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Laron syndrome.
Guleria S, Sharma J, Kaushik SL. Guleria S, et al. J Postgrad Med. 2014 Jul-Sep;60(3):322-3. doi: 10.4103/0022-3859.138816. J Postgrad Med. 2014. PMID: 25121377 No abstract available.
The History of the Insulin-Like Growth Factor System.
Miller BS, Rogol AD, Rosenfeld RG. Miller BS, et al. Horm Res Paediatr. 2022;95(6):619-630. doi: 10.1159/000527123. Epub 2022 Nov 29. Horm Res Paediatr. 2022. PMID: 36446332 Free article. Review.
In addition, this new evidence has expanded our clinical definition of GH insensitivity (GHI) beyond growth hormone receptor mutations (classic Laron syndrome) to include conditions that cause primary IGF deficiency by impacting post-receptor signal transduction, IG …
In addition, this new evidence has expanded our clinical definition of GH insensitivity (GHI) beyond growth hormone receptor mutations (clas …
Laron syndrome - A historical perspective.
Laron Z, Werner H. Laron Z, et al. Rev Endocr Metab Disord. 2021 Mar;22(1):31-41. doi: 10.1007/s11154-020-09595-0. Epub 2020 Sep 22. Rev Endocr Metab Disord. 2021. PMID: 32964395 Review.
Laron Syndrome (LS) [OMIm#262500], or primary GH insensitivity, was first described in 1966 in consanguineous Jewish families from Yemen. ...
Laron Syndrome (LS) [OMIm#262500], or primary GH insensitivity, was first described in 1966 in consanguineous Jewish families …
Insulin-like growth factors and aging: lessons from Laron syndrome.
Werner H, Laron Z. Werner H, et al. Front Endocrinol (Lausanne). 2023 Oct 24;14:1291812. doi: 10.3389/fendo.2023.1291812. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37941907 Free PMC article. Review.
Epidemiological analyses have shown that patients with Laron syndrome (LS), the best-characterized disease under the umbrella of the congenital IGF1 deficiencies, seem to be protected from cancer. ...
Epidemiological analyses have shown that patients with Laron syndrome (LS), the best-characterized disease under the umbrella …
Fanconi Anemia and Laron Syndrome.
Castilla-Cortazar I, de Ita JR, Aguirre GA, Castorena-Torres F, Ortiz-Urbina J, García-Magariño M, de la Garza RG, Diaz Olachea C, Elizondo Leal MI. Castilla-Cortazar I, et al. Am J Med Sci. 2017 May;353(5):425-432. doi: 10.1016/j.amjms.2017.02.001. Epub 2017 Feb 4. Am J Med Sci. 2017. PMID: 28502327 Free article.
In this study, we thereby considered an association between FA and Laron syndrome (LS) (insulin-like growth factor 1 [IGF-1] deficiency). METHODS: A 21-year-old female Mexican patient with a genetic diagnosis of FA was referred to our research department for an eval …
In this study, we thereby considered an association between FA and Laron syndrome (LS) (insulin-like growth factor 1 [IGF-1] d …
Mouse models of growth hormone insensitivity.
Young J, Bell S, Qian Y, Hyman C, Berryman DE. Young J, et al. Rev Endocr Metab Disord. 2021 Mar;22(1):17-29. doi: 10.1007/s11154-020-09600-6. Epub 2020 Oct 10. Rev Endocr Metab Disord. 2021. PMID: 33037595 Free PMC article. Review.
GHI is commonly due to genetic disorders of the GH receptor causing GH receptor deficiency (e.g. Laron Syndrome (LS)), decreased activation of GHR, or defects in post-receptor signaling molecules. ...
GHI is commonly due to genetic disorders of the GH receptor causing GH receptor deficiency (e.g. Laron Syndrome (LS)), decreas …
Clinical and Molecular Features of Laron Syndrome, A Genetic Disorder Protecting from Cancer.
Janecka A, Kołodziej-Rzepa M, Biesaga B. Janecka A, et al. In Vivo. 2016 Jul-Aug;30(4):375-81. In Vivo. 2016. PMID: 27381597 Review.
Laron syndrome (LS) is a rare, genetic disorder inherited in an autosomal recessive manner. ...Patients with LS have characteristic biochemical features, such as a high serum level of GH and low IGF1 concentration. Laron syndrome was first described by …
Laron syndrome (LS) is a rare, genetic disorder inherited in an autosomal recessive manner. ...Patients with LS have character …
IGF-I deficiency, longevity and cancer protection of patients with Laron syndrome.
Laron Z, Kauli R, Lapkina L, Werner H. Laron Z, et al. Mutat Res Rev Mutat Res. 2017 Apr-Jun;772:123-133. doi: 10.1016/j.mrrev.2016.08.002. Epub 2016 Aug 5. Mutat Res Rev Mutat Res. 2017. PMID: 28528685 Review.
Laron syndrome (LS) is a unique model of congenital IGF-I deficiency. It is characterized by dwarfism and obesity, and is caused by deletion or mutations of the growth hormone receptor (GH-R) gene. ...
Laron syndrome (LS) is a unique model of congenital IGF-I deficiency. It is characterized by dwarfism and obesity, and is caus …
LESSONS FROM 50 YEARS OF STUDY OF LARON SYNDROME.
Laron Z. Laron Z. Endocr Pract. 2015 Dec;21(12):1395-402. doi: 10.4158/EP15939.RA. Epub 2015 Sep 24. Endocr Pract. 2015. PMID: 26401581 Review.
OBJECTIVE: To describe the characteristics of untreated and recombinant insulin-like growth factor 1 (IGF-1)- treated patients with the Laron syndrome (LS) as seen in our clinic over a period of over 50 years. In 1966, we reported a new disease, characterized by dwa …
OBJECTIVE: To describe the characteristics of untreated and recombinant insulin-like growth factor 1 (IGF-1)- treated patients with the L …
Laron Syndrome Research Paves the Way for New Insights in Oncological Investigation.
Werner H, Sarfstein R, Nagaraj K, Laron Z. Werner H, et al. Cells. 2020 Nov 9;9(11):2446. doi: 10.3390/cells9112446. Cells. 2020. PMID: 33182502 Free PMC article. Review.
Laron syndrome (LS) is a rare genetic endocrinopathy that results from mutation of the growth hormone receptor (GH-R) gene and is typically associated with dwarfism and obesity. ...
Laron syndrome (LS) is a rare genetic endocrinopathy that results from mutation of the growth hormone receptor (GH-R) gene and …
116 results