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MOOD 2020: A public Benchmark for Out-of-Distribution Detection and Localization on medical Images.
Zimmerer D, Full PM, Isensee F, Jager P, Adler T, Petersen J, Kohler G, Ross T, Reinke A, Kascenas A, Jensen BS, O'Neil AQ, Tan J, Hou B, Batten J, Qiu H, Kainz B, Shvetsova N, Fedulova I, Dylov DV, Yu B, Zhai J, Hu J, Si R, Zhou S, Wang S, Li X, Chen X, Zhao Y, Marimont SN, Tarroni G, Saase V, Maier-Hein L, Maier-Hein K. Zimmerer D, et al. Among authors: maier hein k. IEEE Trans Med Imaging. 2022 Apr 25;PP. doi: 10.1109/TMI.2022.3170077. Online ahead of print. IEEE Trans Med Imaging. 2022. PMID: 35468060
Pseudoprospective Paraclinical Interaction of Radiology Residents With a Deep Learning System for Prostate Cancer Detection: Experience, Performance, and Identification of the Need for Intermittent Recalibration.
Zhang KS, Schelb P, Netzer N, Tavakoli AA, Keymling M, Wehrse E, Hog R, Rotkopf LT, Wennmann M, Glemser PA, Thierjung H, von Knebel Doeberitz N, Kleesiek J, Görtz M, Schütz V, Hielscher T, Stenzinger A, Hohenfellner M, Schlemmer HP, Maier-Hein K, Bonekamp D. Zhang KS, et al. Among authors: maier hein k. Invest Radiol. 2022 Apr 22. doi: 10.1097/RLI.0000000000000878. Online ahead of print. Invest Radiol. 2022. PMID: 35467572
OBJECTIVES: The aim of this study was to estimate the prospective utility of a previously retrospectively validated convolutional neural network (CNN) for prostate cancer (PC) detection on prostate magnetic resonance imaging (MRI). MATERIALS AND METHODS: The biparametric ( …
OBJECTIVES: The aim of this study was to estimate the prospective utility of a previously retrospectively validated convolutional neural net …
IJCARS: BVM 2021 special issue.
Maier A, Deserno TM, Handels H, Maier-Hein K, Palm C, Tolxdorff T. Maier A, et al. Among authors: maier hein k. Int J Comput Assist Radiol Surg. 2021 Dec;16(12):2067-2068. doi: 10.1007/s11548-021-02534-7. Int J Comput Assist Radiol Surg. 2021. PMID: 34792745 Free PMC article. No abstract available.
Comparison of Diffusion Signal Models for Fiber Tractography in Eloquent Glioma Surgery-Determination of Accuracy Under Awake Craniotomy Conditions.
Becker D, Neher P, Jungk C, Jesser J, Pflüger I, Brinster R, Bendszus M, Bruckner T, Maier-Hein K, Scherer M, Unterberg A. Becker D, et al. Among authors: maier hein k. World Neurosurg. 2021 Nov 9:S1878-8750(21)01707-1. doi: 10.1016/j.wneu.2021.11.006. Online ahead of print. World Neurosurg. 2021. PMID: 34767992
Deep-learning-based synthesis of post-contrast T1-weighted MRI for tumour response assessment in neuro-oncology: a multicentre, retrospective cohort study.
Jayachandran Preetha C, Meredig H, Brugnara G, Mahmutoglu MA, Foltyn M, Isensee F, Kessler T, Pflüger I, Schell M, Neuberger U, Petersen J, Wick A, Heiland S, Debus J, Platten M, Idbaih A, Brandes AA, Winkler F, van den Bent MJ, Nabors B, Stupp R, Maier-Hein KH, Gorlia T, Tonn JC, Weller M, Wick W, Bendszus M, Vollmuth P. Jayachandran Preetha C, et al. Among authors: maier hein kh. Lancet Digit Health. 2021 Dec;3(12):e784-e794. doi: 10.1016/S2589-7500(21)00205-3. Epub 2021 Oct 20. Lancet Digit Health. 2021. PMID: 34688602 Free article. Clinical Trial.
BACKGROUND: Gadolinium-based contrast agents (GBCAs) are widely used to enhance tissue contrast during MRI scans and play a crucial role in the management of patients with cancer. However, studies have shown gadolinium deposition in the brain after repeated GBCA administra …
BACKGROUND: Gadolinium-based contrast agents (GBCAs) are widely used to enhance tissue contrast during MRI scans and play a crucial role in …
Improvement of PI-RADS-dependent prostate cancer classification by quantitative image assessment using radiomics or mean ADC.
Zhang KS, Schelb P, Kohl S, Radtke JP, Wiesenfarth M, Schimmöller L, Kuder TA, Stenzinger A, Hohenfellner M, Schlemmer HP, Maier-Hein K, Bonekamp D. Zhang KS, et al. Among authors: maier hein k. Magn Reson Imaging. 2021 Oct;82:9-17. doi: 10.1016/j.mri.2021.06.013. Epub 2021 Jun 18. Magn Reson Imaging. 2021. PMID: 34147597
We have previously developed quantitative RML and ADC classifiers for prediction of clinically significant prostate cancer (sPC) from prostate MRI, however these have not been combined with radiologist PI-RADS assessment. ...Analyses were performed at the individual lesion …
We have previously developed quantitative RML and ADC classifiers for prediction of clinically significant prostate cancer (sPC) from …
Multi-Centre, Multi-Vendor and Multi-Disease Cardiac Segmentation: The M&Ms Challenge.
Campello VM, Gkontra P, Izquierdo C, Martin-Isla C, Sojoudi A, Full PM, Maier-Hein K, Zhang Y, He Z, Ma J, Parreno M, Albiol A, Kong F, Shadden SC, Acero JC, Sundaresan V, Saber M, Elattar M, Li H, Menze B, Khader F, Haarburger C, Scannell CM, Veta M, Carscadden A, Punithakumar K, Liu X, Tsaftaris SA, Huang X, Yang X, Li L, Zhuang X, Vilades D, Descalzo ML, Guala A, Mura L, Friedrich MG, Garg R, Lebel J, Henriques F, Karakas M, Cavus E, Petersen SE, Escalera S, Segui S, Rodriguez-Palomares JF, Lekadir K. Campello VM, et al. Among authors: maier hein k. IEEE Trans Med Imaging. 2021 Dec;40(12):3543-3554. doi: 10.1109/TMI.2021.3090082. Epub 2021 Nov 30. IEEE Trans Med Imaging. 2021. PMID: 34138702 Free article.
The obtained results indicate the importance of intensity-driven data augmentation, as well as the need for further research to improve generalizability towards unseen scanner vendors or new imaging protocols. Furthermore, we present a new resource of 375 heterogeneous CMR …
The obtained results indicate the importance of intensity-driven data augmentation, as well as the need for further research to impro …
Rapid Artificial Intelligence Solutions in a Pandemic - The COVID-19-20 Lung CT Lesion Segmentation Challenge.
Roth H, Xu Z, Diez CT, Jacob RS, Zember J, Molto J, Li W, Xu S, Turkbey B, Turkbey E, Yang D, Harouni A, Rieke N, Hu S, Isensee F, Tang C, Yu Q, Sölter J, Zheng T, Liauchuk V, Zhou Z, Moltz J, Oliveira B, Xia Y, Maier-Hein K, Li Q, Husch A, Zhang L, Kovalev V, Kang L, Hering A, Vilaça J, Flores M, Xu D, Wood B, Linguraru M. Roth H, et al. Among authors: maier hein k. Res Sq. 2021 Jun 4:rs.3.rs-571332. doi: 10.21203/rs.3.rs-571332/v1. Preprint. Res Sq. 2021. PMID: 34100010 Free PMC article.
Comparing methods of detecting and segmenting unruptured intracranial aneurysms on TOF-MRAS: The ADAM challenge.
Timmins KM, van der Schaaf IC, Bennink E, Ruigrok YM, An X, Baumgartner M, Bourdon P, De Feo R, Noto TD, Dubost F, Fava-Sanches A, Feng X, Giroud C, Group I, Hu M, Jaeger PF, Kaiponen J, Klimont M, Li Y, Li H, Lin Y, Loehr T, Ma J, Maier-Hein KH, Marie G, Menze B, Richiardi J, Rjiba S, Shah D, Shit S, Tohka J, Urruty T, Walińska U, Yang X, Yang Y, Yin Y, Velthuis BK, Kuijf HJ. Timmins KM, et al. Among authors: maier hein kh. Neuroimage. 2021 Sep;238:118216. doi: 10.1016/j.neuroimage.2021.118216. Epub 2021 May 27. Neuroimage. 2021. PMID: 34052465 Free article.
