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Year Number of Results
2016 6
2017 4
2018 14
2019 15
2020 15
2021 13
2022 18
2023 15
2024 30
2025 28
2026 6

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144 results

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Page 1
Genotype and phenotype correlations in 441 patients with epidermolysis bullosa from China.
Chen F, Wei R, Deng D, Zhang X, Cao Y, Pan C, Wang Y, Cao Q, Wang J, Zeng M, Huang L, Gu Y, Yao Z, Li M. Chen F, et al. J Eur Acad Dermatol Venereol. 2023 Feb;37(2):411-419. doi: 10.1111/jdv.18692. Epub 2022 Nov 5. J Eur Acad Dermatol Venereol. 2023. PMID: 36287101
In 16 probands with presumptive recessive EB, failed to find the second allele, COL7A1 (10), COL17A1 (4), LAMB3 (1) and ITGB4 (1). De novo mutations are common in dominant EB (63.8% in EBS, 27.5% in DEB) but extremely rare in recessive DEB (RDEB; 0.74%). ...
In 16 probands with presumptive recessive EB, failed to find the second allele, COL7A1 (10), COL17A1 (4), LAMB3 (1) and ITGB4 (1). De …
The lncRNA SNHG26 drives the inflammatory-to-proliferative state transition of keratinocyte progenitor cells during wound healing.
Li D, Liu Z, Zhang L, Bian X, Wu J, Li L, Chen Y, Luo L, Pan L, Kong L, Xiao Y, Wang J, Zhang X, Wang W, Toma M, Piipponen M, Sommar P, Xu Landén N. Li D, et al. Nat Commun. 2024 Oct 5;15(1):8637. doi: 10.1038/s41467-024-52783-8. Nat Commun. 2024. PMID: 39366968 Free PMC article.
A mechanistic study unravels that SNHG26 interacts with and relocates the transcription factor ILF2 from inflammatory genomic loci, such as JUN, IL6, IL8, and CCL20, to the genomic locus of LAMB3. Collectively, our findings suggest that lncRNAs play cardinal roles in exped …
A mechanistic study unravels that SNHG26 interacts with and relocates the transcription factor ILF2 from inflammatory genomic loci, such as …
Genome-wide CRISPR/Cas9 library screen identifies PCMT1 as a critical driver of ovarian cancer metastasis.
Zhang J, Li Y, Liu H, Zhang J, Wang J, Xia J, Zhang Y, Yu X, Ma J, Huang M, Wang J, Wang L, Li Q, Cui R, Yang W, Xu Y, Feng W. Zhang J, et al. J Exp Clin Cancer Res. 2022 Jan 15;41(1):24. doi: 10.1186/s13046-022-02242-3. J Exp Clin Cancer Res. 2022. PMID: 35033172 Free PMC article.
Interestingly, PCMT1 was released from ovarian cancer cells, and interacted with the ECM protein LAMB3, which binds to integrin and activates FAK-Src signaling to promote cancer progression. ...
Interestingly, PCMT1 was released from ovarian cancer cells, and interacted with the ECM protein LAMB3, which binds to integrin and a …
An extracellular matrix niche secreted by epithelial cells drives intestinal organoid formation.
Chrisnandy A, Lutolf MP. Chrisnandy A, et al. Dev Cell. 2025 Nov 17;60(22):3116-3130.e8. doi: 10.1016/j.devcel.2025.06.026. Epub 2025 Jul 17. Dev Cell. 2025. PMID: 40680738 Free article.
We identified ubiquitous expression of laminin chains Lama3, Lamb3, and Lamc2, but Lamb1 and Lamc1 were spatially restricted to the crypt domain. Epithelial-cell-secreted basement membranes extracted from organoids promoted the formation of patterned organoids. ...
We identified ubiquitous expression of laminin chains Lama3, Lamb3, and Lamc2, but Lamb1 and Lamc1 were spatially restricted to the c …
Integrative genomics unveils basement membrane-related diagnostic markers and therapeutic targets in esophageal squamous cell carcinoma.
Zhang H, Zhang X, Huang Z, Zhang H. Zhang H, et al. Biol Direct. 2024 Sep 11;19(1):79. doi: 10.1186/s13062-024-00529-3. Biol Direct. 2024. PMID: 39256753 Free PMC article.
CONCLUSION: Our study identified seven key BMRGs (BGN, LAMB3, SPARC, MMP1, LUM, COL4A1, and NELL2) and established a diagnostic nomogram for ESCC. ...
CONCLUSION: Our study identified seven key BMRGs (BGN, LAMB3, SPARC, MMP1, LUM, COL4A1, and NELL2) and established a diagnostic nomog …
EGFR-mediated local invasiveness and response to Cetuximab in head and neck cancer.
