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Mechanistic insights and potential therapeutic approaches for NUP98-rearranged hematologic malignancies.
Michmerhuizen NL, Klco JM, Mullighan CG. Michmerhuizen NL, et al. Blood. 2020 Nov 12;136(20):2275-2289. doi: 10.1182/blood.2020007093. Blood. 2020. PMID: 32766874 Free PMC article. Review.
Nucleoporin 98 (NUP98) fusion oncoproteins are observed in a spectrum of hematologic malignancies, particularly pediatric leukemias with poor patient outcomes. Although wild-type full-length NUP98 is a member of the nuclear pore complex, the chromosomal translocatio …
Nucleoporin 98 (NUP98) fusion oncoproteins are observed in a spectrum of hematologic malignancies, particularly pediatric leukemias w …
A Review of Childhood Acute Myeloid Leukemia: Diagnosis and Novel Treatment.
Tseng S, Lee ME, Lin PC. Tseng S, et al. Pharmaceuticals (Basel). 2023 Nov 15;16(11):1614. doi: 10.3390/ph16111614. Pharmaceuticals (Basel). 2023. PMID: 38004478 Free PMC article. Review.
The frequency of each genetic abnormality in adult and childhood AML is different; therefore, in this review, we emphasize well-known genetic subtypes in childhood AML, including core-binding factor AML (CBF AML), KMT2Ar (KMT2A/11q23 rearrangement) AML, normal karyotype AM …
The frequency of each genetic abnormality in adult and childhood AML is different; therefore, in this review, we emphasize well-known …
Acute Myeloid Leukemia in Children: Emerging Paradigms in Genetics and New Approaches to Therapy.
Conneely SE, Stevens AM. Conneely SE, et al. Curr Oncol Rep. 2021 Jan 13;23(2):16. doi: 10.1007/s11912-020-01009-3. Curr Oncol Rep. 2021. PMID: 33439382 Free PMC article. Review.
PURPOSE OF REVIEW: Acute myeloid leukemia (AML) in children remains a challenging disease to cure with suboptimal outcomes particularly when compared to the more common lymphoid leukemias. ...RECENT FINDINGS: Recent studies have revealed an increasing number of mutations, …
PURPOSE OF REVIEW: Acute myeloid leukemia (AML) in children remains a challenging disease to cure with suboptimal outcomes particular …
Prognostic importance of NUP98-rearrangements in acute myeloid leukemia: A systematic review and meta-analysis.
Sheikhi M, Siyadat P, Rostami M, Sadeghian MH, Zahiri E, Ghorbani M, Ayatollahi H, Ayatollahi A, Hemmatan Attarbashi R, Khoshnegah Z. Sheikhi M, et al. Caspian J Intern Med. 2024 Aug 30;15(4):579-588. doi: 10.22088/cjim.15.4.579. eCollection 2024 Fall. Caspian J Intern Med. 2024. PMID: 39359452 Free PMC article. Review.
BACKGROUND: NUP98 gene fusions in acute myeloid leukemia (AML) have recently attracted much interest. ...As a result, this meta-analysis was designed to provide further light on the prognostic implications of NUP98 fusions in AML. METHODS: We completed an extensive …
BACKGROUND: NUP98 gene fusions in acute myeloid leukemia (AML) have recently attracted much interest. ...As a result, this meta-analy …
Therapeutic targeting in pediatric acute myeloid leukemia with aberrant HOX/MEIS1 expression.
Juul-Dam KL, Shukla NN, Cooper TM, Cuglievan B, Heidenreich O, Kolb EA, Rasouli M, Hasle H, Zwaan CM. Juul-Dam KL, et al. Eur J Med Genet. 2023 Dec;66(12):104869. doi: 10.1016/j.ejmg.2023.104869. Epub 2023 Oct 29. Eur J Med Genet. 2023. PMID: 38174649 Free PMC article. Review.
