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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1992 3
1993 1
1994 1
1996 3
1999 2
2000 5
2003 2
2004 1
2006 3
2007 3
2008 4
2009 5
2010 8
2011 11
2012 4
2013 7
2014 8
2015 4
2016 5
2017 8
2018 3
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2020 12
2021 6
2022 10
2023 5
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131 results

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Page 1
Acute promyelocytic leukemia current treatment algorithms.
Yilmaz M, Kantarjian H, Ravandi F. Yilmaz M, et al. Blood Cancer J. 2021 Jun 30;11(6):123. doi: 10.1038/s41408-021-00514-3. Blood Cancer J. 2021. PMID: 34193815 Free PMC article. Review.
APL, accounting for 10-15% of the newly diagnosed AML cases, results from a balanced translocation, t(15;17) (q22;q12-21), which leads to the fusion of the promyelocytic leukemia (PML) gene with the retinoic acid receptor alpha (RARA) gene. The PML-RARA fusion oncop …
APL, accounting for 10-15% of the newly diagnosed AML cases, results from a balanced translocation, t(15;17) (q22;q12-21), which leads to th …
RARA fusion genes in acute promyelocytic leukemia: a review.
De Braekeleer E, Douet-Guilbert N, De Braekeleer M. De Braekeleer E, et al. Expert Rev Hematol. 2014 Jun;7(3):347-57. doi: 10.1586/17474086.2014.903794. Epub 2014 Apr 10. Expert Rev Hematol. 2014. PMID: 24720386 Review.
The t(15;17)(q24;q21), generating a PML-RARA fusion gene, is the hallmark of acute promyelocytic leukemia (APL). At present, eight other genes fusing with RARA have been identified. ...
The t(15;17)(q24;q21), generating a PML-RARA fusion gene, is the hallmark of acute promyelocytic leukemia (APL). At present, e …
Genotypic and Phenotypic Characteristics of Acute Promyelocytic Leukemia Translocation Variants.
Mannan A, Muhsen IN, Barragán E, Sanz MA, Mohty M, Hashmi SK, Aljurf M. Mannan A, et al. Hematol Oncol Stem Cell Ther. 2020 Dec;13(4):189-201. doi: 10.1016/j.hemonc.2020.05.007. Epub 2020 May 20. Hematol Oncol Stem Cell Ther. 2020. PMID: 32473106 Free article. Review.
The majority of APL cases are characterized by the fusion gene PML-RARA. Although the PML-RARA fusion gene can be detected in almost all APL cases, translocation variants of APL have been reported. To date, this is the most comprehensive review …
The majority of APL cases are characterized by the fusion gene PML-RARA. Although the PML-RARA fusion gene can b …
Acute promyelocytic leukemia (APL): a review of the literature.
Jimenez JJ, Chale RS, Abad AC, Schally AV. Jimenez JJ, et al. Oncotarget. 2020 Mar 17;11(11):992-1003. doi: 10.18632/oncotarget.27513. eCollection 2020 Mar 17. Oncotarget. 2020. PMID: 32215187 Free PMC article. Review.
A characteristic balanced chromosomal translocation between chromosomes 15 and 17 t (15;17) (q24; q21) is seen in 95% of cases - the translocation results in the formation of the PML-RARA fusion protein. The introduction of retinoic acid (RA) and arsenic trioxide (A …
A characteristic balanced chromosomal translocation between chromosomes 15 and 17 t (15;17) (q24; q21) is seen in 95% of cases - the translo …
Acute Promyelocytic Leukemia: A Constellation of Molecular Events around a Single PML-RARA Fusion Gene.
Liquori A, Ibañez M, Sargas C, Sanz MÁ, Barragán E, Cervera J. Liquori A, et al. Cancers (Basel). 2020 Mar 8;12(3):624. doi: 10.3390/cancers12030624. Cancers (Basel). 2020. PMID: 32182684 Free PMC article. Review.
Although acute promyelocytic leukemia (APL) is one of the most characterized forms of acute myeloid leukemia (AML), the molecular mechanisms involved in the development and progression of this disease are still a matter of study. APL is defined by the PML-RARA rearr …
Although acute promyelocytic leukemia (APL) is one of the most characterized forms of acute myeloid leukemia (AML), the molecular mechanisms …
Targeting PARP proteins in acute leukemia: DNA damage response inhibition and therapeutic strategies.
