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54 results

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Page 1
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.
McKay JD, Hung RJ, Han Y, Zong X, Carreras-Torres R, Christiani DC, Caporaso NE, Johansson M, Xiao X, Li Y, Byun J, Dunning A, Pooley KA, Qian DC, Ji X, Liu G, Timofeeva MN, Bojesen SE, Wu X, Le Marchand L, Albanes D, Bickeböller H, Aldrich MC, Bush WS, Tardon A, Rennert G, Teare MD, Field JK, Kiemeney LA, Lazarus P, Haugen A, Lam S, Schabath MB, Andrew AS, Shen H, Hong YC, Yuan JM, Bertazzi PA, Pesatori AC, Ye Y, Diao N, Su L, Zhang R, Brhane Y, Leighl N, Johansen JS, Mellemgaard A, Saliba W, Haiman CA, Wilkens LR, Fernandez-Somoano A, Fernandez-Tardon G, van der Heijden HFM, Kim JH, Dai J, Hu Z, Davies MPA, Marcus MW, Brunnström H, Manjer J, Melander O, Muller DC, Overvad K, Trichopoulou A, Tumino R, Doherty JA, Barnett MP, Chen C, Goodman GE, Cox A, Taylor F, Woll P, Brüske I, Wichmann HE, Manz J, Muley TR, Risch A, Rosenberger A, Grankvist K, Johansson M, Shepherd FA, Tsao MS, Arnold SM, Haura EB, Bolca C, Holcatova I, Janout V, Kontic M, Lissowska J, Mukeria A, Ognjanovic S, Orlowski TM, Scelo G, Swiatkowska B, Zaridze D, Bakke P, Skaug V, Zienolddiny S, Duell EJ, Butler LM, Koh WP, Gao YT, Houlston RS, McLaughlin J, Stevens VL, Joubert P, Lamontagne M, Nickle DC, Obeidat M, … See abstract for full author list ➔ McKay JD, et al. Nat Genet. 2017 Jul;49(7):1126-1132. doi: 10.1038/ng.3892. Epub 2017 Jun 12. Nat Genet. 2017. PMID: 28604730 Free PMC article.
Gene expression quantitative trait locus (eQTL) analysis in 1,425 normal lung tissue samples highlights RNASET2, SECISBP2L and NRG1 as candidate genes. Other loci include genes such as a cholinergic nicotinic receptor, CHRNA2, and the telomere-related genes OFBC1 and RTEL1 …
Gene expression quantitative trait locus (eQTL) analysis in 1,425 normal lung tissue samples highlights RNASET2, SECISBP2L and NRG1 a …
Systematic proteome-wide Mendelian randomization using the human plasma proteome to identify therapeutic targets for lung adenocarcinoma.
Zhang L, Xiong Y, Zhang J, Feng Y, Xu A. Zhang L, et al. J Transl Med. 2024 Apr 4;22(1):330. doi: 10.1186/s12967-024-04919-z. J Transl Med. 2024. PMID: 38576019 Free PMC article.
Additionally, FLT1 and TFPI are currently under evaluation as therapeutic targets, while NTM, RNASET2, and VWC2 are potentially druggable. These findings shed light on LUAD pathogenesis, highlighting the tumor-promoting effects of RNASET2, TFPI, and NTM, along with …
Additionally, FLT1 and TFPI are currently under evaluation as therapeutic targets, while NTM, RNASET2, and VWC2 are potentially drugg …
Pathogenic Roles for RNASET2 in Clear Cell Renal Cell Carcinoma.
Peak T, Tian Y, Patel A, Shaw T, Obermayer A, Laborde J, Kim Y, Johnson J, Stewart P, Fang B, Teer JK, Koomen J, Berglund A, Marchion D, Francis N, Echevarria PR, Dhillon J, Clark N, Chang A, Sexton W, Zemp L, Chahoud J, Wang L, Manley B. Peak T, et al. Lab Invest. 2024 May;104(5):102041. doi: 10.1016/j.labinv.2024.102041. Epub 2024 Feb 29. Lab Invest. 2024. PMID: 38431116
We sought to better understand the relationship of RNASET2 in the pathogenesis of ccRCC and the interplay with a pathogenic splicing isoform (RNASET2-SV) and the tumor immune microenvironment. ...The presence of the RNASET2-SV was associated with increased ex …
We sought to better understand the relationship of RNASET2 in the pathogenesis of ccRCC and the interplay with a pathogenic splicing …
T2 Family ribonucleases: ancient enzymes with diverse roles.
Luhtala N, Parker R. Luhtala N, et al. Trends Biochem Sci. 2010 May;35(5):253-9. doi: 10.1016/j.tibs.2010.02.002. Epub 2010 Feb 26. Trends Biochem Sci. 2010. PMID: 20189811 Free PMC article. Review.
Moreover, humans lacking RNASET2 manifest a defect in neurological development, perhaps due to aberrant control of the immune system. We review the basic structure and function of RNaseT2 family members and their biological roles....
Moreover, humans lacking RNASET2 manifest a defect in neurological development, perhaps due to aberrant control of the immune system. …
Zebrafish disease model of human RNASET2-deficient cystic leukoencephalopathy displays abnormalities in early microglia.
