Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2007 1
2017 1
2018 4
2019 4
2020 3
2021 2
2022 4
2023 2
2024 2

Text availability

Article attribute

Article type

Publication date

Search Results

17 results

Results by year

Filters applied: . Clear all
Page 1
Potential of PAQosome as a therapeutic target for hepatic fibrosis.
Shi L, Feng G, Yang X, Zhang Y, Zhang Y, Cheng J, Lin S. Shi L, et al. J Gastroenterol Hepatol. 2024 Feb;39(2):381-391. doi: 10.1111/jgh.16427. Epub 2023 Nov 28. J Gastroenterol Hepatol. 2024. PMID: 38016755
RESULTS: We screened and proved that several subunits of the PAQosome regulate the development of liver fibrosis, including the asparagine synthetase domain-containing 1 upstream open reading frame (ASDURF), prefoldin subunit 4 (PFDN4), prefoldin subunit 5 (PFDN5), unconve …
RESULTS: We screened and proved that several subunits of the PAQosome regulate the development of liver fibrosis, including the aspar …
Biallelic pathogenic variants in POLR3D alter tRNA transcription and cause a hypomyelinating leukodystrophy: A case report.
Macintosh J, Perrier S, Pinard M, Tran LT, Guerrero K, Prasad C, Prasad AN, Pastinen T, Thiffault I, Coulombe B, Bernard G. Macintosh J, et al. Front Neurol. 2023 Oct 13;14:1254140. doi: 10.3389/fneur.2023.1254140. eCollection 2023. Front Neurol. 2023. PMID: 37915380 Free PMC article.
Functional studies of the patient's fibroblasts demonstrated significantly decreased RNA-level expression of POLR3D, along with reduced expression of other Pol III subunit genes. Notably, Pol III transcription was also shown to be aberrant, with a significant decrease in …
Functional studies of the patient's fibroblasts demonstrated significantly decreased RNA-level expression of POLR3D, along with reduced expr …
Drugs targeting the particle for arrangement of quaternary structure (PAQosome) and protein complex assembly.
Pinard M, Moursli A, Coulombe B. Pinard M, et al. Expert Opin Drug Discov. 2024 Jan-Jun;19(1):57-71. doi: 10.1080/17460441.2023.2267974. Epub 2024 Jan 8. Expert Opin Drug Discov. 2024. PMID: 37840283 Review.
Indeed, a number of compounds are currently being tested for the development of treatments against diseases, such as cancers and neurodegenerative conditions. EXPERT OPINION: Searching for new drugs targeting the PAQosome requires a better understanding of PAQosome …
Indeed, a number of compounds are currently being tested for the development of treatments against diseases, such as cancers and neurodegene …
Riluzole partially restores RNA polymerase III complex assembly in cells expressing the leukodystrophy-causative variant POLR3B R103H.
Pinard M, Dastpeyman S, Poitras C, Bernard G, Gauthier MS, Coulombe B. Pinard M, et al. Mol Brain. 2022 Nov 30;15(1):98. doi: 10.1186/s13041-022-00974-z. Mol Brain. 2022. PMID: 36451185 Free PMC article.
The mechanism of assembly of RNA polymerase III (Pol III), the 17-subunit enzyme that synthesizes tRNAs, 5 S rRNA, and other small-nuclear (sn) RNAs in eukaryotes, is not clearly understood. The recent discovery of the HSP90 co-chaperone PAQosome (Particle for Arrangement …
The mechanism of assembly of RNA polymerase III (Pol III), the 17-subunit enzyme that synthesizes tRNAs, 5 S rRNA, and other small-nuclear ( …
The Role of Hsp90-R2TP in Macromolecular Complex Assembly and Stabilization.
Lynham J, Houry WA. Lynham J, et al. Biomolecules. 2022 Jul 28;12(8):1045. doi: 10.3390/biom12081045. Biomolecules. 2022. PMID: 36008939 Free PMC article. Review.
Hsp90-R2TP acts through several mechanisms, such as by controlling the transcription of protein complex subunits, stabilizing protein subcomplexes before their incorporation into the entire complex, and by recruiting adaptors that facilitate complex assembly. …