Fully Automatic Deep Learning in Bi-institutional Prostate Magnetic Resonance Imaging: Effects of Cohort Size and Heterogeneity.
Netzer N, Weißer C, Schelb P, Wang X, Qin X, Görtz M, Schütz V, Radtke JP, Hielscher T, Schwab C, Stenzinger A, Kuder TA, Gnirs R, Hohenfellner M, Schlemmer HP, Maier-Hein KH, Bonekamp D. Netzer N, et al. Among authors: maier hein kh. Invest Radiol. 2021 Dec 1;56(12):799-808. doi: 10.1097/RLI.0000000000000791. Invest Radiol. 2021. PMID: 34049336
PURPOSE: The aim of this study was to evaluate the effects of increased and diversified training data (TD) on deep learning performance for detection and segmentation of clinically significant prostate cancer-suspicious lesions. MATERIALS AND METHODS: In this retrospective …
PURPOSE: The aim of this study was to evaluate the effects of increased and diversified training data (TD) on deep learning performance for …
White matter microstructure alterations in cortico-striatal networks are associated with parkinsonism in schizophrenia spectrum disorders.
Wasserthal J, Maier-Hein KH, Neher PF, Wolf RC, Northoff G, Waddington JL, Kubera KM, Fritze S, Harneit A, Geiger LS, Tost H, Hirjak D. Wasserthal J, et al. Among authors: maier hein kh. Eur Neuropsychopharmacol. 2021 Sep;50:64-74. doi: 10.1016/j.euroneuro.2021.04.007. Epub 2021 May 10. Eur Neuropsychopharmacol. 2021. PMID: 33984810
Fully Automated Segmentation of Pulmonary Fibrosis Using Different Software Tools.
Ley-Zaporozhan J, Giannakis A, Norajitra T, Weinheimer O, Kehler L, Dinkel J, Ganter C, Ley S, Van Lunteren C, Eichinger M, Heussel G, Kauczor HU, Maier-Hein KH, Kreuter M, Heussel CP. Ley-Zaporozhan J, et al. Among authors: maier hein kh. Respiration. 2021;100(7):580-587. doi: 10.1159/000515182. Epub 2021 Apr 15. Respiration. 2021. PMID: 33857945
Comparative validation of multi-instance instrument segmentation in endoscopy: Results of the ROBUST-MIS 2019 challenge.
Roß T, Reinke A, Full PM, Wagner M, Kenngott H, Apitz M, Hempe H, Mindroc-Filimon D, Scholz P, Tran TN, Bruno P, Arbeláez P, Bian GB, Bodenstedt S, Bolmgren JL, Bravo-Sánchez L, Chen HB, González C, Guo D, Halvorsen P, Heng PA, Hosgor E, Hou ZG, Isensee F, Jha D, Jiang T, Jin Y, Kirtac K, Kletz S, Leger S, Li Z, Maier-Hein KH, Ni ZL, Riegler MA, Schoeffmann K, Shi R, Speidel S, Stenzel M, Twick I, Wang G, Wang J, Wang L, Wang L, Zhang Y, Zhou YJ, Zhu L, Wiesenfarth M, Kopp-Schneider A, Müller-Stich BP, Maier-Hein L. Roß T, et al. Among authors: maier hein kh. Med Image Anal. 2021 May;70:101920. doi: 10.1016/j.media.2020.101920. Epub 2020 Nov 28. Med Image Anal. 2021. PMID: 33676097 Free article.
While the average detection and segmentation quality of the best-performing algorithms is high, future research should concentrate on detection and segmentation of small, crossing, moving and transparent instrument(s) (parts)....
While the average detection and segmentation quality of the best-performing algorithms is high, future research should concentrate on …
Assessment of tissue perfusion of pancreatic cancer as potential imaging biomarker by means of Intravoxel incoherent motion MRI and CT perfusion: correlation with histological microvessel density as ground truth.
Mayer P, Fritz F, Koell M, Skornitzke S, Bergmann F, Gaida MM, Hackert T, Maier-Hein K, Laun FB, Kauczor HU, Grenacher L, Klauß M, Stiller W. Mayer P, et al. Among authors: maier hein k. Cancer Imaging. 2021 Jan 19;21(1):13. doi: 10.1186/s40644-021-00382-x. Cancer Imaging. 2021. PMID: 33468259 Free PMC article.
CHAOS Challenge - combined (CT-MR) healthy abdominal organ segmentation.
Kavur AE, Gezer NS, Barış M, Aslan S, Conze PH, Groza V, Pham DD, Chatterjee S, Ernst P, Özkan S, Baydar B, Lachinov D, Han S, Pauli J, Isensee F, Perkonigg M, Sathish R, Rajan R, Sheet D, Dovletov G, Speck O, Nürnberger A, Maier-Hein KH, Bozdağı Akar G, Ünal G, Dicle O, Selver MA. Kavur AE, et al. Among authors: maier hein kh. Med Image Anal. 2021 Apr;69:101950. doi: 10.1016/j.media.2020.101950. Epub 2020 Dec 25. Med Image Anal. 2021. PMID: 33421920
Segmentation of abdominal organs has been a comprehensive, yet unresolved, research field for many years. In the last decade, intensive developments in deep learning (DL) introduced new state-of-the-art segmentation systems. ...We conclude that the exploration of those pro …
Segmentation of abdominal organs has been a comprehensive, yet unresolved, research field for many years. In the last decade, intensi …
Pre-examinations Improve Automated Metastases Detection on Cranial MRI.
Deike-Hofmann K, Dancs D, Paech D, Schlemmer HP, Maier-Hein K, Bäumer P, Radbruch A, Götz M. Deike-Hofmann K, et al. Among authors: maier hein k. Invest Radiol. 2021 May 1;56(5):320-327. doi: 10.1097/RLI.0000000000000745. Invest Radiol. 2021. PMID: 33259442
Joint Imaging Platform for Federated Clinical Data Analytics.
Scherer J, Nolden M, Kleesiek J, Metzger J, Kades K, Schneider V, Bach M, Sedlaczek O, Bucher AM, Vogl TJ, Grünwald F, Kühn JP, Hoffmann RT, Kotzerke J, Bethge O, Schimmöller L, Antoch G, Müller HW, Daul A, Nikolaou K, la Fougère C, Kunz WG, Ingrisch M, Schachtner B, Ricke J, Bartenstein P, Nensa F, Radbruch A, Umutlu L, Forsting M, Seifert R, Herrmann K, Mayer P, Kauczor HU, Penzkofer T, Hamm B, Brenner W, Kloeckner R, Düber C, Schreckenberger M, Braren R, Kaissis G, Makowski M, Eiber M, Gafita A, Trager R, Weber WA, Neubauer J, Reisert M, Bock M, Bamberg F, Hennig J, Meyer PT, Ruf J, Haberkorn U, Schoenberg SO, Kuder T, Neher P, Floca R, Schlemmer HP, Maier-Hein K. Scherer J, et al. Among authors: maier hein k. JCO Clin Cancer Inform. 2020 Nov;4:1027-1038. doi: 10.1200/CCI.20.00045. JCO Clin Cancer Inform. 2020. PMID: 33166197 Free PMC article.
Although scientific advances in this area critically depend on the accessibility of large-volume and high-quality data, sharing data between institutions faces various ethical and legal constraints as well as organizational and technical obstacles. METHODS: The Joint Imaging Plat …
Although scientific advances in this area critically depend on the accessibility of large-volume and high-quality data, sharing data between …
The state of the art in kidney and kidney tumor segmentation in contrast-enhanced CT imaging: Results of the KiTS19 challenge.
