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Clinical significance and immunobiology of IL-21 in autoimmunity.
Long D, Chen Y, Wu H, Zhao M, Lu Q. Long D, et al. J Autoimmun. 2019 May;99:1-14. doi: 10.1016/j.jaut.2019.01.013. Epub 2019 Feb 14. J Autoimmun. 2019. PMID: 30773373 Review.
Interleukin-21 (IL-21), an autocrine cytokine predominantly produced by follicular helper T (Tfh) and T helper 17 (Th17) cells, has been proven to play an important role in the immune system, for example, by promoting proliferation and the development of Tfh and Th1
Interleukin-21 (IL-21), an autocrine cytokine predominantly produced by follicular helper T (Tfh) and T helper 17 (Th17) cells
IL-21 and T follicular helper cells.
Spolski R, Leonard WJ. Spolski R, et al. Int Immunol. 2010 Jan;22(1):7-12. doi: 10.1093/intimm/dxp112. Epub 2009 Nov 23. Int Immunol. 2010. PMID: 19933709 Free PMC article. Review.
Although T(FH) cells have been found to produce cytokines characteristic of other T(h) subsets, they represent a distinct lineage whose development is driven by the transcription factor B-cell CLL lymphoma-6 (BCL6). Consistent with their critical role in the generation of …
Although T(FH) cells have been found to produce cytokines characteristic of other T(h) subsets, they represent a distinct lineage whose deve …
Follicular Helper CD4+ T Cells in Human Neuroautoimmune Diseases and Their Animal Models.
Fan X, Lin C, Han J, Jiang X, Zhu J, Jin T. Fan X, et al. Mediators Inflamm. 2015;2015:638968. doi: 10.1155/2015/638968. Epub 2015 Aug 2. Mediators Inflamm. 2015. PMID: 26300592 Free PMC article. Review.
Emerging data have shown that TFH cells and TFH-associated molecules may be involved in the pathogenesis of neuroautoimmune diseases including multiple sclerosis (MS), neuromyelitis optica (NMO)/neuromyelitis optica spectrum disorders (NMOSD), and myasthenia gravis (MG). This …
Emerging data have shown that TFH cells and TFH-associated molecules may be involved in the pathogenesis of neuroautoimmune diseases includi …
[T follicular helper cells and their related molecules in rheumatoid arthritis: A review].
Li Y, Bai S, Zhang J, Shen T, Chen S, Wang Y, Xie C. Li Y, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2019 Mar;35(3):281-286. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2019. PMID: 31030723 Review. Chinese.
In addition, Tfh cell surface molecules C-X-C motif chemokine receptor 5 (CXCR5), inducible costimulatory molecule (ICOS) and programmed death factor 1 (PD-1) and its secreted interleukin 21 (IL-21), B-cell lymphoma 6 (BCL6) have been shown to be involved in …
In addition, Tfh cell surface molecules C-X-C motif chemokine receptor 5 (CXCR5), inducible costimulatory molecule (ICOS) and programmed dea …