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Page 1
NUP98 dysregulation in myeloid leukemogenesis.
Moore MA, Chung KY, Plasilova M, Schuringa JJ, Shieh JH, Zhou P, Morrone G. Moore MA, et al. Ann N Y Acad Sci. 2007 Jun;1106:114-42. doi: 10.1196/annals.1392.019. Epub 2007 Apr 18. Ann N Y Acad Sci. 2007. PMID: 17442773 Review.
Expression of NUP98-HOXA9 in murine bone marrow resulted in a myeloproliferative disease progressing to AML by 7-8 months. ...NUP98-HOXA9 upregulated a number of homeobox genes of the A and B cluster as well as MEIS1 and Pim-1, and downmodulated globin …
Expression of NUP98-HOXA9 in murine bone marrow resulted in a myeloproliferative disease progressing to AML by 7-8 months. ... …
NUP98 fusion in human leukemia: dysregulation of the nuclear pore and homeodomain proteins.
Nakamura T. Nakamura T. Int J Hematol. 2005 Jul;82(1):21-7. doi: 10.1532/IJH97.04160. Int J Hematol. 2005. PMID: 16105755 Review.
Recent studies using mouse models expressing NUP98-HOX have confirmed its leukemogenic potential, and cooperative genes for NUP98-HOXA9 in leukemogenesis have been identified in these studies.Thus, the NUP98 chimera is a unique molecule that provides valuable inform …
Recent studies using mouse models expressing NUP98-HOX have confirmed its leukemogenic potential, and cooperative genes for NUP98- …
HOXA9 Regulome and Pharmacological Interventions in Leukemia.
Aryal S, Lu R. Aryal S, et al. Adv Exp Med Biol. 2024;1459:405-430. doi: 10.1007/978-3-031-62731-6_18. Adv Exp Med Biol. 2024. PMID: 39017854 Review.
HOXA9 expression in leukemia correlates with patient survival outcomes and response to therapy. Chromosomal transformations (such as NUP98-HOXA9), mutations, epigenetic dysregulation (e.g., MLL- MENIN -LEDGF complex or DOT1L/KMT4), transcription factors (such as USF …
HOXA9 expression in leukemia correlates with patient survival outcomes and response to therapy. Chromosomal transformations (such as NUP9 …
Retroviral insertional mutagenesis identifies oncogene cooperation.
Nakamura T. Nakamura T. Cancer Sci. 2005 Jan;96(1):7-12. doi: 10.1111/j.1349-7006.2005.00011.x. Cancer Sci. 2005. PMID: 15649248 Free PMC article. Review.
The use of genetically engineered mice such as NUP98-HOXA9 transgenic mice enabled efficient identification of cooperative genes, which provides important information for the molecular pathway in carcinogenesis/leukemogenesis. ...
The use of genetically engineered mice such as NUP98-HOXA9 transgenic mice enabled efficient identification of cooperative gen …
Chromosome t(7;11)(p15;p15) translocation in acute myeloid leukemia coexisting with multilineage dyspoiesis and mutations in NRAS and WT1: A case report and literature review.
Yang J, Lyu X, Zhu X, Meng X, Zuo W, Ai H, Deng M. Yang J, et al. Oncol Lett. 2017 May;13(5):3066-3070. doi: 10.3892/ol.2017.5823. Epub 2017 Mar 7. Oncol Lett. 2017. PMID: 28521413 Free PMC article.
The chromosomal translocation t(7;11)(p15;p15) and the resulting nucleoporin 98-homeobox A9 (NUP98-HOXA9) gene fusion is rare but recurrent genetic abnormity in acute myeloid leukemia (AML). ...Subsequent molecular and sequencing analysis demonstrated a NUP98 …
The chromosomal translocation t(7;11)(p15;p15) and the resulting nucleoporin 98-homeobox A9 (NUP98-HOXA9) gene fusion is rare …
Converging pathways in leukemogenesis and stem cell self-renewal.
Moore MA. Moore MA. Exp Hematol. 2005 Jul;33(7):719-37. doi: 10.1016/j.exphem.2005.04.011. Exp Hematol. 2005. PMID: 15963848 Free article. Review.
Translocations resulting in development of oncogenic fusion genes are found in AML and the transforming potential of two of these, AML1-ETO and NUP98-HOXA9, will be discussed. Secondary, constitutively activating mutations of the Flt3 and c-kit receptors and of K- a …
Translocations resulting in development of oncogenic fusion genes are found in AML and the transforming potential of two of these, AML1-ETO …
Pathobiological aspects of the local bone marrow renin-angiotensin system: a review.
Haznedaroglu IC, Beyazit Y. Haznedaroglu IC, et al. J Renin Angiotensin Aldosterone Syst. 2010 Dec;11(4):205-13. doi: 10.1177/1470320310379876. Epub 2010 Aug 31. J Renin Angiotensin Aldosterone Syst. 2010. PMID: 20807797 Free article. Review.
The presence of ACE on leukaemic blast cells within leukaemic BM, on erythroleukaemic cells, ACE-expressing macrophages in lymph nodes of Hodgkin disease, renin activity in leukaemic blasts, angiotensin II as an autocrine growth factor for AML, increased renin gene activity durin …
The presence of ACE on leukaemic blast cells within leukaemic BM, on erythroleukaemic cells, ACE-expressing macrophages in lymph nodes of Ho …
NUP98 gene rearrangements and the clonal evolution of chronic myelogenous leukemia.
Ahuja HG, Popplewell L, Tcheurekdjian L, Slovak ML. Ahuja HG, et al. Genes Chromosomes Cancer. 2001 Apr;30(4):410-5. doi: 10.1002/1098-2264(2001)9999:9999<::aid-gcc1108>3.0.co;2-9. Genes Chromosomes Cancer. 2001. PMID: 11241795 Review.
As expected, analysis of the t(7;11)(p15;p15) from one of the patients showed an in-frame NUP98-HOXA9 fusion. The fusion points were similar to previously reported NUP98-HOXA9 fusion points from patients with MDS/AML. ...
As expected, analysis of the t(7;11)(p15;p15) from one of the patients showed an in-frame NUP98-HOXA9 fusion. The fusion point …