Heller N, Isensee F, Maier-Hein KH, Hou X, Xie C, Li F, Nan Y, Mu G, Lin Z, Han M, Yao G, Gao Y, Zhang Y, Wang Y, Hou F, Yang J, Xiong G, Tian J, Zhong C, Ma J, Rickman J, Dean J, Stai B, Tejpaul R, Oestreich M, Blake P, Kaluzniak H, Raza S, Rosenberg J, Moore K, Walczak E, Rengel Z, Edgerton Z, Vasdev R, Peterson M, McSweeney S, Peterson S, Kalapara A, Sathianathen N, Papanikolopoulos N, Weight C. Heller N, et al. Among authors: maier hein kh. Med Image Anal. 2021 Jan;67:101821. doi: 10.1016/j.media.2020.101821. Epub 2020 Oct 2. Med Image Anal. 2021. PMID: 33049579 Free PMC article.
The future of digital health with federated learning.
Rieke N, Hancox J, Li W, Milletarì F, Roth HR, Albarqouni S, Bakas S, Galtier MN, Landman BA, Maier-Hein K, Ourselin S, Sheller M, Summers RM, Trask A, Xu D, Baust M, Cardoso MJ. Rieke N, et al. Among authors: maier hein k. NPJ Digit Med. 2020 Sep 14;3:119. doi: 10.1038/s41746-020-00323-1. eCollection 2020. NPJ Digit Med. 2020. PMID: 33015372 Free PMC article. Review.
However, without access to sufficient data, ML will be prevented from reaching its full potential and, ultimately, from making the transition from research to clinical practice. This paper considers key factors contributing to this issue, explores how federated learning (F …
However, without access to sufficient data, ML will be prevented from reaching its full potential and, ultimately, from making the transitio …
Radiographic Response of Vessel Involvement and Resectability After Neoadjuvant Chemoradiation in Patients With Locally Advanced Pancreatic Cancer.
Naumann P, Ottensmeier F, Farnia B, Ben-Josef E, Liermann J, Maier-Hein KH, Hackert T, Debus J. Naumann P, et al. Among authors: maier hein kh. Am J Clin Oncol. 2020 Nov;43(11):776-783. doi: 10.1097/COC.0000000000000746. Am J Clin Oncol. 2020. PMID: 32815856
OBJECTIVES: Survival of patients with locally advanced pancreatic cancer (LAPC) is improved when neoadjuvant chemoradiation enables subsequent surgical resection. ...
OBJECTIVES: Survival of patients with locally advanced pancreatic cancer (LAPC) is improved when neoadjuvant chemoradiation enables s …
Simulated clinical deployment of fully automatic deep learning for clinical prostate MRI assessment.
Schelb P, Wang X, Radtke JP, Wiesenfarth M, Kickingereder P, Stenzinger A, Hohenfellner M, Schlemmer HP, Maier-Hein KH, Bonekamp D. Schelb P, et al. Among authors: maier hein kh. Eur Radiol. 2021 Jan;31(1):302-313. doi: 10.1007/s00330-020-07086-z. Epub 2020 Aug 7. Eur Radiol. 2021. PMID: 32767102 Free PMC article.
OBJECTIVES: To simulate clinical deployment, evaluate performance, and establish quality assurance of a deep learning algorithm (U-Net) for detection, localization, and segmentation of clinically significant prostate cancer (sPC), ISUP grade group 2, using bi-parametric MR …
OBJECTIVES: To simulate clinical deployment, evaluate performance, and establish quality assurance of a deep learning algorithm (U-Net) for …
Noninvasive Characterization of Tumor Angiogenesis and Oxygenation in Bevacizumab-treated Recurrent Glioblastoma by Using Dynamic Susceptibility MRI: Secondary Analysis of the European Organization for Research and Treatment of Cancer 26101 Trial.
Kickingereder P, Brugnara G, Hansen MB, Nowosielski M, Pflüger I, Schell M, Isensee F, Foltyn M, Neuberger U, Kessler T, Sahm F, Wick A, Heiland S, Weller M, Platten M, von Deimling A, Maier-Hein KH, Østergaard L, van den Bent MJ, Gorlia T, Wick W, Bendszus M. Kickingereder P, et al. Among authors: maier hein kh. Radiology. 2020 Oct;297(1):164-175. doi: 10.1148/radiol.2020200978. Epub 2020 Jul 28. Radiology. 2020. PMID: 32720870 Clinical Trial.
Materials and Methods In this secondary analysis of the prospective randomized phase II/III European Organization for Research and Treatment of Cancer 26101 trial conducted between October 2011 and December 2015 in 596 patients with first recurrence of glioblastoma, …
Materials and Methods In this secondary analysis of the prospective randomized phase II/III European Organization for Research and Tr …
Toward automatic C-arm positioning for standard projections in orthopedic surgery.
Kausch L, Thomas S, Kunze H, Privalov M, Vetter S, Franke J, Mahnken AH, Maier-Hein L, Maier-Hein K. Kausch L, et al. Among authors: maier hein k. Int J Comput Assist Radiol Surg. 2020 Jul;15(7):1095-1105. doi: 10.1007/s11548-020-02204-0. Epub 2020 Jun 12. Int J Comput Assist Radiol Surg. 2020. PMID: 32533315 Free PMC article.
Validation of diffusion MRI phenotypes for predicting response to bevacizumab in recurrent glioblastoma: post-hoc analysis of the EORTC-26101 trial.
Schell M, Pflüger I, Brugnara G, Isensee F, Neuberger U, Foltyn M, Kessler T, Sahm F, Wick A, Nowosielski M, Heiland S, Weller M, Platten M, Maier-Hein KH, Von Deimling A, Van Den Bent MJ, Gorlia T, Wick W, Bendszus M, Kickingereder P. Schell M, et al. Among authors: maier hein kh. Neuro Oncol. 2020 Nov 26;22(11):1667-1676. doi: 10.1093/neuonc/noaa120. Neuro Oncol. 2020. PMID: 32393964 Free PMC article. Clinical Trial.
Quantitative Imaging Informatics for Cancer Research.
Fedorov A, Beichel R, Kalpathy-Cramer J, Clunie D, Onken M, Riesmeier J, Herz C, Bauer C, Beers A, Fillion-Robin JC, Lasso A, Pinter C, Pieper S, Nolden M, Maier-Hein K, Herrmann MD, Saltz J, Prior F, Fennessy F, Buatti J, Kikinis R. Fedorov A, et al. Among authors: maier hein k. JCO Clin Cancer Inform. 2020 May;4:444-453. doi: 10.1200/CCI.19.00165. JCO Clin Cancer Inform. 2020. PMID: 32392097 Free PMC article.
PURPOSE: We summarize Quantitative Imaging Informatics for Cancer Research (QIICR; U24 CA180918), one of the first projects funded by the National Cancer Institute (NCI) Informatics Technology for Cancer Research program. ...RESULTS: Fourteen ne …
PURPOSE: We summarize Quantitative Imaging Informatics for Cancer Research (QIICR; U24 CA180918), one of the first projects fu …
Multiparametric mapping of white matter microstructure in catatonia.
Wasserthal J, Maier-Hein KH, Neher PF, Northoff G, Kubera KM, Fritze S, Harneit A, Geiger LS, Tost H, Wolf RC, Hirjak D. Wasserthal J, et al. Among authors: maier hein kh. Neuropsychopharmacology. 2020 Sep;45(10):1750-1757. doi: 10.1038/s41386-020-0691-2. Epub 2020 May 5. Neuropsychopharmacology. 2020. PMID: 32369829 Free PMC article.
The Image Biomarker Standardization Initiative: Standardized Quantitative Radiomics for High-Throughput Image-based Phenotyping.
Zwanenburg A, Vallières M, Abdalah MA, Aerts HJWL, Andrearczyk V, Apte A, Ashrafinia S, Bakas S, Beukinga RJ, Boellaard R, Bogowicz M, Boldrini L, Buvat I, Cook GJR, Davatzikos C, Depeursinge A, Desseroit MC, Dinapoli N, Dinh CV, Echegaray S, El Naqa I, Fedorov AY, Gatta R, Gillies RJ, Goh V, Götz M, Guckenberger M, Ha SM, Hatt M, Isensee F, Lambin P, Leger S, Leijenaar RTH, Lenkowicz J, Lippert F, Losnegård A, Maier-Hein KH, Morin O, Müller H, Napel S, Nioche C, Orlhac F, Pati S, Pfaehler EAG, Rahmim A, Rao AUK, Scherer J, Siddique MM, Sijtsema NM, Socarras Fernandez J, Spezi E, Steenbakkers RJHM, Tanadini-Lang S, Thorwarth D, Troost EGC, Upadhaya T, Valentini V, van Dijk LV, van Griethuysen J, van Velden FHP, Whybra P, Richter C, Löck S. Zwanenburg A, et al. Among authors: maier hein kh. Radiology. 2020 May;295(2):328-338. doi: 10.1148/radiol.2020191145. Epub 2020 Mar 10. Radiology. 2020. PMID: 32154773 Free PMC article.