Zhou J, He M, Zhao Q, Shi E, Wang H, Ponkshe V, Song J, Wu Z, Ji D, Kranz G, Tscherne A, Schwenk-Zieger S, Razak NA, Hess J, Belka C, Zitzelsberger H, Ourailidis I, Stögbauer F, Boxberg M, Budczies J, Reichel CA, Canis M, Baumeister P, Wang H, Unger K, Mock A, Gires O. Zhou J, et al. Mol Cancer. 2025 Mar 22;24(1):94. doi: 10.1186/s12943-025-02290-1. Mol Cancer. 2025. PMID: 40121428 Free PMC article.
InvGRN comprises the central hubs inhibin subunit beta alpha (INHBA) and snail family transcriptional repressor 2 (SNAI2), and druggable fDEGs integrin subunit beta 4 (ITGB4), laminin 5 (LAMB3/LAMC2), and sphingosine kinase 1 (SPHK1). Blockade of INHBA repressed local inva …
InvGRN comprises the central hubs inhibin subunit beta alpha (INHBA) and snail family transcriptional repressor 2 (SNAI2), and druggable fDE …
LAMB3: Central role and clinical significance in neoplastic and non-neoplastic diseases.
Yu F, Zeng G, Yang L, Zhou H, Wang Y. Yu F, et al. Biomed Pharmacother. 2024 Sep;178:117233. doi: 10.1016/j.biopha.2024.117233. Epub 2024 Aug 6. Biomed Pharmacother. 2024. PMID: 39111076 Free article. Review.
Conversely, it is underexpressed in other conditions, such as hepatocellular carcinoma, epidermolysis bullosa, and amelogenesis imperfecta. Consequently, LAMB3 may serve as a molecular diagnostic and therapeutic target for various diseases through its involvement in critic …
Conversely, it is underexpressed in other conditions, such as hepatocellular carcinoma, epidermolysis bullosa, and amelogenesis imperfecta. …
The LAMB3-EGFR signaling pathway mediates synergistic Anti-Cancer effects of berberine and emodin in Pancreatic cancer.
Xu C, Pascual-Sabater S, Fillat C, Goel A. Xu C, et al. Biochem Pharmacol. 2024 Oct;228:116509. doi: 10.1016/j.bcp.2024.116509. Epub 2024 Aug 28. Biochem Pharmacol. 2024. PMID: 39214450 Free PMC article.
Genomewide transcriptomic profiling identified that LAMB3 was significantly upregulated in PDAC tissue and highly associated with poor overall survival (OS, hazard ratio [HR], 2.99, 95 % confidence interval [CI], 1.46-6.15; p = 0.003) and progress-free survival (PFS, HR, 2 …
Genomewide transcriptomic profiling identified that LAMB3 was significantly upregulated in PDAC tissue and highly associated with poo …
Spatial transcriptomics reveals prognosis-associated cellular heterogeneity in the papillary thyroid carcinoma microenvironment.
Yan K, Liu QZ, Huang RR, Jiang YH, Bian ZH, Li SJ, Li L, Shen F, Tsuneyama K, Zhang QL, Lian ZX, Guan H, Xu B. Yan K, et al. Clin Transl Med. 2024 Mar;14(3):e1594. doi: 10.1002/ctm2.1594. Clin Transl Med. 2024. PMID: 38426403 Free PMC article.
We discovered key ligand-receptor interactions, including LAMB3-ITGA2, FN1-ITGA3 and FN1-SDC4, involved in the transition of PTC cells from FCs to AFCs and eventually to tumour cells. ...
We discovered key ligand-receptor interactions, including LAMB3-ITGA2, FN1-ITGA3 and FN1-SDC4, involved in the transition of PTC cell …
NAT10 regulates tumor progression and immune microenvironment in pancreatic ductal adenocarcinoma via the N4-acetylated LAMB3-mediated FAK/ERK pathway.
Chen E, Wang Q, Wang L, Huang Z, Yang D, Zhao C, Chen W, Zhang S, Xiong S, He Y, Mao Y, Hu H. Chen E, et al. Cancer Commun (Lond). 2025 Sep;45(9):1162-1187. doi: 10.1002/cac2.70045. Epub 2025 Jun 20. Cancer Commun (Lond). 2025. PMID: 40540648 Free PMC article.
NAT10 promoted tumor progression by enhancing the mRNA stability of laminin beta3 (LAMB3) via N4-acetylation modification, thereby activating the focal adhesion kinase (FAK)/extracellular regulated protein kinases (ERK) pathway. ...Regarding the regulatory mechanism, NAT10 …
NAT10 promoted tumor progression by enhancing the mRNA stability of laminin beta3 (LAMB3) via N4-acetylation modification, thereby ac …
144 results