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Page 1
Neonatal leukaemia.
Roberts I, Fordham NJ, Rao A, Bain BJ. Roberts I, et al. Br J Haematol. 2018 Jul;182(2):170-184. doi: 10.1111/bjh.15246. Epub 2018 May 28. Br J Haematol. 2018. PMID: 29806701 Free article. Review.
The most frequently observed cytogenetic/molecular abnormality is t(4;11)(q21.3;q23.3)/KMT2A-AFF1 followed by t(1;22)(p13.3;q13.1)/RBM15-MKL1 and t(8;16)(p11.2;p13.3)/KAT6A-CREBBP. ...A distinctive feature is the occurrence of spontaneous remission in some cases, pa …
The most frequently observed cytogenetic/molecular abnormality is t(4;11)(q21.3;q23.3)/KMT2A-AFF1 followed by t(1;22)(p13.3;q1 …
KMT2A (MLL) rearrangements observed in pediatric/young adult T-lymphoblastic leukemia/lymphoma: A 10-year review from a single cytogenetic laboratory.
Peterson JF, Baughn LB, Pearce KE, Williamson CM, Benevides Demasi JC, Olson RM, Goble TA, Meyer RG, Greipp PT, Ketterling RP. Peterson JF, et al. Genes Chromosomes Cancer. 2018 Nov;57(11):541-546. doi: 10.1002/gcc.22666. Epub 2018 Sep 10. Genes Chromosomes Cancer. 2018. PMID: 30203571
While the underlying frequency of KMT2A (MLL) gene rearrangements has been identified in approximately 4-8% of T-ALL/LBL cases, a paucity of literature is available to characterize further the KMT2A rearrangements in pediatric/young adult T-ALL/LBL. A 10-year retrospective rev …
While the underlying frequency of KMT2A (MLL) gene rearrangements has been identified in approximately 4-8% of T-ALL/LBL cases, a paucity of …
The RS4;11 cell line as a model for leukaemia with t(4;11)(q21;q23): Revised characterisation of cytogenetic features.
Ragusa D, Makarov EM, Britten O, Moralli D, Green CM, Tosi S. Ragusa D, et al. Cancer Rep (Hoboken). 2019 Oct;2(5):e1207. doi: 10.1002/cnr2.1207. Epub 2019 Aug 7. Cancer Rep (Hoboken). 2019. PMID: 32721124 Free PMC article.
Chromosomal translocations involving KMT2A often cause the formation of oncogenic fusion genes, such as the most common translocation t(4;11)(q21;q23) producing the KMT2A-AFF1 chimera. AIM: The aim of this study was to confirm and review the cytogenetic and m …
Chromosomal translocations involving KMT2A often cause the formation of oncogenic fusion genes, such as the most common translocation t(4;11 …
Molecular profiling of adult acute myeloid and lymphoid leukemia in a major referral center in Lebanon: a 10-year experience report and review of the literature.
Assaf N, El-Cheikh J, Bazarbachi A, Salem Z, Farra C, Chakhachiro Z, Nassif S, Zaatari G, Mahfouz R. Assaf N, et al. Mol Biol Rep. 2019 Apr;46(2):2003-2011. doi: 10.1007/s11033-019-04649-2. Epub 2019 Jan 30. Mol Biol Rep. 2019. PMID: 30701458
The ALL panel tests for the presence of BCR-ABL1, ETV6/RUNX1; KMT2A/AFF1, and TCF3-PBX1. We reviewed 580 AML and 175 ALL cases. In the AML cohort, the M:F ratio was 1.3:1 with a mean age of 50 years. t(15;17) was present in 7.6%, t(8;21) in 4.2%, inv(16) in 3.7%, t( …
The ALL panel tests for the presence of BCR-ABL1, ETV6/RUNX1; KMT2A/AFF1, and TCF3-PBX1. We reviewed 580 AML and 175 ALL cases …