In phase I, 487 features were derived from the basic set of 174 features. Twenty-five research teams with unique radiomics software implementations computed feature values directly from a digital phantom, without any additional image processing. In phase II, 15 teams compu …
In phase I, 487 features were derived from the basic set of 174 features. Twenty-five research teams with unique radiomics software i …
Optimal Statistical Incorporation of Independent Feature Stability Information into Radiomics Studies.
Götz M, Maier-Hein KH. Götz M, et al. Among authors: maier hein kh. Sci Rep. 2020 Jan 20;10(1):737. doi: 10.1038/s41598-020-57739-8. Sci Rep. 2020. PMID: 31959832 Free PMC article.
Conducting side experiments termed robustness experiments, to identify features that are stable with respect to rescans, annotation, or other confounding effects is an important element in radiomics research. However, the matter of how to include the finding of these exper …
Conducting side experiments termed robustness experiments, to identify features that are stable with respect to rescans, annotation, or othe …
Automated volumetric assessment with artificial neural networks might enable a more accurate assessment of disease burden in patients with multiple sclerosis.
Brugnara G, Isensee F, Neuberger U, Bonekamp D, Petersen J, Diem R, Wildemann B, Heiland S, Wick W, Bendszus M, Maier-Hein K, Kickingereder P. Brugnara G, et al. Among authors: maier hein k. Eur Radiol. 2020 Apr;30(4):2356-2364. doi: 10.1007/s00330-019-06593-y. Epub 2020 Jan 3. Eur Radiol. 2020. PMID: 31900702
Performance of the ANN was consistent in a clinically derived dataset, with patients presenting all possible disease stages in MRI scans acquired from standard clinical routine rather than with high-quality research sequences. Computer-aided evaluation of MS with ANN could …
Performance of the ANN was consistent in a clinically derived dataset, with patients presenting all possible disease stages in MRI scans acq …
IJCARS: BVM 2019 special issue.
Maier A, Deserno TM, Handels H, Maier-Hein K, Palm C, Tolxdorff T. Maier A, et al. Among authors: maier hein k. Int J Comput Assist Radiol Surg. 2019 Nov;14(11):1823-1824. doi: 10.1007/s11548-019-02086-x. Int J Comput Assist Radiol Surg. 2019. PMID: 31691099 No abstract available.
Author Correction: The challenge of mapping the human connectome based on diffusion tractography.
Maier-Hein KH, Neher PF, Houde JC, Côté MA, Garyfallidis E, Zhong J, Chamberland M, Yeh FC, Lin YC, Ji Q, Reddick WE, Glass JO, Chen DQ, Feng Y, Gao C, Wu Y, Ma J, He R, Li Q, Westin CF, Deslauriers-Gauthier S, González JOO, Paquette M, St-Jean S, Girard G, Rheault F, Sidhu J, Tax CMW, Guo F, Mesri HY, Dávid S, Froeling M, Heemskerk AM, Leemans A, Boré A, Pinsard B, Bedetti C, Desrosiers M, Brambati S, Doyon J, Sarica A, Vasta R, Cerasa A, Quattrone A, Yeatman J, Khan AR, Hodges W, Alexander S, Romascano D, Barakovic M, Auría A, Esteban O, Lemkaddem A, Thiran JP, Cetingul HE, Odry BL, Mailhe B, Nadar MS, Pizzagalli F, Prasad G, Villalon-Reina JE, Galvis J, Thompson PM, De Santiago Requejo F, Laguna PL, Lacerda LM, Barrett R, Dell'Acqua F, Catani M, Petit L, Caruyer E, Daducci A, Dyrby TB, Holland-Letz T, Hilgetag CC, Stieltjes B, Descoteaux M. Maier-Hein KH, et al. Nat Commun. 2019 Nov 4;10(1):5059. doi: 10.1038/s41467-019-12867-2. Nat Commun. 2019. PMID: 31685826 Free PMC article.
Going Beyond Diffusion Tensor Imaging Tractography in Eloquent Glioma Surgery-High-Resolution Fiber Tractography: Q-Ball or Constrained Spherical Deconvolution?
Becker D, Scherer M, Neher P, Jungk C, Jesser J, Pflüger I, Brinster R, Bendszus M, Bruckner T, Maier-Hein K, Unterberg A. Becker D, et al. Among authors: maier hein k. World Neurosurg. 2020 Feb;134:e596-e609. doi: 10.1016/j.wneu.2019.10.138. Epub 2019 Oct 31. World Neurosurg. 2020. PMID: 31678440
Classification of Cancer at Prostate MRI: Deep Learning versus Clinical PI-RADS Assessment.
Schelb P, Kohl S, Radtke JP, Wiesenfarth M, Kickingereder P, Bickelhaupt S, Kuder TA, Stenzinger A, Hohenfellner M, Schlemmer HP, Maier-Hein KH, Bonekamp D. Schelb P, et al. Among authors: maier hein kh. Radiology. 2019 Dec;293(3):607-617. doi: 10.1148/radiol.2019190938. Epub 2019 Oct 8. Radiology. 2019. PMID: 31592731
Background Men suspected of having clinically significant prostate cancer (sPC) increasingly undergo prostate MRI. The potential of deep learning to provide diagnostic support for human interpretation requires further evaluation. ...
Background Men suspected of having clinically significant prostate cancer (sPC) increasingly undergo prostate MRI. The potential of d …
Combined tract segmentation and orientation mapping for bundle-specific tractography.
Wasserthal J, Neher PF, Hirjak D, Maier-Hein KH. Wasserthal J, et al. Among authors: maier hein kh. Med Image Anal. 2019 Dec;58:101559. doi: 10.1016/j.media.2019.101559. Epub 2019 Sep 12. Med Image Anal. 2019. PMID: 31542711 Free article.
The code of our method is openly available at https://github.com/MIC-DKFZ/TractSeg....
The code of our method is openly available at https://github.com/MIC-DKFZ/TractSeg....
Automated brain extraction of multisequence MRI using artificial neural networks.
Isensee F, Schell M, Pflueger I, Brugnara G, Bonekamp D, Neuberger U, Wick A, Schlemmer HP, Heiland S, Wick W, Bendszus M, Maier-Hein KH, Kickingereder P. Isensee F, et al. Among authors: maier hein kh. Hum Brain Mapp. 2019 Dec 1;40(17):4952-4964. doi: 10.1002/hbm.24750. Epub 2019 Aug 12. Hum Brain Mapp. 2019. PMID: 31403237 Free PMC article.
Importantly, the HD-BET algorithm, which shows robust performance in the presence of pathology or treatment-induced tissue alterations, is applicable to a broad range of MRI sequence types and is not influenced by variations in MRI hardware and acquisition parameters encountered …
Importantly, the HD-BET algorithm, which shows robust performance in the presence of pathology or treatment-induced tissue alterations, is a …
Computer-assisted intra-operative verification of surgical outcome for the treatment of syndesmotic injuries through contralateral side comparison.
Thomas S, Isensee F, Kohl S, Privalov M, Beisemann N, Swartman B, Keil H, Vetter SY, Franke J, Grützner PA, Maier-Hein L, Nolden M, Maier-Hein K. Thomas S, et al. Among authors: maier hein k. Int J Comput Assist Radiol Surg. 2019 Dec;14(12):2211-2220. doi: 10.1007/s11548-019-02043-8. Epub 2019 Aug 7. Int J Comput Assist Radiol Surg. 2019. PMID: 31392672
Weight Loss and Changes in Adipose Tissue and Skeletal Muscle Volume after Laparoscopic Sleeve Gastrectomy and Roux-en-Y Gastric Bypass: a Prospective Study with 12-Month Follow-Up.
