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1995 1
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1998 2
1999 2
2000 2
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2002 3
2003 6
2004 4
2005 6
2006 5
2007 4
2008 4
2009 4
2010 6
2011 6
2012 4
2013 2
2014 6
2015 7
2016 1
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2018 6
2019 5
2020 4
2021 4
2022 2
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98 results
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Hsp70 interactions with membrane lipids regulate cellular functions in health and disease.
Balogi Z, Multhoff G, Jensen TK, Lloyd-Evans E, Yamashima T, Jäättelä M, Harwood JL, Vígh L. Balogi Z, et al. Among authors: multhoff g. Prog Lipid Res. 2019 Apr;74:18-30. doi: 10.1016/j.plipres.2019.01.004. Epub 2019 Jan 30. Prog Lipid Res. 2019. PMID: 30710597 Free article. Review.
Beyond guarding the cellular proteome the major stress inducible heat shock protein Hsp70 has been shown to interact with lipids. ...With a special focus on interacting lipids, here we discuss localization-dependent roles of the membrane-bound Hsp70 …
Beyond guarding the cellular proteome the major stress inducible heat shock protein Hsp70 has been shown to interact wi …
Time- and Dose-Dependent Effects of Ionizing Irradiation on the Membrane Expression of Hsp70 on Glioma Cells.
Fellinger H, Stangl S, Hernandez Schnelzer A, Schwab M, Di Genio T, Pieper M, Werner C, Shevtsov M, Haller B, Multhoff G. Fellinger H, et al. Among authors: multhoff g. Cells. 2020 Apr 8;9(4):912. doi: 10.3390/cells9040912. Cells. 2020. PMID: 32276468 Free PMC article.
Depending on its intracellular or membrane localization, Hsp70 either promotes tumor growth or serves as a target for natural killer (NK) cells. The kinetics of the membrane Hsp70 (mHsp70) density on human glioma cells (U87) was studied after different …
Depending on its intracellular or membrane localization, Hsp70 either promotes tumor growth or serves as a target for natural …
Immunohistochemical and Flow Cytometric Analysis of Intracellular and Membrane-Bound Hsp70, as a Putative Biomarker of Glioblastoma Multiforme, Using the cmHsp70.1 Monoclonal Antibody.
Stangl S, Foulds GA, Fellinger H, Pilkington GJ, Pockley AG, Multhoff G. Stangl S, et al. Among authors: multhoff g. Methods Mol Biol. 2018;1709:307-320. doi: 10.1007/978-1-4939-7477-1_22. Methods Mol Biol. 2018. PMID: 29177668
The major stress-inducible 70 kDa heat shock (stress) protein 70 (Hsp70) is frequently overexpressed in highly aggressive tumor cells and thus might serve as a tumor-specific biomarker of aggressive disease. We have previously shown that, in contrast to norma …
The major stress-inducible 70 kDa heat shock (stress) protein 70 (Hsp70) is frequently overexpressed in highly aggressi …
Heat shock protein 70 (Hsp70): membrane location, export and immunological relevance.
Multhoff G. Multhoff G. Methods. 2007 Nov;43(3):229-37. doi: 10.1016/j.ymeth.2007.06.006. Methods. 2007. PMID: 17920520 Review.
Stress or heat shock proteins (HSPs) are remarkably conserved in all living organisms. Their expression is induced in response to a variety of physiological and environmental insults. In the cytosol these proteins play an essential role as molecular ch …
Stress or heat shock proteins (HSPs) are remarkably conserved in all living organisms. Their expression is induced in r …
Overexpression of cytosolic, plasma membrane bound and extracellular heat shock protein 70 (Hsp70) in primary glioblastomas.
Thorsteinsdottir J, Stangl S, Fu P, Guo K, Albrecht V, Eigenbrod S, Erl J, Gehrmann M, Tonn JC, Multhoff G, Schichor C. Thorsteinsdottir J, et al. Among authors: multhoff g. J Neurooncol. 2017 Dec;135(3):443-452. doi: 10.1007/s11060-017-2600-z. Epub 2017 Aug 28. J Neurooncol. 2017. PMID: 28849427
A unique feature in several non-CNS-tumors is the overexpression of heat shock protein 70 (Hsp70, HSPA1A) in the cytosol, but also its unusual plasma membrane expression and release. Although in gliomas, cytosolic Hsp70 levels are not associated …
A unique feature in several non-CNS-tumors is the overexpression of heat shock protein 70 (Hsp70, HSPA1A) in the cytoso …
Targeting Cancer Metabolism Breaks Radioresistance by Impairing the Stress Response.
