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MAP3K1 rs889312 polymorphism and cancer prognosis: A systematic review and meta-analysis.
Aziz MA, Islam MS. Aziz MA, et al. Cancer Rep (Hoboken). 2023 Jan;6(1):e1773. doi: 10.1002/cnr2.1773. Epub 2022 Dec 22. Cancer Rep (Hoboken). 2023. PMID: 36560873 Free PMC article.
Given the potential impact of MAP3K1 rs889312 SNP on the prognosis of various cancers, this meta-analysis was performed to obtain solid and credible evidence. ...CONCLUSIONS: The present study concludes that MAP3K1 gene rs889312 polymorphism plays a prognostic role …
Given the potential impact of MAP3K1 rs889312 SNP on the prognosis of various cancers, this meta-analysis was performed to obtain sol …
Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk.
Wilcox N, Dumont M, González-Neira A, Carvalho S, Joly Beauparlant C, Crotti M, Luccarini C, Soucy P, Dubois S, Nuñez-Torres R, Pita G, Gardner EJ, Dennis J, Alonso MR, Álvarez N, Baynes C, Collin-Deschesnes AC, Desjardins S, Becher H, Behrens S, Bolla MK, Castelao JE, Chang-Claude J, Cornelissen S, Dörk T, Engel C, Gago-Dominguez M, Guénel P, Hadjisavvas A, Hahnen E, Hartman M, Herráez B; SGBCC Investigators; Jung A, Keeman R, Kiechle M, Li J, Loizidou MA, Lush M, Michailidou K, Panayiotidis MI, Sim X, Teo SH, Tyrer JP, van der Kolk LE, Wahlström C, Wang Q, Perry JRB, Benitez J, Schmidt MK, Schmutzler RK, Pharoah PDP, Droit A, Dunning AM, Kvist A, Devilee P, Easton DF, Simard J. Wilcox N, et al. Nat Genet. 2023 Sep;55(9):1435-1439. doi: 10.1038/s41588-023-01466-z. Epub 2023 Aug 17. Nat Genet. 2023. PMID: 37592023 Free PMC article.

Associations between protein-truncating variants and breast cancer were identified for the following six genes at exome-wide significance (P < 2.5 10(-6)): the five known susceptibility genes ATM, BRCA1, BRCA2, CHEK2 and PALB2, together with MAP3K1. Associations were

…
Associations between protein-truncating variants and breast cancer were identified for the following six genes at exome-wide significance (P …
MAP3K1 mutations confer tumor immune heterogeneity in hormone receptor-positive HER2-negative breast cancer.
Cai YW, Liu CC, Zhang YW, Liu YM, Chen L, Xiong X, Shao ZM, Yu KD. Cai YW, et al. J Clin Invest. 2024 Nov 12;135(2):e183656. doi: 10.1172/JCI183656. J Clin Invest. 2024. PMID: 39531335 Free PMC article.
Notably, the immunological heterogeneity of HR+/HER2- breast cancer was related to mitogen-activated protein kinase kinase kinase 1 (MAP3K1) mutation and we validated experimentally that a MAP3K1 mutation could attenuate CD8+ T cell-mediated antitumor immunity. ...I …
Notably, the immunological heterogeneity of HR+/HER2- breast cancer was related to mitogen-activated protein kinase kinase kinase 1 (MAP3 …
Germline DNA Damage Repair Gene Alterations in Patients with Metachronous Breast and Colorectal Cancer.
Villacis RAR, Côrtes L, Basso TR, do Canto LM, Souza JS, Aagaard MM, da Cruz Formiga MN, Aguiar S Jr, Achatz MI, Rogatto SR. Villacis RAR, et al. Int J Mol Sci. 2024 Sep 24;25(19):10275. doi: 10.3390/ijms251910275. Int J Mol Sci. 2024. PMID: 39408606 Free PMC article.
We also identified SNVs recently associated with BC or CRC predisposition (PABPC1, TYRO3, MAP3K1, SLC15A4, and LAMA1). The PABPC1c.1255C>T variant was detected in nine unrelated patients. ...
We also identified SNVs recently associated with BC or CRC predisposition (PABPC1, TYRO3, MAP3K1, SLC15A4, and LAMA1). The PABPC1c.12 …
Comprehensive analysis of MAPK genes in the prognosis, immune characteristics, and drug treatment of renal clear cell carcinoma using bioinformatic analysis and Mendelian randomization.
Zheng X, Wang Y, Qiu X. Zheng X, et al. Eur J Pharmacol. 2024 Oct 5;980:176840. doi: 10.1016/j.ejphar.2024.176840. Epub 2024 Jul 20. Eur J Pharmacol. 2024. PMID: 39038636
We identified a novel prognostic panel of six MAPK-signature genes (MAP3K12, MAP3K1, MAP3K5, MAPK1, MAPK8, MAPK9), and introduced a robust MAPK-signature risk model for predicting ccRCC prognosis. ...
We identified a novel prognostic panel of six MAPK-signature genes (MAP3K12, MAP3K1, MAP3K5, MAPK1, MAPK8, MAPK9), and introduced a r …
Lack of Association of Polymorphism Located Upstream of ABCA1 (rs2472493), in FNDC3B (rs7636836), and Near ANKRD55-MAP3K1 Genes (rs61275591) in Primary Open-Angle Glaucoma Patients of Saudi Origin.
