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114 results

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Page 1
Hsp70 interactions with membrane lipids regulate cellular functions in health and disease.
Balogi Z, Multhoff G, Jensen TK, Lloyd-Evans E, Yamashima T, Jäättelä M, Harwood JL, Vígh L. Balogi Z, et al. Among authors: multhoff g. Prog Lipid Res. 2019 Apr;74:18-30. doi: 10.1016/j.plipres.2019.01.004. Epub 2019 Jan 30. Prog Lipid Res. 2019. PMID: 30710597 Free article. Review.
Beyond guarding the cellular proteome the major stress inducible heat shock protein Hsp70 has been shown to interact with lipids. Non-cytosolic Hsp70 stabilizes membranes during stress challenges and, in pathophysiological states, facilitates en …
Beyond guarding the cellular proteome the major stress inducible heat shock protein Hsp70 has been shown to interact wi …
Radiosensitizing capacity of fenofibrate in glioblastoma cells depends on lipid metabolism.
Alkotub B, Bauer L, Bashiri Dezfouli A, Hachani K, Ntziachristos V, Multhoff G, Kafshgari MH. Alkotub B, et al. Among authors: multhoff g. Redox Biol. 2025 Feb;79:103452. doi: 10.1016/j.redox.2024.103452. Epub 2024 Dec 2. Redox Biol. 2025. PMID: 39667305 Free PMC article.
Interestingly, FF (50 muM) significantly radiosensitizes U87 cells by inducing DNA double-strand breaks through oxidative stress and impairing mitochondrial membrane integrity, but radioprotects LN18 cells by reducing the production of reactive oxygen species (ROS) and sta …
Interestingly, FF (50 muM) significantly radiosensitizes U87 cells by inducing DNA double-strand breaks through oxidative stress and impairi …
Immunohistochemical, Flow Cytometric, and ELISA-Based Analyses of Intracellular, Membrane-Expressed, and Extracellular Hsp70 as Cancer Biomarkers.
Dezfouli AB, Stangl S, Foulds GA, Lennartz P, Pilkington GJ, Pockley AG, Multhoff G. Dezfouli AB, et al. Among authors: multhoff g. Methods Mol Biol. 2023;2693:307-324. doi: 10.1007/978-1-0716-3342-7_23. Methods Mol Biol. 2023. PMID: 37540444
The major stress-inducible 70 kDa heat shock (stress) protein 70 (Hsp70) is frequently overexpressed in highly aggressive tumor cells and thus might serve as a tumor-specific biomarker of aggressive disease and/or therapeutic resistance. We have previously sh …
The major stress-inducible 70 kDa heat shock (stress) protein 70 (Hsp70) is frequently overexpressed in highly aggressi …
Heat shock proteins in immunity.
Multhoff G. Multhoff G. Handb Exp Pharmacol. 2006;(172):279-304. doi: 10.1007/3-540-29717-0_12. Handb Exp Pharmacol. 2006. PMID: 16610364 Review.
This chapter focuses on immunological effects of eukaryotic and microbial heat shock proteins (HSPs), with molecular weights of about 60, 70, and 90 kDa. The search for tumor-specific antigens resulted in the identification of HSPs. ...Moreover, soluble as we …
This chapter focuses on immunological effects of eukaryotic and microbial heat shock proteins (HSPs), with molecular we …
Heat shock protein 70 (Hsp70): membrane location, export and immunological relevance.
Multhoff G. Multhoff G. Methods. 2007 Nov;43(3):229-37. doi: 10.1016/j.ymeth.2007.06.006. Methods. 2007. PMID: 17920520 Review.
Stress or heat shock proteins (HSPs) are remarkably conserved in all living organisms. Their expression is induced in response to a variety of physiological and environmental insults. In the cytosol these proteins play an essential role as molecular ch …
Stress or heat shock proteins (HSPs) are remarkably conserved in all living organisms. Their expression is induced in r …
Crosstalk Between NK Cell Receptors and Tumor Membrane Hsp70-Derived Peptide: A Combined Computational and Experimental Study.
