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Advancing rare disease therapeutics through digital twins: Opportunities in drug development and precision dosing.
Dette CMU, Alberg V, Rüdesheim S, Selzer D, Marok FZ, Bragazzi NL, Fuhr LM, Brunak S, Pearson ER, Zahn T, Kiritsi D, Schwab M, Lehr T. Dette CMU, et al. Among authors: rudesheim s. Comput Struct Biotechnol J. 2025 Nov 23;28:592-608. doi: 10.1016/j.csbj.2025.11.047. eCollection 2025. Comput Struct Biotechnol J. 2025. PMID: 41404110 Free PMC article. Review.
Model-Based Prediction of Clinically Relevant Thrombocytopenia after Allogeneic Hematopoietic Stem Cell Transplantation.
Götz KM, Turki AT, Och K, Selzer D, Brossette C, Graf N, Rauch J, Theobald S, Braun Y, Rohm K, Weiler G, Rüdesheim S, Schwab M, Eisenberg L, Pfeifer N, Kiefer S, Schwarz U, Riede C, Smola S, Beelen DW, Kaddu-Mulindwa D, Rissland J, Bittenbring J, Lehr T. Götz KM, et al. Among authors: rudesheim s. Clin Pharmacol Ther. 2025 May;117(5):1413-1426. doi: 10.1002/cpt.3580. Epub 2025 Feb 6. Clin Pharmacol Ther. 2025. PMID: 39912597 Free PMC article.
Physiologically-based pharmacokinetic modeling of quinidine to establish a CYP3A4, P-gp, and CYP2D6 drug-drug-gene interaction network.
Feick D, Rüdesheim S, Marok FZ, Selzer D, Loer HLH, Teutonico D, Frechen S, van der Lee M, Moes DJAR, Swen JJ, Schwab M, Lehr T. Feick D, et al. Among authors: rudesheim s. CPT Pharmacometrics Syst Pharmacol. 2023 Aug;12(8):1143-1156. doi: 10.1002/psp4.12981. Epub 2023 May 23. CPT Pharmacometrics Syst Pharmacol. 2023. PMID: 37165978 Free PMC article.
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