Kenngott HG, Nickel F, Wise PA, Wagner F, Billeter AT, Nattenmüller J, Nabers D, Maier-Hein K, Kauczor HU, Fischer L, Müller-Stich BP. Kenngott HG, et al. Among authors: maier hein k. Obes Surg. 2019 Dec;29(12):4018-4028. doi: 10.1007/s11695-019-04087-w. Obes Surg. 2019. PMID: 31309523
BACKGROUND: This study aimed to evaluate changes in body tissue composition with obesity surgery regarding visceral fat, subcutaneous fat, and skeletal muscle. DESIGN: Prospective non-randomized single-center cohort study METHODS: Whole-body magnetic resonance imaging (MRI …
BACKGROUND: This study aimed to evaluate changes in body tissue composition with obesity surgery regarding visceral fat, subcutaneous fat, a …
Exploring cortical predictors of clinical response to electroconvulsive therapy in major depression.
Schmitgen MM, Kubera KM, Depping MS, Nolte HM, Hirjak D, Hofer S, Hasenkamp JH, Seidl U, Stieltjes B, Maier-Hein KH, Sambataro F, Sartorius A, Thomann PA, Wolf RC. Schmitgen MM, et al. Among authors: maier hein kh. Eur Arch Psychiatry Clin Neurosci. 2020 Mar;270(2):253-261. doi: 10.1007/s00406-019-01033-w. Epub 2019 Jul 5. Eur Arch Psychiatry Clin Neurosci. 2020. PMID: 31278421
Tractography reproducibility challenge with empirical data (TraCED): The 2017 ISMRM diffusion study group challenge.
Nath V, Schilling KG, Parvathaneni P, Huo Y, Blaber JA, Hainline AE, Barakovic M, Romascano D, Rafael-Patino J, Frigo M, Girard G, Thiran JP, Daducci A, Rowe M, Rodrigues P, Prčkovska V, Aydogan DB, Sun W, Shi Y, Parker WA, Ould Ismail AA, Verma R, Cabeen RP, Toga AW, Newton AT, Wasserthal J, Neher P, Maier-Hein K, Savini G, Palesi F, Kaden E, Wu Y, He J, Feng Y, Paquette M, Rheault F, Sidhu J, Lebel C, Leemans A, Descoteaux M, Dyrby TB, Kang H, Landman BA. Nath V, et al. Among authors: maier hein k. J Magn Reson Imaging. 2020 Jan;51(1):234-249. doi: 10.1002/jmri.26794. Epub 2019 Jun 9. J Magn Reson Imaging. 2020. PMID: 31179595 Free PMC article.
Automated quantitative tumour response assessment of MRI in neuro-oncology with artificial neural networks: a multicentre, retrospective study.
Kickingereder P, Isensee F, Tursunova I, Petersen J, Neuberger U, Bonekamp D, Brugnara G, Schell M, Kessler T, Foltyn M, Harting I, Sahm F, Prager M, Nowosielski M, Wick A, Nolden M, Radbruch A, Debus J, Schlemmer HP, Heiland S, Platten M, von Deimling A, van den Bent MJ, Gorlia T, Wick W, Bendszus M, Maier-Hein KH. Kickingereder P, et al. Among authors: maier hein kh. Lancet Oncol. 2019 May;20(5):728-740. doi: 10.1016/S1470-2045(19)30098-1. Epub 2019 Apr 2. Lancet Oncol. 2019. PMID: 30952559
Independent testing and large-scale application of the ANN for tumour segmentation was done in a single-institution longitudinal testing dataset from the Heidelberg University Hospital and in a multi-institutional longitudinal testing dataset from the prospective randomised phase …
Independent testing and large-scale application of the ANN for tumour segmentation was done in a single-institution longitudinal testing dat …
Author Correction: Why rankings of biomedical image analysis competitions should be interpreted with care.
Maier-Hein L, Eisenmann M, Reinke A, Onogur S, Stankovic M, Scholz P, Arbel T, Bogunovic H, Bradley AP, Carass A, Feldmann C, Frangi AF, Full PM, van Ginneken B, Hanbury A, Honauer K, Kozubek M, Landman BA, März K, Maier O, Maier-Hein K, Menze BH, Müller H, Neher PF, Niessen W, Rajpoot N, Sharp GC, Sirinukunwattana K, Speidel S, Stock C, Stoyanov D, Taha AA, van der Sommen F, Wang CW, Weber MA, Zheng G, Jannin P, Kopp-Schneider A. Maier-Hein L, et al. Among authors: maier hein k. Nat Commun. 2019 Jan 30;10(1):588. doi: 10.1038/s41467-019-08563-w. Nat Commun. 2019. PMID: 30700735 Free PMC article.
Guest editorial of the IJCARS-BVM 2018 special issue.
Maier A, Deserno TM, Handels H, Maier-Hein K, Palm C, Tolxdorff T. Maier A, et al. Among authors: maier hein k. Int J Comput Assist Radiol Surg. 2019 Jan;14(1):1-2. doi: 10.1007/s11548-018-01902-0. Int J Comput Assist Radiol Surg. 2019. PMID: 30617910 No abstract available.
Why rankings of biomedical image analysis competitions should be interpreted with care.
Maier-Hein L, Eisenmann M, Reinke A, Onogur S, Stankovic M, Scholz P, Arbel T, Bogunovic H, Bradley AP, Carass A, Feldmann C, Frangi AF, Full PM, van Ginneken B, Hanbury A, Honauer K, Kozubek M, Landman BA, März K, Maier O, Maier-Hein K, Menze BH, Müller H, Neher PF, Niessen W, Rajpoot N, Sharp GC, Sirinukunwattana K, Speidel S, Stock C, Stoyanov D, Taha AA, van der Sommen F, Wang CW, Weber MA, Zheng G, Jannin P, Kopp-Schneider A. Maier-Hein L, et al. Among authors: maier hein k. Nat Commun. 2018 Dec 6;9(1):5217. doi: 10.1038/s41467-018-07619-7. Nat Commun. 2018. PMID: 30523263 Free PMC article.
To overcome these problems, we recommend best practice guidelines and define open research questions to be addressed in the future....
To overcome these problems, we recommend best practice guidelines and define open research questions to be addressed in the future... …
Challenges in diffusion MRI tractography - Lessons learned from international benchmark competitions.
Schilling KG, Daducci A, Maier-Hein K, Poupon C, Houde JC, Nath V, Anderson AW, Landman BA, Descoteaux M. Schilling KG, et al. Among authors: maier hein k. Magn Reson Imaging. 2019 Apr;57:194-209. doi: 10.1016/j.mri.2018.11.014. Epub 2018 Nov 29. Magn Reson Imaging. 2019. PMID: 30503948 Free PMC article. Review.
Diffusion MRI (dMRI) fiber tractography has become a pillar of the neuroimaging community due to its ability to noninvasively map the structural connectivity of the brain. Despite widespread use in clinical and research domains, these methods suffer from several potential …
Diffusion MRI (dMRI) fiber tractography has become a pillar of the neuroimaging community due to its ability to noninvasively map the struct …
Modern Information Technology for Cancer Research: What's in IT for Me? An Overview of Technologies and Approaches.
Ahlbrandt J, Lablans M, Glocker K, Stahl-Toyota S, Maier-Hein K, Maier-Hein L, Ückert F. Ahlbrandt J, et al. Among authors: maier hein k. Oncology. 2020;98(6):363-369. doi: 10.1159/000493638. Epub 2018 Nov 15. Oncology. 2020. PMID: 30439700 Free article. Review.
Information technology (IT) can enhance or change many scenarios in cancer research for the better. In this paper, we introduce several examples, starting with clinical data reuse and collaboration including data sharing in research networks. ...
Information technology (IT) can enhance or change many scenarios in cancer research for the better. In this paper, we introduc …
Automatic bone segmentation in whole-body CT images.
Klein A, Warszawski J, Hillengaß J, Maier-Hein KH. Klein A, et al. Among authors: maier hein kh. Int J Comput Assist Radiol Surg. 2019 Jan;14(1):21-29. doi: 10.1007/s11548-018-1883-7. Epub 2018 Nov 13. Int J Comput Assist Radiol Surg. 2019. PMID: 30426400
Correlation between genomic index lesions and mpMRI and 68Ga-PSMA-PET/CT imaging features in primary prostate cancer.
