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2022 3
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Diagnostic challenges and management advances in cytochrome P450 oxidoreductase deficiency, a rare form of congenital adrenal hyperplasia, with 46, XX karyotype.
Wang C, Tian Q. Wang C, et al. Front Endocrinol (Lausanne). 2023 Aug 11;14:1226387. doi: 10.3389/fendo.2023.1226387. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37635957 Free PMC article. Review.
Cytochrome P450 oxidoreductase deficiency (PORD) is a rare form of congenital adrenal hyperplasia that can manifest with skeletal malformations, ambiguous genitalia, and menstrual disorders caused by cytochrome P450 oxidoreductase (POR) mutations affec …
Cytochrome P450 oxidoreductase deficiency (PORD) is a rare form of congenital adrenal hyperplasia that can manifest with skele …
ACSM5 Regulates Ferroptosis in Hepatocellular Carcinoma by Up-Regulating POR and Modulating Lipid Metabolism.
Wu Z, Xiong X, Dong M, Luo L, Huang Z, Xu K, Zhao L, Wang F, Wen Z. Wu Z, et al. Cancer Sci. 2025 Aug;116(8):2125-2136. doi: 10.1111/cas.70115. Epub 2025 Jun 2. Cancer Sci. 2025. PMID: 40457725 Free PMC article.
Furthermore, ACSM5 promoted the upregulation of cytochrome P450 oxidoreductase (POR). Knocking down POR blocked the promoting effect of ACSM5 on ferroptosis in HCC. ...
Furthermore, ACSM5 promoted the upregulation of cytochrome P450 oxidoreductase (POR). Knocking down POR blocked the promoting …
Bacterial expression, purification, and characterization of human cytochrome P450 3A4 without N-terminal modifications.
Sun Y, Osawa Y, Zhang H. Sun Y, et al. Arch Biochem Biophys. 2024 Dec;762:110208. doi: 10.1016/j.abb.2024.110208. Epub 2024 Nov 8. Arch Biochem Biophys. 2024. PMID: 39522857 Free PMC article.
In addition, it was found that the 6beta-hydroxylase activity of CYP3A4 WT was less dependent on excess cytochrome P450 oxidoreductase (POR), compared with CYP3A4-NF14. These results suggest that the N-terminal membrane anchor of CYP3A4 WT enhances its interactions …
In addition, it was found that the 6beta-hydroxylase activity of CYP3A4 WT was less dependent on excess cytochrome P450 oxidoreduc …
Rare forms of congenital adrenal hyperplasia: pathogenesis, clinical, treatment and management.
Cavarzere P, Lupieri V, Battiston R, Mancioppi V, Maffeis C. Cavarzere P, et al. J Endocrinol Invest. 2026 Mar;49(3):493-507. doi: 10.1007/s40618-025-02750-x. Epub 2025 Dec 29. J Endocrinol Invest. 2026. PMID: 41460453 Review.
These disorders are 11beta-hydroxylase deficiency (11betaOHD); 17alpha-hydroxylase/17,20-lyase deficiency (17OHD); 3beta-hydroxysteroid dehydrogenase type 2 deficiency (3betaHSD2D); P450 oxidoreductase deficiency (PORD); steroidogenic acute regulatory protein (StAR) …
These disorders are 11beta-hydroxylase deficiency (11betaOHD); 17alpha-hydroxylase/17,20-lyase deficiency (17OHD); 3beta-hydroxysteroid dehy …
Effects of CYP3A4*22 and POR*28 variations on the pharmacokinetics of tacrolimus in renal transplant recipients: a meta-analysis of 18 observational studies.
Li Z, Wang X, Li D, Cheng S, Li Z, Guo H, Dong Y, Zheng Y, Li X. Li Z, et al. BMC Nephrol. 2024 Feb 6;25(1):48. doi: 10.1186/s12882-024-03467-4. BMC Nephrol. 2024. PMID: 38321419 Free PMC article.
