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2023 11
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Page 1
Avian infectious bronchitis virus (AIBV) review by continent.
Rafique S, Jabeen Z, Pervaiz T, Rashid F, Luo S, Xie L, Xie Z. Rafique S, et al. Front Cell Infect Microbiol. 2024 Feb 5;14:1325346. doi: 10.3389/fcimb.2024.1325346. eCollection 2024. Front Cell Infect Microbiol. 2024. PMID: 38375362 Free PMC article. Review.
GIV was found to circulate in Asia, and GVII was identified in Europe and China. Geographically, the GVI-1 lineage is thought to be restricted to Asia. This review highlights that IBV still often arises in commercial chicken flocks despite immunization and biosecurity meas …
GIV was found to circulate in Asia, and GVII was identified in Europe and China. Geographically, the GVI-1 lineage is thought to be r …
The role of the PLA2G6 gene in neurodegenerative diseases.
Deng X, Yuan L, Jankovic J, Deng H. Deng X, et al. Ageing Res Rev. 2023 Aug;89:101957. doi: 10.1016/j.arr.2023.101957. Epub 2023 May 24. Ageing Res Rev. 2023. PMID: 37236368 Review.
PLA2G6-associated neurodegeneration (PLAN) represents a continuum of clinically and genetically heterogeneous neurodegenerative disorders with overlapping features. ...In this review, we discuss PLA2G6 gene structure and protein, functional findings, genetic deficie …
PLA2G6-associated neurodegeneration (PLAN) represents a continuum of clinically and genetically heterogeneous neurodegenerative disor …
Phenotypic and genetic analysis of children with unexplained neurodevelopmental delay and neurodevelopmental comorbidities in a Chinese cohort using trio-based whole-exome sequencing.
Wu R, Li X, Meng Z, Li P, He Z, Liang L. Wu R, et al. Orphanet J Rare Dis. 2024 May 19;19(1):205. doi: 10.1186/s13023-024-03214-w. Orphanet J Rare Dis. 2024. PMID: 38764027 Free PMC article.
By literature review and constructing protein-protein interaction networks among these 9 candidate ASD-risk genes and 102 established ASD genes obtained from the SFARI Gene database, we identified CUL4B, KCNH1, and PLA2G6 as novel possible ASD-risk genes underlying genetic …
By literature review and constructing protein-protein interaction networks among these 9 candidate ASD-risk genes and 102 established ASD ge …
Parkinson's Disease Gene Screening in Familial Cases from Central and South America.
Lorenzo-Betancor O, Mehta S, Ramchandra J, Mumuney S, Schumacher-Schuh AF, Cornejo-Olivas M, Sarapura-Castro EH, Torres L, Inca-Martinez MA, Mazzetti P, Cosentino C, Micheli F, Tumas V, Dieguez E, Raggio V, Borges V, Ferraz HB, Chana-Cuevas P, Jimenez-Del-Rio M, Velez-Pardo C, Moreno S, Lopera F, Orozco-Velez JL, Muñoz-Ospina B, Rieder CRM, Medina-Escobar A, Yearout D, Zabetian CP, Mata IF; Latin American Research Consortium on the Genetics of PD (LARGE‐PD). Lorenzo-Betancor O, et al. Mov Disord. 2024 Oct;39(10):1843-1855. doi: 10.1002/mds.29931. Epub 2024 Jul 25. Mov Disord. 2024. PMID: 39051491 Free PMC article.
RESULTS: We identified pathogenic variants in 41 individuals (12.7%) in FBXO7, GCH1, LRRK2, PARK7, PINK1, PLA2G6, PRKN, SNCA, and TARDBP, GBA1 risk variants in 25 individuals (7.7%), and variants of uncertain significance in another 24 individuals (7.4%) in ATP13A2, ATP1A3 …
RESULTS: We identified pathogenic variants in 41 individuals (12.7%) in FBXO7, GCH1, LRRK2, PARK7, PINK1, PLA2G6, PRKN, SNCA, and TAR …
Genome-wide discovery and integrative genomic characterization of insulin resistance loci using serum triglycerides to HDL-cholesterol ratio as a proxy.
