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Year Number of Results
2001 2
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63 results

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Systematic proteome-wide Mendelian randomization using the human plasma proteome to identify therapeutic targets for lung adenocarcinoma.
Zhang L, Xiong Y, Zhang J, Feng Y, Xu A. Zhang L, et al. J Transl Med. 2024 Apr 4;22(1):330. doi: 10.1186/s12967-024-04919-z. J Transl Med. 2024. PMID: 38576019 Free PMC article.
Additionally, FLT1 and TFPI are currently under evaluation as therapeutic targets, while NTM, RNASET2, and VWC2 are potentially druggable. These findings shed light on LUAD pathogenesis, highlighting the tumor-promoting effects of RNASET2, TFPI, and NTM, along with …
Additionally, FLT1 and TFPI are currently under evaluation as therapeutic targets, while NTM, RNASET2, and VWC2 are potentially drugg …
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.
McKay JD, Hung RJ, Han Y, Zong X, Carreras-Torres R, Christiani DC, Caporaso NE, Johansson M, Xiao X, Li Y, Byun J, Dunning A, Pooley KA, Qian DC, Ji X, Liu G, Timofeeva MN, Bojesen SE, Wu X, Le Marchand L, Albanes D, Bickeböller H, Aldrich MC, Bush WS, Tardon A, Rennert G, Teare MD, Field JK, Kiemeney LA, Lazarus P, Haugen A, Lam S, Schabath MB, Andrew AS, Shen H, Hong YC, Yuan JM, Bertazzi PA, Pesatori AC, Ye Y, Diao N, Su L, Zhang R, Brhane Y, Leighl N, Johansen JS, Mellemgaard A, Saliba W, Haiman CA, Wilkens LR, Fernandez-Somoano A, Fernandez-Tardon G, van der Heijden HFM, Kim JH, Dai J, Hu Z, Davies MPA, Marcus MW, Brunnström H, Manjer J, Melander O, Muller DC, Overvad K, Trichopoulou A, Tumino R, Doherty JA, Barnett MP, Chen C, Goodman GE, Cox A, Taylor F, Woll P, Brüske I, Wichmann HE, Manz J, Muley TR, Risch A, Rosenberger A, Grankvist K, Johansson M, Shepherd FA, Tsao MS, Arnold SM, Haura EB, Bolca C, Holcatova I, Janout V, Kontic M, Lissowska J, Mukeria A, Ognjanovic S, Orlowski TM, Scelo G, Swiatkowska B, Zaridze D, Bakke P, Skaug V, Zienolddiny S, Duell EJ, Butler LM, Koh WP, Gao YT, Houlston RS, McLaughlin J, Stevens VL, Joubert P, Lamontagne M, Nickle DC, Obeidat M, … See abstract for full author list ➔ McKay JD, et al. Nat Genet. 2017 Jul;49(7):1126-1132. doi: 10.1038/ng.3892. Epub 2017 Jun 12. Nat Genet. 2017. PMID: 28604730 Free PMC article.
Gene expression quantitative trait locus (eQTL) analysis in 1,425 normal lung tissue samples highlights RNASET2, SECISBP2L and NRG1 as candidate genes. Other loci include genes such as a cholinergic nicotinic receptor, CHRNA2, and the telomere-related genes OFBC1 and RTEL1 …
Gene expression quantitative trait locus (eQTL) analysis in 1,425 normal lung tissue samples highlights RNASET2, SECISBP2L and NRG1 a …
Pathogenic Roles for RNASET2 in Clear Cell Renal Cell Carcinoma.
Peak T, Tian Y, Patel A, Shaw T, Obermayer A, Laborde J, Kim Y, Johnson J, Stewart P, Fang B, Teer JK, Koomen J, Berglund A, Marchion D, Francis N, Echevarria PR, Dhillon J, Clark N, Chang A, Sexton W, Zemp L, Chahoud J, Wang L, Manley B. Peak T, et al. Lab Invest. 2024 May;104(5):102041. doi: 10.1016/j.labinv.2024.102041. Epub 2024 Feb 29. Lab Invest. 2024. PMID: 38431116 Free PMC article.
We sought to better understand the relationship of RNASET2 in the pathogenesis of ccRCC and the interplay with a pathogenic splicing isoform (RNASET2-SV) and the tumor immune microenvironment. ...The presence of the RNASET2-SV was associated with increased ex …
We sought to better understand the relationship of RNASET2 in the pathogenesis of ccRCC and the interplay with a pathogenic splicing …
The human RNASET2 alarmin-like molecule differentially affects prostate cancer cells behavior in both cell autonomous and non-cell autonomous manners.
Roncoroni R, Baci D, Cucchiara M, de Vito A, Gallazzi M, Palano MT, Olmeo F, Rubuano C, Giannatiempo A, Monti L, Bombelli R, Mercatelli D, Finzi G, Franzi F, La Rosa S, Noonan DM, Bassani B, Mortara L, Bruno A, Acquati F. Roncoroni R, et al. J Transl Med. 2025 May 19;23(1):560. doi: 10.1186/s12967-025-06540-0. J Transl Med. 2025. PMID: 40389981 Free PMC article.
RNASET2 overexpression in 22Rv1 cells was also associated with decreased levels of TWIST, CTNNB1, YAP, and MMP-9. ...RNASET2 overexpression also affected the cytoskeletal organization in both PCa models. ...