PURPOSE: This study aimed to investigate the association between cytochrome P450 (CYP) 3A4*22 and cytochrome P450 oxidoreductase (POR)*28 variations and the pharmacokinetics of tacrolimus. METHODS: Cochrane Central Register of Controlled Trials (CENTRAL), Web of Sci …
PURPOSE: This study aimed to investigate the association between cytochrome P450 (CYP) 3A4*22 and cytochrome P450 oxidoreductase …
Clinical Characteristics and Molecular Aetiology of Cytochrome P450 Oxidoreductase Deficiency Diagnosed in 46,XX Patients.
Zhang D, Ding L, Deng S, Tian Q. Zhang D, et al. Reprod Sci. 2025 Jul;32(7):2474-2483. doi: 10.1007/s43032-025-01878-8. Epub 2025 Jun 18. Reprod Sci. 2025. PMID: 40533672
P450 oxidoreductase deficiency (PORD) affects cytochrome enzyme activities, causing various symptoms, such as adrenal insufficiency, disorders of sex development and skeletal malformations. ...
P450 oxidoreductase deficiency (PORD) affects cytochrome enzyme activities, causing various symptoms, such as adrenal insuffic …
Impacts of pregnane X receptor and cytochrome P450 oxidoreductase gene polymorphisms on trough concentrations of apixaban in patients with non-valvular atrial fibrillation.
Nakagawa J, Kinjo T, Aiuchi N, Ueno K, Tomita H, Niioka T. Nakagawa J, et al. Eur J Clin Pharmacol. 2023 Jan;79(1):127-135. doi: 10.1007/s00228-022-03424-w. Epub 2022 Nov 18. Eur J Clin Pharmacol. 2023. PMID: 36399204
PURPOSE: We examined the impact of polymorphisms in genes encoding cytochrome P450 (CYP) 3A5 (gene code CYP3A5), P-glycoprotein (ABCB1), breast cancer resistance protein (ABCG2), cytochrome P450 oxidoreductase (POR), and pregnane X receptor (PXR; NR1I2) on the daily …
PURPOSE: We examined the impact of polymorphisms in genes encoding cytochrome P450 (CYP) 3A5 (gene code CYP3A5), P-glycoprotein (ABCB1), bre …
The Potential Role of POR*28 and CYP1A2*F Genetic Variations and Lifestyle Factors on Clozapine and N-DesmethylClozapine Plasma Levels in Schizophrenia Patients.
Demirbugen Oz M, Ozdemir F, Tok KC, Dural E, Kir Y, Ulusoy M, Gumustas M, Baskak B, Suzen HS. Demirbugen Oz M, et al. Expert Opin Drug Metab Toxicol. 2023 Jan-Jun;19(5):319-327. doi: 10.1080/17425255.2023.2221849. Epub 2023 Jun 8. Expert Opin Drug Metab Toxicol. 2023. PMID: 37269349
RESEARCH DESIGN AND METHODS: As the potential role in CLZ metabolism is assigned to CYP1A2 enzyme and consequently Cytochrome P450 oxidoreductase (POR) their genetic variations might help to determine CLZ levels in schizophrenia patients. ...
RESEARCH DESIGN AND METHODS: As the potential role in CLZ metabolism is assigned to CYP1A2 enzyme and consequently Cytochrome P450 …
Computational identification and analysis of deleterious non-synonymous single nucleotide polymorphisms (nsSNPs) in the human POR gene: a structural and functional impact.
Kumar R, Jayaraman M, Ramadas K, Chandrasekaran A. Kumar R, et al. J Biomol Struct Dyn. 2024 Feb-Mar;42(3):1518-1532. doi: 10.1080/07391102.2023.2211674. Epub 2023 May 12. J Biomol Struct Dyn. 2024. PMID: 37173831
Cytochrome P450 oxidoreductase (POR) protein is essential for steroidogenesis, and POR gene mutations are frequently associated with P450 Oxidoreductase Deficiency (PORD), a disorder of hormone production. ...The consolidated insights from the computat …
Cytochrome P450 oxidoreductase (POR) protein is essential for steroidogenesis, and POR gene mutations are frequently associate …
23 results