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NLRP1 inflammasome promotes senescence and senescence-associated secretory phenotype.
Muela-Zarzuela I, Suarez-Rivero JM, Gallardo-Orihuela A, Wang C, Izawa K, de Gregorio-Procopio M, Couillin I, Ryffel B, Kitaura J, Sanz A, von Zglinicki T, Mbalaviele G, Cordero MD. Muela-Zarzuela I, et al. Inflamm Res. 2024 Aug;73(8):1253-1266. doi: 10.1007/s00011-024-01892-7. Epub 2024 Jun 21. Inflamm Res. 2024. PMID: 38907167 Free PMC article.
Mechanistically, the NLRP1 inflammasome is activated in response to genomic damage detected by the cytosolic DNA sensor cGMP-AMP (cGAMP) synthase (cGAS). CONCLUSION: Our findings show that NLRP1 is a cGAS-dependent DNA damage sensor during senescence and a mediator …
Mechanistically, the NLRP1 inflammasome is activated in response to genomic damage detected by the cytosolic DNA sensor cGMP-AMP (cGA …
Clinical signature and associated immune metabolism of NLRP1 in pan-cancer.
Liao Y, Yang P, Yang C, Zhuang K, Fahira A, Wang J, Liu Z, Yan L, Huang Z. Liao Y, et al. J Cell Mol Med. 2024 Sep;28(18):e70100. doi: 10.1111/jcmm.70100. J Cell Mol Med. 2024. PMID: 39318060 Free PMC article.
Inflammations have been linked to tumours, suggesting a potential association between NLRP1 and cancer. Nevertheless, a systematic assessment of NLRP1's role across various cancer types currently absent. ...Downregulation of NLRP1 reduced tumour metabolic act …
Inflammations have been linked to tumours, suggesting a potential association between NLRP1 and cancer. Nevertheless, a systematic as …
Exploring the role of pyroptosis and immune infiltration in sepsis based on bioinformatic analysis.
Li ZH, Wang Y, Yu XY. Li ZH, et al. Immunobiology. 2024 Sep;229(5):152826. doi: 10.1016/j.imbio.2024.152826. Epub 2024 Jun 10. Immunobiology. 2024. PMID: 38981197 Free article.
The qRT-PCR results showed that the expression levels of NAIP, IL-18, TP53, CHMP7, NLRC4, ELANE and NLRP1 were consistant with the bioinformatic analyses, while the expression level of AIM2 has no significant difference. CONCLUSION: Our study identified seven potential pyr …
The qRT-PCR results showed that the expression levels of NAIP, IL-18, TP53, CHMP7, NLRC4, ELANE and NLRP1 were consistant with the bi …
DNA methylation of imprint control regions associated with Alzheimer's disease in non-Hispanic Blacks and non-Hispanic Whites.
Cevik SE, Skaar DA, Jima DD, Liu AJ, Østbye T, Whitson HE, Jirtle RL, Hoyo C, Planchart A. Cevik SE, et al. Clin Epigenetics. 2024 Apr 25;16(1):58. doi: 10.1186/s13148-024-01672-4. Clin Epigenetics. 2024. PMID: 38658973 Free PMC article.
Eighty-one ICRs were differentially methylated in NHB-AD, and 27 ICRs were differentially methylated in NHW-AD, with two regions common to both populations that are proximal to the inflammasome gene, NLRP1, and a known imprinted gene, MEST/MESTIT1. These findings indicate …
Eighty-one ICRs were differentially methylated in NHB-AD, and 27 ICRs were differentially methylated in NHW-AD, with two regions common to b …
Identification of PANoptosis-related biomarkers and analysis of prognostic values in head and neck squamous cell carcinoma.
Yang P, Huang G, Li Y, Yu L, Yin Z, Li Q. Yang P, et al. Sci Rep. 2024 Apr 29;14(1):9824. doi: 10.1038/s41598-024-60441-8. Sci Rep. 2024. PMID: 38684755 Free PMC article.
A total of 18 differentially expressed PARGs were identified in HNSCC, and a Cox model including CASP8, FADD, NLRP1, TNF, and ZBP1 was constructed, which showed that the risk score was associated with the prognosis as well as immune infiltration of HNSCC patients, and the …
A total of 18 differentially expressed PARGs were identified in HNSCC, and a Cox model including CASP8, FADD, NLRP1, TNF, and ZBP1 wa …
Pyroptosis-Related Genes as Diagnostic Markers in Chronic Obstructive Pulmonary Disease and Its Correlation with Immune Infiltration.
Shu HM, Lin CQ, He B, Wang W, Wang L, Wu T, He HJ, Wang HJ, Zhou HP, Ding GZ. Shu HM, et al. Int J Chron Obstruct Pulmon Dis. 2024 Jun 27;19:1491-1513. doi: 10.2147/COPD.S438686. eCollection 2024. Int J Chron Obstruct Pulmon Dis. 2024. PMID: 38957709 Free PMC article.