Kesch C, Radtke JP, Wintsche A, Wiesenfarth M, Luttje M, Gasch C, Dieffenbacher S, Pecqueux C, Teber D, Hatiboglu G, Nyarangi-Dix J, Simpfendörfer T, Schönberg G, Dimitrakopoulou-Strauss A, Freitag M, Duensing A, Grüllich C, Jäger D, Götz M, Grabe N, Schweiger MR, Pahernik S, Perner S, Herpel E, Roth W, Wieczorek K, Maier-Hein K, Debus J, Haberkorn U, Giesel F, Galle J, Hadaschik B, Schlemmer HP, Hohenfellner M, Bonekamp D, Sültmann H, Duensing S. Kesch C, et al. Among authors: maier hein k. Sci Rep. 2018 Nov 12;8(1):16708. doi: 10.1038/s41598-018-35058-3. Sci Rep. 2018. PMID: 30420756 Free PMC article.
Magnetic resonance imaging (MRI) and prostate specific membrane antigen (PSMA)- positron emission tomography (PET)/computed tomography (CT)-imaging of prostate cancer (PCa) are emerging techniques to assess the presence of significant disease and tumor progression. ...
Magnetic resonance imaging (MRI) and prostate specific membrane antigen (PSMA)- positron emission tomography (PET)/computed tomography (CT)- …
TractSeg - Fast and accurate white matter tract segmentation.
Wasserthal J, Neher P, Maier-Hein KH. Wasserthal J, et al. Among authors: maier hein kh. Neuroimage. 2018 Dec;183:239-253. doi: 10.1016/j.neuroimage.2018.07.070. Epub 2018 Aug 4. Neuroimage. 2018. PMID: 30086412 Free article.
The code and data are openly available at https://github.com/MIC-DKFZ/TractSeg/ and https://doi.org/10.5281/zenodo.1088277, respectively....
The code and data are openly available at https://github.com/MIC-DKFZ/TractSeg/ and https://doi.org/10.5281/zenodo.1088277, respectiv …
Radiomic Machine Learning for Characterization of Prostate Lesions with MRI: Comparison to ADC Values.
Bonekamp D, Kohl S, Wiesenfarth M, Schelb P, Radtke JP, Götz M, Kickingereder P, Yaqubi K, Hitthaler B, Gählert N, Kuder TA, Deister F, Freitag M, Hohenfellner M, Hadaschik BA, Schlemmer HP, Maier-Hein KH. Bonekamp D, et al. Among authors: maier hein kh. Radiology. 2018 Oct;289(1):128-137. doi: 10.1148/radiol.2018173064. Epub 2018 Jul 31. Radiology. 2018. PMID: 30063191
Global and zone-specific random forest RML and mean ADC models for classification of clinically significant prostate cancer (Gleason grade group 2) were developed on the training set and the fixed models tested on an independent test set. ...
Global and zone-specific random forest RML and mean ADC models for classification of clinically significant prostate cancer (Gleason …
Deep Learning Techniques for Automatic MRI Cardiac Multi-Structures Segmentation and Diagnosis: Is the Problem Solved?
Bernard O, Lalande A, Zotti C, Cervenansky F, Yang X, Heng PA, Cetin I, Lekadir K, Camara O, Gonzalez Ballester MA, Sanroma G, Napel S, Petersen S, Tziritas G, Grinias E, Khened M, Kollerathu VA, Krishnamurthi G, Rohe MM, Pennec X, Sermesant M, Isensee F, Jager P, Maier-Hein KH, Full PM, Wolf I, Engelhardt S, Baumgartner CF, Koch LM, Wolterink JM, Isgum I, Jang Y, Hong Y, Patravali J, Jain S, Humbert O, Jodoin PM. Bernard O, et al. Among authors: maier hein kh. IEEE Trans Med Imaging. 2018 Nov;37(11):2514-2525. doi: 10.1109/TMI.2018.2837502. Epub 2018 May 17. IEEE Trans Med Imaging. 2018. PMID: 29994302
The automation of the corresponding tasks has thus been the subject of intense research over the past decades. In this paper, we introduce the "Automatic Cardiac Diagnosis Challenge" dataset (ACDC), the largest publicly available and fully annotated dataset for the purpose …
The automation of the corresponding tasks has thus been the subject of intense research over the past decades. In this paper, we intr …
Exploiting the potential of unlabeled endoscopic video data with self-supervised learning.
Ross T, Zimmerer D, Vemuri A, Isensee F, Wiesenfarth M, Bodenstedt S, Both F, Kessler P, Wagner M, Müller B, Kenngott H, Speidel S, Kopp-Schneider A, Maier-Hein K, Maier-Hein L. Ross T, et al. Among authors: maier hein k. Int J Comput Assist Radiol Surg. 2018 Jun;13(6):925-933. doi: 10.1007/s11548-018-1772-0. Epub 2018 Apr 27. Int J Comput Assist Radiol Surg. 2018. PMID: 29704196
PURPOSE: Surgical data science is a new research field that aims to observe all aspects of the patient treatment process in order to provide the right assistance at the right time. ...
PURPOSE: Surgical data science is a new research field that aims to observe all aspects of the patient treatment process in order to …
Radiomics Based on Adapted Diffusion Kurtosis Imaging Helps to Clarify Most Mammographic Findings Suspicious for Cancer.
Bickelhaupt S, Jaeger PF, Laun FB, Lederer W, Daniel H, Kuder TA, Wuesthof L, Paech D, Bonekamp D, Radbruch A, Delorme S, Schlemmer HP, Steudle FH, Maier-Hein KH. Bickelhaupt S, et al. Among authors: maier hein kh. Radiology. 2018 Jun;287(3):761-770. doi: 10.1148/radiol.2017170273. Epub 2018 Feb 20. Radiology. 2018. PMID: 29461172
Materials and Methods This institutional study included 222 women at two independent study sites (site 1: training set of 95 patients; mean age standard deviation, 58.6 years 6.6; 61 malignant and 34 benign lesions; site 2: independent test set of 127 patients; mean age, 58.2 yea …
Materials and Methods This institutional study included 222 women at two independent study sites (site 1: training set of 95 patients; mean …
The challenge of mapping the human connectome based on diffusion tractography.
Maier-Hein KH, Neher PF, Houde JC, Côté MA, Garyfallidis E, Zhong J, Chamberland M, Yeh FC, Lin YC, Ji Q, Reddick WE, Glass JO, Chen DQ, Feng Y, Gao C, Wu Y, Ma J, He R, Li Q, Westin CF, Deslauriers-Gauthier S, González JOO, Paquette M, St-Jean S, Girard G, Rheault F, Sidhu J, Tax CMW, Guo F, Mesri HY, Dávid S, Froeling M, Heemskerk AM, Leemans A, Boré A, Pinsard B, Bedetti C, Desrosiers M, Brambati S, Doyon J, Sarica A, Vasta R, Cerasa A, Quattrone A, Yeatman J, Khan AR, Hodges W, Alexander S, Romascano D, Barakovic M, Auría A, Esteban O, Lemkaddem A, Thiran JP, Cetingul HE, Odry BL, Mailhe B, Nadar MS, Pizzagalli F, Prasad G, Villalon-Reina JE, Galvis J, Thompson PM, Requejo FS, Laguna PL, Lacerda LM, Barrett R, Dell'Acqua F, Catani M, Petit L, Caruyer E, Daducci A, Dyrby TB, Holland-Letz T, Hilgetag CC, Stieltjes B, Descoteaux M. Maier-Hein KH, et al. Nat Commun. 2017 Nov 7;8(1):1349. doi: 10.1038/s41467-017-01285-x. Nat Commun. 2017. PMID: 29116093 Free PMC article.
Based on a simulated human brain data set with ground truth tracts, we organized an open international tractography challenge, which resulted in 96 distinct submissions from 20 research groups. Here, we report the encouraging finding that most state-of-the-art algorithms p …
Based on a simulated human brain data set with ground truth tracts, we organized an open international tractography challenge, which resulte …
Improved clinical workflow for simultaneous whole-body PET/MRI using high-resolution CAIPIRINHA-accelerated MR-based attenuation correction.
Freitag MT, Fenchel M, Bäumer P, Heußer T, Rank CM, Kachelrieß M, Paech D, Kopka K, Bickelhaupt S, Dimitrakopoulou-Strauss A, Maier-Hein K, Floca R, Ladd ME, Schlemmer HP, Maier F. Freitag MT, et al. Among authors: maier hein k. Eur J Radiol. 2017 Nov;96:12-20. doi: 10.1016/j.ejrad.2017.09.007. Epub 2017 Sep 13. Eur J Radiol. 2017. PMID: 29103469
Radiomic subtyping improves disease stratification beyond key molecular, clinical, and standard imaging characteristics in patients with glioblastoma.
