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Novel Diagnostic Biomarkers Related to Oxidative Stress and Macrophage Ferroptosis in Atherosclerosis.
Li M, Xin S, Gu R, Zheng L, Hu J, Zhang R, Dong H. Li M, et al. Oxid Med Cell Longev. 2022 Aug 5;2022:8917947. doi: 10.1155/2022/8917947. eCollection 2022. Oxid Med Cell Longev. 2022. PMID: 36035208 Free PMC article.
High ALOX5 and NCF2 expression levels in plaque tissues were confirmed by immunohistochemistry (IHC) and western blotting. ...ALOX5 and NCF2 may be involved in the formation of the necrotic core in AS by regulating macrophage ferroptosis....
High ALOX5 and NCF2 expression levels in plaque tissues were confirmed by immunohistochemistry (IHC) and western blotting. ...ALOX5 a …
NCF2 drives tumor progression and metastasis through NR2F2/LATS2/YAP1 axis in esophageal squamous cell carcinoma.
Zhang H, Wang Z, Song N, Xiao A, Liu Y, Huang A, Yao Z, Huang Z, Sun Q, Qu Y, Xing S, Wan L, Zheng Q, Huang L, Jiang K. Zhang H, et al. Cancer Lett. 2025 Oct 28;631:217902. doi: 10.1016/j.canlet.2025.217902. Epub 2025 Jul 9. Cancer Lett. 2025. PMID: 40645396
Dysregulation of NCF2 expression promotes ESCC progression and lymphatic metastasis in a ROS-independent manner. ...This study establishes that the NCF2/NR2F2/LATS2/YAP1 axis plays a vital role in tumorigenesis and metastasis, suggesting that NCF2 may serve a …
Dysregulation of NCF2 expression promotes ESCC progression and lymphatic metastasis in a ROS-independent manner. ...This study establ …
Neutrophil extracellular traps drive osteoporosis via NCF2-dependent signaling: integrated transcriptomics with mechanistic validation.
Guo X, Wang L, Chen S, Sun C, Qin J, Liu Q, Gan Y, Li Y, Jin Z, Wei X, Zhang Y. Guo X, et al. Redox Rep. 2025 Dec;30(1):2534745. doi: 10.1080/13510002.2025.2534745. Epub 2025 Jul 22. Redox Rep. 2025. PMID: 40696520 Free PMC article.
SMR analysis identified VDAC1, PLCG2, and NCF2 as key genes significantly associated with OP risk, experimentally validated at the tissue and cellular levels. Knockdown of NCF2 reduced NETs formation in neutrophil-like cells and alleviated NETs-induced osteoblast di …
SMR analysis identified VDAC1, PLCG2, and NCF2 as key genes significantly associated with OP risk, experimentally validated at the ti …
An Integrative analysis of single-cell RNA-seq, transcriptome and Mendelian randomization for the Identification and validation of NAD+ Metabolism-Related biomarkers in ulcerative colitis.
Zhang L, Li J, Zhang Q, Gao J, Zhao K, Asai Y, Hu Z, Gao H. Zhang L, et al. Int Immunopharmacol. 2025 Jan 3;145:113765. doi: 10.1016/j.intimp.2024.113765. Epub 2024 Dec 7. Int Immunopharmacol. 2025. PMID: 39647286 Free article.
Single-cell (GSE116222) and spatial transcriptomic analyses (GSE189184) revealed the expression patterns of these key genes in specific cell types. NCF2, IL1B, S100A8, and SLC26A2 were identified as biomarkers, with NCF2 and IL1B serving as protective factors and S1 …
Single-cell (GSE116222) and spatial transcriptomic analyses (GSE189184) revealed the expression patterns of these key genes in specific cell …
M6A-mediated-upregulation of lncRNA BLACAT3 promotes bladder cancer angiogenesis and hematogenous metastasis through YBX3 nuclear shuttling and enhancing NCF2 transcription.
Xie J, Zhang H, Wang K, Ni J, Ma X, Khoury CJ, Prifti V, Hoard B, Cerenzia EG, Yin L, Zhang H, Wang R, Zhuo D, Mao W, Peng B. Xie J, et al. Oncogene. 2023 Sep;42(40):2956-2970. doi: 10.1038/s41388-023-02814-3. Epub 2023 Aug 23. Oncogene. 2023. PMID: 37612524 Free PMC article.
