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Neonatal leukaemia.
Roberts I, Fordham NJ, Rao A, Bain BJ. Roberts I, et al. Br J Haematol. 2018 Jul;182(2):170-184. doi: 10.1111/bjh.15246. Epub 2018 May 28. Br J Haematol. 2018. PMID: 29806701 Free article. Review.
The most frequently observed cytogenetic/molecular abnormality is t(4;11)(q21.3;q23.3)/KMT2A-AFF1 followed by t(1;22)(p13.3;q13.1)/RBM15-MKL1 and t(8;16)(p11.2;p13.3)/KAT6A-CREBBP. Common clinical features include prominent hepatosplenomegaly and a high incidence of …
The most frequently observed cytogenetic/molecular abnormality is t(4;11)(q21.3;q23.3)/KMT2A-AFF1 followed by t(1;22)(p13.3;q13.1)/RBM15 …
RNA-Binding Proteins in Acute Leukemias.
Schuschel K, Helwig M, Hüttelmaier S, Heckl D, Klusmann JH, Hoell JI. Schuschel K, et al. Int J Mol Sci. 2020 May 12;21(10):3409. doi: 10.3390/ijms21103409. Int J Mol Sci. 2020. PMID: 32408494 Free PMC article. Review.
RBPs coordinate RNA dynamics, including subcellular localization, translational efficiency and metabolism, by binding to their target messenger RNAs (mRNAs), thereby controlling the expression of the encoded proteins. In view of the growing interest in these regulators, this r …
RBPs coordinate RNA dynamics, including subcellular localization, translational efficiency and metabolism, by binding to their target messen …
[Classification of myeloid leukemias].
Kuriyama K. Kuriyama K. Nihon Rinsho. 2009 Oct;67(10):1853-62. Nihon Rinsho. 2009. PMID: 19860179 Review. Japanese.
AML with t(9; 11) (p22;q23); MLLT3-MLL, AML with t(6;9) (p23; q34); DEK-NUP214, AML with inv(3) (q21q26.2) or t(3; 3) (q21 ; q26.2); RPN1-EVI1 and AML (megakaryoblastic) with t(1; 22) (p13; q13); RBM15-MKL1 are added to the subtype of AML with recurrent genetic abno …
AML with t(9; 11) (p22;q23); MLLT3-MLL, AML with t(6;9) (p23; q34); DEK-NUP214, AML with inv(3) (q21q26.2) or t(3; 3) (q21 ; q26.2); RPN1-EV …
RBM15-MKL1 (OTT-MAL) fusion transcript in an adult acute myeloid leukemia patient.
Hsiao HH, Yang MY, Liu YC, Hsiao HP, Tseng SB, Chao MC, Liu TC, Lin SF. Hsiao HH, et al. Am J Hematol. 2005 May;79(1):43-5. doi: 10.1002/ajh.20298. Am J Hematol. 2005. PMID: 15849773 Free article.
The t(1;22)(p13;q13) is a nonrandom chromosomal abnormality in acute leukemia with the fusion oncogene, RBM15-MKL1 (OTT-MAL), identified recently. However, this abnormality has been described only in infants and young children with acute megakaryoblastic leukemia (A …
The t(1;22)(p13;q13) is a nonrandom chromosomal abnormality in acute leukemia with the fusion oncogene, RBM15-MKL1 (OTT-MAL), …