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2018 1
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Page 1
Redox-Induced Stabilization of AMBRA1 by USP7 Promotes Intestinal Oxidative Stress and Colitis Through Antagonizing DUB3-Mediated NRF2 Deubiquitination.
Xu W, Hua Z, Wang Y, Tang W, Ge W, Chen Y, Wang Z, Gu Y, Liu CY, Du P. Xu W, et al. Adv Sci (Weinh). 2025 Mar;12(12):e2411320. doi: 10.1002/advs.202411320. Epub 2025 Jan 31. Adv Sci (Weinh). 2025. PMID: 39887666 Free PMC article.
In response to H(2)O(2) stimulation, the interaction between AMBRA1 and ubiquitin-specific protease 7 (USP7) is enhanced, facilitating USP7 to deubiquitinate AMBRA1 at K83 and K86 and stabilize AMBRA1. Notably, the USP7 inhibitor, P5091, inhibits oxidative stress and colit …
In response to H(2)O(2) stimulation, the interaction between AMBRA1 and ubiquitin-specific protease 7 (USP7) is enhanced, facilitating USP7 …
A nonsense variant in KRT31 is associated with autosomal dominant monilethrix.
Xiong X, Cesarato N, Gossmann Y, Wehner M, Kumar S, Thiele H, Demuth S, Oji V, Geyer M, Hamm H, Basmanav FB, Betz RC. Xiong X, et al. Br J Dermatol. 2024 Nov 18;191(6):979-987. doi: 10.1093/bjd/ljae298. Br J Dermatol. 2024. PMID: 39026424
Research has identified three genes responsible for autosomal dominant monilethrix (KRT81, KRT83, KRT86) and one responsible for the autosomal recessive form (DSG4). OBJECTIVES: To investigate the genetic basis of autosomal dominant monilethrix in families with no pathogen …
Research has identified three genes responsible for autosomal dominant monilethrix (KRT81, KRT83, KRT86) and one responsible for the …
Genome-Wide Association Analysis of Single-Breath DlCO.
Sakornsakolpat P, McCormack M, Bakke P, Gulsvik A, Make BJ, Crapo JD, Cho MH, Silverman EK. Sakornsakolpat P, et al. Am J Respir Cell Mol Biol. 2019 May;60(5):523-531. doi: 10.1165/rcmb.2018-0384OC. Am J Respir Cell Mol Biol. 2019. PMID: 30694715 Free PMC article. Clinical Trial.

In addition, 12 loci were suggestively associated with Dl(CO) in European ancestry white (P < 1 10(-5) in the combined analysis and P < 0.05 in both COPDGene and GenKOLS), including variants near NEGR1, CADM2, PCDH7, RETREG1, DACT2, NRG1, ANKRD18A, KRT86, NTN4, ARH

…

In addition, 12 loci were suggestively associated with Dl(CO) in European ancestry white (P < 1 10(-5) in the combined analysis and P &

