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A new transcriptional variant and small azurophilic granules in an acute promyelocytic leukemia case with NPM1/RARA fusion gene.
Kikuma T, Nakamachi Y, Noguchi Y, Okazaki Y, Shimomura D, Yakushijin K, Yamamoto K, Matsuoka H, Minami H, Itoh T, Kawano S. Kikuma T, et al. Int J Hematol. 2015 Dec;102(6):713-8. doi: 10.1007/s12185-015-1857-2. Epub 2015 Sep 5. Int J Hematol. 2015. PMID: 26342691 Review.
We report here the first case of NPM1/RARA-positive acute promyelocytic leukemia (APL) preceded by myeloid sarcoma (MS) in the vertebra. ...As MS was also diagnosed in two of the seven other reported cases of APL with NPM1/RARA, MS may occur more frequ …
We report here the first case of NPM1/RARA-positive acute promyelocytic leukemia (APL) preceded by myeloid sarcoma (MS) in the …
Current views on the genetic landscape and management of variant acute promyelocytic leukemia.
Zhang X, Sun J, Yu W, Jin J. Zhang X, et al. Biomark Res. 2021 May 6;9(1):33. doi: 10.1186/s40364-021-00284-x. Biomark Res. 2021. PMID: 33957999 Free PMC article. Review.
These results indicated that one great heterogeneity existed in the genetics of variant APL. Among them, only NPM1-RARA, NUMA-RARA, FIP1L1-RARA, IRF2BP2-RARA, and TFG-RARA have been demonstrated to be sensitive to ATRA, so combined chemotherapy rather than different …
These results indicated that one great heterogeneity existed in the genetics of variant APL. Among them, only NPM1-RARA, NUMA- …