Yazdi M, Hasanzadeh Kafshgari M, Khademi Moghadam F, Zarezade V, Oellinger R, Khosravi M, Haas S, Hoch CC, Pockley AG, Wagner E, Wollenberg B, Multhoff G, Bashiri Dezfouli A. Yazdi M, et al. Among authors: multhoff g. Adv Sci (Weinh). 2024 Apr;11(14):e2305998. doi: 10.1002/advs.202305998. Epub 2024 Jan 31. Adv Sci (Weinh). 2024. PMID: 38298098 Free PMC article.
It is previously shown that an ex vivo stimulation of patient-derived NK cells with interleukin (IL)-2 and Hsp70-derived peptide TKD (TKDNNLLGRFELSG, aa450-461) results in a significant upregulation of activating receptors including CD94 and CD69 which triggers exhausted N …
It is previously shown that an ex vivo stimulation of patient-derived NK cells with interleukin (IL)-2 and Hsp70-derived peptide TKD …
Heat shock protein 70 (Hsp70) as a target for advancing immunotherapy in solid tumors.
Hachani K, Ghanem M, Pockley AG, Wollenberg B, Bashiri Dezfouli A, Multhoff G. Hachani K, et al. Among authors: multhoff g. Cytokine Growth Factor Rev. 2025 Dec;86:83-95. doi: 10.1016/j.cytogfr.2025.09.002. Epub 2025 Sep 6. Cytokine Growth Factor Rev. 2025. PMID: 40947322 Free article. Review.
Heat shock protein 70 (Hsp70) is a highly conserved molecular chaperone that maintains protein homeostasis (proteostasis) under stress conditions. In cancer, Hsp70 is frequently overexpressed, where it contributes to hallmark features of malignancy by …
Heat shock protein 70 (Hsp70) is a highly conserved molecular chaperone that maintains protein homeostasis (proteostasi …
Membrane heat shock protein 70: a theranostic target for cancer therapy.
Shevtsov M, Huile G, Multhoff G. Shevtsov M, et al. Among authors: multhoff g. Philos Trans R Soc Lond B Biol Sci. 2018 Jan 19;373(1738):20160526. doi: 10.1098/rstb.2016.0526. Philos Trans R Soc Lond B Biol Sci. 2018. PMID: 29203711 Free PMC article. Review.
Apart from its intracellular localization, a tumour-selective HSP70 membrane expression has been determined. A membrane HSP70-positive tumour phenotype is associated with aggressiveness and therapy resistance, but also serves as a recognition structure …
Apart from its intracellular localization, a tumour-selective HSP70 membrane expression has been determined. A membrane …
Hsp70 plasma membrane expression on primary tumor biopsy material and bone marrow of leukemic patients.
Hantschel M, Pfister K, Jordan A, Scholz R, Andreesen R, Schmitz G, Schmetzer H, Hiddemann W, Multhoff G. Hantschel M, et al. Among authors: multhoff g. Cell Stress Chaperones. 2000 Nov;5(5):438-42. doi: 10.1379/1466-1268(2000)005<0438:hpmeop>2.0.co;2. Cell Stress Chaperones. 2000. PMID: 11189449 Free PMC article.
A tumor-selective cell surface localization of heat shock protein 70 (Hsp70), the major heat-inducible member of the Hsp70 group, correlates with an increased sensitivity to lysis mediated by human natural killer (NK) cells and, therefore, might be of …
A tumor-selective cell surface localization of heat shock protein 70 (Hsp70), the major heat-inducible member of the …
Time- and Dose-Dependent Effects of Ionizing Irradiation on the Membrane Expression of Hsp70 on Glioma Cells.
Fellinger H, Stangl S, Hernandez Schnelzer A, Schwab M, Di Genio T, Pieper M, Werner C, Shevtsov M, Haller B, Multhoff G. Fellinger H, et al. Among authors: multhoff g. Cells. 2020 Apr 8;9(4):912. doi: 10.3390/cells9040912. Cells. 2020. PMID: 32276468 Free PMC article.
Depending on its intracellular or membrane localization, Hsp70 either promotes tumor growth or serves as a target for natural killer (NK) cells. The kinetics of the membrane Hsp70 (mHsp70) density on human glioma cells (U87) was studied after different …
Depending on its intracellular or membrane localization, Hsp70 either promotes tumor growth or serves as a target for natural …
114 results