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2018 1
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Page 1
Three-Photon Infrared Stimulation of Endogenous Neuroreceptors in Vivo.
Sortino R, Cunquero M, Castro-Olvera G, Gelabert R, Moreno M, Riefolo F, Matera C, Fernàndez-Castillo N, Agnetta L, Decker M, Lluch JM, Hernando J, Loza-Alvarez P, Gorostiza P. Sortino R, et al. Among authors: matera c. Angew Chem Int Ed Engl. 2023 Dec 18;62(51):e202311181. doi: 10.1002/anie.202311181. Epub 2023 Nov 20. Angew Chem Int Ed Engl. 2023. PMID: 37823736 Free article.
We report the regulation of neuronal activity in zebrafish larvae by three-photon excitation of a photoswitchable muscarinic agonist at 50 pM, a billion-fold lower concentration than used for uncaging, and with mid-infrared light of 1560 nm, the longest reported photoswitc …
We report the regulation of neuronal activity in zebrafish larvae by three-photon excitation of a photoswitchable muscarinic agonist …
Reversible Photocontrol of Dopaminergic Transmission in Wild-Type Animals.
Matera C, Calvé P, Casadó-Anguera V, Sortino R, Gomila AMJ, Moreno E, Gener T, Delgado-Sallent C, Nebot P, Costazza D, Conde-Berriozabal S, Masana M, Hernando J, Casadó V, Puig MV, Gorostiza P. Matera C, et al. Int J Mol Sci. 2022 Sep 4;23(17):10114. doi: 10.3390/ijms231710114. Int J Mol Sci. 2022. PMID: 36077512 Free PMC article.
However, the available tools to dissect the endogenous dopaminergic circuits have limited specificity, reversibility, resolution, or require genetic manipulation. Here, we introduce azodopa, a novel photoswitchable ligand that enables reversible spatiotemporal control of d …
However, the available tools to dissect the endogenous dopaminergic circuits have limited specificity, reversibility, resolution, or require …
Fast Photoswitchable Molecular Prosthetics Control Neuronal Activity in the Cochlea.
Garrido-Charles A, Huet A, Matera C, Thirumalai A, Hernando J, Llebaria A, Moser T, Gorostiza P. Garrido-Charles A, et al. Among authors: matera c. J Am Chem Soc. 2022 Jun 1;144(21):9229-9239. doi: 10.1021/jacs.1c12314. Epub 2022 May 18. J Am Chem Soc. 2022. PMID: 35584208 Free PMC article.
Direct, rapid, and sustained photocontrol of intact neurons could overcome the limitations of established electrical stimulation such as poor selectivity. We have developed fast photoswitchable ligands of glutamate receptors (GluRs) to enable neuronal control in the audito …
Direct, rapid, and sustained photocontrol of intact neurons could overcome the limitations of established electrical stimulation such as poo …
Rational Design of Photochromic Analogues of Tricyclic Drugs.
Riefolo F, Sortino R, Matera C, Claro E, Preda B, Vitiello S, Traserra S, Jiménez M, Gorostiza P. Riefolo F, et al. Among authors: matera c. J Med Chem. 2021 Jul 8;64(13):9259-9270. doi: 10.1021/acs.jmedchem.1c00504. Epub 2021 Jun 23. J Med Chem. 2021. PMID: 34160229 Free article.
Despite the applied chemical modifications to make pirenzepine derivatives sensitive to light stimuli, the most potent candidate of the set, cryptozepine-2, maintained a moderate but promising M(1) vs M(2) subtype selectivity. These photoswitchable "crypto-azologs" of tric …
Despite the applied chemical modifications to make pirenzepine derivatives sensitive to light stimuli, the most potent candidate of the set, …
Control of Brain State Transitions with a Photoswitchable Muscarinic Agonist.
Barbero-Castillo A, Riefolo F, Matera C, Caldas-Martínez S, Mateos-Aparicio P, Weinert JF, Garrido-Charles A, Claro E, Sanchez-Vives MV, Gorostiza P. Barbero-Castillo A, et al. Among authors: matera c. Adv Sci (Weinh). 2021 Jul;8(14):e2005027. doi: 10.1002/advs.202005027. Epub 2021 May 21. Adv Sci (Weinh). 2021. PMID: 34018704 Free PMC article.
As a drug-based light-mediated control, the effect of a photoswitchable muscarinic agonist (Phthalimide-Azo-Iper (PAI)) on a brain network is evaluated in this study. ...
As a drug-based light-mediated control, the effect of a photoswitchable muscarinic agonist (Phthalimide-Azo-Iper (PAI)) on a brain ne …
Optical Control of Cardiac Function with a Photoswitchable Muscarinic Agonist.
Riefolo F, Matera C, Garrido-Charles A, Gomila AMJ, Sortino R, Agnetta L, Claro E, Masgrau R, Holzgrabe U, Batlle M, Decker M, Guasch E, Gorostiza P. Riefolo F, et al. Among authors: matera c. J Am Chem Soc. 2019 May 8;141(18):7628-7636. doi: 10.1021/jacs.9b03505. Epub 2019 Apr 26. J Am Chem Soc. 2019. PMID: 31010281 Free article.
Herein, we present a method to modulate cardiac function with light through a photoswitchable compound and without genetic manipulation. The molecule, named PAI, was designed by introduction of a photoswitch into the molecular structure of an M2 mAChR agonist. ...
Herein, we present a method to modulate cardiac function with light through a photoswitchable compound and without genetic manipulati …
Fluorination of Photoswitchable Muscarinic Agonists Tunes Receptor Pharmacology and Photochromic Properties.
Agnetta L, Bermudez M, Riefolo F, Matera C, Claro E, Messerer R, Littmann T, Wolber G, Holzgrabe U, Decker M. Agnetta L, et al. Among authors: matera c. J Med Chem. 2019 Mar 28;62(6):3009-3020. doi: 10.1021/acs.jmedchem.8b01822. Epub 2019 Mar 19. J Med Chem. 2019. PMID: 30827105
Using the unsubstituted azobenzene core and its tetra- ortho-fluorinated analogue, we have developed a set of uni- and bivalent photoswitchable toolbox derivatives of the highly potent muscarinic acetylcholine receptor agonist iperoxo. ...
Using the unsubstituted azobenzene core and its tetra- ortho-fluorinated analogue, we have developed a set of uni- and bivalent photoswit …
Photoswitchable Antimetabolite for Targeted Photoactivated Chemotherapy.
Matera C, Gomila AMJ, Camarero N, Libergoli M, Soler C, Gorostiza P. Matera C, et al. J Am Chem Soc. 2018 Nov 21;140(46):15764-15773. doi: 10.1021/jacs.8b08249. Epub 2018 Oct 22. J Am Chem Soc. 2018. PMID: 30346152 Free article.
Precise spatiotemporal control over their cytotoxic activity would allow improving chemotherapy treatments, and light-regulated drugs are well suited to this purpose. We have developed phototrexate, the first photoswitchable inhibitor of the human dihydrofolate reductase ( …
Precise spatiotemporal control over their cytotoxic activity would allow improving chemotherapy treatments, and light-regulated drugs are we …