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2023 4
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2025 54

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201 results

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O-GlcNAcylation dictates pyroptosis.
Lang Y, Li J, Zhang L. Lang Y, et al. Front Immunol. 2024 Dec 17;15:1513542. doi: 10.3389/fimmu.2024.1513542. eCollection 2024. Front Immunol. 2024. PMID: 39742284 Free PMC article. Review.
The review also examines the effects of O-GlcNAcylation on the NLRP3 inflammasome and its regulators, including NEK7 and NF-kappaB. Overall, this review emphasizes the role of O-GlcNAcylation in the pathogenesis of conditions such as sepsis, periodontitis, and osteoarthrit …
The review also examines the effects of O-GlcNAcylation on the NLRP3 inflammasome and its regulators, including NEK7 and NF-kappaB. O …
RAC2 gain-of-function variants causing inborn error of immunity drive NLRP3 inflammasome activation.
Doye A, Chaintreuil P, Lagresle-Peyrou C, Batistic L, Marion V, Munro P, Loubatier C, Chirara R, Sorel N, Bessot B, Bronnec P, Contenti J, Courjon J, Giordanengo V, Jacquel A, Barbry P, Couralet M, Aladjidi N, Fischer A, Cavazzana M, Mallebranche C, Visvikis O, Kracker S, Moshous D, Verhoeyen E, Boyer L. Doye A, et al. J Exp Med. 2024 Oct 7;221(10):e20231562. doi: 10.1084/jem.20231562. Epub 2024 Aug 30. J Exp Med. 2024. PMID: 39212656 Free PMC article.
Here, we show that specific RAC2 activating mutations induce the NLRP3 inflammasome activation leading to the secretion of IL-1beta and IL-18 from macrophages. This activation depends on the activation state of the RAC2 variant and is mediated by the downstream kinase PAK1 …
Here, we show that specific RAC2 activating mutations induce the NLRP3 inflammasome activation leading to the secretion of IL-1beta a …
IRE1α silences dsRNA to prevent taxane-induced pyroptosis in triple-negative breast cancer.
Xu L, Peng F, Luo Q, Ding Y, Yuan F, Zheng L, He W, Zhang SS, Fu X, Liu J, Mutlu AS, Wang S, Nehring RB, Li X, Tang Q, Li C, Lv X, Dobrolecki LE, Zhang W, Han D, Zhao N, Jaehnig E, Wang J, Wu W, Graham DA, Li Y, Chen R, Peng W, Chen Y, Catic A, Zhang Z, Zhang B, Mustoe AM, Koong AC, Miles G, Lewis MT, Wang MC, Rosenberg SM, O'Malley BW, Westbrook TF, Xu H, Zhang XH, Osborne CK, Li JB, Ellis MJ, Rimawi MF, Rosen JM, Chen X. Xu L, et al. Cell. 2024 Dec 12;187(25):7248-7266.e34. doi: 10.1016/j.cell.2024.09.032. Epub 2024 Oct 16. Cell. 2024. PMID: 39419025
IRE1alpha RNase silences taxane-induced double-stranded RNA (dsRNA) through regulated IRE1-dependent decay (RIDD) to prevent NLRP3 inflammasome-dependent pyroptosis. Inhibition of IRE1alpha in Trp53(-/-) TNBC allows taxane to induce extensive dsRNAs that are sensed by ZBP1 …
IRE1alpha RNase silences taxane-induced double-stranded RNA (dsRNA) through regulated IRE1-dependent decay (RIDD) to prevent NLRP3 in …
Inhibition of NLRP3 inflammasome activation by A20 through modulation of NEK7.
Yu J, Li H, Wu Y, Luo M, Chen S, Shen G, Wei X, Shao B. Yu J, et al. Proc Natl Acad Sci U S A. 2024 Jun 18;121(25):e2316551121. doi: 10.1073/pnas.2316551121. Epub 2024 Jun 12. Proc Natl Acad Sci U S A. 2024. PMID: 38865260 Free PMC article.
The NLRP3 inflammasome, a pivotal component of innate immunity, has been implicated in various inflammatory disorders. ...Significantly, NEK7 deletion markedly attenuates the activation of the NLRP3 inflammasome in A20-deficient conditions, both in vitro and in vivo …
The NLRP3 inflammasome, a pivotal component of innate immunity, has been implicated in various inflammatory disorders. ...Significant …
The pathogenesis of gout: molecular insights from genetic, epigenomic and transcriptomic studies.
Leask MP, Crișan TO, Ji A, Matsuo H, Köttgen A, Merriman TR. Leask MP, et al. Nat Rev Rheumatol. 2024 Aug;20(8):510-523. doi: 10.1038/s41584-024-01137-1. Epub 2024 Jul 11. Nat Rev Rheumatol. 2024. PMID: 38992217 Review.
