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An update on the molecular pathogenesis and potential therapeutic targeting of AML with t(8;21)(q22;q22.1);RUNX1-RUNX1T1.
Al-Harbi S, Aljurf M, Mohty M, Almohareb F, Ahmed SOA. Al-Harbi S, et al. Blood Adv. 2020 Jan 14;4(1):229-238. doi: 10.1182/bloodadvances.2019000168. Blood Adv. 2020. PMID: 31935293 Free PMC article. Review.
Acute myeloid leukemia (AML) with t(8;21)(q22;q22.1);RUNX1-RUNX1T1, one of the core-binding factor leukemias, is one of the most common subtypes of AML with recurrent genetic abnormalities and is associated with a favorable outcome. The translocation leads to the fo …
Acute myeloid leukemia (AML) with t(8;21)(q22;q22.1);RUNX1-RUNX1T1, one of the core-binding factor leukemias, is one of the mo …
RUNX1T1 function in cell fate.
Hu N, Zou L, Wang C, Song G. Hu N, et al. Stem Cell Res Ther. 2022 Jul 28;13(1):369. doi: 10.1186/s13287-022-03074-w. Stem Cell Res Ther. 2022. PMID: 35902872 Free PMC article. Review.
RUNX1T1 (Runt-related transcription factor 1, translocated to 1), a myeloid translocation gene (MTG) family member, is usually investigated as part of the fusion protein RUNX1-RUNX1T1 for its role in acute myeloid leukemia. In the main, by recruiting histone deacety …
RUNX1T1 (Runt-related transcription factor 1, translocated to 1), a myeloid translocation gene (MTG) family member, is usually investigated …
The RUNX1/RUNX1T1 network: translating insights into therapeutic options.
Swart LE, Heidenreich O. Swart LE, et al. Exp Hematol. 2021 Feb;94:1-10. doi: 10.1016/j.exphem.2020.11.005. Epub 2020 Nov 17. Exp Hematol. 2021. PMID: 33217477 Free PMC article. Review.
RUNX1/RUNX1T1 is the most common fusion gene found in acute myeloid leukemia. Seminal contributions by many different research groups have revealed a complex regulatory network promoting leukemic self-renewal and propagation. Perturbation of RUNX1/RUNX1T1 …
RUNX1/RUNX1T1 is the most common fusion gene found in acute myeloid leukemia. Seminal contributions by many different research …
ASXL1/2 mutations and myeloid malignancies.
Medina EA, Delma CR, Yang FC. Medina EA, et al. J Hematol Oncol. 2022 Sep 6;15(1):127. doi: 10.1186/s13045-022-01336-x. J Hematol Oncol. 2022. PMID: 36068610 Free PMC article. Review.
ASXL1 mutations frequently occur in myeloid malignancies and are associated with a poor prognosis, whereas ASXL2 mutations frequently occur in AML with t(8;21)/RUNX1-RUNX1T1 and less frequently in other subtypes of myeloid malignancies. Herein, we review the …
ASXL1 mutations frequently occur in myeloid malignancies and are associated with a poor prognosis, whereas ASXL2 mutations frequently occur …
RUNX1::RUNX1T1 Positive Acute Myeloid Leukemia Secondary to Isolated Breast Myeloid Sarcoma: A Case Report and Literature Review.
Sang GR, Xu CL, Huang DP, Chen Y. Sang GR, et al. Ann Clin Lab Sci. 2025 May;55(3):443-448. Ann Clin Lab Sci. 2025. PMID: 40750233 Review.
CASE REPORT: We described one case of IMS that occurred in the breast in a 37-year-old female, who progressed to RUNX1::RUNX1T1 positive AML in less than two years. Then, she was treated with Venetoclax plus hypomethylating agents, which showed favorable response. . …
CASE REPORT: We described one case of IMS that occurred in the breast in a 37-year-old female, who progressed to RUNX1::RUNX1T1 …
Acute myeloid leukemia with a RUNX1-RUNX1T1 t(1;21;8)(q21;q22;q22) novel variant: a case report and review of the literature.
Kim H, Moon HW, Hur M, Yun YM, Lee MH. Kim H, et al. Acta Haematol. 2011;125(4):237-41. doi: 10.1159/000323425. Epub 2011 Feb 12. Acta Haematol. 2011. PMID: 21325813 Review.
Cytogenetic analysis revealed a karyotype of 46,XX,t(1;21;8)(q21;q22;q22), and fluorescence in situ hybridization confirmed a RUNX1-RUNX1T1 fusion signal on the derivative chromosome 8. After induction chemotherapy, the patient achieved complete remission and has be …
Cytogenetic analysis revealed a karyotype of 46,XX,t(1;21;8)(q21;q22;q22), and fluorescence in situ hybridization confirmed a RUNX1- …
[Genetic abnormalities in AML].
Nakajima H. Nakajima H. Rinsho Ketsueki. 2019;60(6):584-593. doi: 10.11406/rinketsu.60.584. Rinsho Ketsueki. 2019. PMID: 31281149 Review. Japanese.
Commonly observed chromosomal abnormalities in AML are t (8;21), t (15;17), inv (16), and 11q23-related translocations. These aberrations produce RUNX1-RUNX1T1, PML-RARA, CBF-MYH11, and MLL-fusion genes, respectively, which promote leukemic stem cell formation by in …
Commonly observed chromosomal abnormalities in AML are t (8;21), t (15;17), inv (16), and 11q23-related translocations. These aberrations pr …
[Two cases of systemic mastocytosis with RUNX1-RUNX1T1 positive acute myeloid leukemia treated with sequential avapritinib after allogeneic hematopoietic stem cell transplantation and literature review].
Wang J, Zu YL, Gui RR, Li Z, Zhang Y, Zhou J. Wang J, et al. Zhonghua Xue Ye Xue Za Zhi. 2024 May 14;45(5):505-508. doi: 10.3760/cma.j.cn121090-20240313-00092. Zhonghua Xue Ye Xue Za Zhi. 2024. PMID: 38964927 Free PMC article. Review. Chinese.
Systemic mastocytosis (SM) with RUNX1-RUNX1T1 positive acute myeloid leukemia (AML) is a rare myeloid tumor with no standard treatment. ...Mast cell in bone marrow disappeared, C-KIT mutation and RUNX1-RUNX1T1 fusion gene remained negative. Allo-HSCT s …
Systemic mastocytosis (SM) with RUNX1-RUNX1T1 positive acute myeloid leukemia (AML) is a rare myeloid tumor with no standard t …
Characterization of Acute Myeloid Leukemia With RUNX1/RUNX1T1 Gene Rearrangement: Clinical, Hematological, and Morphological Features.
Maqbool S, Maqbool I, Yousaf M, Farooqi B, Sikandar MZ, Zainab R, Bakht K, Shahid M. Maqbool S, et al. Cureus. 2024 Nov 29;16(11):e74760. doi: 10.7759/cureus.74760. eCollection 2024 Nov. Cureus. 2024. PMID: 39735012 Free PMC article.
OBJECTIVES: This study aimed to determine the frequency of RUNX1/RUNX1T1 gene rearrangement in acute myeloid leukemia (AML) patients by polymerase chain reaction (PCR) and analyze their clinical, hematological, and morphological features of positive patients. ...Twe …
OBJECTIVES: This study aimed to determine the frequency of RUNX1/RUNX1T1 gene rearrangement in acute myeloid leukemia (AML) pa …
47 results