RNASET2 overexpression in 22Rv1 cells was also associated with decreased levels of TWIST, CTNNB1, YAP, and MMP-9. ...RNASET2 o …
Druggable targets for Parkinson's disease: transcriptomics based Mendelian randomization study.
Lyu Q, Chen R, Qiu Z, Wang C, Liu R. Lyu Q, et al. Sci Rep. 2024 Oct 28;14(1):25763. doi: 10.1038/s41598-024-77401-x. Sci Rep. 2024. PMID: 39468243 Free PMC article.
Through MR and SMR analysis, P2RX7 and RNASET2 were identified as feasible PD therapeutic targets, which were highly expressed in PD tissues and increased as the Braak stages increased. Phenome-wide MR analysis revealed other effects of targeting RNASET2. This study …
Through MR and SMR analysis, P2RX7 and RNASET2 were identified as feasible PD therapeutic targets, which were highly expressed in PD …
FBXO6-mediated RNASET2 ubiquitination and degradation governs the development of ovarian cancer.
Ji M, Zhao Z, Li Y, Xu P, Shi J, Li Z, Wang K, Huang X, Liu B. Ji M, et al. Cell Death Dis. 2021 Mar 25;12(4):317. doi: 10.1038/s41419-021-03580-4. Cell Death Dis. 2021. PMID: 33767133 Free PMC article.
RNASET2 (Ribonuclease T2) functions as a tumor suppressor in preventing ovarian tumorigenesis. ...We found that the interaction between FBXO6 and RNASET2 induced RNASET2 instability through the ubiquitin-mediated proteasome degradation pathway. ...
RNASET2 (Ribonuclease T2) functions as a tumor suppressor in preventing ovarian tumorigenesis. ...We found that the interaction betwe …
Regulation of neutrophil associated RNASET2 expression in rheumatoid arthritis.
Passari M, Scutera S, Schioppa T, Tiberio L, Piantoni S, Tamassia N, Bugatti M, Vermi W, Angeli F, Caproli A, Salvi V, Sozio F, Gismondi A, Stabile H, Franceschini F, Bosisio D, Acquati F, Vermeren S, Sozzani S, Andreoli L, Del Prete A, Musso T. Passari M, et al. Sci Rep. 2024 Nov 5;14(1):26820. doi: 10.1038/s41598-024-77694-y. Sci Rep. 2024. PMID: 39500942 Free PMC article.
Here we show that, along the neutrophil maturation cascade, RNASET2 is expressed in segmented and mature PMNs. In human PMNs, RNASET2 colocalized with primary and tertiary granules and was found to be associated with NETs following PMA or Nigericin stimulation. ...T …
Here we show that, along the neutrophil maturation cascade, RNASET2 is expressed in segmented and mature PMNs. In human PMNs, RNAS …
Single-cell and bulk transcriptome analyses revealed the role of macrophage cholesterol metabolism in atherosclerosis.
Ke J, Chen S, Li L, Liao C, Peng F, Chai D, Lin J. Ke J, et al. Lipids Health Dis. 2025 Nov 26;25(1):3. doi: 10.1186/s12944-025-02773-6. Lipids Health Dis. 2025. PMID: 41299485 Free PMC article.
By employing machine learning algorithms to analyse bulk RNA-seq data, three feature genes, FABP4, RNASET2, and FILIP1L, were identified as potential hallmark genes for AS. A risk score model constructed with three feature genes demonstrated high accuracy across multiple e …
By employing machine learning algorithms to analyse bulk RNA-seq data, three feature genes, FABP4, RNASET2, and FILIP1L, were identif …
Human RNASET2: A Highly Pleiotropic and Evolutionary Conserved Tumor Suppressor Gene Involved in the Control of Ovarian Cancer Pathogenesis.
Bruno A, Noonan DM, Valli R, Porta G, Taramelli R, Mortara L, Acquati F. Bruno A, et al. Int J Mol Sci. 2022 Aug 13;23(16):9074. doi: 10.3390/ijms23169074. Int J Mol Sci. 2022. PMID: 36012339 Free PMC article. Review.
Here, we provide a detailed survey on the highly pleiotropic oncosuppressive roles played by the human RNASET2 gene, whose protein product has been consistently reported to establish a functional crosstalk between ovarian cancer cells and key cellular effectors of the inna …
Here, we provide a detailed survey on the highly pleiotropic oncosuppressive roles played by the human RNASET2 gene, whose protein pr …
Expression and purification of the human tumor suppressor protein RNASET2 in CHO-S cells.
Rosini E, De Vito A, Ponti F, Scaldaferri D, Pollegioni L, Acquati F. Rosini E, et al. Protein Expr Purif. 2020 Oct;174:105675. doi: 10.1016/j.pep.2020.105675. Epub 2020 May 23. Protein Expr Purif. 2020. PMID: 32450138
Members of the T2 extracellular ribonucleases family have long been reported as stress response proteins, often involved in host defence, in many different taxonomic groups. In particular, the human RNASET2 protein (hRNASET2) has been reported as an extracellular tumor sup …
Members of the T2 extracellular ribonucleases family have long been reported as stress response proteins, often involved in host defence, in …
63 results