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110 results

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Page 1
Hsp70 interactions with membrane lipids regulate cellular functions in health and disease.
Balogi Z, Multhoff G, Jensen TK, Lloyd-Evans E, Yamashima T, Jäättelä M, Harwood JL, Vígh L. Balogi Z, et al. Among authors: multhoff g. Prog Lipid Res. 2019 Apr;74:18-30. doi: 10.1016/j.plipres.2019.01.004. Epub 2019 Jan 30. Prog Lipid Res. 2019. PMID: 30710597 Free article. Review.
Beyond guarding the cellular proteome the major stress inducible heat shock protein Hsp70 has been shown to interact with lipids. Non-cytosolic Hsp70 stabilizes membranes during stress challenges and, in pathophysiological states, facilitates en …
Beyond guarding the cellular proteome the major stress inducible heat shock protein Hsp70 has been shown to interact wi …
Immunohistochemical, Flow Cytometric, and ELISA-Based Analyses of Intracellular, Membrane-Expressed, and Extracellular Hsp70 as Cancer Biomarkers.
Dezfouli AB, Stangl S, Foulds GA, Lennartz P, Pilkington GJ, Pockley AG, Multhoff G. Dezfouli AB, et al. Among authors: multhoff g. Methods Mol Biol. 2023;2693:307-324. doi: 10.1007/978-1-0716-3342-7_23. Methods Mol Biol. 2023. PMID: 37540444
The major stress-inducible 70 kDa heat shock (stress) protein 70 (Hsp70) is frequently overexpressed in highly aggressive tumor cells and thus might serve as a tumor-specific biomarker of aggressive disease and/or therapeutic resistance. We have previously sh …
The major stress-inducible 70 kDa heat shock (stress) protein 70 (Hsp70) is frequently overexpressed in highly aggressi …
Improved ex vivo fluorescence imaging of human head and neck cancer using the peptide tracer TPP-IRDye800 targeting membrane-bound Hsp70 on tumor cells.
Holzmann KLK, Wolf JL, Stangl S, Lennartz P, Kasajima A, Mogler C, Haller B, Ebert EV, Jira D, Lauterbach MLA, von Meyer F, Stark L, Mauch L, Schmidl B, Wollenberg B, Multhoff G, Wirth M. Holzmann KLK, et al. Among authors: multhoff g. Br J Cancer. 2024 Dec;131(11):1814-1824. doi: 10.1038/s41416-024-02872-8. Epub 2024 Oct 15. Br J Cancer. 2024. PMID: 39406917 Free PMC article.
BACKGROUND: The primary goal of surgery in HNSCC is the complete resection of tumor cells with maximum preservation of normal tissue. The membrane Hsp70-targeting fluorescence labelled peptide TPP-IRDye800 represents a promising tool for real-time intraoperative tum …
BACKGROUND: The primary goal of surgery in HNSCC is the complete resection of tumor cells with maximum preservation of normal tissue. The …
Extracellular Hsp70 and Circulating Endometriotic Cells as Novel Biomarkers for Endometriosis.
Guder C, Heinrich S, Seifert-Klauss V, Kiechle M, Bauer L, Öllinger R, Pichlmair A, Theodoraki MN, Ramesh V, Bashiri Dezfouli A, Wollenberg B, Pockley AG, Multhoff G. Guder C, et al. Among authors: multhoff g. Int J Mol Sci. 2024 Oct 30;25(21):11643. doi: 10.3390/ijms252111643. Int J Mol Sci. 2024. PMID: 39519195 Free PMC article.
Stress-inducible heat shock protein 70 (Hsp70), which functions as a molecular chaperone and is frequently overexpressed in different cancer cell types, is present on the cell surface of tumor cells and is actively released into the circulation in free and ex …
Stress-inducible heat shock protein 70 (Hsp70), which functions as a molecular chaperone and is frequently overexpresse …
Time- and Dose-Dependent Effects of Ionizing Irradiation on the Membrane Expression of Hsp70 on Glioma Cells.
Fellinger H, Stangl S, Hernandez Schnelzer A, Schwab M, Di Genio T, Pieper M, Werner C, Shevtsov M, Haller B, Multhoff G. Fellinger H, et al. Among authors: multhoff g. Cells. 2020 Apr 8;9(4):912. doi: 10.3390/cells9040912. Cells. 2020. PMID: 32276468 Free PMC article.