Weber T, Schlotawa L, Dosch R, Hamilton N, Kaiser J, Schiller S, Wenske B, Gärtner J, Henneke M. Weber T, et al. Biol Open. 2020 May 7;9(5):bio049239. doi: 10.1242/bio.049239. Biol Open. 2020. PMID: 32295832 Free PMC article.
Human infantile-onset RNASET2-deficient cystic leukoencephalopathy is a Mendelian mimic of in utero cytomegalovirus brain infection with prenatally developing inflammatory brain lesions. ...In contrast to wild-type brains, RNASET2-deficient larvae displayed increase …
Human infantile-onset RNASET2-deficient cystic leukoencephalopathy is a Mendelian mimic of in utero cytomegalovirus brain infection w …
Human RNASET2: A Highly Pleiotropic and Evolutionary Conserved Tumor Suppressor Gene Involved in the Control of Ovarian Cancer Pathogenesis.
Bruno A, Noonan DM, Valli R, Porta G, Taramelli R, Mortara L, Acquati F. Bruno A, et al. Int J Mol Sci. 2022 Aug 13;23(16):9074. doi: 10.3390/ijms23169074. Int J Mol Sci. 2022. PMID: 36012339 Free PMC article. Review.
Here, we provide a detailed survey on the highly pleiotropic oncosuppressive roles played by the human RNASET2 gene, whose protein product has been consistently reported to establish a functional crosstalk between ovarian cancer cells and key cellular effectors of the inna …
Here, we provide a detailed survey on the highly pleiotropic oncosuppressive roles played by the human RNASET2 gene, whose protein pr …
Proteogenomic, Epigenetic, and Clinical Implications of Recurrent Aberrant Splice Variants in Clear Cell Renal Cell Carcinoma.
Chang A, Chakiryan NH, Du D, Stewart PA, Zhang Y, Tian Y, Soupir AC, Bowers K, Fang B, Morganti A, Teer JK, Kim Y, Spiess PE, Chahoud J, Noble JD, Putney RM, Berglund AE, Robinson TJ, Koomen JM, Wang L, Manley BJ. Chang A, et al. Eur Urol. 2022 Oct;82(4):354-362. doi: 10.1016/j.eururo.2022.05.021. Epub 2022 Jun 17. Eur Urol. 2022. PMID: 35718636 Free PMC article.
RESULTS AND LIMITATIONS: Our pipeline identified 16 ccRCC-enriched SVs. EGFR, HPCAL1-SV and RNASET2-SV expression was negatively correlated with gene-specific CpG methylation. We derived a survival risk score based primarily on the expression of five SVs (RNASET2, F …
RESULTS AND LIMITATIONS: Our pipeline identified 16 ccRCC-enriched SVs. EGFR, HPCAL1-SV and RNASET2-SV expression was negatively corr …
Novel RNASET2 Pathogenic Variants in an East Asian Child with Delayed Psychomotor Development.
Sun Y, Hu X, Song J, Hu Y, Liu C, Li G. Sun Y, et al. Fetal Pediatr Pathol. 2018 Feb;37(1):15-21. doi: 10.1080/15513815.2017.1388456. Epub 2018 Jan 16. Fetal Pediatr Pathol. 2018. PMID: 29336640
INTRODUCTION: RNASET2 mutation has been reported in patients with cystic leukoencephalopathy without megalencephaly and the Aicardi-Goutieres syndrome. ...CONCLUSION: Our results provided further genetic and phenotypic information of RNASET2 mutation in Chinese pati …
INTRODUCTION: RNASET2 mutation has been reported in patients with cystic leukoencephalopathy without megalencephaly and the Aicardi-G …
Monochromosomal Hybrids and Chromosome Transfer: A Functional Approach for Gene Identification.
Kandpal RP, Sandhu AK, Kaur G, Kaur GP, Athwal RS. Kandpal RP, et al. Cancer Genomics Proteomics. 2017 Mar-Apr;14(2):93-101. doi: 10.21873/cgp.20022. Cancer Genomics Proteomics. 2017. PMID: 28387649 Free PMC article. Review.
We herein describe strategies used for the construction of monochromosomal hybrids and their applications for cloning and characterization of genes related to cell growth, cell senescence and DNA repair. We have cloned RNaseT2, GluR6 (glutamate ionotropic receptor kainate …
We herein describe strategies used for the construction of monochromosomal hybrids and their applications for cloning and characterization o …
Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy.
Kettwig M, Ternka K, Wendland K, Krüger DM, Zampar S, Schob C, Franz J, Aich A, Winkler A, Sakib MS, Kaurani L, Epple R, Werner HB, Hakroush S, Kitz J, Prinz M, Bartok E, Hartmann G, Schröder S, Rehling P, Henneke M, Boretius S, Alia A, Wirths O, Fischer A, Stadelmann C, Nessler S, Gärtner J. Kettwig M, et al. Nat Commun. 2021 Nov 11;12(1):6530. doi: 10.1038/s41467-021-26880-x. Nat Commun. 2021. PMID: 34764281 Free PMC article.
Infantile-onset RNaseT2 deficient leukoencephalopathy is characterised by cystic brain lesions, multifocal white matter alterations, cerebral atrophy, and severe psychomotor impairment. ...Single nuclei RNA sequencing reveals homeostatic dysfunctions in glial cells and neu …
Infantile-onset RNaseT2 deficient leukoencephalopathy is characterised by cystic brain lesions, multifocal white matter alterations, …
54 results