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A rare case of acute promyelocytic leukemia with IRF2BP2-RARA fusion; and literature review.
Liu Y, Xu F, Hu H, Wen J, Su J, Zhou Q, Qu W. Liu Y, et al. Onco Targets Ther. 2019 Aug 2;12:6157-6163. doi: 10.2147/OTT.S217622. eCollection 2019. Onco Targets Ther. 2019. PMID: 31447564 Free PMC article.
CASE PRESENTATION: A rare case of APL was reported after IRF2BP2-RARA was detected in the relapsed process using next-generation RNA-sequencing analysis. ...The patient was resistant to all other chemotherapies and refused any further therapy. The literature revi …
CASE PRESENTATION: A rare case of APL was reported after IRF2BP2-RARA was detected in the relapsed process using next-generati …
Current views on the genetic landscape and management of variant acute promyelocytic leukemia.
Zhang X, Sun J, Yu W, Jin J. Zhang X, et al. Biomark Res. 2021 May 6;9(1):33. doi: 10.1186/s40364-021-00284-x. Biomark Res. 2021. PMID: 33957999 Free PMC article. Review.
Among them, only NPM1-RARA, NUMA-RARA, FIP1L1-RARA, IRF2BP2-RARA, and TFG-RARA have been demonstrated to be sensitive to ATRA, so combined chemotherapy rather than differentiation induction therapy was the standard care for variant APL and these patients would benef …
Among them, only NPM1-RARA, NUMA-RARA, FIP1L1-RARA, IRF2BP2-RARA, and TFG-RARA have been demonstrated to be sensitive to ATRA, …