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Is acute lymphoblastic leukemia with mature B-cell phenotype and KMT2A rearrangements a new entity? A systematic review and meta-analysis.
Hidalgo-Gómez G, Palacio-Garcia C, Gallur L, Blanco A, Tazón-Vega B, Saumell S, Martínez N, Murillo L, Murciano T, Velasco P, Bosch F, Diaz-Heredia C, Ortega M. Hidalgo-Gómez G, et al. Leuk Lymphoma. 2021 Sep;62(9):2202-2210. doi: 10.1080/10428194.2021.1907375. Epub 2021 Apr 7. Leuk Lymphoma. 2021. PMID: 33827367
We describe the clinical-biological characteristics and disease outcome of three pediatric ALL patients with these features treated at our institution, and review 28 cases described in the literature. Most cases occur in children under 2 years-old, presenting a mature B-ce …
We describe the clinical-biological characteristics and disease outcome of three pediatric ALL patients with these features treated at our i …
Lineage switch in a pediatric patient with KMT2A-MLLT3 from acute megakaryoblastic leukemia to T cell acute lymphoblastic leukemia at the fourth relapse after allo-HSCT: with literature review.
Gao L, Lu J, Li J, Hu Y, Lu Y, Du W, Hu S. Gao L, et al. Int J Hematol. 2023 May;117(5):781-785. doi: 10.1007/s12185-022-03504-8. Epub 2022 Dec 6. Int J Hematol. 2023. PMID: 36472792 Review.
We present a patient with acute megakaryoblastic leukemia (AMKL) harboring KMT2A-MLLT3 that converted to T cell acute lymphoblastic leukemia (T-ALL) at her fourth relapse. ...Bone marrow cells at the initial diagnosis and at all four relapses had the same KMT2A …
We present a patient with acute megakaryoblastic leukemia (AMKL) harboring KMT2A-MLLT3 that converted to T cell acute lymphobl …
Comprehensive molecular understanding of pediatric acute myeloid leukemia.
Shiba N. Shiba N. Int J Hematol. 2023 Feb;117(2):173-181. doi: 10.1007/s12185-023-03533-x. Epub 2023 Jan 18. Int J Hematol. 2023. PMID: 36653696 Review.
Recent advances in genetic analysis have enabled the identification of causative genes in > 90% of pediatric AML cases. Fusion genes such as RUNX1::RUNX1T1, CBFB::MYH11, and KMT2A::MLLT3 are frequently detected in > 70% of pediatric AML cases, whereas FLT3-int …
Recent advances in genetic analysis have enabled the identification of causative genes in > 90% of pediatric AML cases. Fusion genes such …
Molecular profiling of adult acute myeloid and lymphoid leukemia in a major referral center in Lebanon: a 10-year experience report and review of the literature.
Assaf N, El-Cheikh J, Bazarbachi A, Salem Z, Farra C, Chakhachiro Z, Nassif S, Zaatari G, Mahfouz R. Assaf N, et al. Mol Biol Rep. 2019 Apr;46(2):2003-2011. doi: 10.1007/s11033-019-04649-2. Epub 2019 Jan 30. Mol Biol Rep. 2019. PMID: 30701458
Genetic profiling of AML cases in our CAP accredited molecular diagnostics laboratory consists of a validated lab developed RT-PCR for the detection of RUNX1/RUNX1T1, CBFB/MYH11, KMT2A/MLLT3, PML-RARA, and BCR-ABL and mutations in the FLT3 receptor, NPM1, c-kit and …
Genetic profiling of AML cases in our CAP accredited molecular diagnostics laboratory consists of a validated lab developed RT-PCR for the d …
KMT2A (MLL) rearrangements observed in pediatric/young adult T-lymphoblastic leukemia/lymphoma: A 10-year review from a single cytogenetic laboratory.
Peterson JF, Baughn LB, Pearce KE, Williamson CM, Benevides Demasi JC, Olson RM, Goble TA, Meyer RG, Greipp PT, Ketterling RP. Peterson JF, et al. Genes Chromosomes Cancer. 2018 Nov;57(11):541-546. doi: 10.1002/gcc.22666. Epub 2018 Sep 10. Genes Chromosomes Cancer. 2018. PMID: 30203571
While the underlying frequency of KMT2A (MLL) gene rearrangements has been identified in approximately 4-8% of T-ALL/LBL cases, a paucity of literature is available to characterize further the KMT2A rearrangements in pediatric/young adult T-ALL/LBL. A 10-year retrospective rev …
While the underlying frequency of KMT2A (MLL) gene rearrangements has been identified in approximately 4-8% of T-ALL/LBL cases, a paucity of …
Pediatric blastic plasmacytoid dendritic cell neoplasm: report of four cases and review of literature.
Liao C, Hu NX, Song H, Zhang JY, Shen DY, Xu XJ, Tang YM. Liao C, et al. Int J Hematol. 2021 May;113(5):751-759. doi: 10.1007/s12185-020-03070-x. Epub 2021 Jan 4. Int J Hematol. 2021. PMID: 33392975 Review.
The point mutation p.D348N was found in three patients and one patient had p.C394Y mutation in the KMT2C gene. Translocation of KMT2A-MLLT3 was found in Case 2. Case 1 had complex karyotype, who was induced by acute myeloid leukemia-like regimens. ...
The point mutation p.D348N was found in three patients and one patient had p.C394Y mutation in the KMT2C gene. Translocation of KMT2A …