Kickingereder P, Neuberger U, Bonekamp D, Piechotta PL, Götz M, Wick A, Sill M, Kratz A, Shinohara RT, Jones DTW, Radbruch A, Muschelli J, Unterberg A, Debus J, Schlemmer HP, Herold-Mende C, Pfister S, von Deimling A, Wick W, Capper D, Maier-Hein KH, Bendszus M. Kickingereder P, et al. Among authors: maier hein kh. Neuro Oncol. 2018 May 18;20(6):848-857. doi: 10.1093/neuonc/nox188. Neuro Oncol. 2018. PMID: 29036412 Free PMC article.
The relevance of hippocampal subfield integrity and clock drawing test performance for the diagnosis of Alzheimer's disease and mild cognitive impairment.
Hirjak D, Sambataro F, Remmele B, Kubera KM, Schröder J, Seidl U, Thomann AK, Maier-Hein KH, Wolf RC, Thomann PA. Hirjak D, et al. Among authors: maier hein kh. World J Biol Psychiatry. 2019 Mar;20(3):197-208. doi: 10.1080/15622975.2017.1355474. Epub 2017 Aug 31. World J Biol Psychiatry. 2019. PMID: 28721741
Fiber tractography using machine learning.
Neher PF, Côté MA, Houde JC, Descoteaux M, Maier-Hein KH. Neher PF, et al. Among authors: maier hein kh. Neuroimage. 2017 Sep;158:417-429. doi: 10.1016/j.neuroimage.2017.07.028. Epub 2017 Jul 15. Neuroimage. 2017. PMID: 28716716
Temperature and concentration calibration of aqueous polyvinylpyrrolidone (PVP) solutions for isotropic diffusion MRI phantoms.
Wagner F, Laun FB, Kuder TA, Mlynarska A, Maier F, Faust J, Demberg K, Lindemann L, Rivkin B, Nagel AM, Ladd ME, Maier-Hein K, Bickelhaupt S, Bach M. Wagner F, et al. Among authors: maier hein k. PLoS One. 2017 Jun 19;12(6):e0179276. doi: 10.1371/journal.pone.0179276. eCollection 2017. PLoS One. 2017. PMID: 28628638 Free PMC article.
Prediction of malignancy by a radiomic signature from contrast agent-free diffusion MRI in suspicious breast lesions found on screening mammography.
Bickelhaupt S, Paech D, Kickingereder P, Steudle F, Lederer W, Daniel H, Götz M, Gählert N, Tichy D, Wiesenfarth M, Laun FB, Maier-Hein KH, Schlemmer HP, Bonekamp D. Bickelhaupt S, et al. Among authors: maier hein kh. J Magn Reson Imaging. 2017 Aug;46(2):604-616. doi: 10.1002/jmri.25606. Epub 2017 Feb 2. J Magn Reson Imaging. 2017. PMID: 28152264
PURPOSE: To assess radiomics as a tool to determine how well lesions found suspicious on breast cancer screening X-ray mammography can be categorized into malignant and benign with unenhanced magnetic resonance (MR) mammography with diffusion-weighted imaging and T(2) -wei …
PURPOSE: To assess radiomics as a tool to determine how well lesions found suspicious on breast cancer screening X-ray mammography ca …
Large-scale Radiomic Profiling of Recurrent Glioblastoma Identifies an Imaging Predictor for Stratifying Anti-Angiogenic Treatment Response.
Kickingereder P, Götz M, Muschelli J, Wick A, Neuberger U, Shinohara RT, Sill M, Nowosielski M, Schlemmer HP, Radbruch A, Wick W, Bendszus M, Maier-Hein KH, Bonekamp D. Kickingereder P, et al. Among authors: maier hein kh. Clin Cancer Res. 2016 Dec 1;22(23):5765-5771. doi: 10.1158/1078-0432.CCR-16-0702. Epub 2016 Oct 10. Clin Cancer Res. 2016. PMID: 27803067 Free PMC article.
Here we analyze the potential of radiomics, an emerging field of research that aims to utilize the full potential of medical imaging. ...CONCLUSIONS: Our radiomic-based superpc signature emerges as a putative imaging biomarker for the identification of patients who may der …
Here we analyze the potential of radiomics, an emerging field of research that aims to utilize the full potential of medical imaging. …
Early Detection of Malignant Transformation in Resected WHO II Low-Grade Glioma Using Diffusion Tensor-Derived Quantitative Measures.
Freitag MT, Maier-Hein KH, Binczyk F, Laun FB, Weber C, Bonekamp D, Tarnawski R, Bobek-Billewicz B, Polanska J, Majchrzak H, Stieltjes B. Freitag MT, et al. Among authors: maier hein kh. PLoS One. 2016 Oct 14;11(10):e0164679. doi: 10.1371/journal.pone.0164679. eCollection 2016. PLoS One. 2016. PMID: 27741525 Free PMC article.
Applicability and discriminative value of a semiautomatic three-dimensional spherical volume for the assessment of the apparent diffusion coefficient in suspicious breast lesions-feasibility study.
Hering J, Laun FB, Lederer W, Daniel H, Kuder TA, Stieber A, Delorme S, Maier-Hein KH, Schlemmer HP, Bickelhaupt S. Hering J, et al. Among authors: maier hein kh. Clin Imaging. 2016 Nov-Dec;40(6):1280-1285. doi: 10.1016/j.clinimag.2016.08.022. Epub 2016 Sep 4. Clin Imaging. 2016. PMID: 27684995
ISLES 2015 - A public evaluation benchmark for ischemic stroke lesion segmentation from multispectral MRI.
Maier O, Menze BH, von der Gablentz J, Ḧani L, Heinrich MP, Liebrand M, Winzeck S, Basit A, Bentley P, Chen L, Christiaens D, Dutil F, Egger K, Feng C, Glocker B, Götz M, Haeck T, Halme HL, Havaei M, Iftekharuddin KM, Jodoin PM, Kamnitsas K, Kellner E, Korvenoja A, Larochelle H, Ledig C, Lee JH, Maes F, Mahmood Q, Maier-Hein KH, McKinley R, Muschelli J, Pal C, Pei L, Rangarajan JR, Reza SMS, Robben D, Rueckert D, Salli E, Suetens P, Wang CW, Wilms M, Kirschke JS, Kr Amer UM, Münte TF, Schramm P, Wiest R, Handels H, Reyes M. Maier O, et al. Among authors: maier hein kh. Med Image Anal. 2017 Jan;35:250-269. doi: 10.1016/j.media.2016.07.009. Epub 2016 Jul 21. Med Image Anal. 2017. PMID: 27475911 Free PMC article.
In this paper we propose a common evaluation framework, describe the publicly available datasets, and present the results of the two sub-challenges: Sub-Acute Stroke Lesion Segmentation (SISS) and Stroke Perfusion Estimation (SPES). A total of 16 research groups participat …
In this paper we propose a common evaluation framework, describe the publicly available datasets, and present the results of the two sub-cha …
Radiomic Profiling of Glioblastoma: Identifying an Imaging Predictor of Patient Survival with Improved Performance over Established Clinical and Radiologic Risk Models.
Kickingereder P, Burth S, Wick A, Götz M, Eidel O, Schlemmer HP, Maier-Hein KH, Wick W, Bendszus M, Radbruch A, Bonekamp D. Kickingereder P, et al. Among authors: maier hein kh. Radiology. 2016 Sep;280(3):880-9. doi: 10.1148/radiol.2016160845. Epub 2016 Jun 20. Radiology. 2016. PMID: 27326665
Independent value of image fusion in unenhanced breast MRI using diffusion-weighted and morphological T2-weighted images for lesion characterization in patients with recently detected BI-RADS 4/5 x-ray mammography findings.
Bickelhaupt S, Tesdorff J, Laun FB, Kuder TA, Lederer W, Teiner S, Maier-Hein K, Daniel H, Stieber A, Delorme S, Schlemmer HP. Bickelhaupt S, et al. Among authors: maier hein k. Eur Radiol. 2017 Feb;27(2):562-569. doi: 10.1007/s00330-016-4400-9. Epub 2016 May 18. Eur Radiol. 2017. PMID: 27193776
Virtual Raters for Reproducible and Objective Assessments in Radiology.
