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1995 1
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2002 3
2003 6
2004 4
2005 6
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2007 4
2008 4
2009 4
2010 6
2011 6
2012 4
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2018 6
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Hsp70 interactions with membrane lipids regulate cellular functions in health and disease.
Balogi Z, Multhoff G, Jensen TK, Lloyd-Evans E, Yamashima T, Jäättelä M, Harwood JL, Vígh L. Balogi Z, et al. Among authors: multhoff g. Prog Lipid Res. 2019 Apr;74:18-30. doi: 10.1016/j.plipres.2019.01.004. Epub 2019 Jan 30. Prog Lipid Res. 2019. PMID: 30710597 Free article. Review.
Beyond guarding the cellular proteome the major stress inducible heat shock protein Hsp70 has been shown to interact with lipids. ...With a special focus on interacting lipids, here we discuss localization-dependent roles of the membrane-bound Hsp70
Beyond guarding the cellular proteome the major stress inducible heat shock protein Hsp70 has been shown to interact wi …
Membrane heat shock protein 70: a theranostic target for cancer therapy.
Shevtsov M, Huile G, Multhoff G. Shevtsov M, et al. Among authors: multhoff g. Philos Trans R Soc Lond B Biol Sci. 2018 Jan 19;373(1738):20160526. doi: 10.1098/rstb.2016.0526. Philos Trans R Soc Lond B Biol Sci. 2018. PMID: 29203711 Free PMC article. Review.
Heat shock protein 70 (HSP70), also termed HSPA1A, the major stress-inducible member of this family is overexpressed in a large variety of different tumour types. ...Herein, we want to shed light on the multiplicity of different activities of HSP70, de
Heat shock protein 70 (HSP70), also termed HSPA1A, the major stress-inducible member of this family is overexpressed in
Immunohistochemical and Flow Cytometric Analysis of Intracellular and Membrane-Bound Hsp70, as a Putative Biomarker of Glioblastoma Multiforme, Using the cmHsp70.1 Monoclonal Antibody.
Stangl S, Foulds GA, Fellinger H, Pilkington GJ, Pockley AG, Multhoff G. Stangl S, et al. Among authors: multhoff g. Methods Mol Biol. 2018;1709:307-320. doi: 10.1007/978-1-4939-7477-1_22. Methods Mol Biol. 2018. PMID: 29177668
The major stress-inducible 70 kDa heat shock (stress) protein 70 (Hsp70) is frequently overexpressed in highly aggressive tumor cells and thus might serve as a tumor-specific biomarker of aggressive disease. We have previously shown that, in contrast to norma …
The major stress-inducible 70 kDa heat shock (stress) protein 70 (Hsp70) is frequently overexpressed in highly aggressi …
Overexpression of cytosolic, plasma membrane bound and extracellular heat shock protein 70 (Hsp70) in primary glioblastomas.
Thorsteinsdottir J, Stangl S, Fu P, Guo K, Albrecht V, Eigenbrod S, Erl J, Gehrmann M, Tonn JC, Multhoff G, Schichor C. Thorsteinsdottir J, et al. Among authors: multhoff g. J Neurooncol. 2017 Dec;135(3):443-452. doi: 10.1007/s11060-017-2600-z. Epub 2017 Aug 28. J Neurooncol. 2017. PMID: 28849427
A unique feature in several non-CNS-tumors is the overexpression of heat shock protein 70 (Hsp70, HSPA1A) in the cytosol, but also its unusual plasma membrane expression and release. Although in gliomas, cytosolic Hsp70 levels are not associated …
A unique feature in several non-CNS-tumors is the overexpression of heat shock protein 70 (Hsp70, HSPA1A) in the cytoso …
Selection of an Anticalin® against the membrane form of Hsp70 via bacterial surface display and its theranostic application in tumour models.
Friedrich L, Kornberger P, Mendler CT, Multhoff G, Schwaiger M, Skerra A. Friedrich L, et al. Among authors: multhoff g. Biol Chem. 2018 Feb 23;399(3):235-252. doi: 10.1515/hsz-2017-0207. Biol Chem. 2018. PMID: 29140786
While found intracellularly in normal cells, Hsp70 is frequently exposed in a membrane-bound state on the surface of tumour cells and, even more pronounced, in metastases or after radiochemotherapy. ...This Anticalin, which recognises a linear peptide epitope locate …
While found intracellularly in normal cells, Hsp70 is frequently exposed in a membrane-bound state on the surface of tumour ce …
Granzyme B Functionalized Nanoparticles Targeting Membrane Hsp70-Positive Tumors for Multimodal Cancer Theranostics.
