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148 results

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Page 1
Acute promyelocytic leukemia current treatment algorithms.
Yilmaz M, Kantarjian H, Ravandi F. Yilmaz M, et al. Blood Cancer J. 2021 Jun 30;11(6):123. doi: 10.1038/s41408-021-00514-3. Blood Cancer J. 2021. PMID: 34193815 Free PMC article. Review.
APL, accounting for 10-15% of the newly diagnosed AML cases, results from a balanced translocation, t(15;17) (q22;q12-21), which leads to the fusion of the promyelocytic leukemia (PML) gene with the retinoic acid receptor alpha (RARA) gene. The PML-RARA fusion oncop …
APL, accounting for 10-15% of the newly diagnosed AML cases, results from a balanced translocation, t(15;17) (q22;q12-21), which leads to th …
Function of PML-RARA in Acute Promyelocytic Leukemia.
Testa U, Pelosi E. Testa U, et al. Adv Exp Med Biol. 2024;1459:321-339. doi: 10.1007/978-3-031-62731-6_14. Adv Exp Med Biol. 2024. PMID: 39017850 Review.
APL is a paradigm for oncoprotein-targeted cure.APL is caused by a 15/17 chromosomal translocation which generates the PML-RARA fusion protein and can be cured by the chemotherapy-free approach based on the combination of two therapies targeting PML-RARA …
APL is a paradigm for oncoprotein-targeted cure.APL is caused by a 15/17 chromosomal translocation which generates the PML-RARA …
Genotypic and Phenotypic Characteristics of Acute Promyelocytic Leukemia Translocation Variants.
Mannan A, Muhsen IN, Barragán E, Sanz MA, Mohty M, Hashmi SK, Aljurf M. Mannan A, et al. Hematol Oncol Stem Cell Ther. 2020 Dec;13(4):189-201. doi: 10.1016/j.hemonc.2020.05.007. Epub 2020 May 20. Hematol Oncol Stem Cell Ther. 2020. PMID: 32473106 Free article. Review.
The majority of APL cases are characterized by the fusion gene PML-RARA. Although the PML-RARA fusion gene can be detected in almost all APL cases, translocation variants of APL have been reported. To date, this is the most comprehensive review …
The majority of APL cases are characterized by the fusion gene PML-RARA. Although the PML-RARA fusion gene can b …
Acute Promyelocytic Leukemia: A Constellation of Molecular Events around a Single PML-RARA Fusion Gene.
Liquori A, Ibañez M, Sargas C, Sanz MÁ, Barragán E, Cervera J. Liquori A, et al. Cancers (Basel). 2020 Mar 8;12(3):624. doi: 10.3390/cancers12030624. Cancers (Basel). 2020. PMID: 32182684 Free PMC article. Review.
Although acute promyelocytic leukemia (APL) is one of the most characterized forms of acute myeloid leukemia (AML), the molecular mechanisms involved in the development and progression of this disease are still a matter of study. APL is defined by the PML-RARA rearr …
Although acute promyelocytic leukemia (APL) is one of the most characterized forms of acute myeloid leukemia (AML), the molecular mechanisms …
Therapy-induced PML/RARA proteolysis and acute promyelocytic leukemia cure.
Nasr R, Lallemand-Breitenbach V, Zhu J, Guillemin MC, de Thé H. Nasr R, et al. Clin Cancer Res. 2009 Oct 15;15(20):6321-6. doi: 10.1158/1078-0432.CCR-09-0209. Epub 2009 Oct 6. Clin Cancer Res. 2009. PMID: 19808868 Review.
Cyclic AMP triggered PML/RARA phosphorylation also enhances RA-induced APL regression, PML/RARA degradation, and LIC clearance, raising new options for therapy-resistant patients. Although differentiation has a major role in debulking of the tumor, …
Cyclic AMP triggered PML/RARA phosphorylation also enhances RA-induced APL regression, PML/RARA degradation, and …
Acute promyelocytic leukemia (APL): a review of the literature.