Kondkar AA, Sultan T, Azad TA, Osman EA, Almobarak FA, Lobo GP, Al-Obeidan SA. Kondkar AA, et al. Genes (Basel). 2023 Mar 13;14(3):704. doi: 10.3390/genes14030704. Genes (Basel). 2023. PMID: 36980976 Free PMC article.
Polymorphisms rs2472493 near ABCA1, rs7636836 in FNDC3B, and rs61275591 near the ANKRD55-MAP3K1 genes were previously reported to exhibit genome-wide significance in primary open-angle glaucoma (POAG). ...Our study did not replicate the genetic association of rs2472493 (AB …
Polymorphisms rs2472493 near ABCA1, rs7636836 in FNDC3B, and rs61275591 near the ANKRD55-MAP3K1 genes were previously reported to exh …
Deafness DFNB128 Associated with a Recessive Variant of Human MAP3K1 Recapitulates Hearing Loss of Map3k1-Deficient Mice.
Faridi R, Yousaf R, Inagaki S, Olszewski R, Gu S, Morell RJ, Wilson E, Xia Y, Qaiser TA, Rashid M, Fenollar-Ferrer C, Hoa M, Riazuddin S, Friedman TB. Faridi R, et al. Genes (Basel). 2024 Jun 27;15(7):845. doi: 10.3390/genes15070845. Genes (Basel). 2024. PMID: 39062623 Free PMC article.
Our single-cell transcriptome data of mouse cochlea mRNA show expression of Map3k1 and its signaling partners in several inner ear cell types suggesting a requirement of wild-type MAP3K1 for normal hearing. ...(Arg1487His) predicts a subtle structural alteration in …
Our single-cell transcriptome data of mouse cochlea mRNA show expression of Map3k1 and its signaling partners in several inner ear ce …
Mutational Signatures and Clonal Hematopoiesis in Intestinal Metaplasia across Countries with Varying Stomach Cancer Incidence.
Huang KK, Hagihara T, Lian BSX, Ong ZX, Lim SK, Chong RHH, Srivastava S, Kang JX, Lee MY, Tan AL, Lee M, Ho SWT, Binte Abdul Ghani SA, Ng CSY, Liang R, Liu L, Tay ST, Ong X, Zhu F, Chen H, Li Z, Ang TL, Gotoda T, Huang RJ, Khor CJL, Kim HS, Lau LHS, Lee YC, Takasu A, Teh M, Thian MY, Tam WL, Lu X, Wong SH, So JBY, Chung H, Lee J, Yeoh KG, Tan P. Huang KK, et al. Cancer Discov. 2026 Mar 2;16(3):497-520. doi: 10.1158/2159-8290.CD-25-0778. Cancer Discov. 2026. PMID: 41532847 Free PMC article.
High-depth targeted sequencing of more than 1,500 IM samples from six countries identified 47 significantly mutated genes, including driver genes associated with high-risk populations and worse prognosis (ARID1A), KRAS/MAPK signaling (KRAS, BRAF, MAP2K1, MAP3K1, and MAP2K4 …
High-depth targeted sequencing of more than 1,500 IM samples from six countries identified 47 significantly mutated genes, including driver …
Whole exome sequencing identifies MAP3K1, MSH2, and MLH1 as potential cancer-predisposing genes in familial early-onset colorectal cancer.
Fatemi N, Tu SJ, Chung CC, Moghadam PK, Mojarad EN, Sadeghi A, Totonchi M, Aghdaei HA, Chang JG. Fatemi N, et al. Kaohsiung J Med Sci. 2023 Sep;39(9):896-903. doi: 10.1002/kjm2.12715. Epub 2023 Jun 14. Kaohsiung J Med Sci. 2023. PMID: 37314251 Free PMC article.
In addition, we identified a rare heterozygote variant (c.175C>T) with suspected pathogenic potential in the MAP3K1 gene; formally the variant is of uncertain significance (VUS). Our findings support the hypothesis that CRC onset may be oligogenic and molecularly hetero …
In addition, we identified a rare heterozygote variant (c.175C>T) with suspected pathogenic potential in the MAP3K1 gene; formally …
Novel Molecular Therapies and Genetic Landscape in Selected Rare Diseases with Hematologic Manifestations: A Review of the Literature.
Ręka G, Stefaniak M, Lejman M. Ręka G, et al. Cells. 2023 Jan 30;12(3):449. doi: 10.3390/cells12030449. Cells. 2023. PMID: 36766791 Free PMC article. Review.
In histiocytosis, several mutation variants are described: BRAF, MAP2K1, MAP3K1, ARAF, ERBB3, NRAS, KRAS, PICK1, PIK3R2, and PIK3CA. Genes like HPLH1, PRF1, UNC13D, STX11, STXBP2, SH2D1A, BIRC4, ITK, CD27, MAGT1, LYST, AP3B1, and RAB27A are possible reasons for hemophagocy …
In histiocytosis, several mutation variants are described: BRAF, MAP2K1, MAP3K1, ARAF, ERBB3, NRAS, KRAS, PICK1, PIK3R2, and PIK3CA. …
63 results