Kleesiek J, Petersen J, Döring M, Maier-Hein K, Köthe U, Wick W, Hamprecht FA, Bendszus M, Biller A. Kleesiek J, et al. Among authors: maier hein k. Sci Rep. 2016 Apr 27;6:25007. doi: 10.1038/srep25007. Sci Rep. 2016. PMID: 27118379 Free PMC article.
IVIM DW-MRI of autoimmune pancreatitis: therapy monitoring and differentiation from pancreatic cancer.
Klauß M, Maier-Hein K, Tjaden C, Hackert T, Grenacher L, Stieltjes B. Klauß M, et al. Among authors: maier hein k. Eur Radiol. 2016 Jul;26(7):2099-106. doi: 10.1007/s00330-015-4041-4. Epub 2015 Oct 8. Eur Radiol. 2016. PMID: 26449558
CONCLUSIONS: The found differences in f between AIP, AIP during steroid treatment and pancreatic cancer suggest that IVIM-diffusion MRI could serve as imaging biomarker during treatment in AIP-patients and as a helpful tool for differentiation between PC and AIP. KEY POINT …
CONCLUSIONS: The found differences in f between AIP, AIP during steroid treatment and pancreatic cancer suggest that IVIM-diffusion M …
The DTI Challenge: Toward Standardized Evaluation of Diffusion Tensor Imaging Tractography for Neurosurgery.
Pujol S, Wells W, Pierpaoli C, Brun C, Gee J, Cheng G, Vemuri B, Commowick O, Prima S, Stamm A, Goubran M, Khan A, Peters T, Neher P, Maier-Hein KH, Shi Y, Tristan-Vega A, Veni G, Whitaker R, Styner M, Westin CF, Gouttard S, Norton I, Chauvin L, Mamata H, Gerig G, Nabavi A, Golby A, Kikinis R. Pujol S, et al. Among authors: maier hein kh. J Neuroimaging. 2015 Nov-Dec;25(6):875-82. doi: 10.1111/jon.12283. Epub 2015 Aug 11. J Neuroimaging. 2015. PMID: 26259925 Free PMC article.
DALSA: Domain Adaptation for Supervised Learning From Sparsely Annotated MR Images.
Goetz M, Weber C, Binczyk F, Polanska J, Tarnawski R, Bobek-Billewicz B, Koethe U, Kleesiek J, Stieltjes B, Maier-Hein KH. Goetz M, et al. Among authors: maier hein kh. IEEE Trans Med Imaging. 2016 Jan;35(1):184-96. doi: 10.1109/TMI.2015.2463078. Epub 2015 Jul 30. IEEE Trans Med Imaging. 2016. PMID: 26259241
Correlation of Histological Vessel Characteristics and Diffusion-Weighted Imaging Intravoxel Incoherent Motion-Derived Parameters in Pancreatic Ductal Adenocarcinomas and Pancreatic Neuroendocrine Tumors.
Klau M, Mayer P, Bergmann F, Maier-Hein K, Hase J, Hackert T, Kauczor HU, Grenacher L, Stieltjes B. Klau M, et al. Among authors: maier hein k. Invest Radiol. 2015 Nov;50(11):792-7. doi: 10.1097/RLI.0000000000000187. Invest Radiol. 2015. PMID: 26186280
Neurological soft signs in recent-onset schizophrenia: Focus on the cerebellum.
Hirjak D, Wolf RC, Kubera KM, Stieltjes B, Maier-Hein KH, Thomann PA. Hirjak D, et al. Among authors: maier hein kh. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Jul 3;60:18-25. doi: 10.1016/j.pnpbp.2015.01.011. Epub 2015 Jan 29. Prog Neuropsychopharmacol Biol Psychiatry. 2015. PMID: 25640318
Widespread white matter degeneration preceding the onset of dementia.
Maier-Hein KH, Westin CF, Shenton ME, Weiner MW, Raj A, Thomann P, Kikinis R, Stieltjes B, Pasternak O. Maier-Hein KH, et al. Alzheimers Dement. 2015 May;11(5):485-493.e2. doi: 10.1016/j.jalz.2014.04.518. Epub 2014 Jul 14. Alzheimers Dement. 2015. PMID: 25035154 Free PMC article.
Methodological considerations on tract-based spatial statistics (TBSS).
Bach M, Laun FB, Leemans A, Tax CM, Biessels GJ, Stieltjes B, Maier-Hein KH. Bach M, et al. Among authors: maier hein kh. Neuroimage. 2014 Oct 15;100:358-69. doi: 10.1016/j.neuroimage.2014.06.021. Epub 2014 Jun 16. Neuroimage. 2014. PMID: 24945661
Disorder-specific white matter alterations in adolescent borderline personality disorder.
Maier-Hein KH, Brunner R, Lutz K, Henze R, Parzer P, Feigl N, Kramer J, Meinzer HP, Resch F, Stieltjes B. Maier-Hein KH, et al. Biol Psychiatry. 2014 Jan 1;75(1):81-8. doi: 10.1016/j.biopsych.2013.03.031. Epub 2013 Jun 12. Biol Psychiatry. 2014. PMID: 23768862
Our findings unify previously documented deficits in emotion recognition and regulation and suggest that a large-scale network of emotion processing is disrupted in BPD. Continued research is essential to evaluate the predictive value of these early disruptions in a clinic …
Our findings unify previously documented deficits in emotion recognition and regulation and suggest that a large-scale network of emotion pr …
The Medical Imaging Interaction Toolkit: challenges and advances : 10 years of open-source development.
Nolden M, Zelzer S, Seitel A, Wald D, Müller M, Franz AM, Maleike D, Fangerau M, Baumhauer M, Maier-Hein L, Maier-Hein KH, Meinzer HP, Wolf I. Nolden M, et al. Among authors: maier hein kh. Int J Comput Assist Radiol Surg. 2013 Jul;8(4):607-20. doi: 10.1007/s11548-013-0840-8. Epub 2013 Apr 16. Int J Comput Assist Radiol Surg. 2013. PMID: 23588509
CONCLUSIONS: MITK provides a versatile platform with a high degree of modularization and interoperability and is well suited to meet the challenging tasks of today's and tomorrow's clinically motivated research....
CONCLUSIONS: MITK provides a versatile platform with a high degree of modularization and interoperability and is well suited to meet the cha …
Reduced lateralization in early onset schizophrenia.
Freitag MT, van Bruggen T, Fritzsche KH, Henze R, Brunner R, Parzer P, Resch F, Stieltjes B. Freitag MT, et al. Among authors: fritzsche kh. Neurosci Lett. 2013 Mar 14;537:23-8. doi: 10.1016/j.neulet.2013.01.024. Epub 2013 Jan 28. Neurosci Lett. 2013. PMID: 23370283
MITK diffusion imaging.
Fritzsche KH, Neher PF, Reicht I, van Bruggen T, Goch C, Reisert M, Nolden M, Zelzer S, Meinzer HP, Stieltjes B. Fritzsche KH, et al. Methods Inf Med. 2012;51(5):441-8. doi: 10.3414/ME11-02-0031. Epub 2012 Sep 28. Methods Inf Med. 2012. PMID: 23038239
OBJECTIVES: This work illustrates our strategy that encompasses the development of a modularized and open software tool for data processing, visualization and interactive exploration in diffusion imaging research and aims at reinforcing sustainable evaluation and progress …
OBJECTIVES: This work illustrates our strategy that encompasses the development of a modularized and open software tool for data processing, …
Computer-assisted trajectory planning for percutaneous needle insertions.
Seitel A, Engel M, Sommer CM, Radeleff BA, Essert-Villard C, Baegert C, Fangerau M, Fritzsche KH, Yung K, Meinzer HP, Maier-Hein L. Seitel A, et al. Among authors: fritzsche kh. Med Phys. 2011 Jun;38(6):3246-59. doi: 10.1118/1.3590374. Med Phys. 2011. PMID: 21815399
[Introduction to the basic principles and techniques of diffusion-weighted imaging].
Laun FB, Fritzsche KH, Kuder TA, Stieltjes B. Laun FB, et al. Among authors: fritzsche kh. Radiologe. 2011 Mar;51(3):170-9. doi: 10.1007/s00117-010-2057-y. Radiologe. 2011. PMID: 21424762 Review. German.
Finally, an overview of current developments in diffusion imaging and its application in research is presented....
Finally, an overview of current developments in diffusion imaging and its application in research is presented....