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2022 17
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Hutchinson-Gilford Progeria Syndrome: Cellular Mechanisms and Therapeutic Perspectives.
Cisneros B, García-Aguirre I, De Ita M, Arrieta-Cruz I, Rosas-Vargas H. Cisneros B, et al. Arch Med Res. 2023 Jul;54(5):102837. doi: 10.1016/j.arcmed.2023.06.002. Epub 2023 Jun 28. Arch Med Res. 2023. PMID: 37390702 Free article. Review.
In humans, aging is characterized by a gradual decline of physical and psychological functions, with the concomitant onset of chronic-degenerative diseases, which ultimately lead to death. The study of Hutchinson-Gilford progeria syndrome (HGPS), a premature aging d …
In humans, aging is characterized by a gradual decline of physical and psychological functions, with the concomitant onset of chronic-degene …
Hutchinson-Gilford progeria.
Sharma A, Swarnkar B, Sethuraman G. Sharma A, et al. BMJ Case Rep. 2023 Sep 18;16(9):e256203. doi: 10.1136/bcr-2023-256203. BMJ Case Rep. 2023. PMID: 37723091 Free PMC article. No abstract available.
The Molecular and Cellular Basis of Hutchinson-Gilford Progeria Syndrome and Potential Treatments.
Batista NJ, Desai SG, Perez AM, Finkelstein A, Radigan R, Singh M, Landman A, Drittel B, Abramov D, Ahsan M, Cornwell S, Zhang D. Batista NJ, et al. Genes (Basel). 2023 Feb 27;14(3):602. doi: 10.3390/genes14030602. Genes (Basel). 2023. PMID: 36980874 Free PMC article. Review.
Hutchinson-Gilford progeria syndrome (HGPS) is a rare, autosomal-dominant, and fatal premature aging syndrome. ...
Hutchinson-Gilford progeria syndrome (HGPS) is a rare, autosomal-dominant, and fatal premature aging syndrome. ...
Endothelial-to-Mesenchymal Transition Contributes to Accelerated Atherosclerosis in Hutchinson-Gilford Progeria Syndrome.
Hamczyk MR, Nevado RM, Gonzalo P, Andrés-Manzano MJ, Nogales P, Quesada V, Rosado A, Torroja C, Sánchez-Cabo F, Dopazo A, Bentzon JF, López-Otín C, Andrés V. Hamczyk MR, et al. Circulation. 2024 Nov 12;150(20):1612-1630. doi: 10.1161/CIRCULATIONAHA.123.065768. Epub 2024 Aug 29. Circulation. 2024. PMID: 39206565 Free article.
BACKGROUND: Atherosclerosis is the main medical problem in Hutchinson-Gilford progeria syndrome, a rare premature aging disorder caused by the mutant lamin-A protein progerin. ...CONCLUSIONS: Progerin-induced VSMC alterations promote EC dysfunction and EndMT through …
BACKGROUND: Atherosclerosis is the main medical problem in Hutchinson-Gilford progeria syndrome, a rare premature aging disord …
Endothelial YAP/TAZ activation promotes atherosclerosis in a mouse model of Hutchinson-Gilford progeria syndrome.
Barettino A, González-Gómez C, Gonzalo P, Andrés-Manzano MJ, Guerrero CR, Espinosa FM, Carmona RM, Blanco Y, Dorado B, Torroja C, Sánchez-Cabo F, Quintas A, Benguría A, Dopazo A, García R, Benedicto I, Andrés V. Barettino A, et al. J Clin Invest. 2024 Oct 1;134(22):e173448. doi: 10.1172/JCI173448. J Clin Invest. 2024. PMID: 39352768 Free PMC article.
Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare disease caused by the expression of progerin, an aberrant protein produced by a point mutation in the LMNA gene. ...
Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare disease caused by the expression of progerin, an aberrant pro …
Vascular organoid model of Hutchinson-Gilford progeria syndrome uncovers repression of the SRF pathway in premature aging.