BLACAT3 recruits YBX3 to shuttle into the nucleus, synergistically enhances NCF2 transcription, and promotes BLCa angiogenesis and hematogenous metastasis by activating downstream NF-kappaB signaling. ...
BLACAT3 recruits YBX3 to shuttle into the nucleus, synergistically enhances NCF2 transcription, and promotes BLCa angiogenesis and he …
Key Disease-Related Genes and Immune Cell Infiltration Landscape in Inflammatory Bowel Disease: A Bioinformatics Investigation.
Alghamdi KS, Kassar RH, Farrash WF, Obaid AA, Idris S, Siddig A, Shakoori AM, Alshehre SM, Minshawi F, Mujalli A. Alghamdi KS, et al. Int J Mol Sci. 2024 Sep 9;25(17):9751. doi: 10.3390/ijms25179751. Int J Mol Sci. 2024. PMID: 39273699 Free PMC article.
Disease module construction using the NeDRex platform identified nine out of 14 disease-associated genes (CYBB, RAC2, GNAI2, ITGA4, CYBA, NCF4, CPT1A, NCF2, and PCK1). Immune infiltration profile assessment revealed a significantly higher degree of infiltration of neutroph …
Disease module construction using the NeDRex platform identified nine out of 14 disease-associated genes (CYBB, RAC2, GNAI2, ITGA4, CYBA, NC …
Accelerated biological aging and its hallmarks in DNA methylation drive the association between unhealthy lifestyles and the onset of colorectal cancer.
Sun J, Liu M, Zhang X, Li X, Ye J, Zhao J, Zhou S, Ji H, Tan Y, Bian Z, Zhang D, Dunlop MG, Song M, Smith-Warner SA, Wu H, Theodoratou E, Cao Q, Li X. Sun J, et al. EBioMedicine. 2025 Dec;122:106005. doi: 10.1016/j.ebiom.2025.106005. Epub 2025 Nov 5. EBioMedicine. 2025. PMID: 41197401 Free PMC article.
Altered methylation at 15 aging-related CpGs was associated with CRC and was prioritized with high colocalization evidence. Four mapped genes (TNF, BICC1, NCF2, DIP2B) were significantly associated with CRC. The lower expression of TNF, NCF2, and DIP2B mediated the …
Altered methylation at 15 aging-related CpGs was associated with CRC and was prioritized with high colocalization evidence. Four mapped gene …
Development and Experimental Validation of Machine Learning-Based Disulfidptosis-Related Ferroptosis Biomarkers in Inflammatory Bowel Disease.
Liu Y, Shao J, Zhang J, Sang M, Xu Q, Mao L. Liu Y, et al. Genes (Basel). 2025 Apr 27;16(5):496. doi: 10.3390/genes16050496. Genes (Basel). 2025. PMID: 40428318 Free PMC article.
Functional annotation demonstrated that IBD-associated genes regulate diverse pathways, with a network analysis revealing their functional synergy. The PPI networks prioritized DUOX2, NCF2, ACSL4, GPX2, CBS, and LPCAT3 as central hubs. Two immune subtypes exhibited diverge …
Functional annotation demonstrated that IBD-associated genes regulate diverse pathways, with a network analysis revealing their functional s …
Identification and Functional Validation of Novel Pathogenic Variants in Primary Immunodeficiencies.
Vr A, Govindaraj GM, Iyer AR, Paul S, Edavazhippurath A, Jain A, Gupta P, Deshmukh GY, Singh S, Saravanakumar V, Bhardwaj J, Sharma S, Benny TP, Saravanan P, Bhoyar RC, Imran M, Senthivel V, Divakar MK, Vignesh H, Jolly B, Dalvi A, Bargir UA, Madkaikar M, Bk B, Sivasubbu S, Ramalingam S, Scaria V. Vr A, et al. Eur J Immunol. 2025 Oct;55(10):e70057. doi: 10.1002/eji.70057. Eur J Immunol. 2025. PMID: 41116289
In this study, we identified five novel variants in PID-related genes in six families using whole-exome sequencing. These variants include FCHO1 (E44K), NCF2 (A206P), NCF2 (c.174 + 1G > A), STAT1 (L199F), and a copy number deletion in LRBA (exon 9-17). Functional …
In this study, we identified five novel variants in PID-related genes in six families using whole-exome sequencing. These variants include F …
62 results