Padella A, Ghelli Luserna Di Rorà A, Marconi G, Ghetti M, Martinelli G, Simonetti G. Padella A, et al. J Hematol Oncol. 2022 Jan 22;15(1):10. doi: 10.1186/s13045-022-01228-0. J Hematol Oncol. 2022. PMID: 35065680 Free PMC article. Review.
The most studied members, PARP1, PARP2 and PARP3, act as sensors of DNA damages, in order to activate different intracellular repair pathways, including single-strand repair, homologous recombination, conventional and alternative non-homologous end joining. This review rec …
The most studied members, PARP1, PARP2 and PARP3, act as sensors of DNA damages, in order to activate different intracellular repair pathway …
Therapy-induced PML/RARA proteolysis and acute promyelocytic leukemia cure.
Nasr R, Lallemand-Breitenbach V, Zhu J, Guillemin MC, de Thé H. Nasr R, et al. Clin Cancer Res. 2009 Oct 15;15(20):6321-6. doi: 10.1158/1078-0432.CCR-09-0209. Epub 2009 Oct 6. Clin Cancer Res. 2009. PMID: 19808868 Review.
Cyclic AMP triggered PML/RARA phosphorylation also enhances RA-induced APL regression, PML/RARA degradation, and LIC clearance, raising new options for therapy-resistant patients. Although differentiation has a major role in debulking of the tumor, …
Cyclic AMP triggered PML/RARA phosphorylation also enhances RA-induced APL regression, PML/RARA degradation, and …
Synergy against PML-RARa: targeting transcription, proteolysis, differentiation, and self-renewal in acute promyelocytic leukemia.
Dos Santos GA, Kats L, Pandolfi PP. Dos Santos GA, et al. J Exp Med. 2013 Dec 16;210(13):2793-802. doi: 10.1084/jem.20131121. J Exp Med. 2013. PMID: 24344243 Free PMC article. Review.
Acute promyelocytic leukemia (APL) is a hematological malignancy driven by a chimeric oncoprotein containing the C terminus of the retinoic acid receptor-a (RARa) fused to an N-terminal partner, most commonly promyelocytic leukemia protein (PML). Mechanistically, PML-RA …
Acute promyelocytic leukemia (APL) is a hematological malignancy driven by a chimeric oncoprotein containing the C terminus of the retinoic …
Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukemia.
van Dongen JJ, Macintyre EA, Gabert JA, Delabesse E, Rossi V, Saglio G, Gottardi E, Rambaldi A, Dotti G, Griesinger F, Parreira A, Gameiro P, Diáz MG, Malec M, Langerak AW, San Miguel JF, Biondi A. van Dongen JJ, et al. Leukemia. 1999 Dec;13(12):1901-28. doi: 10.1038/sj.leu.2401592. Leukemia. 1999. PMID: 10602411 Review.
A total of nine well-defined chromosome aberrations with fusion gene transcripts were selected: t(1;19) with E2A-PBX1, t(4;11) with MLL-AF4, t(8;21) with AML1-ETO, t(9;22) with BCR-ABL p190 and BCR-ABL p210, t(12;21) with TEL-AML1, t(15;17) with PML-RARA, inv (16) w …
A total of nine well-defined chromosome aberrations with fusion gene transcripts were selected: t(1;19) with E2A-PBX1, t(4;11) with MLL-AF4, …
RARA and PML genes in acute promyelocytic leukemia.
Chen Z, Chen SJ. Chen Z, et al. Leuk Lymphoma. 1992 Nov;8(4-5):253-60. doi: 10.3109/10428199209051004. Leuk Lymphoma. 1992. PMID: 1337847 Review.
Molecular cloning and sequence analysis of the PML gene demonstrated a complex splicing pattern and this gene may encode a transcription factor. Different isoforms of the PML-RARA fusion transcripts were discovered which are produced as a result of distinct PML gene …
Molecular cloning and sequence analysis of the PML gene demonstrated a complex splicing pattern and this gene may encode a transcription fac …
131 results