…
Gene detection in a family with monilethrix and treatment with 5% topical minoxidil.
Shen Q, Fu Z, Du P, Wang J. Shen Q, et al. Skin Res Technol. 2023 Jan;29(1):e13233. doi: 10.1111/srt.13233. Epub 2022 Nov 16. Skin Res Technol. 2023. PMID: 36382623 Free PMC article.
RESULTS: The proband and her father have the heterozygous missense variant c.1204G > A (p.E402K) in exon 7 of the KRT86 gene. However, the mutation was not found in the mother and healthy controls. The proband was treated with 5% topical minoxidil. ...
RESULTS: The proband and her father have the heterozygous missense variant c.1204G > A (p.E402K) in exon 7 of the KRT86 gene. Howe …
SUMO modifies GβL and mediates mTOR signaling.
Park SLL, Ramírez-Jarquín UN, Shahani N, Rivera O, Sharma M, Joshi PS, Hansalia A, Dagar S, McManus FP, Thibault P, Subramaniam S. Park SLL, et al. J Biol Chem. 2024 Apr;300(4):105778. doi: 10.1016/j.jbc.2024.105778. Epub 2024 Feb 21. J Biol Chem. 2024. PMID: 38395307 Free PMC article.
Using mutagenesis and mass spectrometry, we identified that GbetaL is SUMOylated at lysine sites K86, K215, K245, K261, and K305. We found that SUMO depletion reduces mTOR-Raptor (regulatory protein associated with mTOR) and mTOR-Rictor (rapamycin-insensitive companion of …
Using mutagenesis and mass spectrometry, we identified that GbetaL is SUMOylated at lysine sites K86, K215, K245, K261, and K305. We …
Investigating the role of keratin proteins and microbial associations in hereditary and pathogenic alopecia.
Liquat N, Hassan MU, Shafique F, Khan S, Alanzi AR, Khan NU. Liquat N, et al. Arch Dermatol Res. 2024 Oct 26;316(10):718. doi: 10.1007/s00403-024-03436-9. Arch Dermatol Res. 2024. PMID: 39460809
Additionally, among 14 proteins lacking prior structural information, four proteins namely Keratin, type II cuticular Hb3 (KR1), Keratin, type II cuticular Hb6 (KR2), Keratin, type II cytoskeletal 74 (KR3) and Keratin, type II cuticular Hb1 (KR4) exhibited common 'K-head' …
Additionally, among 14 proteins lacking prior structural information, four proteins namely Keratin, type II cuticular Hb3 (KR1), Keratin, ty …
Human identification of single hair shaft using a mass spectrometry mRNA typing system.
Fan J, Yu H, Yang H, Zhang Y, Zhang M, Wang J, Liu Z, Liu J, Li Z, Zhang G. Fan J, et al. Forensic Sci Int Genet. 2025 Jan;74:103158. doi: 10.1016/j.fsigen.2024.103158. Epub 2024 Oct 9. Forensic Sci Int Genet. 2025. PMID: 39406031
To address this problem and further develop the analysis technology of hairs, we established a mass spectrometry system for human identification based on a single hair shaft using 25 polymorphic SNPs located on 18 mRNA molecules (KRT31, RFK, KRT86, KRT35, PABPC1, KMT2D, LE …
To address this problem and further develop the analysis technology of hairs, we established a mass spectrometry system for human identifica …
Ginkgetin alleviates sepsis-induced acute lung injury by promoting autophagy via inhibiting ubiquitination of Laptm5 in macrophages.
Liang H, Yuan Z, Liu R, Hu H, Chen Q, Lin Z, Gu Z, Qiu Y, Wang Q, Zhu B, Deng Y, Huang S, Peng Z, Zhang X, Liu Y. Liang H, et al. Phytomedicine. 2026 Apr;153:157894. doi: 10.1016/j.phymed.2026.157894. Epub 2026 Jan 28. Phytomedicine. 2026. PMID: 41666511 Free article.
Further, we found that GK inhibited the K48-linked ubiquitination of Laptm5 and revealed the ubiquitination sites of Laptm5 (K86 and K122) for the first time. Biotin pulldown and DARTS identified ubiquitin-protein ligase E3C (Ube3c) as a target of GK in inhibiting Laptm5 u …
Further, we found that GK inhibited the K48-linked ubiquitination of Laptm5 and revealed the ubiquitination sites of Laptm5 (K86 and …
Effect of E2 and long control region polymorphisms on disease severity in human papillomavirus type 11 mediated mucosal disease: Protein modelling and functional analysis.
Nagy Z, Pethő Z, Kardos G, Major T, Szűcs A, Szarka K. Nagy Z, et al. Infect Genet Evol. 2021 Sep;93:104948. doi: 10.1016/j.meegid.2021.104948. Epub 2021 Jun 2. Infect Genet Evol. 2021. PMID: 34089910 Free article.
The unique polymorphism Q86K changed the negative surface charge of E2 (Q86) to positive (K86). The unique polymorphisms S245F and N247T in the hinge region disrupt a probable phosphorylation site in a RXXS motif targeted by protein kinase A and B, but do not affect direct …
The unique polymorphism Q86K changed the negative surface charge of E2 (Q86) to positive (K86). The unique polymorphisms S245F and N2 …
15 results