Menin inhibitors disrupt the menin-KMT2A complex in preclinical models of KMT2A-r, NUP98-r and NPM1c acute leukemias and its occupancy at target genes leading to leukemic cell differentiation and apoptosis. ...Menin inhibitors in combination with standard chemotherapy or o …
Menin inhibitors disrupt the menin-KMT2A complex in preclinical models of KMT2A-r, NUP98-r and NPM1c acute leukemias and its occupanc …
Combination of menin and kinase inhibitors as an effective treatment for leukemia with NUP98 translocations.
Miao H, Chen D, Ropa J, Purohit T, Kim E, Sulis ML, Ferrando A, Cierpicki T, Grembecka J. Miao H, et al. Leukemia. 2024 Aug;38(8):1674-1687. doi: 10.1038/s41375-024-02312-9. Epub 2024 Jun 18. Leukemia. 2024. PMID: 38890447 Free PMC article.
The oncogenic activity of NUP98 fusion proteins is dependent on the interaction between Mixed Lineage Leukemia 1 and menin. NUP98-rearranged (NUP98-r) leukemia cells also rely on specific kinases, including CDK6 and/or FLT3, suggesting that simultaneous targe …
The oncogenic activity of NUP98 fusion proteins is dependent on the interaction between Mixed Lineage Leukemia 1 and menin. NUP98 …
NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights.
Gough SM, Slape CI, Aplan PD. Gough SM, et al. Blood. 2011 Dec 8;118(24):6247-57. doi: 10.1182/blood-2011-07-328880. Epub 2011 Sep 26. Blood. 2011. PMID: 21948299 Free PMC article. Review.
Approximately half of the NUP98 fusion partners encode homeodomain proteins, and at least 5 NUP98 fusions involve known histone-modifying genes. Several of the NUP98 fusions, including NUP98-homeobox (HOX)A9, NUP98-HOXD13, and NUP98-JARID …
Approximately half of the NUP98 fusion partners encode homeodomain proteins, and at least 5 NUP98 fusions involve known histon …
HOXA9 Regulome and Pharmacological Interventions in Leukemia.
Aryal S, Lu R. Aryal S, et al. Adv Exp Med Biol. 2024;1459:405-430. doi: 10.1007/978-3-031-62731-6_18. Adv Exp Med Biol. 2024. PMID: 39017854 Review.
HOXA9 expression in leukemia correlates with patient survival outcomes and response to therapy. Chromosomal transformations (such as NUP98-HOXA9), mutations, epigenetic dysregulation (e.g., MLL- MENIN -LEDGF complex or DOT1L/KMT4), transcription factors (such as USF1/USF2) …
HOXA9 expression in leukemia correlates with patient survival outcomes and response to therapy. Chromosomal transformations (such as NUP9 …
Murine Models of Acute Myeloid Leukemia.
Kurtz KJ, Conneely SE, O'Keefe M, Wohlan K, Rau RE. Kurtz KJ, et al. Front Oncol. 2022 Jun 8;12:854973. doi: 10.3389/fonc.2022.854973. eCollection 2022. Front Oncol. 2022. PMID: 35756660 Free PMC article. Review.
The rapid evolution of genetic engineering techniques over the past 20 years has greatly advanced the use of murine models to mirror specific genetic subtypes of human AML, define cell-intrinsic and extrinsic disease mechanisms, study the interaction between co-occurring genetic …
The rapid evolution of genetic engineering techniques over the past 20 years has greatly advanced the use of murine models to mirror specifi …
Nucleoplasmic Nup98 controls gene expression by regulating a DExH/D-box protein.
Capitanio JS, Montpetit B, Wozniak RW. Capitanio JS, et al. Nucleus. 2018 Jan 1;9(1):1-8. doi: 10.1080/19491034.2017.1364826. Epub 2017 Sep 21. Nucleus. 2018. PMID: 28934014 Free PMC article. Review.
The nucleoporin Nup98 has been linked to the regulation of transcription and RNA metabolism, (1-3) but the mechanisms by which Nup98 contributes to these processes remains largely undefined. Recently, we uncovered interactions between Nup98 and several DExH/D …
The nucleoporin Nup98 has been linked to the regulation of transcription and RNA metabolism, (1-3) but the mechanisms by which Nup …
77 results