Jimenez JJ, Chale RS, Abad AC, Schally AV. Jimenez JJ, et al. Oncotarget. 2020 Mar 17;11(11):992-1003. doi: 10.18632/oncotarget.27513. eCollection 2020 Mar 17. Oncotarget. 2020. PMID: 32215187 Free PMC article. Review.
A characteristic balanced chromosomal translocation between chromosomes 15 and 17 t (15;17) (q24; q21) is seen in 95% of cases - the translocation results in the formation of the PML-RARA fusion protein. The introduction of retinoic acid (RA) and arsenic trioxide (A …
A characteristic balanced chromosomal translocation between chromosomes 15 and 17 t (15;17) (q24; q21) is seen in 95% of cases - the translo …
Utilization of RT-PCR and Optical Genome Mapping in Acute Promyelocytic Leukemia with Cryptic PML::RARA Rearrangement: A Case Discussion and Systemic Literature Review.
George GV, Elsadawi M, Evans AG, Ali S, Zhang B, Iqbal MA. George GV, et al. Genes (Basel). 2024 Dec 25;16(1):7. doi: 10.3390/genes16010007. Genes (Basel). 2024. PMID: 39858554 Free PMC article.
RESULTS: RT-PCR revealed a cryptic PML::RARA fusion transcript. OGM further confirmed the nature and orientation of a cryptic rearrangement with an insertion of RARA into PML at intron 3 (bcr3). In light of these findings, we performed a systematic literature rev …
RESULTS: RT-PCR revealed a cryptic PML::RARA fusion transcript. OGM further confirmed the nature and orientation of a cryptic …
RARA and PML genes in acute promyelocytic leukemia.
Chen Z, Chen SJ. Chen Z, et al. Leuk Lymphoma. 1992 Nov;8(4-5):253-60. doi: 10.3109/10428199209051004. Leuk Lymphoma. 1992. PMID: 1337847 Review.
Molecular cloning and sequence analysis of the PML gene demonstrated a complex splicing pattern and this gene may encode a transcription factor. Different isoforms of the PML-RARA fusion transcripts were discovered which are produced as a result of distinct PML gene …
Molecular cloning and sequence analysis of the PML gene demonstrated a complex splicing pattern and this gene may encode a transcription fac …
Synergy against PML-RARa: targeting transcription, proteolysis, differentiation, and self-renewal in acute promyelocytic leukemia.
Dos Santos GA, Kats L, Pandolfi PP. Dos Santos GA, et al. J Exp Med. 2013 Dec 16;210(13):2793-802. doi: 10.1084/jem.20131121. J Exp Med. 2013. PMID: 24344243 Free PMC article. Review.
Acute promyelocytic leukemia (APL) is a hematological malignancy driven by a chimeric oncoprotein containing the C terminus of the retinoic acid receptor-a (RARa) fused to an N-terminal partner, most commonly promyelocytic leukemia protein (PML). Mechanistically, PML-RA …
Acute promyelocytic leukemia (APL) is a hematological malignancy driven by a chimeric oncoprotein containing the C terminus of the retinoic …
Typical, atypical and cryptic t(15;17)(q24;q21) (PML::RARA) observed in acute promyelocytic leukemia: A retrospective review of 831 patients with concurrent chromosome and PML::RARA dual-color dual-fusion FISH studies.
Gagnon MF, Berg HE, Meyer RG, Sukov WR, Van Dyke DL, Jenkins RB, Greipp PT, Thorland EC, Hoppman NL, Xu X, Baughn LB, Reichard KK, Ketterling RP, Peterson JF. Gagnon MF, et al. Genes Chromosomes Cancer. 2022 Oct;61(10):629-634. doi: 10.1002/gcc.23070. Epub 2022 Jun 10. Genes Chromosomes Cancer. 2022. PMID: 35639830
The diagnosis of acute promyelocytic leukemia (APL) relies on the identification of PML::RARA fusion. While the majority of APL cases harbor a typical t(15;17)(q24;q21), atypical genetic mechanisms leading to the oncogenic PML::RARA fusion have been re …
The diagnosis of acute promyelocytic leukemia (APL) relies on the identification of PML::RARA fusion. While the majority of AP …
148 results