Sun X, Che S, Wang H, Fan Y, Ding Y, Tan A, Yang K, Hu J, Zhang Y, Ma M, Hu J, Sun S, Ma S, Wang S, Izpisua Belmonte JC, Qu J, Zhang W, Liu GH. Sun X, et al. Dev Cell. 2026 Mar 11;61(3):505-517.e7. doi: 10.1016/j.devcel.2025.10.019. Epub 2025 Nov 27. Dev Cell. 2026. PMID: 41314218
Vascular aging is a key driver of cardiovascular disease, yet models capturing its complexity in humans are lacking. Hutchinson-Gilford progeria syndrome (HGPS), a premature aging disorder caused by the LMNA mutation, provides a model to study accelerated vascular d …
Vascular aging is a key driver of cardiovascular disease, yet models capturing its complexity in humans are lacking. Hutchinson-Gi …
Nicotinamide Mononucleotide Alleviates Aging Defects in Hutchinson-Gilford Progeria Syndrome.
Xu Y, Wu M, Fan Y, Zhang J, Xue D, Zhang M, Shao R, Cai L, Liao X, Zhang L, Zhang J. Xu Y, et al. FASEB J. 2025 Aug 15;39(15):e70875. doi: 10.1096/fj.202500469RR. FASEB J. 2025. PMID: 40742332
Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder caused by mutations in the LMNA gene, leading to progerin accumulation and accelerated aging. ...
Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder caused by mutations in the LMNA gene, leading to proger …
Long live lamins.
Jin Q, Worman HJ. Jin Q, et al. J Cell Biol. 2024 Jan 1;223(1):e202311193. doi: 10.1083/jcb.202311193. Epub 2023 Dec 11. J Cell Biol. 2024. PMID: 38078930 Free PMC article.
(https://doi.org/10.1083/jcb.202307049) show that lamin A/C and the prelamin A variant in Hutchinson-Gilford progeria syndrome have relatively long lifetimes in affected tissues....
(https://doi.org/10.1083/jcb.202307049) show that lamin A/C and the prelamin A variant in Hutchinson-Gilford progeria syndrome …
Recurrent somatic mutation and progerin expression in early vascular aging of chronic kidney disease.
Revêchon G, Witasp A, Viceconte N, Helgadottir HT, Machtel P, Stefani F, Whisenant D, Sola-Carvajal A, McGuinness D, Abutaleb NO, Artiach G, Arzt EW, Soveri I, Babler A, Ziegler S, Kramann R, Bäck M, Thorell A, Truskey GA, Wennberg L, Shiels PG, Wernerson A, Stenvinkel P, Eriksson M. Revêchon G, et al. Nat Aging. 2025 Jun;5(6):1046-1062. doi: 10.1038/s43587-025-00882-6. Epub 2025 Jun 10. Nat Aging. 2025. PMID: 40495018 Free PMC article.
Here we found progerin, the protein responsible for the premature aging disease Hutchinson-Gilford progeria syndrome, steadily recurring in vascular smooth muscle cells of patients with CKD. ...
Here we found progerin, the protein responsible for the premature aging disease Hutchinson-Gilford progeria syndrome, steadily …
Impaired end joining induces cardiac atrophy in a Hutchinson-Gilford progeria mouse model.
Chen Y, Huang S, Cui Z, Sun X, Tang Y, Zhang H, Chen Z, Jiang R, Zhang W, Li X, Chen J, Liu B, Jiang Y, Wei K, Mao Z. Chen Y, et al. Proc Natl Acad Sci U S A. 2023 Nov 21;120(47):e2309200120. doi: 10.1073/pnas.2309200120. Epub 2023 Nov 15. Proc Natl Acad Sci U S A. 2023. PMID: 37967221 Free PMC article.
Patients with Hutchinson-Gilford progeria syndrome (HGPS) present with a number of premature aging phenotypes, including DNA damage accumulation, and many of them die of cardiovascular complications. ...
Patients with Hutchinson-Gilford progeria syndrome (HGPS) present with a number of premature aging phenotypes, including DNA d …
118 results