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Year Number of Results
1995 1
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1999 2
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2002 3
2003 6
2004 4
2005 6
2006 5
2007 4
2008 4
2009 4
2010 6
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103 results

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Page 1
Hsp70 interactions with membrane lipids regulate cellular functions in health and disease.
Balogi Z, Multhoff G, Jensen TK, Lloyd-Evans E, Yamashima T, Jäättelä M, Harwood JL, Vígh L. Balogi Z, et al. Among authors: multhoff g. Prog Lipid Res. 2019 Apr;74:18-30. doi: 10.1016/j.plipres.2019.01.004. Epub 2019 Jan 30. Prog Lipid Res. 2019. PMID: 30710597 Free article. Review.
Beyond guarding the cellular proteome the major stress inducible heat shock protein Hsp70 has been shown to interact with lipids. ...With a special focus on interacting lipids, here we discuss localization-dependent roles of the membrane-bound Hsp70 …
Beyond guarding the cellular proteome the major stress inducible heat shock protein Hsp70 has been shown to interact wi …
Time- and Dose-Dependent Effects of Ionizing Irradiation on the Membrane Expression of Hsp70 on Glioma Cells.
Fellinger H, Stangl S, Hernandez Schnelzer A, Schwab M, Di Genio T, Pieper M, Werner C, Shevtsov M, Haller B, Multhoff G. Fellinger H, et al. Among authors: multhoff g. Cells. 2020 Apr 8;9(4):912. doi: 10.3390/cells9040912. Cells. 2020. PMID: 32276468 Free PMC article.
Depending on its intracellular or membrane localization, Hsp70 either promotes tumor growth or serves as a target for natural killer (NK) cells. The kinetics of the membrane Hsp70 (mHsp70) density on human glioma cells (U87) was studied after different …
Depending on its intracellular or membrane localization, Hsp70 either promotes tumor growth or serves as a target for natural …
Heat shock protein 70 (Hsp70): membrane location, export and immunological relevance.
Multhoff G. Multhoff G. Methods. 2007 Nov;43(3):229-37. doi: 10.1016/j.ymeth.2007.06.006. Methods. 2007. PMID: 17920520 Review.
Stress or heat shock proteins (HSPs) are remarkably conserved in all living organisms. Their expression is induced in response to a variety of physiological and environmental insults. In the cytosol these proteins play an essential role as molecular ch …
Stress or heat shock proteins (HSPs) are remarkably conserved in all living organisms. Their expression is induced in r …
Immunohistochemical and Flow Cytometric Analysis of Intracellular and Membrane-Bound Hsp70, as a Putative Biomarker of Glioblastoma Multiforme, Using the cmHsp70.1 Monoclonal Antibody.
Stangl S, Foulds GA, Fellinger H, Pilkington GJ, Pockley AG, Multhoff G. Stangl S, et al. Among authors: multhoff g. Methods Mol Biol. 2018;1709:307-320. doi: 10.1007/978-1-4939-7477-1_22. Methods Mol Biol. 2018. PMID: 29177668
The major stress-inducible 70 kDa heat shock (stress) protein 70 (Hsp70) is frequently overexpressed in highly aggressive tumor cells and thus might serve as a tumor-specific biomarker of aggressive disease. We have previously shown that, in contrast to norma …
The major stress-inducible 70 kDa heat shock (stress) protein 70 (Hsp70) is frequently overexpressed in highly aggressi …
Immunohistochemical, Flow Cytometric, and ELISA-Based Analyses of Intracellular, Membrane-Expressed, and Extracellular Hsp70 as Cancer Biomarkers.
Dezfouli AB, Stangl S, Foulds GA, Lennartz P, Pilkington GJ, Pockley AG, Multhoff G. Dezfouli AB, et al. Among authors: multhoff g. Methods Mol Biol. 2023;2693:307-324. doi: 10.1007/978-1-0716-3342-7_23. Methods Mol Biol. 2023. PMID: 37540444
The major stress-inducible 70 kDa heat shock (stress) protein 70 (Hsp70) is frequently overexpressed in highly aggressive tumor cells and thus might serve as a tumor-specific biomarker of aggressive disease and/or therapeutic resistance. We have previously sh …
The major stress-inducible 70 kDa heat shock (stress) protein 70 (Hsp70) is frequently overexpressed in highly aggressi …
CAR T Cells Targeting Membrane-Bound Hsp70 on Tumor Cells Mimic Hsp70-Primed NK Cells.
