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Approaching hemophagocytic lymphohistiocytosis.
Chinnici A, Beneforti L, Pegoraro F, Trambusti I, Tondo A, Favre C, Coniglio ML, Sieni E. Chinnici A, et al. Front Immunol. 2023 Jun 22;14:1210041. doi: 10.3389/fimmu.2023.1210041. eCollection 2023. Front Immunol. 2023. PMID: 37426667 Free PMC article. Review.
Genetic analysis is mandatory to confirm familial hemophagocytic lymphohistiocytosis (FHL) and Next Generation Sequencing is increasingly adopted to extend the spectrum of genetic predisposition to HLH, though its results should be critically discussed with s …
Genetic analysis is mandatory to confirm familial hemophagocytic lymphohistiocytosis (FHL) and Next Generation Sequenci …
Consensus-Based Guidelines for the Recognition, Diagnosis, and Management of Hemophagocytic Lymphohistiocytosis in Critically Ill Children and Adults.
Hines MR, von Bahr Greenwood T, Beutel G, Beutel K, Hays JA, Horne A, Janka G, Jordan MB, van Laar JAM, Lachmann G, Lehmberg K, Machowicz R, Miettunen P, La Rosée P, Shakoory B, Zinter MS, Henter JI. Hines MR, et al. Crit Care Med. 2022 May 1;50(5):860-872. doi: 10.1097/CCM.0000000000005361. Epub 2021 Oct 5. Crit Care Med. 2022. PMID: 34605776
Early steroid treatment is indicated for patients with familial hemophagocytic lymphohistiocytosis and is often valuable in patients with acquired hemophagocytic lymphohistiocytosis (i.e., secondary hemophagocytic lymphohistiocytosis) without previous therapy …
Early steroid treatment is indicated for patients with familial hemophagocytic lymphohistiocytosis and is often valuabl …
Cytokine Storm Syndrome.
Cron RQ, Goyal G, Chatham WW. Cron RQ, et al. Annu Rev Med. 2023 Jan 27;74:321-337. doi: 10.1146/annurev-med-042921-112837. Epub 2022 Oct 13. Annu Rev Med. 2023. PMID: 36228171 Free article. Review.
A variety of hyperinflammatory conditions associated with multiorgan system failure can be lumped under the CSS umbrella, including familial hemophagocytic lymphohistiocytosis (HLH) and secondary HLH associated with infections, hematologic malignancies, and a …
A variety of hyperinflammatory conditions associated with multiorgan system failure can be lumped under the CSS umbrella, including famil …
Diagnostic guidelines for familial hemophagocytic lymphohistiocytosis revisited.
Henter JI, Sieni E, Eriksson J, Bergsten E, Hed Myrberg I, Canna SW, Coniglio ML, Cron RQ, Kernan KF, Kumar AR, Lehmberg K, Minoia F, Naqvi A, Ravelli A, Tang YM, Bottai M, Bryceson YT, Horne A, Jordan MB. Henter JI, et al. Blood. 2024 Nov 28;144(22):2308-2318. doi: 10.1182/blood.2024025077. Blood. 2024. PMID: 39046779 Free PMC article.
Current hemophagocytic lymphohistiocytosis 2004 (HLH-2004)-based diagnostic criteria for familial hemophagocytic lymphohistiocytosis (FHL) are based on expert opinion. Here, we performed a case-control study to test and possibly improve these criteria. ...
Current hemophagocytic lymphohistiocytosis 2004 (HLH-2004)-based diagnostic criteria for familial hemophagocytic lymphohist …
Genetics of Familial Hemophagocytic Lymphohistiocytosis (HLH).
Zhang K, Meyer LK, Machowicz R, Coniglio ML, Sieni E, Nichols KE. Zhang K, et al. Hematol Oncol Clin North Am. 2025 Jun;39(3):531-551. doi: 10.1016/j.hoc.2025.02.002. Epub 2025 Apr 7. Hematol Oncol Clin North Am. 2025. PMID: 40199664 Review.
Familial hemophagocytic lymphohistiocytosis (fHLH) represents a group of rare, inherited immune system disorders characterized by uncontrolled inflammatory responses. fHLH results from genetic mutations that impair CD8 T cell and natural killer cell cytotoxic …
Familial hemophagocytic lymphohistiocytosis (fHLH) represents a group of rare, inherited immune system disorders charac …
Clinical Characteristics and Treatment of Familial Hemophagocytic Lymphohistiocytosis.
Meyer LK, Keenan C, Nichols KE. Meyer LK, et al. Hematol Oncol Clin North Am. 2025 Jun;39(3):553-575. doi: 10.1016/j.hoc.2025.02.003. Epub 2025 Mar 24. Hematol Oncol Clin North Am. 2025. PMID: 40133142 Review.
Familial hemophagocytic lymphohistiocytosis (fHLH) comprises a group of autosomal recessive disorders characterized by germline loss-of-function variants that negatively impact lymphocyte cytotoxicity. ...
Familial hemophagocytic lymphohistiocytosis (fHLH) comprises a group of autosomal recessive disorders characterized by …
Etoposide Therapy of Cytokine Storm Syndromes.
Henter JI, von Bahr Greenwood T. Henter JI, et al. Adv Exp Med Biol. 2024;1448:525-551. doi: 10.1007/978-3-031-59815-9_35. Adv Exp Med Biol. 2024. PMID: 39117837 Review.
Neonatal COVID and Familial Hemophagocytic Lymphohistiocytosis.
Hon KLE, Leung KKY, Hui WF, Cheung WL, Leung WH. Hon KLE, et al. Pediatr Emerg Care. 2022 Mar 1;38(3):e1094-e1096. doi: 10.1097/PEC.0000000000002643. Pediatr Emerg Care. 2022. PMID: 35226638 Free PMC article. No abstract available.
Atypical familial hemophagocytic lymphohistiocytosis type 3 in children: A report of cases and literature review.
Zhao Q, Zhao Q, Tang X, An Y, Zhang Z, Tomomasa D, Hijikata A, Yang X, Kanegane H, Zhao X. Zhao Q, et al. Pediatr Allergy Immunol. 2024 May;35(5):e14136. doi: 10.1111/pai.14136. Pediatr Allergy Immunol. 2024. PMID: 38747707 Review.
BACKGROUND: Familial hemophagocytic lymphohistiocytosis type 3 (FHL3) is caused by UNC13D variants. ...
BACKGROUND: Familial hemophagocytic lymphohistiocytosis type 3 (FHL3) is caused by UNC13D variants. ...
Familial Hemophagocytic Lymphohistiocytosis Screening in Neonatal Sepsis.
Kadi Ozan Z, Erduran E, Ceylaner S, Aslan Y, Bahadir A, Reis GP, Mutlu M. Kadi Ozan Z, et al. J Pediatr Hematol Oncol. 2024 Aug 1;46(6):e393-e401. doi: 10.1097/MPH.0000000000002906. Epub 2024 Jul 2. J Pediatr Hematol Oncol. 2024. PMID: 38968556
OBJECTIVE: Neonatal sepsis and familial hemophagocytic lymphohistiocytosis (fHLH) have similar clinical and laboratory symptoms and the possibility of overlooking fHLH diagnosis is high in newborns with sepsis. ...
OBJECTIVE: Neonatal sepsis and familial hemophagocytic lymphohistiocytosis (fHLH) have similar clinical and laboratory …
72 results