers C, Blits B, Lubelski J, Kovarova H, Ellederova Z, van Deventer SJ, Petry H, Motlik J, Konstantinova P. Evers MM, et al. Mol Ther. 2018 Sep 5;26(9):2163-2177. doi: 10.1016/j.ymthe.2018.06.021. Epub 2018 Jun 25. Mol Ther. 2018. PMID: 30007561 Free PMC article.
Huntington's disease (HD) is a fatal neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in the huntingtin gene. ...
Huntington's disease (HD) is a fatal neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in the huntingt
Modern approaches for modelling dystonia and Huntington's disease in vitro and in vivo.
Zhunina OA, Yabbarov NG, Orekhov AN, Deykin AV. Zhunina OA, et al. Int J Exp Pathol. 2019 Apr;100(2):64-71. doi: 10.1111/iep.12320. Epub 2019 May 15. Int J Exp Pathol. 2019. PMID: 31090117 Free PMC article. Review.
Dystonia associated with Huntington's disease, Parkinson's disease or other neurodegenerative diseases substantially affects patients' quality of life and is a major health problem worldwide. ...In this review, we provide an overview of cellular and animal mo …
Dystonia associated with Huntington's disease, Parkinson's disease or other neurodegenerative diseases substantially af …
Huntington's Disease Clinical Trials Corner: June 2019.
Rodrigues FB, Ferreira JJ, Wild EJ. Rodrigues FB, et al. J Huntingtons Dis. 2019;8(3):363-371. doi: 10.3233/JHD-199003. J Huntingtons Dis. 2019. PMID: 31381524 Free PMC article.
In this edition of the Huntington's Disease Clinical Trials Corner we expand on the HD-DBS and on the TRIHEP3 trials, and we list all currently registered and ongoing clinical trials in Huntington's disease....
In this edition of the Huntington's Disease Clinical Trials Corner we expand on the HD-DBS and on the TRIHEP3 trials, and we l …
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