Bashiri Dezfouli A, Yazdi M, Benmebarek MR, Schwab M, Michaelides S, Miccichè A, Geerts D, Stangl S, Klapproth S, Wagner E, Kobold S, Multhoff G. Bashiri Dezfouli A, et al. Among authors: multhoff g. Front Immunol. 2022 Jun 1;13:883694. doi: 10.3389/fimmu.2022.883694. eCollection 2022. Front Immunol. 2022. PMID: 35720311 Free PMC article.
However, these approaches are critically dependent on tumor-specific antigens while circumventing the suppressive power of the solid tumor microenvironment and avoiding off-tumor toxicities. Previously, we have shown that the stress-inducible heat shock protein 70 ( …
However, these approaches are critically dependent on tumor-specific antigens while circumventing the suppressive power of the solid tumor m …
Overexpression of cytosolic, plasma membrane bound and extracellular heat shock protein 70 (Hsp70) in primary glioblastomas.
Thorsteinsdottir J, Stangl S, Fu P, Guo K, Albrecht V, Eigenbrod S, Erl J, Gehrmann M, Tonn JC, Multhoff G, Schichor C. Thorsteinsdottir J, et al. Among authors: multhoff g. J Neurooncol. 2017 Dec;135(3):443-452. doi: 10.1007/s11060-017-2600-z. Epub 2017 Aug 28. J Neurooncol. 2017. PMID: 28849427
A unique feature in several non-CNS-tumors is the overexpression of heat shock protein 70 (Hsp70, HSPA1A) in the cytosol, but also its unusual plasma membrane expression and release. Although in gliomas, cytosolic Hsp70 levels are not associated …
A unique feature in several non-CNS-tumors is the overexpression of heat shock protein 70 (Hsp70, HSPA1A) in the cytoso …
Membrane heat shock protein 70: a theranostic target for cancer therapy.
Shevtsov M, Huile G, Multhoff G. Shevtsov M, et al. Among authors: multhoff g. Philos Trans R Soc Lond B Biol Sci. 2018 Jan 19;373(1738):20160526. doi: 10.1098/rstb.2016.0526. Philos Trans R Soc Lond B Biol Sci. 2018. PMID: 29203711 Free PMC article. Review.
Apart from its intracellular localization, a tumour-selective HSP70 membrane expression has been determined. A membrane HSP70-positive tumour phenotype is associated with aggressiveness and therapy resistance, but also serves as a recognition structure …
Apart from its intracellular localization, a tumour-selective HSP70 membrane expression has been determined. A membrane …
The role of heat shock protein 70 (Hsp70) in radiation-induced immunomodulation.
Multhoff G, Pockley AG, Schmid TE, Schilling D. Multhoff G, et al. Cancer Lett. 2015 Nov 28;368(2):179-84. doi: 10.1016/j.canlet.2015.02.013. Epub 2015 Feb 11. Cancer Lett. 2015. PMID: 25681671 Free article. Review.
Given their key influence on a number of biological and immunological parameters, this article considers the influence of irradiation-induced stress proteins on radiation-induced immunomodulation. Depending on its location, the major stress-inducible Heat shock …
Given their key influence on a number of biological and immunological parameters, this article considers the influence of irradiation-induce …
Distinguishing integral and receptor-bound heat shock protein 70 (Hsp70) on the cell surface by Hsp70-specific antibodies.
Multhoff G, Hightower LE. Multhoff G, et al. Cell Stress Chaperones. 2011 May;16(3):251-5. doi: 10.1007/s12192-010-0247-1. Epub 2010 Dec 17. Cell Stress Chaperones. 2011. PMID: 21165727 Free PMC article. Review.
Cell Stress & Chaperones journal has become a major outlet for papers and review articles about anti-heat shock protein (HSP) antibodies. In the last decade, it became evident that apart from their intracellular localization, members of the heat shock …
Cell Stress & Chaperones journal has become a major outlet for papers and review articles about anti-heat shock protein (H …
103 results