CAR T Cells Targeting Membrane-Bound Hsp70 on Tumor Cells Mimic Hsp70-Primed NK Cells.
Bashiri Dezfouli A, Yazdi M, Benmebarek MR, Schwab M, Michaelides S, Miccichè A, Geerts D, Stangl S, Klapproth S, Wagner E, Kobold S, Multhoff G.
Bashiri Dezfouli A, et al. Among authors: multhoff g.
Front Immunol. 2022 Jun 1;13:883694. doi: 10.3389/fimmu.2022.883694. eCollection 2022.
Front Immunol. 2022.
PMID: 35720311
Free PMC article.
However, these approaches are critically dependent on tumor-specific antigens while circumventing the suppressive power of the solid tumor microenvironment and avoiding off-tumor toxicities. Previously, we have shown that the stress-inducible heat shock protein 70 ( …
However, these approaches are critically dependent on tumor-specific antigens while circumventing the suppressive power of the solid tumor m …