A diagnostic signature including eight genes (CASP4, CASP5, ELANE, GPX4, NLRP1, GSDME, NOD1and IL18) was also constructed. Immune cell infiltration calculated by the ESTIMATE score, Stroma scores and Immune scores were also compared on the basis of pyroptosis-related molec …
A diagnostic signature including eight genes (CASP4, CASP5, ELANE, GPX4, NLRP1, GSDME, NOD1and IL18) was also constructed. Immune cel …
Inflammasome-Related Genetic Polymorphisms as Severity Biomarkers of COVID-19.
Pulito-Cueto V, Sebastián Mora-Gil M, Ferrer-Pargada D, Remuzgo-Martínez S, Genre F, Lera-Gómez L, Alonso-Lecue P, Batista-Liz JC, Tello-Mena S, Abascal-Bolado B, Izquierdo S, Ruiz-Cubillán JJ, Armiñanzas-Castillo C, Blanco R, González-Gay MA, López-Mejías R, Cifrián JM. Pulito-Cueto V, et al. Int J Mol Sci. 2024 Mar 27;25(7):3731. doi: 10.3390/ijms25073731. Int J Mol Sci. 2024. PMID: 38612539 Free PMC article.
A total of 24 polymorphisms located in inflammasome-related genes (NLRP3, NLRC4, NLRP1, CARD8, CASP1, IL1B, IL18, NFKB1, ATG16L1, and MIF) were genotyped in all of the patients and in the 192 healthy controls (HCs) (who were without COVID-19 at the time of and before the s …
A total of 24 polymorphisms located in inflammasome-related genes (NLRP3, NLRC4, NLRP1, CARD8, CASP1, IL1B, IL18, NFKB1, ATG16L1, and …
Investigating the influence of inflammasome complex genes on Turner syndrome.
Samanta Moraes Laranjeira R, Eduarda de Albuquerque Borborema M, Milene Dos Santos Barbosa A, Vieira de Barros Arcoverde J, Albertina Dantas de Lima C, de Rezende Duarte A, Guiomar Sales Gomes da Silva B, de Azevêdo Silva J, Santos N. Samanta Moraes Laranjeira R, et al. Hum Immunol. 2024 Nov;85(6):111164. doi: 10.1016/j.humimm.2024.111164. Epub 2024 Oct 23. Hum Immunol. 2024. PMID: 39447524
In addition, mRNA expression levels of IL1B, NLRP3, and NLRP1 were also compared in 17 TS patients and 17 healthy females (control group) using qPCR-based fluorogenic probes. ...Expression analysis revealed a downregulation of IL1B and NLRP3 (fold change: FC = -6.78 and -1 …
In addition, mRNA expression levels of IL1B, NLRP3, and NLRP1 were also compared in 17 TS patients and 17 healthy females (control gr …
Elucidating the molecular landscape of tendinitis: the role of inflammasome-related genes and immune interactions.
Xu H, Lu X, Yu Y, Zhou Y, Qi T, Zheng Y. Xu H, et al. Front Immunol. 2024 Jun 11;15:1393851. doi: 10.3389/fimmu.2024.1393851. eCollection 2024. Front Immunol. 2024. PMID: 38919626 Free PMC article.
Through comprehensive gene expression analysis and bioinformatics approaches, we identified distinct expression profiles of inflammasome genes, such as NLRP6, NLRP1, and MEFV, which showed significant correlations with immune checkpoint molecules, indicating a pivotal role …
Through comprehensive gene expression analysis and bioinformatics approaches, we identified distinct expression profiles of inflammasome gen …
Genetic variant in the AGT gene (rs699-GG) is associated with severe COVID-19 in Brazilian patients.
Farias PCS, Cabral LP, Neves PAF, Januário CAB, Cordeiro BM, Silva Júnior WJD, Baseggio C, Paiva Júnior SSL, Araújo PSR, Lorena VMB, Balbino VQ, Lima Neto RG. Farias PCS, et al. An Acad Bras Cienc. 2024 Nov 29;96(suppl 3):e20240274. doi: 10.1590/0001-3765202420240274. eCollection 2024. An Acad Bras Cienc. 2024. PMID: 39630802 Free article.
This study aimed to analyze the frequency and association between specific SNPs rs3806268 (NLRP3), rs4925543 (NLRP3), rs12150220 (NLRP1), rs455060 (NLRC4), rs699 (AGT), rs1137101 (LEPR), and rs1801133 (MTHFR) and severe/critical outcomes in Brazilian patients with COVID-19 …
This study aimed to analyze the frequency and association between specific SNPs rs3806268 (NLRP3), rs4925543 (NLRP3), rs12150220 (NLRP1
14 results