The pathogenesis of gout involves a series of steps beginning with hyperuricaemia, followed by the deposition of monosodium urate crystal in articular structures and culminating in an innate immune response, mediated by the NLRP3 inflammasome, to the deposited crystals. La …
The pathogenesis of gout involves a series of steps beginning with hyperuricaemia, followed by the deposition of monosodium urate crystal in …
A mechanism for hypoxia-induced inflammatory cell death in cancer.
Bhardwaj A, Panepinto MC, Ueberheide B, Neel BG. Bhardwaj A, et al. Nature. 2025 Jan;637(8045):470-477. doi: 10.1038/s41586-024-08136-y. Epub 2024 Nov 6. Nature. 2025. PMID: 39506105
Decreased CYLD/SPATA2 levels lead to NF-kappaB activation and induction of the NLRP3 inflammasome which, together with hypoxia-induced endoplasmic reticulum stress, triggers pyroptotic cell death. Consistent with this model, CYLD deletion phenocopies, whereas NLRP3 …
Decreased CYLD/SPATA2 levels lead to NF-kappaB activation and induction of the NLRP3 inflammasome which, together with hypoxia-induce …
A genome-wide association analysis reveals new pathogenic pathways in gout.
Major TJ, Takei R, Matsuo H, Leask MP, Sumpter NA, Topless RK, Shirai Y, Wang W, Cadzow MJ, Phipps-Green AJ, Li Z, Ji A, Merriman ME, Morice E, Kelley EE, Wei WH, McCormick SPA, Bixley MJ, Reynolds RJ, Saag KG, Fadason T, Golovina E, O'Sullivan JM, Stamp LK, Dalbeth N, Abhishek A, Doherty M, Roddy E, Jacobsson LTH, Kapetanovic MC, Melander O, Andrés M, Pérez-Ruiz F, Torres RJ, Radstake T, Jansen TL, Janssen M, Joosten LAB, Liu R, Gaal OI, Crişan TO, Rednic S, Kurreeman F, Huizinga TWJ, Toes R, Lioté F, Richette P, Bardin T, Ea HK, Pascart T, McCarthy GM, Helbert L, Stibůrková B, Tausche AK, Uhlig T, Vitart V, Boutin TS, Hayward C, Riches PL, Ralston SH, Campbell A, MacDonald TM; FAST Study Group; Nakayama A, Takada T, Nakatochi M, Shimizu S, Kawamura Y, Toyoda Y, Nakaoka H, Yamamoto K, Matsuo K, Shinomiya N, Ichida K; Japan Gout Genomics Consortium; Lee C; Asia Pacific Gout Consortium; Bradbury LA, Brown MA, Robinson PC, Buchanan RRC, Hill CL, Lester S, Smith MD, Rischmueller M, Choi HK, Stahl EA, Miner JN, Solomon DH, Cui J, Giacomini KM, Brackman DJ, Jorgenson EM; GlobalGout Genetics Consortium; Liu H, Susztak K; 23andMe Research Team; Shringarpure S, So A, Okada Y, Li C, Shi Y,… See abstract for full author list ➔ Major TJ, et al. Nat Genet. 2024 Nov;56(11):2392-2406. doi: 10.1038/s41588-024-01921-5. Epub 2024 Oct 15. Nat Genet. 2024. PMID: 39406924
A prioritization scheme identified candidate genes in the inflammatory process of gout, including genes involved in epigenetic remodeling, cell osmolarity and regulation of NOD-like receptor protein 3 (NLRP3) inflammasome activity. Mendelian randomization analysis provided …
A prioritization scheme identified candidate genes in the inflammatory process of gout, including genes involved in epigenetic remodeling, c …
Inhibition of METTL3 Alleviates NLRP3 Inflammasome Activation via Increasing Ubiquitination of NEK7.
Zhou X, Yang X, Huang S, Lin G, Lei K, Wang Q, Lin W, Li H, Qi X, Seriwatanachai D, Yang S, Shao B, Yuan Q. Zhou X, et al. Adv Sci (Weinh). 2024 Jul;11(26):e2308786. doi: 10.1002/advs.202308786. Epub 2024 May 2. Adv Sci (Weinh). 2024. PMID: 38696610 Free PMC article.
Here, it is reported that genetic deletion of Mettl3 alleviates periodontal destruction via suppressing NLRP3 inflammasome activation. Mechanistically, the stability of TNFAIP3 (also known as A20) transcript is significantly attenuated upon m(6)A modification. When silenci …
Here, it is reported that genetic deletion of Mettl3 alleviates periodontal destruction via suppressing NLRP3 inflammasome activation …
201 results