Depending on its intracellular or membrane localization, Hsp70 either promotes tumor growth or serves as a target for natural killer (NK) cells. The kinetics of the membrane Hsp70 (mHsp70) density on human glioma cells (U87) was studied after different …
Depending on its intracellular or membrane localization, Hsp70 either promotes tumor growth or serves as a target for natural …
Overexpression of cytosolic, plasma membrane bound and extracellular heat shock protein 70 (Hsp70) in primary glioblastomas.
Thorsteinsdottir J, Stangl S, Fu P, Guo K, Albrecht V, Eigenbrod S, Erl J, Gehrmann M, Tonn JC, Multhoff G, Schichor C. Thorsteinsdottir J, et al. Among authors: multhoff g. J Neurooncol. 2017 Dec;135(3):443-452. doi: 10.1007/s11060-017-2600-z. Epub 2017 Aug 28. J Neurooncol. 2017. PMID: 28849427
A unique feature in several non-CNS-tumors is the overexpression of heat shock protein 70 (Hsp70, HSPA1A) in the cytosol, but also its unusual plasma membrane expression and release. Although in gliomas, cytosolic Hsp70 levels are not associated …
A unique feature in several non-CNS-tumors is the overexpression of heat shock protein 70 (Hsp70, HSPA1A) in the cytoso …
CAR T Cells Targeting Membrane-Bound Hsp70 on Tumor Cells Mimic Hsp70-Primed NK Cells.
Bashiri Dezfouli A, Yazdi M, Benmebarek MR, Schwab M, Michaelides S, Miccichè A, Geerts D, Stangl S, Klapproth S, Wagner E, Kobold S, Multhoff G. Bashiri Dezfouli A, et al. Among authors: multhoff g. Front Immunol. 2022 Jun 1;13:883694. doi: 10.3389/fimmu.2022.883694. eCollection 2022. Front Immunol. 2022. PMID: 35720311 Free PMC article.
Previously, we have shown that the stress-inducible heat shock protein 70 (Hsp70) is frequently and specifically expressed on the cell surface of many different, highly aggressive tumors but not normal tissues. We could take advantage of tumors expressing …
Previously, we have shown that the stress-inducible heat shock protein 70 (Hsp70) is frequently and specifically expres …
Radiosensitizing capacity of fenofibrate in glioblastoma cells depends on lipid metabolism.
Alkotub B, Bauer L, Bashiri Dezfouli A, Hachani K, Ntziachristos V, Multhoff G, Kafshgari MH. Alkotub B, et al. Among authors: multhoff g. Redox Biol. 2025 Feb;79:103452. doi: 10.1016/j.redox.2024.103452. Epub 2024 Dec 2. Redox Biol. 2025. PMID: 39667305 Free PMC article.
Interestingly, FF (50 muM) significantly radiosensitizes U87 cells by inducing DNA double-strand breaks through oxidative stress and impairing mitochondrial membrane integrity, but radioprotects LN18 cells by reducing the production of reactive oxygen species (ROS) and sta …
Interestingly, FF (50 muM) significantly radiosensitizes U87 cells by inducing DNA double-strand breaks through oxidative stress and impairi …
Heat shock protein 70 (Hsp70): membrane location, export and immunological relevance.
Multhoff G. Multhoff G. Methods. 2007 Nov;43(3):229-37. doi: 10.1016/j.ymeth.2007.06.006. Methods. 2007. PMID: 17920520 Review.
Stress or heat shock proteins (HSPs) are remarkably conserved in all living organisms. Their expression is induced in response to a variety of physiological and environmental insults. In the cytosol these proteins play an essential role as molecular ch …
Stress or heat shock proteins (HSPs) are remarkably conserved in all living organisms. Their expression is induced in r …
Differential Hsp70 plasma-membrane expression on primary human tumors and metastases in mice with severe combined immunodeficiency.
Botzler C, Schmidt J, Luz A, Jennen L, Issels R, Multhoff G. Botzler C, et al. Among authors: multhoff g. Int J Cancer. 1998 Sep 11;77(6):942-8. doi: 10.1002/(sici)1097-0215(19980911)77:6<942::aid-ijc25>3.0.co;2-1. Int J Cancer. 1998. PMID: 9714069
To study the role of cell-surface expression of a tumor-selective heat-shock protein 70 (Hsp70) in vivo, the colon-carcinoma cell line CX2, and the clonal sub-lines CX+ and CX-, which differ in Hsp70 cell-surface expression, but not in MHC and adhesion …
To study the role of cell-surface expression of a tumor-selective heat-shock protein 70 (Hsp70) in vivo, the colon-carc …
110 results