Schwab M, Thunborg K, Azimzadeh O, von Toerne C, Werner C, Shevtsov M, Di Genio T, Zdralevic M, Pouyssegur J, Renner K, Kreutz M, Multhoff G. Schwab M, et al. Among authors: multhoff g. Cancers (Basel). 2021 Jul 27;13(15):3762. doi: 10.3390/cancers13153762. Cancers (Basel). 2021. PMID: 34359663 Free PMC article.
The heightened energetic demand increases lactate dehydrogenase (LDH) activity, the corresponding oncometabolite lactate, expression of heat shock proteins (HSPs) and thereby promotes therapy resistance in many malignant tumor cell types. ...An altered lipid …
The heightened energetic demand increases lactate dehydrogenase (LDH) activity, the corresponding oncometabolite lactate, expression of h …
Hsp70 in Liquid Biopsies-A Tumor-Specific Biomarker for Detection and Response Monitoring in Cancer.
Werner C, Stangl S, Salvermoser L, Schwab M, Shevtsov M, Xanthopoulos A, Wang F, Dezfouli AB, Thölke D, Ostheimer C, Medenwald D, Windberg M, Bache M, Schlapschy M, Skerra A, Multhoff G. Werner C, et al. Among authors: multhoff g. Cancers (Basel). 2021 Jul 23;13(15):3706. doi: 10.3390/cancers13153706. Cancers (Basel). 2021. PMID: 34359606 Free PMC article.
In contrast to normal cells, tumor cells of multiple entities overexpress the Heat shock protein 70 (Hsp70) not only in the cytosol, but also present it on their plasma membrane in a tumor-specific manner. Furthermore, membrane Hsp70-posi …
In contrast to normal cells, tumor cells of multiple entities overexpress the Heat shock protein 70 (Hsp70) not only in …
Selection of an Anticalin® against the membrane form of Hsp70 via bacterial surface display and its theranostic application in tumour models.
Friedrich L, Kornberger P, Mendler CT, Multhoff G, Schwaiger M, Skerra A. Friedrich L, et al. Among authors: multhoff g. Biol Chem. 2018 Feb 23;399(3):235-252. doi: 10.1515/hsz-2017-0207. Biol Chem. 2018. PMID: 29140786
While found intracellularly in normal cells, Hsp70 is frequently exposed in a membrane-bound state on the surface of tumour cells and, even more pronounced, in metastases or after radiochemotherapy. ...This Anticalin, which recognises a linear peptide epitope locate …
While found intracellularly in normal cells, Hsp70 is frequently exposed in a membrane-bound state on the surface of tumour ce …
Potential Role of Hsp70 and Activated NK Cells for Prediction of Prognosis in Glioblastoma Patients.
Lobinger D, Gempt J, Sievert W, Barz M, Schmitt S, Nguyen HT, Stangl S, Werner C, Wang F, Wu Z, Fan H, Zanth H, Shevtsov M, Pilz M, Riederer I, Schwab M, Schlegel J, Multhoff G. Lobinger D, et al. Among authors: multhoff g. Front Mol Biosci. 2021 May 17;8:669366. doi: 10.3389/fmolb.2021.669366. eCollection 2021. Front Mol Biosci. 2021. PMID: 34079819 Free PMC article.
Depending on its intra- or extracellular localization the major stress-inducible heat shock protein 70 (Hsp70) fulfills different tasks. In the cytosol Hsp70 interferes with pro-apoptotic signaling pathways and thereby protects tumor cells from program …
Depending on its intra- or extracellular localization the major stress-inducible heat shock protein 70 (Hsp70) fulfills …
Hsp70 translocates into the plasma membrane after stress and is released into the extracellular environment in a membrane-associated form that activates macrophages.
Vega VL, Rodríguez-Silva M, Frey T, Gehrmann M, Diaz JC, Steinem C, Multhoff G, Arispe N, De Maio A. Vega VL, et al. Among authors: multhoff g. J Immunol. 2008 Mar 15;180(6):4299-307. doi: 10.4049/jimmunol.180.6.4299. J Immunol. 2008. PMID: 18322243 Free article.
Heat shock proteins (hsps) are intracellular chaperones that play a key role in the recovery from stress. ...These observations suggest that Hsp70 translocates into the plasma membrane after stress and is released within membranous struct …
Heat shock proteins (hsps) are intracellular chaperones that play a key role in the recovery from stress. ...These obse …
98 results