Shevtsov M, Stangl S, Nikolaev B, Yakovleva L, Marchenko Y, Tagaeva R, Sievert W, Pitkin E, Mazur A, Tolstoy P, Galibin O, Ryzhov V, Steiger K, Smirnov O, Khachatryan W, Chester K, Multhoff G. Shevtsov M, et al. Among authors: multhoff g. Small. 2019 Mar;15(13):e1900205. doi: 10.1002/smll.201900205. Epub 2019 Mar 4. Small. 2019. PMID: 30828968
Membrane-bound 70 kDa heat shock protein (mHsp70) is ubiquitously expressed on the cell membrane of various tumor types but not normal cells and therefore provides a tumor-specific target. ...Following binding to Hsp70, GrB is rapidly internaliz
Membrane-bound 70 kDa heat shock protein (mHsp70) is ubiquitously expressed on the cell membrane of various tumo
Molecular AFM imaging of Hsp70-1A association with dipalmitoyl phosphatidylserine reveals membrane blebbing in the presence of cholesterol.
Lamprecht C, Gehrmann M, Madl J, Römer W, Multhoff G, Ebner A. Lamprecht C, et al. Among authors: multhoff g. Cell Stress Chaperones. 2018 Jul;23(4):673-683. doi: 10.1007/s12192-018-0879-0. Epub 2018 Feb 5. Cell Stress Chaperones. 2018. PMID: 29404895 Free PMC article.
The anchoring mechanism is still under debate, as Hsp70-1A lacks conventional signaling sequences for translocation from the cytosol to exoplasmic leaflet of the plasma membrane and common membrane binding domains. ...In the presence of cholesterol, this crit …
The anchoring mechanism is still under debate, as Hsp70-1A lacks conventional signaling sequences for translocation from the cytosol …
Preclinical Evaluation of the Hsp70 Peptide Tracer TPP-PEG(24)-DFO[(89)Zr] for Tumor-Specific PET/CT Imaging.
Stangl S, Tei L, De Rose F, Reder S, Martinelli J, Sievert W, Shevtsov M, Öllinger R, Rad R, Schwaiger M, D'Alessandria C, Multhoff G. Stangl S, et al. Among authors: multhoff g. Cancer Res. 2018 Nov 1;78(21):6268-6281. doi: 10.1158/0008-5472.CAN-18-0707. Epub 2018 Sep 18. Cancer Res. 2018. PMID: 30228173 Free article.
An epitope of the oligomerization domain of Hsp70 is exclusively exposed on the membrane of a large variety of tumor types, but not on normal cells, and thus provides a universal tumor-specific target. Here we developed a novel PET tracer TPP-PEG(24)-DFO[(89)Zr] bas …
An epitope of the oligomerization domain of Hsp70 is exclusively exposed on the membrane of a large variety of tumor types, bu …
Heat shock protein 70 (Hsp70) membrane expression on head-and-neck cancer biopsy-a target for natural killer (NK) cells.
Kleinjung T, Arndt O, Feldmann HJ, Bockmühl U, Gehrmann M, Zilch T, Pfister K, Schönberger J, Marienhagen J, Eilles C, Rossbacher L, Multhoff G. Kleinjung T, et al. Among authors: multhoff g. Int J Radiat Oncol Biol Phys. 2003 Nov 1;57(3):820-6. doi: 10.1016/s0360-3016(03)00629-1. Int J Radiat Oncol Biol Phys. 2003. PMID: 14529789
PURPOSE: Heat shock protein 70 (Hsp70) was detected on the cell membrane of human tumor cell lines, but not on normal cells. ...The corresponding control tissue was negative for membrane-bound Hsp70. Biopsies (6 of 6) of patients after in …
PURPOSE: Heat shock protein 70 (Hsp70) was detected on the cell membrane of human tumor cell lines, but not on n …
Role of membrane Hsp70 in radiation sensitivity of tumor cells.
Murakami N, Kühnel A, Schmid TE, Ilicic K, Stangl S, Braun IS, Gehrmann M, Molls M, Itami J, Multhoff G. Murakami N, et al. Among authors: multhoff g. Radiat Oncol. 2015 Jul 22;10:149. doi: 10.1186/s13014-015-0461-1. Radiat Oncol. 2015. PMID: 26197988 Free PMC article.
BACKGROUND: The major stress-inducible heat shock protein 70 (Hsp70) is frequently overexpressed in the cytosol and integrated in the plasma membrane of tumor cells via lipid anchorage. Following stress such as non-lethal irradiation Hsp70 synth …
BACKGROUND: The major stress-inducible heat shock protein 70 (Hsp70) is frequently overexpressed in the cytosol and int …
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