DeForest N, Wang Y, Zhu Z, Dron JS, Koesterer R, Natarajan P, Flannick J, Amariuta T, Peloso GM, Majithia AR. DeForest N, et al. Nat Commun. 2024 Sep 14;15(1):8068. doi: 10.1038/s41467-024-52105-y. Nat Commun. 2024. PMID: 39277575 Free PMC article.
We highlight two phospholipase encoding genes, PLA2G12A and PLA2G6, which liberate arachidonic acid and improve insulin sensitivity, and VGLL3, a transcriptional co-factor that increases insulin resistance partially through enhanced adiposity. ...
We highlight two phospholipase encoding genes, PLA2G12A and PLA2G6, which liberate arachidonic acid and improve insulin sensitivity, …
Lp-PLA2 Activity and Genotype-Guided Dual Antiplatelet Therapy in Minor Stroke or Transient Ischemic Attack.
Lin J, Zhou H, Wang Y, Jin A, Li S, Zhang L, Meng X, Xie X, Jing J, Jiang Y, Wang Y, Zhao X, Li H, Li Z, Wang Y; CHANCE-2 Investigators. Lin J, et al. Stroke. 2026 Apr;57(4):890-896. doi: 10.1161/STROKEAHA.125.052954. Epub 2026 Jan 13. Stroke. 2026. PMID: 41527826 Free PMC article. Clinical Trial.
BACKGROUND: Lp-PLA2 (lipoprotein-associated phospholipase A2) is a sensitive biomarker of vascular inflammation and atherosclerosis. ...The P value was 0.45 for the treatment Lp-PLA2 activity interaction effect on stroke recurrence. The risk of bleeding associated …
BACKGROUND: Lp-PLA2 (lipoprotein-associated phospholipase A2) is a sensitive biomarker of vascular inflammation and atherosclerosis. …
MSI1 Accelerates Prostate Cancer Cell Proliferation, Migration and Glycolysis by Promoting ABHD2 Transcription.
Huang D, Zheng Q, Zhou L. Huang D, et al. Biochem Genet. 2026 Feb;64(1):1146-1160. doi: 10.1007/s10528-025-11079-2. Epub 2025 Mar 11. Biochem Genet. 2026. PMID: 40067652
Glucose uptake and lactate production were assessed to measure cell glycolysis. The interaction between SP1 and PLA2G6 was evaluated using dual-luciferase reporter assay and ChIP assay. MSI1 had increased expression in PCa tissues and cells. ...
Glucose uptake and lactate production were assessed to measure cell glycolysis. The interaction between SP1 and PLA2G6 was evaluated …
Combining optical genome mapping and RNA-seq for structural variants detection and interpretation in unsolved neurodevelopmental disorders.
Xiao B, Luo X, Liu Y, Ye H, Liu H, Fan Y, Yu Y. Xiao B, et al. Genome Med. 2024 Sep 19;16(1):113. doi: 10.1186/s13073-024-01382-9. Genome Med. 2024. PMID: 39300495 Free PMC article.
This combined approach solved three cases-two cases with de novo SVs in genes associated with autosomal dominant NDDs, including a deletion encompassing the promoter and 5'UTR of MBD5 and an intragenic duplication of PAFAH1B1, and a third case possessing an intragenic duplication …
This combined approach solved three cases-two cases with de novo SVs in genes associated with autosomal dominant NDDs, including a deletion …
A systematic analysis of genotype-phenotype associations with PLA2G6.
Xue J, Ding DX, Xu GY, Wang PZ, Ge YL, Zhang JR, Cheng XY, Wang YM, Jin H, Luo SY, Zheng YH, Chen J, Wang F, Li D, Mao CJ, Li K, Liu CF. Xue J, et al. Parkinsonism Relat Disord. 2023 Jul;112:105477. doi: 10.1016/j.parkreldis.2023.105477. Epub 2023 Jun 1. Parkinsonism Relat Disord. 2023. PMID: 37285793
BACKGROUND: PLA2G6-associated neurodegeneration (PLAN) can be categorized into infantile neuroaxonal dystrophy (INAD), atypical neuroaxonal dystrophy (aNAD), neurodegeneration with brain iron accumulation (NBIA), and early-onset parkinsonism (EOP). OBJECTIVES: To determine …
BACKGROUND: PLA2G6-associated neurodegeneration (PLAN) can be categorized into infantile neuroaxonal dystrophy (INAD), atypical neuro …
54 results