Hsp90-R2TP acts through several mechanisms, such as by controlling the transcription of protein complex subunits, stabilizing …
Unphosphorylated Form of the PAQosome Core Subunit RPAP3 Binds Ribosomal Preassembly Complexes to Modulate Ribosome Biogenesis.
Pinard M, Cloutier P, Poitras C, Gauthier MS, Coulombe B. Pinard M, et al. J Proteome Res. 2022 Apr 1;21(4):1073-1082. doi: 10.1021/acs.jproteome.1c00938. Epub 2022 Feb 7. J Proteome Res. 2022. PMID: 35129352
The PAQosome (particle for arrangement of quaternary structure) is a 12-subunit HSP90 co-chaperone involved in the biogenesis of several human protein complexes. ...Here, we describe a third client selection mechanism by showing that RPAP3, one of the core …
The PAQosome (particle for arrangement of quaternary structure) is a 12-subunit HSP90 co-chaperone involved in the biogenesis of seve …
Assembly principles of the human R2TP chaperone complex reveal the presence of R2T and R2P complexes.
Seraphim TV, Nano N, Cheung YWS, Aluksanasuwan S, Colleti C, Mao YQ, Bhandari V, Young G, Höll L, Phanse S, Gordiyenko Y, Southworth DR, Robinson CV, Thongboonkerd V, Gava LM, Borges JC, Babu M, Barbosa LRS, Ramos CHI, Kukura P, Houry WA. Seraphim TV, et al. Structure. 2022 Jan 6;30(1):156-171.e12. doi: 10.1016/j.str.2021.08.002. Epub 2021 Sep 6. Structure. 2022. PMID: 34492227 Free article.
NOPCHAP1 is a PAQosome cofactor that helps loading NOP58 on RUVBL1/2 during box C/D snoRNP biogenesis.
Abel Y, Paiva ACF, Bizarro J, Chagot ME, Santo PE, Robert MC, Quinternet M, Vandermoere F, Sousa PMF, Fort P, Charpentier B, Manival X, Bandeiras TM, Bertrand E, Verheggen C. Abel Y, et al. Nucleic Acids Res. 2021 Jan 25;49(2):1094-1113. doi: 10.1093/nar/gkaa1226. Nucleic Acids Res. 2021. PMID: 33367824 Free PMC article.
Among the main PAQosome clients are C/D snoRNPs and in particular their core protein NOP58. ...Interestingly, NOPCHAP1 interaction with RUVBL1/2 is disrupted upon ATP binding. Moreover, while it robustly binds both yeast and human NOP58, it makes littl …
Among the main PAQosome clients are C/D snoRNPs and in particular their core protein NOP58. ...Interestingly, NOPCHAP1 inte …
R2TP/PAQosome as a promising chemotherapeutic target in cancer.
Kakihara Y, Kiguchi T, Ohazama A, Saeki M. Kakihara Y, et al. Jpn Dent Sci Rev. 2020 Dec;56(1):38-42. doi: 10.1016/j.jdsr.2019.08.001. Epub 2019 Dec 11. Jpn Dent Sci Rev. 2020. PMID: 31890057 Free PMC article. Review.
R2TP/PAQosome (particle for arrangement of quaternary structure) is a novel multisubunit chaperone specialized in the assembly/maturation of protein complexes that are involved in essential cellular processes such as PIKKs (phosphatidylinositol 3-kinase-like kinases …
R2TP/PAQosome (particle for arrangement of quaternary structure) is a novel multisubunit chaperone specialized in the assembly/matura …
RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer.
Yenerall P, Das AK, Wang S, Kollipara RK, Li LS, Villalobos P, Flaming J, Lin YF, Huffman K, Timmons BC, Gilbreath C, Sonavane R, Kinch LN, Rodriguez-Canales J, Moran C, Behrens C, Hirasawa M, Takata T, Murakami R, Iwanaga K, Chen BPC, Grishin NV, Raj GV, Wistuba II, Minna JD, Kittler R. Yenerall P, et al. Cell Chem Biol. 2020 Jan 16;27(1):105-121.e14. doi: 10.1016/j.chembiol.2019.12.005. Epub 2019 Dec 26. Cell Chem Biol. 2020. PMID: 31883965 Free PMC article.
Utilizing a specific inhibitor of RUVBL1/2 ATPase activity, we show that RUVBL1/2 ATPase activity is necessary for the maturation or dissociation of the PAQosome, a large RUVBL1/2-dependent multiprotein complex. We also show that RUVBL1/2 have roles in DNA replication, as …
Utilizing a specific inhibitor of RUVBL1/2 ATPase activity, we show that RUVBL1/2 ATPase activity is necessary for the maturation or dissoci …
17 results